Category: thiazole

924287-65-0, Methyl 2-bromo-4-fluorobenzo[d]thiazole-6-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,924287-65-0

To a 100 mL round-bottom flask purged with nitrogen was added (lR,3R,5S)-8- azabicyclo[3.2.1]octan-3-yl 5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-l,2-oxazole-4- carboxylate 14e (360 nig, 0,85 mmol, 1.0 equiv.), DMSO (10 mL), methyl 2-bromo-4-fluoro- l,3-benzothiazole-6-carboxylate Al (294 mg, 1.01 mmol, 1.2 equiv.), and CsF (389 mg, 3.0 equiv.). The resulting mixture was stirred overnight at 115 C and then ethyl acetate was added (100 mL). The resulting mixture was washed with brine (20 mL x 2), dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. The resulting residue was purified via silica gel chromatography eluting with ethyl acetate/petroleum ether (1 :2) to afford methyl 2- [(lR,3R,5S)-3-([5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-l,2-oxazol-4-yl]carbonyloxy)-8- azabicyclo[3.2.1]octan-8-yl]-4-fluoro-l ,3-benzothiazole-6-carboxylate 14f (440 mg, 82%) as a light yellow solid.

The synthetic route of 924287-65-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ARDELYX, INC.; CHAO, Jianhua; JAIN, Rakesh; HU, Lily; LEWIS, Jason Gustaf; BARIBAULT, Helene; CALDWELL, Jeremy; (249 pag.)WO2018/39384; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19759-66-1,2-Aminobenzothiazole-6-carbonitrile,as a common compound, the synthetic route is as follows.

19759-66-1, General procedure: A mixture of intermediate 4 (10 mmol), potassium carbonate (12 mmol) and various 2-aminobenzothiazoles (10 mmol) in acetone solvent (30 mL) was refluxed for 8 h. The progress of the reaction was monitored by TLC. After cooling to room temperature, the reaction mixture was treated with 200 mL cold water, and the resulting precipitate was filtered off. The crude products 5a-j were recrystallized from DMF.

As the paragraph descriping shows that 19759-66-1 is playing an increasingly important role.

Reference£º
Article; Patel, Amit B.; Raval, Rinku M.; Research on Chemical Intermediates; vol. 42; 3; (2016); p. 2163 – 2175;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55661-33-1,Thiazol-2-ylmethanamine,as a common compound, the synthetic route is as follows.,55661-33-1

Preparation of 3,5-di-tert-butyl-4-hydroxy-N-(1-(thiazol-2-ylmethylcarbamoyl)cyclopropyl)-benzamide; 1-(3,5-Di-tert-butyl-4-hydroxybenzamido)cyclopropanecarboxylic acid (100 mg, 0.3 mmol), thiazol-2-ylmethanamine (50 mg, 0.45 mmol), HATU (171 mg, 0.45 mmol) and DIPEA (0.15 mL, 0.9 mmol) were stirred in DCM at rt for 16 h. The organics were washed sequentially with saturated NaHCO3, 0.1 M HCl, dried (Na2SO4), concentrated in-vacuo and the residue purified by Biotage (5% MeOH/DCM) to give 3,5-di-tert-butyl-4-hydroxy-N-(1-(thiazol-2-ylmethylcarbamoyl)cyclopropyl)-benzamide (57 mg, 45.0%). MS: m/z=430.2 (calc’d for C23H31N3O3S 429.2).

As the paragraph descriping shows that 55661-33-1 is playing an increasingly important role.

Reference£º
Patent; Galemmo, JR., Robert; Holland, Richard; Hum, Gabriel; Pajouhesh, Hossein; Chahal, Navjot; Seid-Bagherzadeh, Mehran; Girard, Amy; US2009/270394; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.143577-46-2,(R)-Tetrahydro-3H-pyrrolo[1,2-c][1,2,3]oxathiazole 1,1-dioxide,as a common compound, the synthetic route is as follows.

To a solution of anhydrous THF (100 ml) containing compound 87 (3.42 g, 9.69 mmol) was added 3.9 ml n-Buli (2.5 M in hexane) dropwise (-78 C. under N2). After the addition, the resulting solution was stirred for 60 minutes at -78 C. At this temperature, a solution of 35 (1.58 g, 9.69 mmol) in 10 ml THF was added dropwise (5 minutes). After the addition of 35, the temperature was raised to -20 C. and the resulting solution was stirred for 2 hours. The mixture was allowed to warm to ambient temperature and stirred for another 2 hours.The reaction mixture was concentrated and the residue was dissolved in 40 ml 1N HCl, 40 ml EtOH and 40 ml THF. The mixture was stirred at 80 C. for 18 hours. The reaction mixture was concentrated in vacuo. MeOH (25 ml) was added and the mixture was concentrated on 25 g SiO2, Subsequent flash chromatography (MeOH/triethylamine (98/2) afforded the title compound: (R)-3-Pyrrolidin-2-ylmethyl-1H-pyrrolo[3,2-b]pyridine.(compound 88), (amorphous, 0.32 g, 0.72 mmol, 9.3%). 1H-NMR (400 MHz, CDCl3): delta 9.1 (bs, 1H), 8.42 (dd, J=5 Hz, 2 Hz, 1H), 7.58 (dd, J=8 Hz, 2 Hz, 1H), 7.20 (s, 1H), 7.06 (dd, J=8 Hz, 5 Hz, 1H), 3.59-3.51 (m, 1H), 3.14-3.02 (m, 2H), 2.97-2.85 (m, 2H), 2.0-1.90 (m, 1H), 1.86-1.71 (m, 2H), 1.54-1.43 (m, 1H). LCMS: Rt; 0.64 min, ([M+H]+=202). [alpha]D25-10 (c 1, dioxane).

143577-46-2, The synthetic route of 143577-46-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; STOIT, Axel; Coolen, Hein K.A.C.; Van Der Neut, Martina A. W.; Kruse, Cornelis G.; US2008/9514; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.185613-91-6,4-(Benzo[d][1,3]dioxol-5-yl)thiazol-2-amine,as a common compound, the synthetic route is as follows.

4-(Benzo[d] [1,3]dioxol-5-yl)thiazol-2-amine(2) (1.00 g, 4.54 mmol) and NaH (0.164 g, 6.82 mmol) to THF (15 ml) todissolved and then allowed to react at room temperature for 1 hour under a nitrogen stream. Then slowly added dropwise atroom temperature 3a(trifluoromethyl) benzyl bromide (1.63 g, 6.82 mmol) and allowed to react for 10 minutes. After thereaction was finished, it was concentrated under reduced pressure and extracted three times into a saturated solution ofNaHCO3 is dissolved in ethyl acetate. The ethyl acetate layer was separated and dried with anhydrous Na2SO4, then purifiedby column chromatography (Ethyl acetate: Hexane = 1: 5) to give the compound 1c to give. Yield 17.2%

185613-91-6, The synthetic route of 185613-91-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chungbuk National University Industry-Academic Cooperation Foundation; Jung, Jae Kyung; Kim, Young Soo; Lee, Hee Sun; (27 pag.)KR101651208; (2016); B1;,
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Thiazole | chemical compound | Britannica

41731-52-6, Ethyl 2-chlorothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 3-tert-butyl phenol (100 mg, 0.65 mmol) in dry THF (5 ml) was added potassium tert-butoxide (75 mg, 0.65 mmol) and the mixture was heated to reflux for 1 h. Upon cooling, the volatiles were removed in vacuo before the residue was taken up into dimethylsulf oxide (DMSO; 20 ml). Ethyl 2-chiorothiazole-4-carboxylate (prepared according to the procedure of T. R. Kelly and F. Lang, J. Org. Chem., 1996, 61 , 4623-4633; however in our EPO hands the material produced by this synthesis was a 2:1 mixture of the 2- chloro- and 5-chloro-thiazole-4-carboxylates; 130 mg, 0.67 mmol) was then added before the mixture was heated to 85 G for 16 h. Upon cooling the reaction mixture was partitioned between ethyl acetate (25 ml) and water (25 ml) and after rigorous shaking the aqueous later was separated and extracted further with ethyl acetate (3 x 25 ml). The combined organic phase was washed with brine (50 ml) and dried (MgSO4) before being concentrated in vacuo. The crude product was then purified by column chromatography (SiO2; 49:1 light petroleum-ethyl acetate to 19:1) to afford the title compound as a pale yellow oil (100 mg, 50 %). 1H NMR delta 8.20 (1 H, s), 7.20-7.27 (3 H, m), 7.01-7.05 (1 H, m), 4.31 (2 H, q), 1.31 (3 H, t) and 1.26 (9 H, s).

41731-52-6, As the paragraph descriping shows that 41731-52-6 is playing an increasingly important role.

Reference£º
Patent; PARADIGM THERAPEUTICS LTD.; WO2007/582; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55661-33-1,Thiazol-2-ylmethanamine,as a common compound, the synthetic route is as follows.

General procedure: 5.1.5 2-(1-(4-Fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide (7a) To a solution of 6a (2.00 g, 5.98 mmol), EDCI (1.50 g, 7.82 mmol) and iPr2NEt (2.67 mL, 15.64 mmol) in N,N-dimethylformamide (80 mL) was added HOBt (1.00 g, 7.40 mmol). The reaction mixture was stirred at ambient temperature for 15 min, followed by addition of 3-(aminomethyl)pyridine (0.73 mL, 7.16 mmol). After stirring for 17 h at ambient temperature, the reaction mixture was diluted with ethyl acetate (300 mL) and sequentially washed with water, saturated NaHCO3 solution, water and brine. The organic solution was dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated in vacuo, and the residue was crystallized from ethyl acetate and hexanes to yield 7a as an off-white solid (1.93 g, 76%), mp 178-180 C (ethyl acetate/hexanes); By a similar procedure as described for 7a, 7h was obtained as an off-white solid (0.17g, 66%). Mp 189-190C (ethyl acetate/hexanes); 1H NMR (300MHz, CDCl3) delta 8.25 (s, 1H), 7.74 (br s, 1H), 7.40-7.31 (m, 3H), 7.06-6.97 (m, 2H), 6.78 (t, J=5.4Hz, 1H), 4.97 (s, 2H), 4.92 (d, J=5.4Hz, 2H), 2.67 (s, 3H); MS (ES+) m/z 431.1 (M+1), 55661-33-1

55661-33-1 Thiazol-2-ylmethanamine 2756507, athiazole compound, is more and more widely used in various.

Reference£º
Article; Sun, Shaoyi; Zhang, Zaihui; Pokrovskaia, Natalia; Chowdhury, Sultan; Jia, Qi; Chang, Elaine; Khakh, Kuldip; Kwan, Rainbow; McLaren, David G.; Radomski, Chris C.; Ratkay, Leslie G.; Fu, Jianmin; Dales, Natalie A.; Winther, Michael D.; Bioorganic and Medicinal Chemistry; vol. 23; 3; (2015); p. 455 – 465;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2942-23-6,2,7-Dichlorobenzo[d]thiazole,as a common compound, the synthetic route is as follows.

In a nitrogen atmosphere 2,7-dichlorobenzo[d]thiazole (10.0 g, 49.3mmol) and (9-phenyl-9H-carbazol-3-yl)boronic acid(28.3 g, 98.6 mmol) was added to 300 ml of dioxane, stirred and refluxed. Then potassium carbonate (27.2 g, 197.1 mmol)Was dissolved in 50 ml of water and stirred sufficiently, followed by bis(tri-tertiary-butylphosphine)palladium (1.0 g, 4 mol%) Was added. After the reaction for 12 hours, the temperature was reduced to room temperature, the organic layer and the water layer were separated, and then the organic layer was distilled under reduced pressure.After distillate was extracted with chloroform and water, the organic layer was dried using magnesium sulfate. After drying the organic layer, compound 1 (13.4 g, 44%) was prepared through recrystallization of ethyl acetate., 2942-23-6

The synthetic route of 2942-23-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; LG Chem, Ltd.; Jeong Min-u; Lee Dong-hun; Jang Bun-jae; Lee Jeong-ha; Han Su-jin; Park Seul-chan; Hwang Seong-hyeon; (37 pag.)KR2020/6503; (2020); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

55661-33-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55661-33-1,Thiazol-2-ylmethanamine,as a common compound, the synthetic route is as follows.

Example 3; 2-(2-oxo-3,3-diphenylpyrrolidin-l-yl)-7V-(l,3-thiazol-2-ylmethyl)acetamide; N1-((ethylimino)methylene)-Lambda/3,Lambda/3-dimethylpropane-l ,3-diamine hydrochloride(0.049 g, 0.254 mmol) , 2-(2-oxo-3,3-diphenylpyrrolidin-l-yl)acetic acid (Example 1C, 0.050 g, 0.169 mmol) and thiazol-2-ylmethanamine (0.021 g, 0.186 mmol) were combined and stirred together in dichloromethane (0.5 mL) at room temperature. After stirring overnight, the reaction was loaded directly onto a SF 15- 12 silica gel column (Analogix, Burlington, WI), and the title compound was eluted using a gradient of 5% to 100% ethyl acetate/hexanes over 20 minutes (flow = 30 mL/minute). 1H NMR (300 MHz, CDCl3) delta ppm 7.69 (d, J= 3.3 Hz, 1 H), 7.19-7.38 (m, 11 H), 6.77 (t, J= 5.8 Hz, 1 H), 4.67 (d, J= 5.8 Hz, 2 H), 4.09 (s, 2 H), 3.53 (t, J= 6.5 Hz, 2 H), 2.84 (t, J= 6.5 Hz, 2H); MS (ESI+) m/z 392 (M+H)+.

55661-33-1 Thiazol-2-ylmethanamine 2756507, athiazole compound, is more and more widely used in various.

Reference£º
Patent; ABBOTT LABORATORIES; BHATIA, Pramila, A.; DOHERTY, George, A.; DRIZIN, Irene; MACK, Helmut; PERNER, Richard, J.; STEWART, Andrew, O.; ZHANG, Qing Wei; WO2010/39947; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29927-08-0,5,6-Dimethylbenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

General procedure: To the solution of beta-naphthol (1mmol) in methanol were added respective substituted 2-aminobenzothiazole (1mmol) and the synthesized pyrazole aldehyde31 (1mmol). The reaction mixture was refluxed for 5h. The reaction was monitored by TLC and the advantage of this method is that a solid product (white ppt) was formed in the round bottom flask after completion of the reaction. The solid compound was collected by filtration and purified by column chromatography to obtain pure pyrazole linked benzothiazole-beta-naphthol derivatives in good to excellent yields., 29927-08-0

The synthetic route of 29927-08-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Nagaraju, Burri; Kovvuri, Jeshma; Kumar, C. Ganesh; Routhu, Sunitha Rani; Shareef, Md. Adil; Kadagathur, Manasa; Adiyala, Praveen Reddy; Alavala, Sateesh; Nagesh, Narayana; Kamal, Ahmed; Bioorganic and Medicinal Chemistry; vol. 27; 5; (2019); p. 708 – 720;,
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Thiazole | chemical compound | Britannica