Category: thiazole

Ichihara, Osamu published the artcileDevelopment of self-indicating resin, Computed Properties of 92-36-4, the publication is Combinatorial Chemistry & High Throughput Screening (2007), 10(4), 261-267, database is CAplus and MEDLINE.

The development and application of self-indicating resins (SIR), materials which can indicate the presence or absence of amines in the reaction solution by the conspicuous color change of a phenolsulfophthalein type dye immobilized on resin beads has been reported. Although the functionality necessary for attaching the dye to the resins could be readily introduced by the Suzuki-Miyaura coupling during the synthesis of the SIR, this approach was only applicable to the dyes containing suitable functionality for the cross-coupling reaction. A new approach to immobilizing the indicating dyes onto the resin support is now reported. The dyes suitable for loading onto aminomethyl polystyrene (PS) resin were prepared by Friedel-Crafts reaction of 2-sulfoterephthalic anhydride with a wide range of phenols. Using this new route, polymer-supported dye I was readily prepared in >100g quantities. Use of I in the synthesis of a 144 member urea library was demonstrated and the SIR successfully indicated the endpoint of the reaction between amines and isocyanates.

Combinatorial Chemistry & High Throughput Screening published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Computed Properties of 92-36-4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Artem’ev, Alexander V. published the artcileCuI-based coordination polymers with 2-thiazolyl sulfide ligands: First examples, COA of Formula: C4H5NS2, the publication is Polyhedron (2018), 171-176, database is CAplus.

The reaction of CuI with 2-(methylthio)thiazole (MTT) in a 1:1 or 2:1 molar ratio (MeCN, rt, 1h) leads to the coordination polymer [CuI(MTT)]_n (CP1) or [(CuI)₂(MTT)]_n (CP2), resp. CP1 consists of (-Cu-I-Cu-I-)_n zigzag chains wherein the adjacent Cu atoms are bridged by the MTT ligand through the thiazole N and sulfide S atoms. 1-D chains of CP2 are assembled from corner-sharing [CuI₃N] and [CuI₃S] tetrahedra, which alternate in a zigzag fashion. By contrast, 2-(methylthio)benzothiazole (MTBT) reacts with CuI, regardless of the reactants ratio, to give the dinuclear complex [Cu₂I₂(MTBT)₂], where the planar [Cu(μ₂-I)]₂ core is supported by the two ligands in the N-monodentate manner. At ambient temperature, CP1 exhibits a weak yellow luminescence (λ_max=570nm), while CP2 emits in the deep-red region (λ_max=705nm).

Polyhedron published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C4H5NS2, COA of Formula: C4H5NS2.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Rogovoy, Maxim I. published the artcileSelf-assembly of Ag(I)-based complexes and layered coordination polymers bridged by (2-thiazolyl)sulfides, COA of Formula: C4H5NS2, the publication is Inorganica Chimica Acta (2019), 19-26, database is CAplus.

Dinuclear complex, [Ag₂(2-Mt)₂(MeCN)₂(NO₃)₂] (1) as well as layered (2D) coordination polymers (CPs), [Ag₂(2-Mt)₂(NO₃)₂]_n (2) and [Ag₄(2-Mt)₄(NO₃)₄·2H₂O]_n (3), are self-assembled from 2-(methylthio)thiazole (2-Mt) and AgNO₃ under different conditions. These compounds contain a [Ag₂(2-Mt)₂] unit consisting of two metal atoms bridged by 2-Mt ligands (μ₂-N,S) in head-to-tail (for 1 and 2) and head-to-head (for 3) manner. 2-(Methylthio)benzothiazole (2-Mbt) reacts with AgNO₃ to assemble complex [Ag₂(2-Mbt)₂(MeCN)₂(NO₃)₂] (4), showing interesting dual emission behavior associated with the presence of fluorescence and phosphorescence, contributions of which depends on the excitation wavelength.

Inorganica Chimica Acta published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C4H5NS2, COA of Formula: C4H5NS2.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Horn, Christoph published the artcileChemical design of hydrogels with immobilized laccase for the reduction of persistent trace compounds in wastewater, Computed Properties of 30931-67-0, the publication is ACS Applied Polymer Materials (2021), 3(5), 2823-2834, database is CAplus.

Hydrogels with immobilized enzymes are increasingly applied in biocatalytic industrial processes. Here, polymer hydrogels containing 2-hydroxyethyl methacrylate (HEMA), itaconic acid (ITA), (2-((2-(ethoxycarbonyl)prop-2-en-1-yl)oxy)ethyl) phosphonic acid (ECPPA), and N,N′-diethyl-1,3-bis(acrylamido)propane (BAAP) as the cross-linker are synthesized by UV-initiated radical polymerization Laccase from Trametes versicolor (LAC) is modified by reaction with itaconic anhydride (ITAn) yielding the LAC-immobilized monomer ITA-LAC with enhanced enzyme activity. ITA-LAC paves the way to an in situ method for enzyme immobilization. Hydrogels with HEMA, ECPPA, and BAAP with stepwise varied chem. composition and functionalization are prepared The influence of the composition on the morphol., the swelling behavior, the mech. stability, and the enzymic activity is studied. The polymerization is monitored by the conversion of double bonds with in situ attenuated total reflection Fourier transform IR (ATR-FTIR) spectroscopy. The polymerization of HEMA is complete after 10 min of UV exposure, whereas hydrogels of HEMA/ITA/ECPPA (85/5/10) with 5 mol % cross-linker require 30 min. These hydrogels are compared with those containing ITA-LAC instead of ITA. The covalent binding of LAC is proven by ATR-FTIR spectroscopy and results in an enhanced enzyme activity. The incorporation of ECPPA induces pH-dependent swelling with an equilibrium degree of swelling of up to 6 at pH 8. Only a weak influence of temperature on the degree of swelling is found. The morphol. strongly depends on the hydrogel composition LAC-ITA hydrogels are characterized by an open morphol. providing access to catalytic centers. The enzyme-immobilized hydrogels are used as granules as well as coatings on porous Al₂O₃ ceramic substrates as biocatalysts to convert models for organic trace compounds [bisphenol A (BPA), diclofenac, p-chlorophenol (pCP), 17α-ethinylestradiol (EED), triclosan, paracetamol, and 4-tert-octylphenol]. The highest conversion after 24 h in water is achieved for triclosan (>90%), while pCP, BPA, and EED reach a conversion between 60% and 70%. The conversions are even higher in citrate buffer.

ACS Applied Polymer Materials published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, Computed Properties of 30931-67-0.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Sillero, Leyre published the artcileExtraction of flavonoid compounds from bark using sustainable deep eutectic solvents, Application In Synthesis of 30931-67-0, the publication is Sustainable Chemistry and Pharmacy (2021), 100544, database is CAplus.

The use of green solvents in extraction processes, especially for applications of lignocellulosic biomass, has been extensively studied over the last years. Among the range of different green solvents, deep eutectic solvents (DES) show promising results for extraction processes. Therefore, the aim of this work was the use of DES as additives in aqueous mixtures for the selective extraction of flavonoid compounds from the bark of Larix decidua. For this purpose, bark has been treated using different solvent ratios consisting of a DES/H2O mixture (0, 25, 50 and 75 wt%). Two DES were studied, choline chloride:urea and choline chloride:1,4-butanediol. In order to study the success of the extractions, the extracts and the remaining solid fraction were characterized. From the results, it was concluded that the choline chloride:1,4-butanediol (75 wt%) gave the best results, obtaining the richest extracts in flavonoids (383 mg CE/g dried bark extract), as well as those with the highest antioxidant capacity. These good results confirm the capacity of this DES to obtain active biomols. for further application.

Sustainable Chemistry and Pharmacy published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C24H12, Application In Synthesis of 30931-67-0.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Pan, Zi-Tong published the artcileRegulable cross-coupling of alcohols and benzothiazoles via a noble-metal-free photocatalyst under visible light, Recommanded Product: 6-Chlorobenzothiazol-2-ylamine, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(63), 8810-8813, database is CAplus and MEDLINE.

Two series of alkyl-derived benzothiazoles I [R = Et, iPr, cyclohexyl, etc.; R¹ = H, 4-Cl, 7-Br, etc.] and acetyl-derived benzothiazoles II [R² = Me, Et, n-Bu, etc.; R³ = H, 4-Cl, 6-Br, etc.] were synthesized via noble-metal-free photocatalyzed regulable cross-coupling reaction of benzothiazoles and alcs. with the highest isolated yields of up to 99% and 90% resp.

Chemical Communications (Cambridge, United Kingdom) published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, Recommanded Product: 6-Chlorobenzothiazol-2-ylamine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Capaldo, Luca published the artcilePhotoelectrochemical cross-dehydrogenative coupling of benzothiazoles with strong aliphatic C-H bonds, HPLC of Formula: 95-24-9, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(36), 4424-4427, database is CAplus and MEDLINE.

A photoelectrochem. strategy for the cross-dehydrogenative coupling of unactivated aliphatic H donors (e.g. alkanes) with benzothiazoles is reported. The authors used Bu₄N decatungstate as the photocatalyst to activate strong C(sp³)-H bonds in the chosen substrates, while electrochem. scavenged the extra electrons.

Chemical Communications (Cambridge, United Kingdom) published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, HPLC of Formula: 95-24-9.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Buckley, Dennis L. published the artcileHaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins, Formula: C11H8N2OS, the publication is ACS Chemical Biology (2015), 10(8), 1831-1837, database is CAplus and MEDLINE.

Small mol.-induced protein degradation is an attractive strategy for the development of chem. probes. One method for inducing targeted protein degradation involves the use of PROTACs, heterobifunctional mols. that can recruit specific E3 ligases to a desired protein of interest. PROTACs have been successfully used to degrade numerous proteins in cells, but the peptidic E3 ligase ligands used in previous PROTACs have hindered their development into more mature chem. probes or therapeutics. The authors report the design of a novel class of PROTACs that incorporate small mol. VHL ligands to successfully degrade HaloTag7 fusion proteins. These HaloPROTACs will inspire the development of future PROTACs with more drug-like properties. Addnl., these HaloPROTACs are useful chem. genetic tools, due to their ability to chem. knock down widely used HaloTag7 fusion proteins in a general fashion.

ACS Chemical Biology published new progress about 1448190-10-0. 1448190-10-0 belongs to thiazole, auxiliary class Thiazoles, name is 2-Hydroxy-4-(4-methylthiazol-5-yl)benzonitrile, and the molecular formula is C11H8N2OS, Formula: C11H8N2OS.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Mallikarjun, G. published the artcileSynthesis and antimicrobial evaluation of benzothiazole linked isoxazole Schiff bases, Category: thiazole, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (2021), 60B(11), 1463-1470, database is CAplus.

A new series of benzothiazole linked isoxazole Schiff base derivatives have been prepared I [R = R¹ = H, OMe, RR¹ = -OCH₂O-, R² = H, OMe; R³ = 5-Cl, 4-OMe, 6-CF₃, etc.] characterized by suitable spectroscopic methods via ¹H and ¹³C NMR, ESI-MS and IR spectra. These compounds have been further screened for their antimicrobial activity against a panel of microorganisms. Among them, compounds [R = R¹ = OMe, R² = H, R³ = 6-Me (II); R = H, R¹ = OMe, R² = H, R³ = 6-OMe (III); R = R¹ = R² = OMe, R³ = 6-F (IV)] demonstrate promising antimicrobial activity against all the tested strains with MIC values ranging between 3.9 – 62.5μg/mL. Further, compounds II, III and IV exhibit promising antifungal activity with MIC values ranging between 7.8 – 32.5μg/mL. Further studies are underway for determining the antifungal mol. mechanisms of these potential compounds

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, Category: thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Samei, Amit published the artcileSimultaneous estimation of related impurities of tizanidine hydrochloride in its active pharmaceutical ingredient by reversed-phase liquid chromatography, Recommanded Product: 5-Chlorobenzo[c][1,2,5]thiadiazol-4-amine, the publication is Asian Journal of Chemistry (2009), 21(1), 176-182, database is CAplus.

A simple method was developed for qual. and quant. estimation of tizanidine hydrochloride and its 5 structurally related impurities using a reversed-phase liquid chromatog. This method was validated as per ICH guidelines for ‘validation for anal. procedures’ Q2B. The liquid chromatog. was set up in UV detection mode at 310 nm. A separation was achieved between tizanidine and all 5 impurities in a gradient programming using YMC Pack Pro C₁₈ (250 mm × 4.6 mm), 5 μ column at 1 mL/min flow rate. This method was established to be linear in a concentration range of (0.5-4.0 μg/mL) for all the components considered in this study. Limit of detection (LOD) and limit of quantification (LOQ) values were found to be (0.1-0.15 μg/mL) and (0.3-0.45 μg/mL) for tizanidine hydrochloride and its 5 related impurities, resp. Recoveries of all spiked impurities in tizanidine hydrochloride were in a range of (95-105%). Robustness and sample solution stability studies demonstrated the ruggedness of this method. This method is simple, sensitive and provides precisely accurate results.

Asian Journal of Chemistry published new progress about 30536-19-7. 30536-19-7 belongs to thiazole, auxiliary class Other Aromatic Heterocyclic,Chloride,Amine, name is 5-Chlorobenzo[c][1,2,5]thiadiazol-4-amine, and the molecular formula is C6H4ClN3S, Recommanded Product: 5-Chlorobenzo[c][1,2,5]thiadiazol-4-amine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica