Category: thiazole

24295-03-2, 2-Acetylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 7 2-(2-Thiazolyl)-1,8-naphthyridine 2-Aminonicotinaldehyde (1.5 g, 12.3 mmol) and 2-acetylthiazole (1.64 g, 12.9 mmol) are dissolved in 12 ml of MeOH and the mixture is treated with 1.5 ml of 40% KOH. After 3 h, the reaction is complete and the mixture is poured onto water. The solid which is deposited is filtered off with suction, washed and dried. 1.22 g (yield 46%) of the desired product are obtained. M.p. 160-165 C., 24295-03-2

The synthetic route of 24295-03-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BASF Aktiengesellschaft; US5723413; (1998); A;,
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61296-22-8, 2-Amino-5-bromothiazole monohydrobromide is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

61296-22-8, 5-Thiocyanatothiazol-2-amine (Compound 0107) A mixture of 2-amino-5-bromothiazole hydrobromide (0106, 53.0 g, 0.204 mol) and potassium thiocyanate (78.5 g, 0.808 mol) in methanol (1.4 L) was stirred at room temperature for 20 h. Methanol was evaporated and water (180 ml) was added. The pH of the aqueous solution was adjusted to pH=12 with 10% NaOH and precipitate formed. The solid was collected by filtration to yield compound 0107 (14.0 g, 44%) as a brownish solid: LCMS: 157 [M+l]+.

As the paragraph descriping shows that 61296-22-8 is playing an increasingly important role.

Reference£º
Patent; CURIS, INC.; QIAN, Changgeng; CAI, Xiong; ZHAI, Haixiao; WO2010/75542; (2010); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2289-75-0,4,5-Dimethylthiazol-2-amine,as a common compound, the synthetic route is as follows.

A mixture of 4,5-dimethylthiazol-2-ylamine (1.0 g, 7.8 mmol) and (2-bromo-ethoxy)benzene (1.9 g, 9.4 mmol) were heated neat to 85 0C for 19 hours. The mixture was cooled to ambient temperature and the residue was crystallized from isopropanol. The solid was collected by filtration and dried under vacuum to afford 1.3 g (50%) of the title compound. MS (DCIZNH3) mZz 249 (M+H)+, 2289-75-0

2289-75-0 4,5-Dimethylthiazol-2-amine 73238, athiazole compound, is more and more widely used in various.

Reference£º
Patent; ABBOTT LABORATORIES; WO2009/67613; (2009); A1;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19654-14-9,2-(3-Bromophenyl)benzothiazole,as a common compound, the synthetic route is as follows.

Intermediate 6 (10.4 g, 35.8 mmol), intermediate 7 (9.20 g, 39.3 mmol), a mixed solution of toluene / ethanol (2: 1, 195 mL), aqueous tripotassium phosphate (2.0 M, ) Were sequentially added, and nitrogen bubbling was carried out for 30 minutes.Pd (PPh 3) 4 (1.00 g, 0.87 mmol) was added thereto, and the mixture was stirred for 3 hours while heating under reflux. After returning to room temperature, distilled water was added and extraction was carried out using toluene.The organic layer was washed with a saturated aqueous sodium chloride solution, dried over magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was subjected to silica gel column chromatography to give Intermediate 8 (13.6 g, yield 95%). Intermediate 6 was synthesized by referring to the method described in International Publication No. 2015/087961., 19654-14-9

As the paragraph descriping shows that 19654-14-9 is playing an increasingly important role.

Reference£º
Patent; MITSUBISHI CHEMICAL CORPORATION; KOMATSU, HIDEJI; ISHIBASHI, KOICHI; NAGAYAMA, KAZUHIRO; (41 pag.)JP2018/58797; (2018); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1003-60-7,2-Methylthiazole-5-carbaldehyde,as a common compound, the synthetic route is as follows.

(a) An aqueous solution of 2% sodium hydroxide (3 ml) was added to a solution of 2-methyl-thiazole-5-carboxaldehyde (2.5 g) in acetone (20 ml) and water (10 ml). The mixture was stirred for 24 hours at ambient temperature, diluted with water (150 ml) and extracted with chloroform (2*50 ml). The organic layer was washed with water then dried over anhydrous magnesium sulphate and filtered. Evaporation of the solvent gave 1-(2-methyl-5-thiazolyl)but-1-en-3-one as a low-melting point solid (1.4 g, 43%). Pmr spectrum (CDCl3; delta in ppm): 2.30 (3H,s); 2.72 (3H,s); 6.36 (1H,d); 7.56 (1H,d); 7.74 (1H,s).

1003-60-7, 1003-60-7 2-Methylthiazole-5-carbaldehyde 13934728, athiazole compound, is more and more widely used in various.

Reference£º
Patent; ICI Australia Limited; US4604132; (1986); A;,
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Thiazole | chemical compound | Britannica

1452-15-9, 4-Cyanothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The mixture was heated to distill off 130 ml of 1-butanol+water. When the pot temperature reached about 70 C., all of the o-phenylenediamine monohydrochloride salt was in solution. When half (~65 ml) of the 1-butanol+water has been distilled, 55 g (0.5 mole) of 4-cyanothiazole were added to the reaction flask and a water scrubber (200 ml of water) was added to the exit of the condenser. After a total of 130 ml of 1-butanol+water was distilled, which took about 40 minutes, the Dean-Stark trap was removed from the system. During the removal of 1-butanol+water, the temperature of the reaction mixture rose to 115 C. As the reaction progressed the reflux temperature gradually decreased to 110 C. from an initial reflux temperature of 115 C. Thiabendazole formed during refluxing as a precipitate., 1452-15-9

1452-15-9 4-Cyanothiazole 15069, athiazole compound, is more and more widely used in various.

Reference£º
Patent; E. I. Du Pont de Nemours and Company; US5310923; (1994); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.80945-83-1,2-Chlorobenzothiazole-6-carbonitrile,as a common compound, the synthetic route is as follows.

80945-83-1, Step 1 : 2-(4-(2-chloro-4-((5-cvclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-4- hvdroxypiperidin-1-yl)benzo[d]thiazole-6-carbonitrile To a sealed tube equipped with a magnetic stirring bar, 4-(2-chloro-4-((5-cyclopropyl-3-(2,6- dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)piperidin-4-ol hydrochloride (General synthesis 4, step 2) (100 mg, 0.19 mmol), 2-chlorobenzo[d]thiazole-6-carbonitrile (54.1 mg, 0.23 mmol), potassium carbonate (234 mg, 3.8 mmol) and DMF ( 2 mL) were added. The tube was sealed and the mixture was heated at 80 ¡ãC for 40 minutes. Water (20 mL) was added and the resulting mixture was extracted with EtOAc (50 mL X 3), the combined organic phases were washed with brine (20 mL), dried over Na2S04, filtered, and concentrated in vacuo. Silica gel column chromatography gave the desired product (37 mg, 30percent yield).

The synthetic route of 80945-83-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GILEAD SCIENCES, INC.; KINZEL, Olaf; KREMOSER, Claus; BLOMGREN, Peter, A.; CURRIE, Kevin, S.; KROPF, Jeffrey, E.; SCHMITT, Aaron; WATKINS, William, J.; XU, Jianjun; GEGE, Christian; (92 pag.)WO2016/96116; (2016); A1;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5198-88-9,2-Bromothiazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.,5198-88-9

a) Preparation of Intermediate V.1 N-[2-(Aminocarbonyl)phenyl]-2-bromo-4-thiazolecarboxamide (Intermediate V.1) 2-Bromo-4-thiazolecarboxylic acid (1 g), HATU (2.01 g) and 2-aminobenz-amide (0.65 g) are introduced into N,N-dimethylformamide (DMF) (20 ml). The mixture is cooled with an ice bath, and N,N-diisopropylethylamine (0.90 ml) is added. The reaction mixture is stirred at room temperature for 6 days, poured into ice-water and allowed to thaw with stirring, and the precipitated solid is filtered off with suction, washed twice with water, twice with diethyl ether and dried in vacuo. Intermediate V.1 is obtained as a solid (1.4 g). C11H8BrN3O2S, M=326.2. 1H-NMR (300 MHz, D6-DMSO): delta=7.20 (m, 1H), 7.56 (m, 1H), 7.79 (s, 1H), 7.84 (m, 1H), 8.30 (s, 1H), 8.47 (m, 1H), 8.67 (m, 1H), 12.9 (s, 1H).

As the paragraph descriping shows that 5198-88-9 is playing an increasingly important role.

Reference£º
Patent; Ulrich, BOTHE; Arne, Von Bonin; Duy, Nguyen; Ulf, Bomer; Judith, Guenther; US2009/163486; (2009); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34272-64-5,2-(4-Methyl-2-thioxo-2,3-dihydrothiazol-5-yl)acetic acid,as a common compound, the synthetic route is as follows.

EXAMPLE 172 7-beta-Amino-3-(5-carboxymethyl-4-methyl-1,3-thiazol-2-yl-thiomethyl)-ceph-3-em-4-carboxylic acid 2.7 g (0.01 mole) of 7-aminocephalosporanic acid and 1.9 g (0.01 mole) of 5-carboxymethyl-2-mercapto-4-methyl-1,3-thiazole are suspended in 250 ml of water. Sodium bicarbonate is added until a clear solution has formed. The reaction solution is heated to 50 C. for 4 hours, whilst keeping the pH value constant at the neutral point. The solution is allowed to cool and is extracted several times with ethyl acetate and the aqueous phase is adjusted to a pH value of 2 with 2 N HCl. The precipitate is filtered off, washed several times with alcohol and ether and dried. 3.7 g of the title compound of melting point 195-196 C. (decomposition) are obtained. NMR (d6 -DMSO, 60 MHz): delta=2.17 ppm (s, 3H, =C–CH3), delta=3.52 ppm (AB, 2H, 2–CH2 –), delta=3.68 ppm (s, 2H, =C–CH2 –COO–) delta=4.31 ppm (AB, 2H, 3–CH2 –S–) and delta=4.80 ppm (m, 2H, 6–CH–+7–CH–)., 34272-64-5

As the paragraph descriping shows that 34272-64-5 is playing an increasingly important role.

Reference£º
Patent; Hoechst Aktiengesellschaft; US4278793; (1981); A;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.67899-00-7,2-Amino-4-methylthiazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: The suspension of acid (2.00 mmol) in DMF (10 mL) was cooled to 0 C in an ice bath. N-methylmorpholine (0.49 mL, 4.40 mmol) and TBTU (0.84 g, 2.60 mmol) were added, and the reaction mixture was stirred at 0 C for 0.5 h. Then it was allowed to reach room temperature, and amine (2.00 mmol) was added to the solution.The reaction mixture was stirred overnight at room temperature, after which the solvent was evaporated under reduced pressure.The residue was dissolved in ethyl acetate (40 mL) and washed witha saturated aqueous solution of NaHCO3 (3 x 20 mL), 10% citric acid(3 x 20 mL) and brine (20 mL). The organic phase was dried over Na2SO4, and filtered, and the solvent was removed under reduced pressure. The crude product was purified by crystallization or flash column chromatography., 67899-00-7

67899-00-7 2-Amino-4-methylthiazole-5-carboxylic acid 832243, athiazole compound, is more and more widely used in various.

Reference£º
Article; ?kedelj, Veronika; Perdih, Andrej; Brvar, Matja?; Krofli?, Ana; Dubbee, Vincent; Savage, Victoria; O’Neill, Alex J.; Solmajer, Tom; Be?ter-Roga?, Marija; Blanot, Didier; Hugonnet, Jean-Emmanuel; Magnet, Sophie; Arthur, Michel; Mainardi, Jean-Luc; Stojan, Jure; Zega, Anamarija; European Journal of Medicinal Chemistry; vol. 67; (2013); p. 208 – 220;,
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Thiazole | chemical compound | Britannica