Category: thiazole

21344-90-1, 4-(2-Chlorophenyl)thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

276A N-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]-4-propylbenzenesulfonamide The title compound was prepared from 4-(2-chlorophenyl)-1,3-thiazol-2-amine and 4-n-propylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (30.9 mg) with purity >90percent. MS (pos) m/z 393.1.

21344-90-1, As the paragraph descriping shows that 21344-90-1 is playing an increasingly important role.

Reference£º
Patent; Kurz, Guido; Nilsson, Marianne; US2003/166689; (2003); A1;,
Thiazole | C3H3NS – PubChem
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160844-75-7, Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 5:Preparation of febuxostat2-(3-Cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester (100 gm) was dissolved in ethanol (500 ml) at room temperature and then added a solution of sodium hydroxide (13 gm) in water. (250 ml) slowly for 30 minutes. The contents were heated to 65C and maintained for 1 hour. The reaction mass was then cooled to 50C and pH of the reaction mass was adjusted to 2.0 with hydrochloric acid solution (15%). The reaction mass was stirred for 15 minutes at 50C and then cooled to room temperature. The contents were maintained for 3 hours at room temperature and filtered. The solid thus obtained was dissolved in ethanol (500 ml) and then heated to 60C. The reaction mass was treated with carbon at 60C and filtered. The filtrate obtained was then cooled to room temperature and stirred for 2 hours. The reaction mass was further cooled to 10C and maintained for 1 hour. The solid obtained was collected by filtration and washed with chilled ethanol to obtain a wet solid. To the wet solid was added a mixture of ethanol and water (9: 1 ; 500 ml) at room temperature and then heated to 60C to obtain a solution. The solution was stirred for 30 minutes at 60C and then cooled to 25C. The reaction mass was maintained for 1 hour at 25C and the mass was further cooled to 10C. The solid obtained was collected by filtration and dried with vacuum sucking for 15 minutes to obtain 65 gm of febuxostat., 160844-75-7

160844-75-7 Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate 9884549, athiazole compound, is more and more widely used in various.

Reference£º
Patent; HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; MURALIDHARA REDDY, Dasari; RAMAKRISHNA REDDY, Matta; VAMSI KRISHNA, Bandi; WO2012/168948; (2012); A2;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3034-55-7,5-Bromothiazole,as a common compound, the synthetic route is as follows.

A solution containing 300 mg of 16h, 180 mul of 5-Br-thiazole, 350 mul of diisopropyl amine, 21mg of PdCl2(benzonitrile)2, 250 mul of IM tri-te/t-butyl phosphine (in toluene), 12 mg of CuI in 2 ml of degassed dioxane was stirred overnight at RT under a N2 atmosphere. The mixture was poured onto 5% aq. NH4CI and extracted with ethyl acetate. The extract was dried, concentrated and the crude material was purified by chromatography over silica gel, using a gradient of heptane/ethyl acetate as eluent. This afforded 320 mg 16i as a colorless oil. Rf 0.45 (heptane/ethyl acetate 1/1). MS-ESI: [M+l] 337.17NMR (CDCl3) delta 8.64 and 7.88 (2x s, 2, thiazole H), 1.40 (m, 2, CH2), 1.48 (s, 9, tertC49), 1.64 (m, 4, 2x CH2), 2.46 (t, 2, CH2), 3.20 (m, 2, CH2), 3.83 (s, 3, OCH3).

3034-55-7, As the paragraph descriping shows that 3034-55-7 is playing an increasingly important role.

Reference£º
Patent; N.V. ORGANON; LOOZEN, Hubert, Jan, Jozef; TIMMERS, Cornelis, Marius; STOCK, Herman, Thijs; WO2011/12600; (2011); A1;,
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161798-01-2, Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example-2 Preparation of Ethyl-2-(3-cyano-4-hydroxyphenyl)-4-methyl thiozole-5-carboxylate A mixture of 10.0 g of Ethyl-2-(3-formyl-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate and 2.85 g of hydroxylamine hydrochloride were stirred for 30 minutes in 30 g of Dimethylformamide. To this reaction mixture 3.3 grams of acetyl chloride was added and stirred at 90¡ã C. for 2-3 hours. Reaction mass was cooled to room temperature and diluted with 100 ml of water and stir for 2 hours. The reaction mass was filtered and washed with purified water to give 10.0 g of Ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate (yield 99.0percent)., 161798-01-2

161798-01-2 Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate 135404723, athiazole compound, is more and more widely used in various.

Reference£º
Patent; Vellanki, Siva Rama Prasad; Sahu, Arabinda; Raavi, Satyanarayana; Nuchu, Ravi; Dandala, Ramesh; US2013/303780; (2013); A1;,
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5198-88-9,5198-88-9, 2-Bromothiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 5Preparation of Compound 5To a solution of 2-bromo-thiazole-5-carboxylic acid (0.050 mmol, 10 mg), lambda/,lambda/-diisopropylethylamine (0.20 mmol, 26 mg) and HATU (0.050 mmol, 19 mg) in DMF (1 ml_) was added 4-(2-aminophenyl)-piperazine-1-carboxylic acid tert-butyl ester (0.10 mmol, 28 mg). The resulting reaction was heated to 80 0C and allowed to stir at this temperature for 15 hours, after which time the reaction mixture was cooled to room temperature and concentrated in vacuo. The resulting residue was reacted with TFA (0.5 ml_) for 10 minutes. The TFA solution was then concentrated in vacuo Xo provide a crude residue which was purified using reverse phase HPLC to provide Compound 5.

The synthetic route of 5198-88-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SCHERING CORPORATION; WO2008/54702; (2008); A1;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.399-74-6,2-Chloro-6-fluorobenzo[d]thiazole,as a common compound, the synthetic route is as follows.

General procedure: Examples 103 and 104: N-i4,4-Difluoro-2-r(6-fluoro-l,3-benzothiazol-2- yl)amino]cyclopentyl}-2-(2 -l,2,3-triazol-2-yl)benzamide To a solution of N-(2-amino-4,4-difluorocyclopentyl)-2-(2H-l,2,3-triazol-2-yl)benzamide hydrochloride (Intermediate 28; 120 mg, 0.349 mmol) in dry DMSO (1.2 ml) was added 2-chloro-6-fluoro-l,3-benzothiazole (CAS number 399-74-6; 72 mg, 0.384 mmol) and DIPEA (183 mu, 1.047 mmol). The reaction was sealed and stirred at 140 C in a sand bath for 17 hours. The reaction was partitioned between ethyl acetate and water, washing with water, filtered through a hydrophobic frit and concentrated in vacuo. The crude product was then purified by column chromatography (basic silica, 0-100 % ethyl acetate / petrol). The racemic mixture was then purified by SFC to give two enantiomers (Enantiomer 1/Example 103 and Enantiomer 2/Example 104) of the title compound.Example 103 (Enantiomer 1)1H NMR (400 MHz, OCM-d2) delta ppm 2.02 – 2.28 (m, 2 H), 2.72 – 2.98 (m, 2 H), 4.19 – 4.43 (m, 2 H), 6.91 – 7.14 (m, 1 H), 7.20 – 7.35 (m, 3 H), 7.36 – 7.42 (m, 1 H), 7.44 – 7.51 (m, 1 H), 7.52 – 7.60 (m, 1 H), 7.67 (s, 2 H), 7.74 – 7.84 (m, 1 H) MS ES+: 459Example 104 (Enantiomer 2)1H NMR (400 MHz, OCM-d2) delta ppm 2.02 – 2.28 (m, 2 H), 2.72 – 2.98 (m, 2 H), 4.19 – 4.43 (m, 2 H), 6.91 – 7.14 (m, 1 H), 7.20 – 7.35 (m, 3 H), 7.36 – 7.42 (m, 1 H), 7.44 – 7.51 (m, 1 H), 7.52 – 7.60 (m, 1 H), 7.67 (s, 2 H), 7.74 – 7.84 (m, 1 H)MS ES+: 459, 399-74-6

399-74-6 2-Chloro-6-fluorobenzo[d]thiazole 2049870, athiazole compound, is more and more widely used in various.

Reference£º
Patent; TAKEDA CAMBRIDGE LIMITED; TAKEDA PHARMACEUTICAL COMPANY LIMITED; FIELDHOUSE, Charlotte; GLEN, Angela; ROBINSON, John Stephen; FUJIMOTO, Tatsuhiko; WO2015/55994; (2015); A1;,
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42182-65-0, Benzo[d]thiazol-2-ylmethanamine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of (4-chloro-6-methylpyrimidin-2-yl)aminosulfonyl chloride (8) (1 mmol), benzoxazol-2-amine (2a)/benzothiazol-2-amine (2b)/1H-benzimidazol-2-amine (2c)/(benzoxazol-2-yl) methanamine (3a)/(benzothiazol-2-yl)methanamine (3b)/(1H-benzimidazol-2-yl)methanamine (3c), (2.2 mmol), dry ethanol (8 ml) and acatalytic amount of methanesulfonic acid (0.4 ml) wererefluxed for 3-5 h. The contents of the flask were cooledand diluted with water (25 ml). The separated solid wasfiltered, washed with water, dried and recrystallized from 2-propanol.

42182-65-0, 42182-65-0 Benzo[d]thiazol-2-ylmethanamine 350414, athiazole compound, is more and more widely used in various.

Reference£º
Article; Seenaiah, Dandu; Rekha, Tamatam; Padmaja, Adivireddy; Padmavathi, Venkatapuram; Medicinal Chemistry Research; vol. 26; 2; (2017); p. 431 – 441;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.170961-15-6,tert-Butyl thiazol-2-ylcarbamate,as a common compound, the synthetic route is as follows.

General procedure: n-BuLi (2.5M in THF, 1.4equiv) was added drop wise to a mixture of compound 1a or 1b (1equiv) and aldehyde (1.2equiv) in THF (?20mL) at -78C for 2h. The reaction was quenched by adding a saturated aqueous solution of NH4Cl, extracted with EtOAc, washed with water and then brine. The organic phase was dried over anhydrous Na2SO4, evaporated, and the residue was purified by silica gel column chromatography, 170961-15-6

The synthetic route of 170961-15-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Khalil, Ahmed; Edwards, Jessica A.; Rappleye, Chad A.; Tjarks, Werner; Bioorganic and Medicinal Chemistry; vol. 23; 3; (2015); p. 532 – 547;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1747-60-0,2-Amino-6-methoxybenzothiazole,as a common compound, the synthetic route is as follows.

The starting material 2-bromo-6-methoxy-benzothiazole is prepared by using a PEG- assisted Sandmeyer reaction of the commercially available 2-amino-6-methoxy- benzothiazole according to a literature procedure (N. Suzuki et al., Chemistry Express 1992, 7, 717).

1747-60-0, As the paragraph descriping shows that 1747-60-0 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; WO2008/89933; (2008); A2;,
Thiazole | C3H3NS – PubChem
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24295-03-2,2-Acetylthiazole,as a common compound, the synthetic route is as follows.

In a 50 ml round bottom flask, 8 ml of anhydrous diethyl ether and 0.311 ml (2.2 mmol) of diisopropylamine were added and the solution was cooled to -60C.Then, 2.5 N n-hexane solution of BuLi (2.2 mmol) was added dropwise to the upper reaction system, and the reaction system was warmed to 0 C. and stirred for 15 minutes. Then, sclareolide(500 mg, 2.0 mmol) was added dropwise thereto at -60 C. Ether solution,The reaction mixture was stirred for a further 40 min and then a solution of 2-acetylthiazole (254.3 mg, 2.0 mmol) in diethyl ether was added dropwise to the upper reaction system. The reaction system is stirred at this temperature for 50 min and quenched with water.The organic layer was separated, washed with saturated sodium chloride, dried over anhydrous sodium sulfate, filtered, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography to give CYL-2-QX-3A in a yield of 60.0%.

24295-03-2, The synthetic route of 24295-03-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sichuan China National Tobacco Industry Co., Ltd.; Chongqing China National Tobacco Industry Co., Ltd.; Tao Feiyan; Yang Wenmin; Feng Guanglin; Dai Ya; Li Chaorong; Ding Wei; Wang Yao; Zhou Sheng; Zhou Zhigang; Qiu Guangming; Liu Rucan; Zhang Ting; (11 pag.)CN105061418; (2017); B;,
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Thiazole | chemical compound | Britannica