Category: thiazole

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2289-75-0,4,5-Dimethylthiazol-2-amine,as a common compound, the synthetic route is as follows.

A mixture of 2-amino-4,5-dimethylthiazole (1 ,0 g, 7 8 mmol) and (bromomethyl)cyclobutane (0.88 mL, 7.8 mmol) was warmed to 85 0C and stirred for 18 hours. The mixture was cooled to ambient temperature and the residue was purified via column chromatography (SiO2, 10% methanol in ethyl acetate then 9:1:0.1 CH2Cl2 : methanol : NH4OH) to afford the title compound. MS (DCI/NH3) m/z l97 (M+H)+, 2289-75-0

As the paragraph descriping shows that 2289-75-0 is playing an increasingly important role.

Reference£º
Patent; ABBOTT LABORATORIES; WO2007/140439; (2007); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

78364-55-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78364-55-3,6-Fluoro-2-hydrazinylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.

General procedure: The mixture of 6-fluoro-2-hydrazinylbenzo[d]thiazole (2) (0.01 mol) and benzalde-hyde/substituted benzaldehyde (0.01 mol) was reuxed in ethanol (15 ml) at 70?80 ¡ãC for 3 h. The separated product obtained was ltered off, washed withdistilled water and recrystallized from methanol to give the correspondinghydrazone. The product obtained was further dissolved in acetic acid (20 ml) atroom temperature followed by the addition of sodium acetate (0.5 g). Bromine(2 mmol) in acetic acid (10 ml) was added dropwise to the reuxing reactionmixture. After 1 h, the mixture was poured onto crushed ice (100 g). The precipitateobtained was ltered off and crystallized from ethanol-dimethylformamide (1:1) togive crystals of (3a?3t).

As the paragraph descriping shows that 78364-55-3 is playing an increasingly important role.

Reference£º
Article; Kukreja, Sharu; Sidhu, Anjali; Sharma, Vineet K.; Research on Chemical Intermediates; vol. 42; 12; (2016); p. 8329 – 8344;,
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34272-64-5, 2-(4-Methyl-2-thioxo-2,3-dihydrothiazol-5-yl)acetic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Each resin from Step 3 was distributed into 24 fritted syringes (Torvig, 50 mg each, 50 mumol), for a total of 96 syringes, and was swelled in NMP (1 mL) for 30 min. The solvent was removed by filtration. Twenty-four solutions of the building blocks listed below (10 mmol each) and DIBA (3.5 mL, 20 mmol) in NMP (10 mL) were prepared. 3 mL of the 24 solutions was added to the 24 syringes for each resin from Step 3, accordingly. The suspensions were then shaken for 20 h on a Titer Plate Shaker. The reaction mixture was filtered and washed 5 times with methylene chloride (5 mL), 3 times with THF (5 mL), 3 times THF/H2O (3/1 v/v, 5 mL), and 3 times with THF (5 mL). The resins were then dried overnight under vacuum., 34272-64-5

34272-64-5 2-(4-Methyl-2-thioxo-2,3-dihydrothiazol-5-yl)acetic acid 3035180, athiazole compound, is more and more widely used in various.

Reference£º
Patent; Kong, Xianqi; Wu, Xinfu; Valade, Isabelle; Gervais, Francine; US2006/167057; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

185613-91-6, 4-(Benzo[d][1,3]dioxol-5-yl)thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-(Benzo[d][1,3]dioxol-5-yl)thiazol-2-amine(2) (1.00 g, 4.54 mmol) and NaH (0.164 g, 6.82 mmol) to THF (15 ml) todissolved and then allowed to react at room temperature for 1 hour under a nitrogen stream. After dropwise addition of 2-chlorobenzylbromide (1.40 g, 6.82 mmol) slowly at room temperature and reacted for 10 minutes. After the reaction wasfinished, it was concentrated under reduced pressure and extracted three times into a saturated solution of NaHCO3 isdissolved in ethyl acetate. The ethyl acetate layer was separated and dried with anhydrous Na2SO4, then purified by columnchromatography (Ethyl acetate: Hexane = 1: 5) to give the compound 1e to give. Yield 17.6%, 185613-91-6

As the paragraph descriping shows that 185613-91-6 is playing an increasingly important role.

Reference£º
Patent; Chungbuk National University Industry-Academic Cooperation Foundation; Jung, Jae Kyung; Kim, Young Soo; Lee, Hee Sun; (27 pag.)KR101651208; (2016); B1;,
Thiazole | C3H3NS – PubChem
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74531-15-0, 4,5-Dimethylthiazole-2-carbaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Representative procedure for the conversion of thiazole-2-carbaldehyde derivatives into (1,3-thiazol-2-yl)methylamine derivatives. Under argon, a solution of 4,5-dimethyl-1,3-thiazole-2-carbaldehyde (644.9 mg, 4.57 mmol), hydroxylamine hydrochloride (648.1 mg, 9.143 mmol) and sodium methoxide (493.7 mg, 9.14 mmol) in ethanol (9 mL) was stirred at room temperature overnight. The white solid was filtered off, rinsed with methanol and the solution was evaporated. The crude oxime was dissolved in acetic acid (25 mL), zinc dust (1.8 g, 27.5 mmol) was added portionwise at room temperature and the reaction mixture was stirred at room temperature for 3 hours. The mixture was then filtered over a pad of celite and rinsed with methanol. Toluene was added and the filtrate was concentrated. An aqueous solution of ammonium chloride was added, the solution was acidified to pH = 2 with hydrochloric acid 1N and extracted with diethyl ether and ethyl acetate. These organic layers were discarded. The aqueous layer was basified with aqueous sodium hydroxide to pH = 10, and then extracted with diethyl ether and ethyl acetate. Combined organic extracts were dried over sodium sulfate, filtered and evaporated to give crude (4,5-dimethyl-1,3-thiazol-2-yl)methylamine (321.7 mg, 49%) as a pale yellow oil which was used in the next steps without purification. ESI-MS m/z 143 (M+ H)+., 74531-15-0

As the paragraph descriping shows that 74531-15-0 is playing an increasingly important role.

Reference£º
Patent; Mutabilis; EP2141164; (2010); A1;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7709-58-2,4-(Chloromethyl)thiazole hydrochloride,as a common compound, the synthetic route is as follows.,7709-58-2

Reference Example 5 6,7,8-Trifluoro-1-(4-thiazolylmethyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 1.5 g of ethyl 6,7,8-trifluoro-4-hydroxyquinoline-3-carboxylate was dissolved in 30 ml of DMF, and 0.43 g of 60% oily sodium hydride was added, followed by stirring at 80 C. in a nitrogen gas stream for 20 minutes. To this solution, 1.9 g of 4-chloromethylthiazole hydrochloride was added, followed by stirring at constant temperature for 15 hours, after which the reaction mixture was concentrated to dryness. The residue was dissolved in CHCl3; the organic layer was washed with water and dried over anhydrous magnesium sulfate and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane-ethyl acetate=1:2) to yield 0.46 g of ethyl 6,7,8-trifluoro-1-(4-thiazolylmethyl)-1,4-dihydro-4-oxoquinoline-3-carboxylate as a colorless powder.

The synthetic route of 7709-58-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Takeda Chemical Industries, Ltd.; US5519024; (1996); A;,
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Thiazole | chemical compound | Britannica

769-20-0, 6-Amino-7-bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,769-20-0

Example 30; 7-Bromo-benzothiazoleSodium nitrite (0.229 g, 3.3 mmol) was added to a solution of 7-bromo-benzothiazol-6-ylamine (0.380 g, 1.66 mmol, described in WO 97/31636) in sulfuric acid (10 mL) and the resulting mixture was stirred at room temperature for 20 min. Hypophosphorous acid (10 mL) was added and the mixture was heated at 50 C. overnight. The pH was adjusted to 9-10 by addition of sodium carbonate, and the crude product was removed by filtration and washed with water. Purification by prep-HPLC gave 0.265 g (75% yield) of the title compound as a white solid: LC-MS (EI) m/z 213 (M++1).

The synthetic route of 769-20-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AstraZeneca AB; US2011/98292; (2011); A1;,
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Thiazole | chemical compound | Britannica

768-11-6, 5-Bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,768-11-6

At room temperature, the iodobenzene (0.4mmol, 1 equiv), selenium (1.2mmol, 3 equiv), 5 – bromo and thiazole (0.8mmol, 2 equiv), CuO (0.04mmol), cesium carbonate (1.2mmol, 3 equiv) is added to the reaction tube, and then the nitrogen, and replace the three times, the reaction environment under nitrogen, then adding the reaction solvent 2 ml DMI, in the 140 C the reaction temperature under stirring 24h. By thin-layer chromatographic monitoring after the reaction, the reaction mixture is cooled, then adding ethyl acetate dilution, the diluted solution in the transfer to the separatory funnel, saturated salt water for extraction, the aqueous phase and the organic phase separated, then the ethyl acetate extract the aqueous phase 3 times, merge all organic phase (namely the saturated salt water extraction and separation of the organic phase and the ethyl acetate extraction and separation of the organic phase), adding 5g anhydrous sodium sulfate, stirring 5 minutes after the filtering, the filter cake washing 3 times, for each time 5 ml ethyl acetate wash, then evaporate the solvent, column chromatography (petroleum ether and ethyl ether volume ratio 100:1 mixture as eluant, silica gel as 300 – 400 mesh silica gel) product is obtained after the 5 – bromo -2 – (benzene selenium) benzothiazole, white solid, yield 88%.

The synthetic route of 768-11-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Wenzhou University; Liu, Miaocheng; Gao, Chao; Gao, Wenxia; Chen, Jiuxi; Huang, Xiaobo; Wu, Huayue; (16 pag.)CN106565629; (2017); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.74537-49-8,2-(Methylthio)benzo[d]thiazol-6-ol,as a common compound, the synthetic route is as follows.,74537-49-8

Step 1. Preparation of 6-(2-chloropyridin-4-yloxy)-2-(methylthio)benzo[d]thiazole To the mixture of 2-(methylthio)benzo[d]thiazol-6-ol (1 g, 5.08 mmol) and cesium carbonate (4.55 g, 14 mmol) in 15 ml of NMP was added 2-chloro-4-fluoropyridine (1.32 mg, 10 mmol). The reaction mixture was stirred at 55 C. for overnight. The reaction mixture was poured into 80 ml of aq. saturated NaHCO3 and extracted with ethyl acetate (2*150 ml). The combined organic layers were washed with aq. 0.1M NaHSO4 (60 ml), water (2*60 ml) and brine (60 ml), then dried over MgSO4, filtered and evaporated in vacuo to give 6-(2-chloropyridin-4-yloxy)-2-(methylthio)benzo[d]thiazole (1.72 g) as brown oil that carried on to next step without purification. ES/MS m/z 308.9 (MH+).

The synthetic route of 74537-49-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Novartis AG; US2008/45528; (2008); A1;,
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74370-93-7, 4-(tert-Butyl)thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,74370-93-7

Into a Vial was added the 6-Chloro-pyridine-3-sulfonic thiazol-2-ylamide (35 mg, 0.00013 mol), Sodium tert-butoxide (36 mg, 0.00038 mol), 9,9-DIMETHYL-4,5-BIS(DIPHENYLPHOSPHINO)XANTHENE (8.8 mg, 0.000015 mol), Tris(dibenzylideneacetone)dipalladium(0) (4.6 mg, 0.0000051 mol), 2-AMINO-4-(4-CHLOROPHENYL)THIAZOLE and the de-gased anhydrous 1,4-Dioxane (1.7 mL, 0.022 mol). The reaction mixture was heated at 150 C. for 1 h in microwave. The reaction mixture was filtered through celite and the filtrate was concentrated to give the crude product that was purified on Gilson (semi-prep, reverse phase, Phenomenex 100¡Á21.2 mm 10 micron C18 column, 20 mL/min, Gradient 85% A to 100% B over 25 min. Solvent A: 7800 water/200 acetonitrile/8 TFA. Solvent B: 7200 acetonitrile/800 water/8 TFA). Fractions were checked by LC/MS and then dried on a lyophilizer to give the desired product as TFA salt (yellow powder).

The synthetic route of 74370-93-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Icagen; US2009/23740; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica