Category: thiazole

64987-08-2, Ethyl 2-(2-aminothiazol-4-yl)-2-oxoacetate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 96 {2-[2-(3-Chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-thiazol-4-yl}-oxo-acetic acid ethyl ester A solution of triphenylphosphine (238 mg, 0.91 mmol) in methylene chloride (10 mL) was cooled to 0 C. and then treated with N-bromosuccinimide (183 mg, 1.03 mmol). The reaction mixture was stirred at 0 C. until it was completely dissolved and became light purple in color. The reaction mixture was then treated with 2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionic acid (prepared as in Example 92, 200 mg, 0.61 mmol) and stirred at 0 C. for 20 min and then warmed to 25 C. where it was stirred for 30 min. After such time, the reaction mixture was treated with 2-(aminothiazol-4-yl)-oxo-acetic acid ethyl ester (182 mg, 0.91 mmol) and pyridine (0.088 mL, 1.09 mmol), and the reaction mixture was stirred at 25 C. for 16 h. The reaction was then diluted with water (10 mL) and then extracted with methylene chloride (3*15 mL). The combined organic layers were dried over sodium sulfate, filtered, and concentrated in vacuo. Flash chromatography (Merck Silica gel 60, 230-400 mesh, 75/25 hexanes/ethyl acetate) afforded {2-[2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-thiazol-4-yl}-oxo-acetic acid ethyl ester (208 mg, 67%) as a clear colorless oil: EI-HRMS m/e calcd for C22H25ClN2O6S2 (M+) 513.0921, found 513.0919.

As the paragraph descriping shows that 64987-08-2 is playing an increasingly important role.

Reference£º
Patent; Hoffman-La Roche Inc.; US6610846; (2003); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2516-40-7, 2-Bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-Chlorobenzothiazole(169 mg, 1 mmol) and EtOH (5 ml), and 3-fluoro-4-hydroxyaniline (127 mg, 1 mmol) was dissolved in and p-TsOH*H2O (30.4 mg, 0.1 mmol) was added and the mixture was stirred for 4 hours at 80 ¡ã C. After checking the completion of the reaction, then cooled at room temperature, then evaporated under reducedpressure to remove the solvent. The concentrated residue was extracted with ethyl acetate (5 ml) and water (3 x 3ml). The extractedorganic layer was filtered and then dried over anhydrous magnesium sulfate, the reduced pressure of the filtrate was evaporated,and purified by column chromatography, and diluted with an equal volume of HCl solution and dried. As a result, 4-(benzo[d]thiazol-2-ylamino)-2-fluorophenol was obtained (222 mg, 75percent yield).

The synthetic route of 2516-40-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Gyeonggi Science & Technology Agency; Koo, Jin Moh; Jung, Kwi Wan; Kim, Soo Mi; Park, Jong Hyun; Noh, Jae Sung; Lee, Jung Heon; Park, Sun Min; Jung, Dae Yeon; Lee, Kwang Nyung; Choe, Joo Hyung; (36 pag.)KR101659952; (2016); B1;,
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10200-59-6, 2-Thiazolecarboxaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 6-[4-(methylsulfonyl)phenyl]-5-phenyl-4-piperazin-1-yl-2-(trifluoromethyl)pyrimidine (0.2 g, 0.43 mmol, prepared according to the procedure described in preparation 2) in dichloroethane (25 ml) was added thiazole-2-carboxaldehyde (0.144 g, 1.3 mmol) under stirring at 37¡ã C. After five minutes, sodium triacetoxy borohydride (0.364 g, 1.72 mmol) was added to reaction mixture and then after 10 minutes, acetic acid (0.1 ml) was added to it. The reaction mixture was stirred for 36 hours under the same conditions. Subsequently the reaction mixture was treated with ethyl acetate:water (1:1, 100 ml) and extracted with ethyl acetate (50 ml*3). The organic layer was washed with brine (100 ml) and dried over anhydrous sodium sulphate. The solid obtained upon evaporation was purified by column chromatography using methanol:dichloromethane (0.5:99.5) as an eluent to afford the title compound (0.1 g, yield 45.6percent). 1H-NMR (CDCl3) delta: 0.88-0.89 (m, 2H), 1.25-1.28 (t, 2H), 1.33-1.38 (t, 2H), 2.85 (s, 6H), 2.97 (s, 3H), 7.04-7.74 (m, 9H). MS m/z: 544.59 (M++1).

10200-59-6 2-Thiazolecarboxaldehyde 2734903, athiazole compound, is more and more widely used in various.

Reference£º
Patent; ORCHID RESEARCH LABORATORIES LIMITED.; US2007/167413; (2007); A1;,
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41731-83-3, Ethyl 2-bromothiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 5; (R)-2-(2-(1-(4-(1-hydroxyhexyl)phenyl)-5-oxopyrrolidin-2-yl)ethylthio)thiazole-5-carboxylic acid (22); Step 1. Conversion of 10 to 20Ethyl 2-bromothiazole-5-carboxylate (15 muL, 0.10 mmol), tributylphosphine (5 muL, 0.02 mmol), and potassium carbonate (20 mg, 0.15 mmol), were added sequentially to a solution of thioacetate 10 (crude from example 1, step 8, 45 mg, 0.094 mmol) in absolute EtOH (0.38 mL). After stirring overnight at room temperature, the volatiles were removed under a stream of nitrogen. The resulting residue was suspended in EtOAc and then decanted and concentrated in vacuo. The crude residue was purified on 4 g silica (hexanes?EtOAc, gradient) to afford 55 mg (99%) of 20.

As the paragraph descriping shows that 41731-83-3 is playing an increasingly important role.

Reference£º
Patent; Allergan, Inc.; US2008/269498; (2008); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.160844-75-7,Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate,as a common compound, the synthetic route is as follows.

Example-4 Preparation of Febuxostat Potassium (IA-b) 3.7 N potassium hydroxide solution was added to a reaction mass of (50.0 g) 2-(4-isobutoxy-3-cyanophenyl)-4-methylthiazole-5-ethyl carboxylate in (250.0 ml) isopropyl alcohol. The reaction mixture was stirred and heated to get complete potassium salt of febuxostat. The febuxostat potassium was isolated by filtration. The moisture content of the said compound is 6.03percent. HPLC purity: >99percent The XRPD of potassium salt of febuxostat is attached as .

160844-75-7 Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate 9884549, athiazole compound, is more and more widely used in various.

Reference£º
Patent; CADILA HEALTHCARE LIMITED; Dwivedi, Shriprakash Dhar; Prasad, Ashok; Roy, Rushikesh Udaykumar; Patel, Mayur Ramnikbhai; US2013/190366; (2013); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.67899-00-7,2-Amino-4-methylthiazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.

13.4 g (84.7 mmol) 2-Amino-4-methyl-thiazole-5-carboxylic acid and 35.8 mL (279 mmol) propionic anhydride in 90 mL propionic acid are stirred at 10000 over night. The resulting mixture is cooled to r.t., 200 mL water are added and stirred for 30 mm. The precipitate is filtered off and treated with 200 mL water. After stirring for 30 mm the precipitate is filtered off, washed with water and dried at 50CC.C8H10N203S (M = 214.2 g/mol)ESI-MS: 215 [M-i-H] R (HPLC): 0.68 mm (method J)

67899-00-7 2-Amino-4-methylthiazole-5-carboxylic acid 832243, athiazole compound, is more and more widely used in various.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ROTH, Gerald Juergen; FLECK, Martin; HAEBEL, Peter Wilhelm; HEIMANN, Annekatrin; HEINE, Niklas; (172 pag.)WO2016/41845; (2016); A1;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.64485-82-1,(Z)-Ethyl 2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetate,as a common compound, the synthetic route is as follows.

Example 4 Preparation of Ethyl (2Z)-2-(2-Aminothiazol-4-yl)-2-(3-N-tert-butoxycarbonylaminopropoxyimino)acetate To a mixture of ethyl 2-amino-alpha-(hydroxyimino)-4-thiazoleacetate (139.9 g, 650 mmol), tert-butyl 3-bromopropylcarbamate (209.0 g, 877.5 mmol) and powdered potassium carbonate (157.2 g, 1137.5 mmol) was added DMF (550 mL) and water (24.4 mL). The resulting mixture was stirred at 30 C. for about 11 h. The reaction mixture was cooled to room temperature and ethyl acetate (2.3 L) and water (1.7 L) were added and the resulting mixture was stirred for 5 min. The mixture was allowed to stand for 60 min and the lower layer (aqueous layer) was separated and discarded. An aqueous sodium bicarbonate solution (10 wt. %, 600 mL) was added and the resulting mixture was stirred for 5 min. The mixture was allowed to stand for 60 min and the lower layer (aqueous layer) was separated and discarded. An aqueous sodium chloride solution (10 wt. %, 600 mL) was added and the resulting mixture was stirred for 5 min. The mixture was allowed to stand for 60 min and the lower layer (aqueous layer) was separated and discarded. The organic layer was concentrated to a volume of about 600 mL. Hexanes (250 mL) were added dropwise to the concentrate with gently stirring at 0 C. for 1 h to form a precipitate. The precipitate was collected by vacuum filtration to give the title compound (232 g, 96% yield) as an off-white crystalline solid. 1H NMR (400 MHz, DMSO-d6) delta 7.25 (s, 2H), 6.89 (s, 1H), 6.82 (brs, 1H), 4.26 (q, J=8 Hz, 2H), 4.08 (t, J=6.4 Hz, 2H), 2.97 (q, J=6.4 Hz, 2H), 1.72 (m, J=6.4 Hz, 2H), 1.37 (s, 9H), 1.26 (t, J=8 Hz, 3H).

64485-82-1 (Z)-Ethyl 2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetate 6738988, athiazole compound, is more and more widely used in various.

Reference£º
Patent; THERAVANCE, INC.; Zhang, Weijiang; Cheung, Ronnie; Filipov, Dimitar; Green, Jack; Lee, Junning; US2014/274877; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57626-37-6,Ethyl 6-methylimidazo[2,1-b]thiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

To the stirred solution of ethyl 6-methylimidazo[2,1-b]thiazole-5-carboxylate (2a) (5.20 g) in ethanol (40 mL) was added 35%aqueous solution of N2H4H2O (40 mL) and refluxed for 3 h. Thereaction mixture was concentrated to half volume and cooled onice bath, the solids formed were filtered and dried in vacuum ovento get 6-methylimidazo[2,1-b]thiazole-5-carbohydrazide (3a)(4.30 g, 89%) as an Off-white solid. ESI-MS showed 197 [M+H]+.

The synthetic route of 57626-37-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Samala, Ganesh; Devi, Parthiban Brindha; Saxena, Shalini; Meda, Nikhila; Yogeeswari, Perumal; Sriram, Dharmarajan; Bioorganic and Medicinal Chemistry; vol. 24; 6; (2016); p. 1298 – 1307;,
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Thiazole | chemical compound | Britannica

494769-44-7, tert-Butyl (4-(hydroxymethyl)thiazol-2-yl)carbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The intermediate (3) (0.5 g, 0.00217 mol), EDCl (0.622 g, 0.00325 mol), DMAP (0.345 g, 0.0028 mol) were stirred in dichloromethane (6 mL) at 0 C, and the substituted acid (0.00217 mol) were dissolved in (4 mL) of dichloromethane and charged to the reaction mixture and stirred at room temperature for 8 h. The reaction completion was monitored by TLC. Reaction was completed. The reaction mixture was diluted with (10 mL) of dichloromethane, and was washed with 10% NaHCO3 (10 mL). Separated the organic layer and was washed with saturated brine solution (10 mL). The organic layer was dried over sodium sulfate and concentrated the organic layer under reduced pressure to afford compounds 4a-t. The spectral data of compounds 4(a-t) are given below.

The synthetic route of 494769-44-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Karuvalam, Ranjith P.; Haridas, Karickal R.; Nayak, Susanta K.; Guru Row, Tayur N.; Rajeesh; Rishikesan; Kumari, N. Suchetha; European Journal of Medicinal Chemistry; vol. 49; (2012); p. 172 – 182;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica