Category: thiazole

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1024583-33-2,Methyl 2-bromobenzo[d]thiazole-6-carboxylate,as a common compound, the synthetic route is as follows.

4-(((2-Azabicyclo[4.1.0]heptane-5-yl)oxy)methyl)-5-cyclopropyl-3-(2,6-dichlorophenyl) The crude product of the above-mentioned oxazole, 2-bromobenzo[d]thiazolidine methyl-6-carboxylate (240 mg, 0.88 mmol) and cesium carbonate (429 mg,1.32 mmol) was dissolved in DMA (6 mL), and subjected to microwave reaction at 110 C for 40 minutes. After completion of the reaction, 100 mL of water and 30 mL of ethyl acetate were added and the mixture was separated, and the aqueous phase was extracted with ethyl acetate (30 mL¡Á2). concentrate, The residue was subjected to silica gel column chromatography ( petroleum ether: ethyl acetate = 2:1)The product was obtained in 183 mg in two-step yield: 72.9%.

1024583-33-2 Methyl 2-bromobenzo[d]thiazole-6-carboxylate 46911877, athiazole compound, is more and more widely used in various.

Reference£º
Patent; Hainan Xuanzhu Pharmaceutical Technology Co., Ltd.; Fang Wenkui; (39 pag.)CN109575008; (2019); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

5464-79-9, 2-Amino-4-methoxybenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step A. A solution of AICl3 (5 mmole) in EtSH (10 mL) was cooled to 0 C. and treated with 2-amino-4-methoxybenzothiazole (1 mmole). The mixture was stirred at 0-5 C. for 2 h. Evaporation and extraction gave 2-amino-4-hydroxybenzothiazole as white solid.

The synthetic route of 5464-79-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; METABASIS THERAPEUTICS, INC.; US2002/173490; (2002); A1;,
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Thiazole | chemical compound | Britannica

61296-22-8, 2-Amino-5-bromothiazole monohydrobromide is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5.9 ml (42.3 mmol) of acetic anhydride are added to a solution of 10 g (38. 5 mmol) of 2-amino-5- bromothiazole hydrobromide in 100 ml of dichloromethane and 11 ml (77 mmol) of triethylamine, cooled to 0oC. The reaction medium is stirred for 30 minutes at 0oC and then for 18 hours at room temperature. After addition of water, the pH is adjusted to pH 8 with aqueous 1M sodium hydroxide solution and the reaction medium is extracted with dichloromethane. The dichloro- methane phase is dried over magnesium sulfate, filtered and evaporated. The residue obtained is used in step b without purification.

The synthetic route of 61296-22-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GALDERMA RESEARCH & DEVELOPMENT, S.N.C.; WO2004/113331; (2004); A1;,
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Thiazole | chemical compound | Britannica

247037-82-7, Thiazole-2-carboximidamide hydrochloride is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A 1000 L glass-lined reactor equipped with mechanical stirrer, thermometer and nitrogen bubbler was charged 2-chloro-4-fluoro-benzaldehyde (30.8 kg, 194 mol, compound 11-a) andIPA (188.0 kg). To the solution was then added methyl acetoacetate (22.7 kg, 195 mol, compound 11-b) followed by addition of piperidine (1.74 kg, 20.4 mol) and acetic acid (1.32 kg, 22.0 mol). The reaction mixture was then heated to 43 C-47 C and stirred at such temperature for 5 hours. Then to the reaction mixture was added thiazole-2-carboxamidine hydrochloride salt (19.8 kg, 121.0 mol, compound 8-c) followed by addition of triethylamine (20.0 kg, 198.0 mol).The reaction mixture was heated to 80 C – 85 C and stirred for 7 hours. After reaction was completed, the reaction mixture was cooled to 20 C-25 C and then added water (52.0 kg). The resulting suspension was stirred at 20 C-25 C for 2 hours. The solid was collected by centrifuge and washed with isopropanollwater (42 kg, v/v=10/3). The wet solid was dried in vacuum oven to afford Example 11 (35.05 kg, purity: 95.8%, Yield: 79.2%) as yellow solid. MS mle = 366.2[M+H] .

The synthetic route of 247037-82-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; CHEN, Junli; (58 pag.)WO2017/140750; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.79836-78-5,Ethyl 2-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

To a stirred solution of ethyl 2-methylthiazole-5-carboxylate (1 eq) in dry THF (5 mL) at 0 Patent; MERCK PATENT GMBH; YU, Henry; LIU-BUJALSKI, Lesley; JOHNSON, Theresa L.; WO2014/159234; (2014); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.302964-24-5,2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide,as a common compound, the synthetic route is as follows.

5mmol N,N-dimethylglycine,2mmol CuI,20mmol 4,6-dichloro-2-methylpyrimidine is soluble100 mL of N,N-dimethylformamide (DMF),22 mmol of N-hydroxyethylpiperazine was added with stirring.40mmol K3PO4, stir at room temperature for 40min,22 mmol of 2-amino-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide was added with stirring.Passing N2 and reacting at 120 C for 6 h,The copper salt was dissolved in 50 mL of aqueous ammonia, and extracted with 50 mL of EtOAc (EtOAc).The crude product was added to 100 mL of an 80% aqueous ethanol solution, and stirred.2 g of activated carbon was added, refluxed for 30 min, filtered while hot, and the filtrate was recrystallized overnight, filtered, and the filter cake was washed with ice-cold 80% aqueous ethanol solution and dried.That is, 8.64 g of a white solid was obtained, the yield was 88.41%, and the purity was 99.92%.

As the paragraph descriping shows that 302964-24-5 is playing an increasingly important role.

Reference£º
Patent; Shandong Luoxin Pharmaceutical Group Co., Ltd.; Shandong Luoxin Pharmaceutical Group Hengxin Pharmaceutical Co., Ltd.; Shandong Yuxin Pharmaceutical Co., Ltd.; Gao Hongjun; Ren Qingwei; Zhang Qingdong; (12 pag.)CN109879869; (2019); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

53332-78-8, Thiazol-2-ylmethanamine dihydrochloride is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 24.2-Chloro-7-methyl-8-propoxy-N-(thiazol-2-ylmethyl)-7H-purin-6- amine A mixture of 2,6-dichloro-7-methyl-8-propoxy-7H-purine (28 mg, 0.11 mmol), thiazol-2-ylmethanamine dihydrochloride (70 mg, 0.37 mmol) and triethylamine (0.16 mL, 1.14 mmol) in DMSO (1.5 mL) was stirred at 60 C for 2 h. After this time the mixture was cooled to room temperature, diluted with EtOAc and washed with water and brine. The organic layer was concentrated and the resulting residue was purified by column chromatography (silica, 0-5% MeOH in CH2Cl2) to provide 2-chloro-7-methyl- 8-propoxy-N-(thiazol-2-ylmethyl)-7H-purin-6-amine (21 mg, 56%): ESI MS (M+H) 339; 1H NMR (500 MHz, DMSO-d6) G 7.93 (s, 1H), 7.73 (d, J = 3.3 Hz, 1H), 7.61 (d, J = 3.3 Hz, 1H), 4.90 (s, 2H), 4.44 (t, J = 6.5 Hz, 2H), 3.73 (s, 3H), 1.84-1.76 (m, 2H), 0.99 (t, J = 7.4 Hz, 3H).

As the paragraph descriping shows that 53332-78-8 is playing an increasingly important role.

Reference£º
Patent; THE GENERAL HOSPITAL CORPORATION; UNITED STATES DEPARTMENT OF HEALTH AND HUMAN SERVICES; SLAUGENHAUPT, Susan, A.; JOHNSON, Graham; PAQUETTE, William, D.; ZHANG, Wei; MARUGAN, Juan; (306 pag.)WO2016/115434; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.41731-83-3,Ethyl 2-bromothiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

To a mixture of ethyl 2-bromo-1 ,3-thiazole-5-carboxylate (1.01 g, 4.29 mmol), K2CO3 (2.0 g, 14.47 mmol) and Pd(Pt-Bu3)2 (280 mg, 0.548 mmol) in 1 ,4-dioxane (8 ml.) and water (1.6 ml.) was added 1 -methyl-5-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)- 1 H-pyrazole (1.76 g, 8.47 mmol) [prepared in Preparation 2]. The reaction was stirred at 120 0C for 45 min in a microwave reactor and cooled to room temperature. The mixture was partitioned between CHCI3 / H2O and the aqueous layer was washed several times with CHCI3. The combined organic fractions were dried over Na2SO4, concentrated, and purified via column chromatography (silica, 0-50%EtOAc/hexanes) affording the title compound (0.7 g, 61%) as a yellow solid: LC-MS (ES) m/z = 238 (M+H)+.

41731-83-3 Ethyl 2-bromothiazole-5-carboxylate 3614103, athiazole compound, is more and more widely used in various.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2009/158372; (2009); A1;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.80945-83-1,2-Chlorobenzothiazole-6-carbonitrile,as a common compound, the synthetic route is as follows.

Step B:; A solution of 2-chlorobenzothiazole-6-carbonitrile (14.9 g, 0.077 mol) in DMF (250 ml.) was added drop-wise at 100C to a mixture of anhydrous piperazine (60 g, 0.698 mol) and DMF (30OmL). Then the mixture was stirred for 2 h. Water (1 ,550 ml.) was added and the mixture was extracted with dichloromethane (5 x 500 ml_). The combined organic extracts was washed with water (6 x 500 ml_), dried (Na2SO4), filtered and evaporated to give a residue which was re-crystallised from ethyl acetate. This afforded 10.5 g (56 percent) of 2-(piperazin-1- yl)benzothiazole-6-carbonitrile. A mixture of this piperazine derivative (19.4 g, O.Odeltamol), sodium iodide (1.94 g), triethylamine (9.6 g, 0.095mol) and DMF (8OmL) was heated with stir- ring to give a red liquid. A solution of 2-bromopropane (14.7 g, 0.12mol) in DMF (8OmL) was added drop-wise at 117 0C within in 1 h. The reaction mixture was stirred at 1 10-117 0C for another 3 h and then allowed to cool to room temperature. Water (110 ml.) was added and the mixture was filtered. The filter cake was washed until the filtrate was colourless and then dried. The solid was dissolved in DMF (250 ml.) and filtered to remove a solid residue. Water (1000 ml.) was added to the filtrate with stirring to give a precipitate. The solid was isolated, washed with water and dried to give 9.4 g (41 percent) of 2-(4-lsopropylpiperazin-1-yl)benzo- thiazole-6-carbonitrile.1H-NMR delta 8.25 (s, 1 H), 7.61 (d, 1 H), 7.45 (d, 1 H), 3.55 (t, 4H), 2.68 (m, 1 H), 2.51 (m, 4H), 0.93 (d, 6H).

As the paragraph descriping shows that 80945-83-1 is playing an increasingly important role.

Reference£º
Patent; NOVO NORDISK A/S; WO2007/110364; (2007); A1;,
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Thiazole | chemical compound | Britannica

35272-15-2, 2-Methylthiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General Procedure: To a 100 mL round bottom flask equipped with a stir bar were added 2- methyl-l,3-thiazole-4-carboxylic acid (1.0 g, 6.98 mmol), potassium carbonate (3.86 g, 27.9 mmol), N,N-dimethylformamide (20 mL) and iodomethane (0.52 mL 8.38 mmol). The reaction mixture was stirred at room temperature over the weekend, diluted with ethyl acetate (100 mL) and washed with water (100 mL). The aqueous layer was then extracted with ethyl acetate (3×75 mL). The combined organic layer was washed with brine (100 mL), dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue was purified on silica gel using hexanes:ethyl acetate = 80:20 to 50:50 in a gradient fashion, to give the desired product as an off-white solid (1.06 g, 97 percent). 1H NMR (300 MHz, CDCl3): delta 8.06 (s, IH), 3.95 (s, 3H), 2.78 (s, 3H).

As the paragraph descriping shows that 35272-15-2 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2007/87135; (2007); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica