Category: thiazole

1759-28-0, 4-Methyl-5-vinylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1,3-bis(dicyclohexylphosphino)propane (dcypp: 20.0 mol%, 21.9mg) was dissolved in o-dichlorobenzene (1.0 mL) in a two-necked flask equipped under argon atmosphere. Then, RhH(CO)(PPh3)3 (10.0 mol%, 23.0 mg), 4-phenylthiazole 1a (0.25 mmol, 40.3 mg)and 2-methylthiothiazole 5 (0.75 mmol, 78 L) were added to the solution, and the mixture was heated at reflux for 3 h. Then, the solvent was removed under reduced pressure, and the residue was purified byflash columm chromatography on silica gel giving 2-(methylthio)-4-phenylthiazole 3a (38.5 mg, 74%). 3a11

The synthetic route of 1759-28-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Arisawa, Mieko; Nihei, Yuri; Yamaguchi, Masahiko; Heterocycles; vol. 90; 2; (2015); p. 939 – 949;,
Thiazole | C3H3NS – PubChem
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5198-88-9,2-Bromothiazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.

2-Bromo-l,3-thiazole-4-carboxylic acid (200.0 mg, 961 pmol), TEA (671 pL, 4.80 mmol), HATU (547.0 mg, 1.44 mmol) and (R)-N-((S)-l,3-dihydrospiro[indene-2,4′- piperidin]-l-yl)-2-methylpropane-2-sulfmamide (352.0 mg, 1.15 pmol, synthesized via Step a of Example 120) were placed into DMF(l5 mL). The reaction mixture was evacuated and refilled 3 times using N2, and the reaction mixture was stirred at 25 C for 1 hour. The mixture was then diluted with EtOAc (100 mL) and the mixture was washed with H20 (30 mL x 5), brine (50 mL), dried over anhydrous Na2S04, filtered and concentrated to give a residue. The residue was purified by silica gel chromatography (ethyl acetate in petroleum ether = 0% to 80%) to afford (S)-N-((S)- ‘-(2-bromothiazole-4-carbonyl)- 1 ,3- dihydrospiro[indene-2,4’-piperidin]-l-yl)-2-methylpropane-2-sulfmamide (458 mg, 96% yield) as yellow oil. LC-MS (ESI+) m/z: 498.0 (M+H)+.

The synthetic route of 5198-88-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; RELAY THERAPEUTICS, INC.; D.E. SHAW RESEARCH, LLC; TAYLOR, Alexander, M.; LESCARBEAU, Andre; KELLEY, Elizabeth, H.; SHORTSLEEVES, Kelley, C.; WALTERS, W., Patrick; MURCKO, Mark, Andrew; MCLEAN, Thomas, H.; GUNAYDIN, Hakan; GIORDANETTO, Fabrizio; THERRIEN, Eric; (607 pag.)WO2019/183367; (2019); A1;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.432047-36-4,1-(2-Thiazolyl)ethylamine,as a common compound, the synthetic route is as follows.

Example 86: N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}-N’-[(1S)-1-(1,3-thiazol-2-yl)ethyl]urea 4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,5-dimethylaniline (30 mg) was dissolved in chloroform (1 ml) and triethylamine (0.1 ml) to prepare a solution. A solution of triphosgene (35 mg) in chloroform (0.2 ml) was then added to the solution, and the mixture was stirred at room temperature for one hr. Next, a solution of (1S)-1-(1,3-thiazol-2-yl)-1-ethylamine (35 mg) in chloroform (0.2 ml) was added thereto, and the mixture was stirred at room temperature for 10 hr. The stirred mixture was purified by chromatography on silica gel using chloroform/methanol for development to give the title compound (30 mg, yield 68%). 1H-NMR (CDCl3, 400 MHz): delta 1.68 (d, J = 6.8 Hz, 3H), 2.10 (s, 3H), 2.30 (s, 3H), 4.09 (s, 3H), 4.11 (s, 3H), 5.33 – 5.39 (m, 1H), 6.29 (br, 1H), 6.47 (d, J = 6.1 Hz, 1H), 6.92 (s, 1H), 7.16 (br, 1H), 7.63 (s, 1H), 7.67 (d, J = 3.2 Hz, 1H), 7.75 (s, 1H), 7.84 (s, 1H), 8.38 (d, J = 6.1 Hz, 1H)

The synthetic route of 432047-36-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; KIRIN BEER KABUSHIKI KAISHA; EP1535910; (2005); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3048-45-1,4-Chlorobenzo[d]thiazole,as a common compound, the synthetic route is as follows.

General procedure: To a solution of benzothiazoles or benzoxazoles (1, 1 mmol) in DMSO (3 mL), was added KOH (280 mg, 5 equiv) and 1,3-propanedithiol (207 muL, 2 mmol). The reaction mixture was heated under argon at 130 C for 12 h. After cooling to room temperature, water (10 mL) was added. The pH of the reaction mixture was adjusted to 3-4 using 5% HCl. The resulting mixture was extracted with ethyl acetate (15 mL ¡Á2). The organic layer was washed with water and brine, dried over anhydrous MgSO4 and concentrated using rotary evaporator. The crude product was purified by silica gel column chromatography using ethyl acetate/n-hexane as eluent to afford the corresponding heteroaryl thiols 3.

The synthetic route of 3048-45-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Xiao, Yan; Jing, Bing; Liu, Xiaoxia; Xue, Hongyu; Liu, Yajun; Beilstein Journal of Organic Chemistry; vol. 15; (2019); p. 279 – 284;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.69812-29-9,2-Acetamido-4-methylthiazole-5-sulfonyl chloride,as a common compound, the synthetic route is as follows.

a) To a stirred solution of 2-(methylamino)-ethanol (0.44 g, 5.86 mmol) in THF (12 ml) was added at 0 C. (ice water bath) commercially available 2-acetamido-4-methylthiazole-5-sulfonyl chloride (1.0 g, 3.92 mmol) and triethylamine (0.6 ml, 4.32 mmol). The light yellow suspension was stirred at room temperature for 17 h, and evaporated. The crude product was further purified by flash chromatography on silica gel (dichloromethane/MeOH) and subsequent crystallization (dichloromethane/MeOH/hexane) to yield 2-acetamido-4-methyl-thiazole-5-sulfonic acid (2-hydroxy-ethyl)-methyl-amide (0.93 g, 81%) as a white solid. MS (ISP) 294.0 [(M+H)+]; mp 189 C.

As the paragraph descriping shows that 69812-29-9 is playing an increasingly important role.

Reference£º
Patent; Gatti McArthur, Silvia; Goetschi, Erwin; Wichmann, Juergen; Woltering, Thomas Johannes; US2006/183756; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.45865-42-7,5-(tert-Butyl)-4-methylthiazol-2-amine,as a common compound, the synthetic route is as follows.

A mixture of 5-tert-butyl-4-methylthiazole-2-ylamine (1.5 g, 8.8 mmol) and 2-bromoethyl methyl ether (0.91 mL, 9.7 mmol) was warmed to 85 0C and allowed to stir for 24 hours. The crude material was dissolved in ~5 mL of a 1 :1 mixture OfCH2Cl2 and CH3OH and a small amount of silica gel was added. This mixture was concentrated to dryness and the residue was purified via flash column chromatography (SiO2, 9:1 :0.1 CH2Cl2 :CH3OH:NH4OH) to afford the title compound (1.0 g, 4.4 mmol, 50% yield). 1H NMR (300 MHz, CD3OD) delta ppm 1.41 (s, 9 H) 2.38 (s, 3 H) 3.35 (s, 3 H) 3.66 (t, J=4.70 Hz, 2 H) 4.16 (t, J=4.70 Hz, 2 H); MS (DCI/NH3) m/z 229 (M+H)+

45865-42-7 5-(tert-Butyl)-4-methylthiazol-2-amine 1081536, athiazole compound, is more and more widely used in various.

Reference£º
Patent; ABBOTT LABORATORIES; WO2009/67613; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13750-63-5,(4-Methylthiazol-2-yl)methanol,as a common compound, the synthetic route is as follows.

Preparation 37; 2-Bromomethyl-5-chloro-thiopheneCool (5-chloro-thiophen-2-yl)-methanol (Preparation 30) (330 mg, 2.22 mmol) to 0 0C and add acetyl bromide (709 mg, 430 muL, 5.76 mmol). Allow to warm to room temperature over 18 h, dilute with EtOAc (10 mL), and cautiously add saturated aqueous NaHCO3 (3 mL). When the carbon dioxide evolution stops, load the mixture onto a Varian Chem Elut CE1005 solid phase extraction cartridge (Varian part number 12198006). Elute with EtOAc, collect, and concentrate about 50 mL to obtain the crude product. Purify on silica gel (12 g) using 0-15% EtOAc/hexanes to afford 250 mg (53%) of the title compound as a yellow oil. MS (EI): 210,212; 1H NMR (CDCl3): delta 6.92 (d, IH, /=3.5 Hz), 6.78 (d, IH, /=4.0 Hz), 4.66 (s, 2H).

13750-63-5 (4-Methylthiazol-2-yl)methanol 17750909, athiazole compound, is more and more widely used in various.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2007/2181; (2007); A2;,
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Thiazole | chemical compound | Britannica

35272-15-2, 2-Methylthiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 32lambda/-(6-Bromo-1H-indazol-4-yl)-2-methyl-1,3-thiazole-4-carboxamide 2-Methyl-1 ,3-thiazole-4-carboxylic acid (4.59g) (available from Maybridge), HATU (13.41g) and DIPEA (16.80ml) were stirred in DMF (140ml) for 30min at 2O0C. 6-Bromo- 1 H-indazol-4-amine (3.4g) (available from Sinova) was added and the reaction stirred at 2O0C for 2 days. The solvent was reduced to ~40ml and the reaction mixture was applied across 5×70 g aminopropyl SPE cartridges and left to stand for 3h. The cartridges were eluted with DCM:methanol (1 :1 ) and the combined solvent was evaporated in vacuo. The residue was suspended in DCM:methanol, adsorbed onto Florisil.(R). and purified by chromatography on silica gel (10Og cartridge) eluting with 0 – 15percent gradient of methanol (containing 1percent triethylamine) in DCM over 60min to give title compound (1.02g). LC/MS Rt 0.95min m/z 337 [MH+]. Method B

35272-15-2 2-Methylthiazole-4-carboxylic acid 284728, athiazole compound, is more and more widely used in various.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2009/147188; (2009); A1;,
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Thiazole | chemical compound | Britannica

3364-80-5, Thiazole-4-carboxaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[623] Example 158 – 3-ri-Methyl-5-(4-methyl-cvclohexyl)-l,2,3,6-tetrahydro-pyridin-4-yl1-5-r4-; [624] A mixture of 4-bromobenzyl bromide (1.00 g, 4.00 mmol) and triphenylphosphine (1.70 g, 6.00 mmol) in toluene (10 mL) was stirred at 80 ¡ãC overnight. The reaction mixture wasconcentrated, followed by sonication in hexane, filtration, and a subsequent hexane wash gave a white solid, which was dried in vacuo. This white solid (906 mg, 1.77 mmol) was dissolved in THF (10 mL), cooled to 0 ¡ãC, and lithium hexamethyl disilazide (1 M) in THF (1.95 mL, 1.95 mmol) was added. After 0.5 hr, thiazole-4-carboxaldehyde (200 mg, 1.77 mmol) was added, the ice bath was removed, and the mixture stirred for 0.5 hr. The reaction mixture was quenched by the addition of water, extracted with EtOAc (2×30 mL), the organic layer was washed with brine, dried over MgS04, concentrated and filtered through a silica plug using 30percent -100percent EtOAc/hexane to give 158A as a clear oil. MS calcd: M+H)+ = 267. + = 267.

3364-80-5 Thiazole-4-carboxaldehyde 2763214, athiazole compound, is more and more widely used in various.

Reference£º
Patent; COCRYSTAL DISCOVERY, INC.; LEE, Sam, Sk; SHEN, Wang; ZHENG, Xiaoliang; JACOBSON, Irina, C.; WO2012/83105; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

56354-98-4, 6-Aminobenzo[d]thiazol-2(3H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Asolution of 2,6-difluoro-3nitropyridine (0.20g. 1.3 mrnol) and &aminobenzo[d]thiazol.-2(3H)-one (0.20 g, 1.2 mmol) in DMF (6 mL) was heated at 100 C for 1 h. Benzaldehyde (0.15 g, 1.4 mmol) was added to the mixture and the reaction was let stir for 30 mm followed by addition of sodium dithionite (0.65g. 3.8 mmoi). After 12 hat 100 C the reaction was cooled, diluted with EtOAc (50mL), and washed with H20 (25 mL x 3). The organic layer was dried (Na2504) and concentrated in vaeuo. Purification FCC. Si02, EtOAc/hexanes) afforded the title compound (0.10 g, 22%). MS (ESfl: mass caicd. for C,9H, ,FN4OS, 362.1; miz found, 363.1 [M+Hf. ?H NMR (400 MHz, DMSO-d6) oe 12.19 (br s, 11-I), 8.39 (dd, ,j:::: 8.5, 7.2 Hz. ifI). 7.79 (d, J::: 2.1 Hz, IH), 7.60 7.53 (m, 21-I), 7.48 — 7.37 (m. 31:1), 7.31 (dd, J: 8.4. 2.1 Fiz, 11-I), 7.24 (d, ,j:::: 8.4 Hz, IH), 7,14 (dd, J::::8.5.0.8Hz, 11-I).

56354-98-4 6-Aminobenzo[d]thiazol-2(3H)-one 6453329, athiazole compound, is more and more widely used in various.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BERRY, Cynthia G.B.; CHEN, Gang; JOURDAN, Fabrice Loic; LEBOLD, Terry Patrick; LIN, David Wei; PENA PINON, Miguel Angel; RAVULA, Suchitra; SAVALL, Bradley M.; SWANSON, Devin M.; WU, Dongpei; ZHANG, Wei; AMERIKS, Michael K.; (407 pag.)WO2016/176460; (2016); A1;,
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Thiazole | chemical compound | Britannica