Category: thiazole

39136-60-2, 5-Ethylthiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-(6-Methyl-1 H-indol-3-yl)acetic acid (100 mg, 0.53 mmol) was dissolved in DMF (7mL). 5-Ethylthiazol-2-amine (74.5 mg, 0.58 mmol) and DIPEA (0.18 mL, 0.7mmol) were added. PyBOP (302.5 mg, 0.58 mmol) was added and the reaction was stirred for 16 h at room temperature. The solvent was removed in vacuo. The residue was dis20 solved in EtOAc and washed twice with sat. aq. sodium bicarbonate solution, once withwater and once with sat. aq. sodium chloride solution. The organic phase was evaporated and the residue was purified by flash chromatography (gradient: 20-100% ethyl acetate in n-heptane). The solvent was evaporated and the title compound was obtained as an orange solid (107 mg, 0.36 mmol, 68% yield). UPLO-MS (Positive mode)m/z 300 (M+H). Retention time 1 .525 mm.

39136-60-2 5-Ethylthiazol-2-amine 12737257, athiazole compound, is more and more widely used in various.

Reference£º
Patent; EUROPEAN MOLECULAR BIOLOGY LABORATORY; WILL, David William; REID, George; CHARAPITSA, Iryna; LEWIS, Joe; (118 pag.)WO2018/229195; (2018); A1;,
Thiazole | C3H3NS – PubChem
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3034-48-8, 2-Bromo-5-nitrothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(1) 1-(5-Nitrothiazol-2-yl)piperazine To a solution of piperazine (18.2 g) and potassium carbonate (12.6 g) in acetonitrile (150 ml) was added 2-bromo-5-nitrothiazole (14.7 g) at 40¡ã C. and the mixture was stirred at 60¡ã C. for 40 min. The reaction mixture was poured into water and extracted with chloroform. The extract was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated to give a brown solid (11.2 g). The obtained brown solid was purified by silica gel column chromatography (developing solvent; chloroform_methanol=9:1) to give the title compound (4.8 g) as yellow crystals. 1H-NMR(DMSO-d6)(delta: 2.80(4H, t, J=5.3 Hz), 3.55(4H, t, J=5.3 Hz), 8.37(1H, s); MS(EI): 214(M+);

As the paragraph descriping shows that 3034-48-8 is playing an increasingly important role.

Reference£º
Patent; Mitsubishi Pharma Corporation; US6455528; (2002); B1;,
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61323-26-0, Ethyl 5-methylthiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

N, N’-dimethyl-3,3′-dithiodipropionamide, ethyl acetate and potassium iodide were continuously fed into the preheating system at a ratio of 100: 500: 0.2,Preheat the mixture to 40 ~ 45 C.The solid-liquid mixture is uniformly mixed into a slurry through a static mixer, and then sent to a pipeline reactor for reaction. The pipeline reactor is fed with chlorine gas at multiple points and controlled by a temperature control system.The reaction temperature is 50 to 55 C, and the residence time is 15 minutes.After the reaction liquid from the pipeline reactor is separated by gas and liquid, it enters the post-processing system.After the post-treatment process, a 14% CMIT / MIT aqueous solution was obtained, the chlorine ratio was 3: 1, and the yield was 95%.During the process, all hydrogen chloride gas enters the hydrogen chloride absorption system to produce by-product hydrochloric acid.

As the paragraph descriping shows that 61323-26-0 is playing an increasingly important role.

Reference£º
Patent; Dalian Baiao Chemical Co., Ltd.; Zhao Jianxin; Han Yi; Chen Qi; Qiang Xinxin; Yang Zhaohui; Qu Zhenbin; Zhang Yulong; Yang Mingcheng; Liu Shukuan; Liu Fang; Gu Zhenpeng; (7 pag.)CN110483438; (2019); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.556-90-1,2-aminothiazol-4(5H)-one,as a common compound, the synthetic route is as follows.

General procedure: To a stirred solution of dimethyl acetylenedicarboxylate (0.14 g, 1 mmol) and 2-imino-1,3-thiazolidin-4-one (3) (0.118 g, 1 mmol) in anhydrous CH2Cl2 (5 mL) was added dropwise a solution of cyclohexyl isocyanide (0.083 g, 1 mmol) in anhydrous CH2Cl2 (3 mL) at rt over 10 min. The reaction mixture was then stirred for 24 h. The solvent was removed under reduced pressure and the residue purified by silica gel (Merck 230-240 mesh) column chromatography using hexane-EtOAc as eluent to yield 4a.

556-90-1 2-aminothiazol-4(5H)-one 11175, athiazole compound, is more and more widely used in various.

Reference£º
Article; Esmaeili, Abbas Ali; Zangouei, Mahdieh; Fakhari, Ali Reza; Habibi, Azizollah; Tetrahedron Letters; vol. 53; 11; (2012); p. 1351 – 1353;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20358-03-6,2-Amino-5-bromobenzothiazole,as a common compound, the synthetic route is as follows.

A mixture of 5-bromo-1,3-benzothiazol-2-amine (200 mg, 0.87 mmol, 1.0 eq.) and 4-nitrophenyl 5?bromo-2-hydroxybenzoate (325 mg, 0.96 mmol, 1.1 eq.) was melted at 200¡ãC for 80 minutes. The solid was taken up in ethanol and heated at reflux temperature during 20 minutes. The solid product was filtered and then, triturated with diethyl ether to afford26bas an off-white solid (160 mg, 43 percent).1H NMR(DMSO-d6, 600 MHz):d(ppm): 7.03 (1H, d, J3-4= 8.7Hz, H3), 7.52 (1H, dd, J6?-7?= 8.5Hz, J6?-4?= 1.4Hz, H6?), 7.64 (1H, dd, J4-3= 8.7Hz, J4-6= 2.3Hz, H4), 7.94 (1H, bs, H4?), 8.00 (1H, d, J7?-6?= 8.5Hz, H7?), 8.04 (1H, d, J6-4= 2.3Hz, H6), 12.25 (1H, bs, amide H).13C NMR (DMSO-d6, 150 MHz):d(ppm): 111.0 (C5), 119.7 (C5?), 119.9 (C7a?), 120.1 (C3), 124.5 (C7?), 127.1 (C6?), 132.8 (C6), 137.3 (C4).HRMS calcd for C14H979Br81Br N2O2S: m/z = 428.8726, found: 428.8774.

The synthetic route of 20358-03-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Labriere, Christophe; Gong, Huansheng; Finlay, B. Brett; Reiner, Neil E.; Young, Robert N.; European Journal of Medicinal Chemistry; vol. 125; (2017); p. 1 – 13;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.144163-97-3,4-Nitrophenyl (thiazol-5-ylmethyl) carbonate,as a common compound, the synthetic route is as follows.

Example 21 Alternative Preparation of (2S,3S,5S)-5-Amino-2-(N-((5-thiazolyl)methoxycarbonyl)amino)-1,6-diphenyl-3-hydroxyhexane Alternative A The product of Example 17F (9.5 g, 33.4 mmol) and phenylboronic acid (4.1 g, 33.6 mmol) were combined in toluene (150 mL) and refluxed for 2.5 hours with azeotropic water removal (Dean-Stark trap). Toluene (100 mL) was distilled out at atmospheric pressure, then the remaining toluene was removed under vacuum, to provide a yellow syrup which was dissolved in DMF (50 mL) and cooled to -60 C. A solution of 5-(p-nitrophenyloxycarbonyloxymethyl)thiazole (9.5 g, 33.5 mmol) in DMF (50 mL) was added over 45 minutes. The resulting mixture was stirred for 8 hours at -55+-5 C., then 14 hours at -25 C., then was allowed to warm to room temperature. The reaction mixture was diluted with 1 N HCl (250 mL) and washed with CH2 Cl2 (2*80 mL). The combined organic layers were back-extracted with 1 N HCl (60 mL). The combined aqueous HCl layers were cooled in an ice-bath to 2 C., and conc. (37%) HCL (30 mL) was added over 5 minutes. The desired product (bis HCl salt) began to precipitate within 30 minutes. The slurry was stirred 3 hours at 2-5 C., then the product (bis HCl salt) was collected by filtration and dried in a vacuum oven at 55-60 C. Yield 11.4 g (68%).

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Reference£º
Patent; Abbott Laboratories; US5559158; (1996); A;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.61296-22-8,2-Amino-5-bromothiazole monohydrobromide,as a common compound, the synthetic route is as follows.

B.[00199] To a solution of Part A compound (180 mg, 1.175 mmol) in acetone (5 mL) was added 2-amino-5-bromothiazole monohydrobromide (611 mg, 2.351 mmol) and Cs2CO3 (957 mg, 2.94 mmol). The mixture was stirred at reflux (55 0C) for 18 h, then was cooled to RT and was filtered. The filtrate was concentrated in vacuo. The residue was taken up in EtOAc and was washed with H2O and brine, then was dried (MgSO4), filtered, and concentrated in vacuo. The residue was purified by preparative HPLC (Phenomenex Luna AXIA 5u C18 30 x l00 mm column; detection at 220 nm; flow rate = 40 mL/min; continuous gradient from 30% B to 100% B over 10 min + 5 min hold time at 100% B, where A = 90: 10:0.1 H2O:MeOH:TFA and B = 90: 10:0.1 MeOH:H2O:TFA) to give Part B compound (200 mg, 67% yield) as a yellow solid.

61296-22-8 2-Amino-5-bromothiazole monohydrobromide 2723848, athiazole compound, is more and more widely used in various.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2008/154563; (2008); A1;,
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93-85-6, 2-Aminobenzo[d]thiazole-6-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(3)4-amino-3-thio-benzoic acid 25.0g potassium hydroxide was weighed, dissolved in 50ml water, slightly cooled, added with 8.3g (0.04mol) 2-amino-benzo[d]thiazole-6-formic acid under nitrogen gas protection, reacted under refluxing and stirring for 24h, after the end of reaction, cooled with ice bath, added with hydrochloric acid for acidification, stood and filtered to obtain a white solid product 5.2g (67.9percent).mp 280-284¡ãC. 1H-NMR delta (ppm, d6-DMSO): 6.75(d,J=8.69 Hz.1H), 7.46(d,J=1.96 Hz, 1H), 7.63 (dd, J1= 1.96Hz,J2=8.40Hz,1H), 12.13(br-s, 1H,CO2H).

The synthetic route of 93-85-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China; EP2354136; (2011); A1;,
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302964-20-1, tert-Butyl (5-(chlorocarbonyl)thiazol-2-yl)carbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Solution of tert-butyl (5-(chlorocarbonyl)thiazol-2-yl)carbamate (1.2 eq.) in dichloromethane (0.35 M) was added dropwise to a stirred solution of starting compound (5a-e) and triethylamine (2 eq.) in dichloromethane (0.075 M) at 0 C. The reaction mixture was stirred for 15 h at room temperature followed by removal of solvent under reduced pressure to obtain a crude product, which was purified by flash column chromatography using dichloromethane/methanol (19/1) or EtOAc as eluant.

302964-20-1 tert-Butyl (5-(chlorocarbonyl)thiazol-2-yl)carbamate 45117870, athiazole compound, is more and more widely used in various.

Reference£º
Article; Trstenjak, Uro?; Ila?, Janez; Kikelj, Danijel; European Journal of Medicinal Chemistry; vol. 64; (2013); p. 302 – 313;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.924287-65-0,Methyl 2-bromo-4-fluorobenzo[d]thiazole-6-carboxylate,as a common compound, the synthetic route is as follows.

To a 50 mL round-bottom flask purged and maintained under an inert atmosphere of nitrogen was added (1S,4S,5R)-5-[[l-cyclopropyl-4-(2,6-dichlorophenyl)-1H-pyrazol-5- yl]methoxy]-2-azabicyclo [2.2.1] heptane 41g (80 mg, 0.21 mmol, 1.00 equiv.), DMA (2 mL), methyl 2-bromo-4-fluoro-l,3-benzothiazole-6-carboxylate 30c (74 mg, 0.26 mmol, 2.00 equiv.), and Cs2CO3 (137 mg, 0.42 mmol, 2.00 equiv.). The resulting mixture was heated at 60C overnight. Upon cooling to room temperature, the mixture was diluted with water (50 mL), extracted with ethyl acetate (50 mL x 3), and the combined organic extracts were washed with brine (30 mL x 3), dried over anhydrous sodium sulfate and concentrated under vacuum. The residue was purified by silica gel column chromatography eluting with ethyl acetate/petroleum ether (1 :5) to afford methyl 2-[(1S,4S,5R)-5-[[l-cyclopropyl-4-(2,6-dichlorophenyl)-1H- pyrazol-5-yl]methoxy]-2-azabicyclo[2.2.1]heptan-2-yl]-4-fluoro-l,3-benzothiazole-6- carboxylate 47a (50 mg, 40%) as an off-white solid.

924287-65-0 Methyl 2-bromo-4-fluorobenzo[d]thiazole-6-carboxylate 57527206, athiazole compound, is more and more widely used in various.

Reference£º
Patent; ARDELYX, INC.; CHAO, Jianhua; (231 pag.)WO2019/55808; (2019); A1;,
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Thiazole | chemical compound | Britannica