Category: thiazole

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.383865-57-4,4-Methoxy-7-morpholinobenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

3-Hydroxymethyl-piperidine-1-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide Using 4-methoxy-7-morpholin-4-yl-benzothiazol-2-ylamine and 3-hydroxymethyl-piperidine the title compound was obtained as white solid (69%). MS: m/e=436 (M+H+).

The synthetic route of 383865-57-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Alanine, Alexander; Flohr, Alexander; Miller, Aubry Kern; Norcross, Roger David; Riemer, Claus; US2002/45615; (2002); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2933-29-1,2-Amino-4,5,6,7-tetrahydrobenzothiazole,as a common compound, the synthetic route is as follows.

General procedure: A cold solution of NaNO2 in 5mL water was added dropwise tothe well-cooled solution of 4, 5, 6, 7-tetrahydro-1, 3-benzothiazole-2-amine (1) in 10mL HCl and stirred for 2 h at 0-5 C. Aftercompletion of the diazotization, the resulting diazonium salt solutionwas slowly added to the ice-cold solution of coupling components(3a-3e) in acetic acid and stirred for another 2 h at thesame temperature. The pH of the reaction mixture was maintainedat 5e6 by adding the required volume of the saturated solution ofsodium bicarbonate. Further, the obtained colored precipitate ofthe respective azo dyes (4a-4e) was separated by filtration, washedwith distilled water, dried and recrystallized from ethanol. Theschematic representation of the synthesis of azo dyes was presentedin Scheme 1.

The synthetic route of 2933-29-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Maliyappa; Keshavayya; Mallikarjuna; Murali Krishna; Shivakumara; Sandeep, Telkar; Sailaja, Krishnamurty; Nazrulla, Mohammed Azeezulla; Journal of Molecular Structure; vol. 1179; (2019); p. 630 – 641;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

106092-09-5, (S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of carboxylic acid (1 mmol) in CH2Cl2 (10 ml) were added Et3N (2 mmol) and TBTU (1.1 mmol) and the mixture was stirred at room temperature for 15 min. Then amine 1 or 3 (1 mmol)and Et3N (2 mmol) were added and the reaction mixture was stirred at room temperature for 2.5 h. The reaction mixture was diluted with CH2Cl2 (15 ml) and washed with saturated aqueous NaHCO3 solution (2×15 ml). Combined water phases were extracted with CH2Cl2 (1 20 ml). Combined organic phases weredried over Na2SO4, filtered and the solvent removed under reduced pressure.

As the paragraph descriping shows that 106092-09-5 is playing an increasingly important role.

Reference£º
Article; Hodnik, ?iga; Toma?i?, Tihomir; Ma?i?, Lucija Peterlin; Chan, Fiona; Kirby, Robert W.; Madge, David J.; Kikelj, Danijel; European Journal of Medicinal Chemistry; vol. 70; (2013); p. 154 – 164;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

298694-30-1, 4-Bromo-2-methylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 4-bromo-2-methyl-thiazole (1.5 g, 8.52 mmol), 4-chloropyridin-2- amine (1 .3 g, 10.22 mmol) and CS2003 (6.92 g, 21 .3 mmol) in 1,4 dioxane(30 ml) was degassed with nitrogen for 20 mm. Pd2(dba)3 (0.389 g, 0.42 mmol) and Xantphos (0.24 g, 0.42 mmol) were added and the resulting mixture was stirred at 90 00 for 16 h. When cooled to rt the mixture was filtered through celite, concentrated and purified by preparative HPLC to give the product as a solid (600 mg, 31%). 1H NMR (400 MHz, DMSO-d6) 6 10.15 (s, 1 H), 8.15 (d, 1 H), 7.37 (s, 1 H), 7.03 (d, 1 H), 6.85-6.84 (m, 1 H), 2.61 (s, 3 H). MS ES+ m/z226 [M+H].

The synthetic route of 298694-30-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SPRINT BIOSCIENCE AB; LINDSTROeM, Johan; FORSBLOM, Rickard; GINMAN, Tobias; RAHM, Fredrik; VIKLUND, Jenny; (93 pag.)WO2019/38389; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2719-23-5, 2-Acetamidothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

STEP B: 3-isopropyl-1,3-dihydro-1-[(2-thiazolyl)-imino]-5-(trifluoromethyl)-furo-[3,4-b]-quinolin-9-ol 10.6 g of N-(2-thiazolyl)-acetamide, 325 ml of tetrahydrofuran and 106 ml of n-butyllithium in hexane titrating 1.4M and 11.4 g of 2-(1-chloro-2-methylpropyl)-8-(trifluoromethyl)-4H-3,1-benzoxazin-4-one of Step A in solution in 80 ml of tetrahydrofuran were reacted by the procedure of Step A of Example 6 of Belgian Pat. No. 896,941 to obtain 13.8 g of 2-[(2-chloro-1-oxo-3-methylbutyl)-amino]-beta-oxo-N-(2-thiazolyl)-3-(trifluoromethyl)-benzene propanamide melting at 186 C. 11.65 g of the latter product in 200 ml of tetrahydrofuran and 3.8 g of 4-dimethylaminopyridine were refluxed for 16 hours and the tetrahydrofuran was eliminated under reduced pressure. 200 ml of water were added to the residue, and the pH was adjusted to 1-2 with N hydrochloric acid addition. After separating, washing with water and drying under reduced pressure at 100 C., 10.2 g of 3-isopropyl-1,3-dihydro-1-[(2-thiazolyl)-imino]-5-(trifluoromethyl)-furo-[3,4-b]-quinolin-9-ol melting at 246 to 248 C. were obtained.

As the paragraph descriping shows that 2719-23-5 is playing an increasingly important role.

Reference£º
Patent; Roussel Uclaf; US4735951; (1988); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.74370-93-7,4-(tert-Butyl)thiazol-2-amine,as a common compound, the synthetic route is as follows.

Synthesis of 2-bromo-4-tert-butylthiazole 85% strength phosphoric acid (50 ml) and 65% strength nitric acid (20 ml) were combined at 0 C. 3.12 g (20.0 mmol) of 4-tert-butylthiazol-2-ylamine were added to this solution and a solution of 1.38 g (20 mmol) of NaNO2 in water (10 ml) was subsequently added dropwise at 0 C. in the course of 30 min. The reaction solution was stirred at 0 C. 1 h and then added dropwise to a suspension of 20.0 g of NaBr and 5.8 g of CuBr in water (20 ml) cooled to 0 C. The mixture was stirred until evolution of gas could no longer be observed. Subsequently, the mixture was adjusted to a pH>10 using 50% strength aq. KOH solution and the product was separated off by steam distillation. The distillate was extracted with EE. The organic phase was dried over MgSO4, filtered, and concentrated in vacuo. 3.03 g (13.8 mmol, 69%) of 2-bromo-4-tert-butylthiazole were obtained as a residue.

The synthetic route of 74370-93-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Gruenenthal GmbH; US2007/112011; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

18903-18-9, Ethyl 5-aminothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 61 Sodium hydride (60% disp. in oil; 2.79g, 69.68mmol) was suspended in dry tetrahydrofuran (60m L). To this, 5-amino-thiazole-4-carboxylic acid ethyl ester (4g, 23.23mmol) was added at 0C and the mixture was stirred for 10 minutes. To this, 4- nitrobenzenesulfonyl chloride (6.2g, 27.87mmol) was added at 0C and the mixture stirred at room temperature for 2 hours. The mixture was diluted with ammonium chloride solution and diethyl ether. The solid formed collected by filtration, washed with ether and dried under vacuum to give Intermediate 61 (3.2g) as a yellow solid. LCMS (Method 37) Rt 1.56 min; m/z(M-H)” 356

18903-18-9 Ethyl 5-aminothiazole-4-carboxylate 12620181, athiazole compound, is more and more widely used in various.

Reference£º
Patent; ANTABIO SAS; LEMONNIER, Marc; DAVIES, David; PALLIN, David; WO2014/198849; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

29182-42-1, Ethyl 2-(benzo[d]thiazol-2-yl)acetate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-4. Synthesis of 3-(Benzo[d]thiazol-2-yl)-7-(isopropyl(prop-2-ynyl)amino)-2H-chromen-2-one Compound of Chemical Formula 1 To a solution in which the 2-hydroxy-4-(isopropyl(prop-2-ynyl)amino)benzaldehyde (1.8 g, 8.28 mmol) compound of Chemical Formula 4 was dissolved in ethanol (15 mL), ethyl 2-(benzo[d]thiazol-2-yl)acetate (1.83 g, 8.28 mmol) and piperidine (1.63 mL, 16.56 mmol) were added consecutively at room temperature. The reaction mixture was heated under reflux for 2 hours, cooled to room temperature, and 3-(benzo[d]thiazol-2-yl)-7-(isopropyl(prop-2-ynyl)amino)-2H-chromen-2-one (1.54 g, 50%) was obtained by filtering the precipitated solid. 1H NMR (500 MHz, CDCl3) d 8.94 (s, 1H), 8.02 (d, 1H, J=8.2 Hz), 7.94 (d, 1H, J=7.8 Hz), 7.54 (d, 1H, J=8.7 Hz), 7.47-7.50 (m, 1H), 7.35-7.38 (m, 1H), 6.88 (dd, 1H, J=2.3, 8.7 Hz), 6.80 (d, 1H, J=2.3 Hz), 4.21-4.26 (m, 1H), 4.04 (d, 2H, J=2.3 Hz), 2.26 (t, 1H, J=2.2 Hz), 1.34 (d, 6H, J=6.4 Hz); 13C NMR (125 MHz, CDCl3) d 161.5, 161.0, 156.7, 152.6, 152.4, 142.0, 136.4, 130.6, 126.2, 124.7, 122.3, 121.7, 113.9, 111.0, 109.8, 98.8, 80.0, 72.3, 49.5, 33.5, 20.2 (2).

As the paragraph descriping shows that 29182-42-1 is playing an increasingly important role.

Reference£º
Patent; ACCOBIOTECH SDN BHD.; GENBODY INC.; Park, Hyun; Kim, Hak Sung; Song, Hyun Ok; Chong, Chom Kyu; Kim, Sung Yeon; US2014/350227; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

934-34-9, Benzothiazolone is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6-(4-Nitrobenzoyl)-1,3-benzothiazol-2(3H)-one (1; Table I-B). In a 100 ml flask containing 35.0 g (265 mmol) aluminium chloride, add drop by drop and with magnetic stirring 5.9 ml of dimethylformamide (76 mmol). Continue stirring for 25 minutes, slowly add 5.0 g (33 mmol) of 2(3H)-benzothiazolone and heat to 90 C. Add drop by drop 7.36 g of 4-nitrobenzoyl chloride (40 mmol) and continue to stir at 100-110 C. for 4 hours. Slowly pour the reaction mixture onto ice while stirring vigorously. Add 15 ml of 37% hydrochloric acid and then stir for 15 minutes. Spin out the precipitate then wash with water until the wash water is neutral. Dry the product obtained and recrystallise it in dioxane (5.85 g, 59%). Rf=0.39 (EtOAc/Cyclohexane=4/6): mp 260-265 C.; ir gamma NH 3369 cm-1, CO 1682 cm-1, 1651 cm-1, NO2 1521 cm-1; 1H-NMR (300 MHz, DMSO-d6) delta 7.26 (d, 1H, H4, J4-5=7.8 Hz), 7.72-7.74 (m, 1H, H5), 7.92 (d, 2H, H3′, H5′, J=9.0 Hz), 8.09 (s, 1H, H7), 8.36 (d, 2H, H2′, H6′, J=9.0 Hz), 12.3 (br s, 1H, NH, exchangeable with D2O). Anal. (C14H8N2O4S)

The synthetic route of 934-34-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Park, Chang-Ha; Yous, Said; Nativelle-Serpentini, Celine; Seralini, Gilles-Eric; Chang, Soon-Jae; Lesieur, Daniel; US2007/54899; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

4175-76-2, 2,4-Dichlorothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation 194-chloro-2-morpholino-thiazoleTo a mixture of 2,4-dichlorothiazole (34 g, 0.22 mol) in acetonitrile (425 mL) add potassium carbonate (60.9 g, 0.44 mol) and then morpholine (21.2 mL, 0.225 mol) dropwise over 30 min. Reflux the mixture at 40 0C and then cool to 22 C. Filter the mixture and evaporate the filtrate. Triturate the residue with /-propyl alcohol (60 mL) at 22 0C for one hour. Filter the solids and dry under vacuum to a constant weight to afford the title compound (34.5 g, 76%). ES/MS m/z (35Cl) 205 (M+l)+.

As the paragraph descriping shows that 4175-76-2 is playing an increasingly important role.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2008/36579; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica