Category: thiazole

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51640-36-9,2-Chlorothiazole-5-carbonitrile,as a common compound, the synthetic route is as follows.

To a solution of Example 1A (1.18 g, 7.75 mmol) in N,N-dimethylformamide (50 mL) was added potassium carbonate (1.1 g, 7.96 mmol), 2-chlorothiazole-5-carbonitrile (CAS 51640-36-9, 1.12 g, 7.75 mmol) and then the reaction was stirred at room temperature overnight. The reaction mixture was diluted with ethyl acetate (100 mL) and washed with water (3¡Á50 mL) and brine (50 mL). The organics were dried over magnesium sulfate, filtered, and evaporated. The product was purified via silica-gel column chromatography using dichloromethane as the eluent. The title compound was obtained as white solid (2.0 g), 1H NMR (300 MHz, CDCl3) delta ppm 7.76 (s, 1H) 7.12-7.23 (m, 2 H) 6.87-7.00 (m, 2 H) 4.44-4.65 (heptet, J=6.25 Hz, 1 H) 1.36 (d, J=6.25 Hz, 6 H), MS (DCI): m/z 261 (M+H)+.

51640-36-9 2-Chlorothiazole-5-carbonitrile 1485222, athiazole compound, is more and more widely used in various.

Reference£º
Patent; Gu, Yu Gui; Weitzberg, Moshe; Xu, Xiangdong; Clark, Richard F.; Zhang, Tianyuan; Li, Qun; Hansen, Todd M.; Sham, Hing; Beutel, Bruce A.; Camp, Heidi S.; Wang, Xiaojun; US2007/225332; (2007); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.182344-57-6,4-Bromo-2-chlorobenzo[d]thiazole,as a common compound, the synthetic route is as follows.

EXAMPLE 183 (+)-(4aR)-(10bR)-4-methyl-8-(4-bromo-2-benzothiazolylthio)-10b-methyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolin-3-one A 15 mL round bottom flask was charged with (+)-(4aR)-(10bR)-4-methyl-8-mercapto-10b-methyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolin-3-one (100 mg, 0.38 mmol), potassium carbonate (158 mg, 1.14 mmol), 2-chloro-4-bromobenzothiazole (114 mg, 0.46 mmol) and 1 mL of anhydrous dimethylformamide, fitted with a reflux condenser, and the stirred mixture was heated at 60, under nitrogen, for 18 h. The mixture was cooled, diluted with ethyl acetate (75 mL) and washed with brine (2*25 mL). The combined organic extracts were dried over sodium sulfate, concentrated, and purified by silica gel chromatography (ethyl acetate eluent) to give 142 mg (79%) of the title compound as an off white solid. mp 206-210. FDMS: m/e=474. alpha[D]589 =+56.25 (c=0.59, chloroform).

182344-57-6 4-Bromo-2-chlorobenzo[d]thiazole 2049865, athiazole compound, is more and more widely used in various.

Reference£º
Patent; Eli Lilly and Company; US5550134; (1996); A;; ; Patent; ELi Lilly and Company; US5629007; (1997); A;,
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22900-83-0, Ethyl 2-bromo-4-methylthiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 4-aminothiophenol (1.25 g, 10.0 mmol), ethyl 2-bromo-4-methylthiazole-5-carboxylate (2.75 g, 11.0 mmol) and potassium carbonate (1.52 g,11.0 mmol) in acetonitrile (10 mL) was heated to 80 ¡ãC and stirred for 20 hours under an N2 atmosphere. The reaction mixture was then cooled to rt. The resulting mixture was filtered and the filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography (PE/EtOAc (v/v) = 10/1) to give the title compound as a white solid (1.0 g,34.0percent). The compound was characterized by the following spectroscopic data:LC-MS (ESI, pos. ion) m/z: 295.1 [M + H] and?H NMR(400 MHz, CDC13) (ppm): 7.46 (d, J = 8.4 Hz, 2H), 6.77 (d, J = 8.4 Hz, 2H), 4.25 (q, J 7.2 Hz, 2H), 2.67 (s, 3H), 1.30 (d, J 7.2 Hz, 3H).

As the paragraph descriping shows that 22900-83-0 is playing an increasingly important role.

Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; JIN, Chuanfei; CHENG, Changchung; WO2015/169180; (2015); A1;,
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78364-55-3, 6-Fluoro-2-hydrazinylbenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 ¡ãC for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized to give compounds 3-29.

As the paragraph descriping shows that 78364-55-3 is playing an increasingly important role.

Reference£º
Article; Gabr, Moustafa T.; El-Gohary, Nadia S.; El-Bendary, Eman R.; El-Kerdawy, Mohamed M.; Ni, Nanting; Chinese Chemical Letters; vol. 27; 3; (2016); p. 380 – 386;,
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10200-59-6, 2-Thiazolecarboxaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Thiazole-2-carbaldehyde (301 mg, 2.66 mmol) was dissolved in methanol (15 mL) at 0 ¡ã C,Sodium borohydride (151 mg, 3.99 mmol) was added to the system and reacted for 2 h. The reaction solution was poured into water (10 mL)The solvent was spin-dried, extracted with ethyl acetate (15 mL ¡Á 3), washed with saturated brine (15 mL), dried over anhydrous sodium sulfate,The solvent was removed and the residue was subjected to column chromatography (eluent:PE / EtOAc (v / v) = 5/1) to give 285 mg of a pale yellow oil, yield: 93percent.

As the paragraph descriping shows that 10200-59-6 is playing an increasingly important role.

Reference£º
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Liu Bing; Bai Shun; Zhou Youbo; Yang Tiping; He Wei; Zhang Yingjun; Zheng Changchun; (103 pag.)CN106749268; (2017); A;,
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494769-44-7, tert-Butyl (4-(hydroxymethyl)thiazol-2-yl)carbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

tert-Butyl 4-(hydroxymethyl)thiazol-2-ylcarbamate (2.0 g, 8.68 mmol) was taken up in 25 mL of CH2Cl2 along with Et3N (1.82 mL, 13.05 mmol) and cooled to 0 C. Methanesulfonyl chloride (0.85 mL, 10.88 mmol) was added and the resulting reaction mixture was stirred at 0 C for 60 min. Morpholine (3.0 mL, 35 mmol) was then added and the reaction mixture was stirred at room temp for 18 h. The reaction mixture was concentrated under reduced pressure. The resulting residue was taken up in EtOAc and washed with dilute aqueous NaHCO3, brine, dried with Na2SO4, and concentrated under reduced pressure. This material was purified by filtering through a short column of silica gel. The filtrate was concentrated to afford tert-butyl 4-(morpholinomethyl)thiazol-2-ylcarbamate (1.88 g, 69 % yield).

494769-44-7 tert-Butyl (4-(hydroxymethyl)thiazol-2-yl)carbamate 22280475, athiazole compound, is more and more widely used in various.

Reference£º
Patent; GlaxoSmithKline LLC; CASAUBON, Rebecca, L.; NARAYAN, Radha; OALMANN, Christopher; VU, Chi, B.; (583 pag.)EP2768509; (2017); B1;,
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173979-01-6, 4-(Tributylstannyl)thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(R)-7-(4-bromo-lH-imidazol-l-yl)-5-cyclopentyl-4-ethyl-4,5-dihydro- [l,2,4]triazolo[4,3-f]pteridine (Example 93), 4-(tributylstannyl)thiazole (1 eq, seeExample 693) and Pd(PPli3)4 (0.1 eq) are dissolved in DMF in a screw cap vial and a stream of nitrogen is bubbled through the mixture for 2 minutes. The vial is sealed and the resulting solution is stirred at 100 C for 19 h. The reaction mixture is diluted with brine, extracted with EtOAc, dried with Na2S04 then purified by flash chromatography with a silica gel column by eluting with a mixture of Hexane:EtOAc and then further purified by preparative HPLC to give the title compound.

The synthetic route of 173979-01-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ELAN PHARMACEUTICALS, INC.; NEITZ, R., Jeffrey; TROUNG, Anh, P.; GALEMMO, Robert, A.; YE, Xiaocong, Michael; SEALY, Jennifer; ADLER, Marc; BOWERS, Simeon; BEROZA, Paul; ANDERSON, John, P.; AUBELE, Danielle, L.; ARTIS, Dean, Richard; HOM, Roy, K.; ZHU, Yong-liang; WO2012/48129; (2012); A2;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78485-37-7,Ethyl 2-chloro-6-benzothiazolecarboxylate,as a common compound, the synthetic route is as follows.

To ethyl 2-chlorobenzo[d]thiazole-6-carboxylate (1d-1) (305 mg, 1.263 mmol) and (1R,3R,5S)-N-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methyl)-8-azabicyclo[3.2.1]octan-3-amine hydrochloride (1c-1) (430 mg, 0.842 mmol, ?84% by weight) in DMA (5 ml) was added cesium carbonate (686 mg, 2.105 mmol). The resulting mixture was heated up to 60 C. for 16 h, cooled down to room temperature. The mixture was diluted with ethyl acetate, washed with water (4*), brine, dried, filtered, and concentrated. The residue was chromatographed by CombiFlash eluting with hexane to 70% ethyl acetate/hexane to give ethyl 2-((1R,3R,5S)-3-(((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methyl)amino)-8-azabicyclo[3.2.1]octan-8-yl)benzo[d]thiazole-6-carboxylate (Example 1) (198 mg). LC/MS observed [M+H], 597.15.

As the paragraph descriping shows that 78485-37-7 is playing an increasingly important role.

Reference£º
Patent; Enanta Pharmaceuticals, Inc.; Ma, Jun; Wang, Guoqiang; Wang, Bin; Xing, Xuechao; Shen, Ruichao; He, Jing; Or, Yat Sun; (530 pag.)US2018/99957; (2018); A1;,
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7305-71-7, 2-Amino-5-methylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a stirred solution of -corresponding hetero amines a?e (0.04?mol) and triethyl amine (0.04?mol) in chloroform (200?ml) was added drop wise chloroacetyl chloride (0.04?mol) at 0?5?¡ãC. After addition, the resulting mixture was stirred overnight at room temperature. Reaction completion was monitored through thin layer chromatography using hexane:ethyl acetate (8:2) as mobile phase. The reaction mixture was concentrated to get solid and as such taken in the methanol solution. The precipitates thus separated out were allowed to stand 2?h. The resultant solid 1a?e was filtered, washed, dried and as such taken for the next step.

As the paragraph descriping shows that 7305-71-7 is playing an increasingly important role.

Reference£º
Article; Patel, Navin B.; Purohit, Amit C.; Rajani, Dhanji P.; Moo-Puc, Rosa; Rivera, Gildardo; European Journal of Medicinal Chemistry; vol. 62; (2013); p. 677 – 687;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.88982-82-5,4-Bromo-1,3-thiazole-2-carboxylic acid,as a common compound, the synthetic route is as follows.

To a solution of 4-bromothiazole-2-carboxylic acid (40.0 mg, 0.19 mmol) in DMF (3.0mL), HBTU (86 mg, 0.23 mmol) was added dropwise, and then DMF (2 drops) was added. The mixture was stirred at room temp for 2 h, concentrated under reduced pressure and dried by vacuum. DCM (3.0 mL) was added to the residue and the resulting solution was cooled to 0 C and 2-aminopyridine (20.0 mg, 0.20 mmol),TEA (0.2 mL, 1.43 mmol) was added. The mixture was stirred at room temperature 3 h. The subsequent mixture was concentrated under reduced pressure andextracted with H2O/ethyl acetate. The combined organic layer wasdried by Na2SO4, concentrated under reduced pressure and purified by column chromatography on silica gel (hexane/ethyl acetate = 5:1) toafford the title compound 6be (25.0 mg, 46 %) as white solid; 1H-NMR(400 MHz, CDCl3) delta 9.56(s, 1H), 8.36 (dq, J = 4.8, 0.8 Hz,1H), 8.27 (d, J = 8.4 Hz , 1H), 7.76(t, J = 7.6 Hz, 1H), 7.54 (s, 1H),7.11 (ddd, J = 7.2, 4.8, 0.8 Hz, 1H).13C-NMR (100 MHz, CDCl3) delta 163.3, 156.4, 150.3, 148.4, 138.4, 126.1,124.1, 120.6, 114.2. LC/MS (ESI-) 283.9 (M+H)+.

As the paragraph descriping shows that 88982-82-5 is playing an increasingly important role.

Reference£º
Article; Vu, Hoang Nam; Kim, Ji Young; Hassan, Ahmed H.E.; Choi, Kihang; Park, Jong-Hyun; Park, Ki Duk; Lee, Jae Kyun; Pae, Ae Nim; Choo, Hyunah; Min, Sun-Joon; Cho, Yong Seo; Bioorganic and Medicinal Chemistry Letters; vol. 26; 1; (2016); p. 140 – 144;,
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Thiazole | chemical compound | Britannica