Heterocyclic Building Blocks-Thiazole

On April 6, 2022, Dong, Yuyang; Schuppe, Alexander W.; Mai, Binh Khanh; Liu, Peng; Buchwald, Stephen L. published an article.Related Products of 24295-03-2 The title of the article was Confronting the Challenging Asymmetric Carbonyl 1,2-Addition Using Vinyl Heteroarene Pronucleophiles: Ligand-Controlled Regiodivergent Processes through a Dearomatized Allyl-Cu Species. And the article contained the following:

A CuH-catalyzed regiodivergent coupling of vinyl heteroarenes with carbonyl-containing electrophiles, in which the selectivity was controlled by the ancillary ligand. This approach leverages an in situ generated benzyl- or dearomatized allyl-Cu intermediate, yielding either the dearomatized or exocyclic addition products, resp. The method exhibited excellent regio-, diastereo-, and enantioselectivity and tolerated a range of common functional groups and heterocycles. The dearomative pathway allowed direct access to a variety of functionalized saturated heterocyclic structures. The reaction mechanism was probed using a combination of exptl. and computational approach. D. functional theory studies suggested that the ligand-controlled regioselectivity results from the C-H/π interaction and steric repulsion in transition states leading to the major and minor regioisomers, resp. Hydrocupration of vinyl heteroarene pronucleophile was the enantiodetermining step, whereas the diastereoselectivity was enforced by steric interactions between the benzylic or allyl-Cu intermediate and carbonyl-containing substrates in a six-membered cyclic transition state. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Related Products of 24295-03-2

The Article related to vinyl hetero arene aldehyde ketone copper catalyst reductive coupling, hydroxy vinyl heteroarene regio diastereo enantioselective preparation, General Organic Chemistry: Synthetic Methods and other aspects.Related Products of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 30, 2020, Mariammal, Balasubramanian; Shylaja, Adaikalam; Kumar, Sundaravel Vivek; Rubina, Stephen Raja; Kumar, Raju Ranjith published an article.Electric Literature of 24295-03-2 The title of the article was Thiazole-tethered biaryls as fluorescent chemosensors for the selective detection of Fe3+ ions. And the article contained the following:

3-Amino-5-(thiazol-2-yl)-[1,1′-biaryl]-2,4-dicarbonitriles have been synthesized employing a facile one-pot pseudo four-component domino strategy. All these thiazole-tethered biaryls exhibited blue fluorescence under UV lamp. Based on the high relative quantum yield, three compounds namely, 4a, 4d, and 4i, were chosen to explore the metal interference studies. Against several metal ions, these three thiazole-tethered biphenyl probes were found to be effective fluorescent chemosensors for the selective and sensitive detection of Fe3+ ions with a lower detection limit of 0.18, 0.12, and 0.16μM, resp. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Electric Literature of 24295-03-2

The Article related to thiazole tethered biaryls fluorescent chemosensor iron, Inorganic Analytical Chemistry: Determinations and other aspects.Electric Literature of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On December 31, 2020, Ruiz-Moyano, Santiago; Hernandez, Alejandro; Galvan, Ana I.; Cordoba, Maria G.; Casquete, Rocio; Serradilla, Manuel J.; Martin, Alberto published an article.COA of Formula: C5H5NOS The title of the article was Selection and application of antifungal VOCs-producing yeasts as biocontrol agents of grey mould in fruits. And the article contained the following:

Rotting caused by gray mold (Botrytis cinerea) is a concerning disease for numerous crops both pre- and postharvest stages. Application of antagonistic yeasts is a promising strategy for controlling gray mold incidence which could mitigate undesirable consequences of using synthetic fungicides. In this work, a screening for detection of yeasts isolated from figs producers of antifungal volatile organic compounds (VOCs) were performed by confrontation in double dishes systems. Eleven out of 34 yeasts confronted reduced B. cinerea growth parameter in vitro. This reduction was correlated (p ≤ 0.050) with the production of 10 volatile compounds: two acids (acetic acid and octanoic acid), 7 esters (Et propionate, n-Pr acetate, Iso-Bu acetate, 2-methylbutyl acetate, furfuryl acetate, phenylmethyl acetate, 2-phenylethyl acetate) and one ketone (Heptan-2-one). In bases on in vitro assay, Hanseniaspora uvarum 793 was applied to in vivo assays with strawberries and cherries. The reduction of incidence of B. cinerea in strawberries at 7°C and 25°C was 54.9 and 72.1% after 6 and 3 days, resp. The reduction of incidence of B. cinerea in cherries at 7°C and 25°C was 48.9 and 45.6% after 5 and 4 days, resp. These results showed that VOCs produced by Hanseniaspora uvarum 793 are effective in the control of incidence of Botrytis cinerea in fruits, being a potential alternative to chem. fungicide. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).COA of Formula: C5H5NOS

The Article related to antifungal volatile compound yeast gray mold fruit, antifungal volatile compounds, botrytis cinerea, cherry, postharvest, strawberry, Food and Feed Chemistry: Feeds and Animal Foods and other aspects.COA of Formula: C5H5NOS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 24, 2017, Liu, Denggui; Yang, Kunyu; Zhou, Wei; Chen, Hao; Zeng, Qingdong published a patent.Quality Control of Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate The title of the patent was Preparation of 2-(4-methyl-1-oxo-2-penten-1-yl)-4-thiazolecarboxylic acid ethyl ester. And the patent contained the following:

The invention discloses a preparation method of anti-cancer medicament intermediate, using glyceraldehyde acetonide and L-cysteine hydrochloride as raw materials, through steps such as cyclization, oxidation, de-propylidene, reoxidizing, and halohydrin to obtain an intermediate compound, which was further reacted with isobutyric aldehyde through Wittig, and compound 2-(4-methyl-1-oxo-2-penten-1-yl)-4-thiazolecarboxylic acid Et ester is obtained. The experimental process involved the reaction of Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate(cas: 944559-46-0).Quality Control of Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate

The Article related to thiazolecarboxylic acid ethyl ester preparation, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Quality Control of Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 31, 2021, Berenguer, Cristina; Pereira, Jorge A. M.; Camara, Jose S. published an article.SDS of cas: 24295-03-2 The title of the article was Fingerprinting the volatile profile of traditional tobacco and e-cigarettes: A comparative study. And the article contained the following:

Electronic cigarettes (e-cigarettes) have become popular alternatives to traditional tobacco. Despite this, a comprehensive evaluation of their long-term effects and safety for the consumers and the environment is missing. To contribute to filling this gap, headspace solid-phase microextraction combined with gas chromatog.-mass spectrometry (HS-SPME/GC-MS) was employed to establish and compare the volatile fingerprints of traditional tobacco and e-cigarettes. The anal. of traditional tobacco included two popular brands and different parts of the cigarette (solid tobacco, cigarette smoke, cigarette paper and filter). Regarding the e-cigarettes, two e-liquids, with and without nicotine, their main constituents (e-bases) and corresponding vapors, obtained under default vaping (power) conditions, were analyzed. A total of 80 volatile organic compounds (VOCs) were identified in traditional tobacco, of which 14 carbonyl compounds, 9 benzene derivatives, 9 Et esters and 9 hydrocarbons. Slight differences in the volatile profile of cigarette paper and filter between the two brands were also detected, showing that exogenous components of tobacco influence the flavor and harmfulness perceived by the smokers. In turn, 92 VOCs were identified in e-cigarettes, including 31 Et esters, 18 alcs. and 10 hydrocarbons. No VOCs with potentially toxic or harmful effects were identified in the vapor of Do It Yourself (DIY) liquids and Premium samples. Therefore, taking into consideration the volatile compositions obtained for smoking and vaping procedures under normal conditions of operation and using certified e-liquid mixtures, the e-cigarettes analyzed seemed to constitute a valid and less harmful alternative to traditional tobacco for smokers, second-hand smokers and the environment. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).SDS of cas: 24295-03-2

The Article related to traditional tobacco cigarette volatile profile fingerprinting, Plant Biochemistry: Tobacco and Tobacco Products and other aspects.SDS of cas: 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On October 15, 2021, Hu, Yuanyuan; Hu, Chunfang; Pan, Guangxing; Yu, Congwei; Ansari, Mohammad Fawad; Yadav Bheemanaboina, Rammohan R.; Cheng, Yu; Zhou, Chenghe; Zhang, Jiaheng published an article.Formula: C5H5NOS The title of the article was Novel chalcone-conjugated, multi-flexible end-group coumarin thiazole hybrids as potential antibacterial repressors against methicillin-resistant Staphylococcus aureus. And the article contained the following:

The increasing resistance of methicillin-resistant Staphylococcus aureus (MRSA) to antibiotics has led to a growing effort to design and synthesize novel structural candidates of chalcone-conjugated, multi-flexible end-group coumarin thiazole hybrids with outstanding bacteriostatic potential. Bioactivity screening showed that hybrid 5i, which was modified with methoxybenzene, exerted a significant inhibitory activity against MRSA (MIC = 0.004 mM), which was 6 times better than the anti-MRSA activity of the reference drug norfloxacin (MIC = 0.025 mM). Compound 5i neither conferred apparent resistance onto MRSA strains even after multiple passages nor triggered evident toxicity to human hepatocyte LO2 cells and normal mammalian cells (RAW 264.7). Mol. docking showed that highly active mol. 5i might bind to DNA gyrase by forming stable hydrogen bonds. In addition, mol. electrostatic potential surfaces were developed to explain the high antibacterial activity of the target compounds Furthermore, preliminary mechanism studies suggested that hybrid 5i could disrupt the bacterial membrane of MRSA and insert itself into MRSA DNA to impede its replication, thus possibly becoming a potential antibacterial repressor against MRSA. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Formula: C5H5NOS

The Article related to staphylococcus methicillin resistance antibacterial chalcone macrophage hepatocyte, antibacterial, chalcone, coumarin, dna, mrsa, thiazole, Microbial, Algal, and Fungal Biochemistry: Other and other aspects.Formula: C5H5NOS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Kucukbay, F. Zehra; Bugday, Nesrin; Kucukbay, Hasan; Tanc, Muhammet; Supuran, Claudiu T. published an article in 2016, the title of the article was Synthesis, characterization and carbonic anhydrase inhibitory activity of novel benzothiazole derivatives.Electric Literature of 92-36-4 And the article contains the following content:

N-protected amino acids I [Pg = Cbz, Boc, R = H, Me; Pg =Boc, R = CH2Ph] were reacted with substituted benzothiazoles to give the corresponding N-protected amino acid-benzothiazole conjugates II [Pg = Cbz, R = H; Pg = Boc, R = H, CH2Ph], III [Pg = Cbz, R = H, Me; Pg = Boc, R = H, CH2Ph] and IV [Pg = CBz, R = H, Me; Pg = Boc, R = H, Me, CH2Ph] (60-89%). Their structures were confirmed by proton NMR (1H NMR), carbon-13 NMR (13C NMR), IR and elemental anal. Their carbonic anhydrase (CA, EC 4.2.1.1) inhibitory activities were determined against two cytosolic human isoforms (hCA I and hCA II), one membrane-associated (hCA IV) and one transmembrane (hCA XII) enzyme by a stopped-flow CO2 hydrase assay method. The new compounds showed rather weak, micromolar inhibitory activity against most of these enzymes. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Electric Literature of 92-36-4

The Article related to amino acid benzothiazole amide preparation carbonic anhydrase inhibition, amino acid-benzothiazole conjugates, benzothiazole, carbonic anhydrase, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Electric Literature of 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On March 20, 2003, Karlsson, H. Jonas; Lincoln, Per; Westman, Gunnar published an article.HPLC of Formula: 92-36-4 The title of the article was Synthesis and DNA binding studies of a new asymmetric cyanine dye binding in the minor groove of [poly(dA-dT)]2. And the article contained the following:

A new asym. cyanine dye has been synthesized and its interaction with different DNA has been investigated. In this dye, BEBO, the structure of the known intercalating cyanine dye BO has been extended with a benzothiazole substituent. The resulting crescent-shape of the mol. is similar to that of the well-known minor groove binder Hoechst 33258. Indeed, comparative studies of BO illustrate a considerable change in binding mode induced by this structural modification. Linear and CD studies indicate that BEBO binds in the minor groove to [poly (dA-dT)]2, but that the binding to calf thymus DNA is heterogeneous, although still with a significant contribution of minor groove binding. Similar to other DNA binding asym. cyanine dyes, BEBO has a large increase in fluorescence intensity upon binding and a relatively large quantum yield when bound. The minor groove binding of BEBO to [poly (dA-dT)]2 affords roughly a 180-fold increase in intensity, which is larger than to that of the commonly used minor groove binding probes DAPI and Hoechst 33258. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).HPLC of Formula: 92-36-4

The Article related to dna cyanine dye preparation, Biochemical Methods: Spectral and Related Methods and other aspects.HPLC of Formula: 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On August 31, 1987, Yoshioka, Mitsuru published an article.Synthetic Route of 64987-16-2 The title of the article was Synthetic studies related to oral β-lactam antibiotics. And the article contained the following:

A review. Review with 10 references on the development of an industrial process for producing 7432-S (I), a new oral cephem in 36-42% overall yields from penicillin G. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Synthetic Route of 64987-16-2

The Article related to review cephem 7432 s manufacture, Biomolecules and Their Synthetic Analogs: Reviews and other aspects.Synthetic Route of 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On February 28, 2008, Du, Hongying; Wang, Jie; Watzl, June; Zhang, Xiaoyun; Hu, Zhide published an article.Electric Literature of 92-36-4 The title of the article was Classification structure-activity relationship (CSAR) studies for prediction of genotoxicity of thiophene derivatives. And the article contained the following:

The grid search support vector machine (GS-SVM) was used to build a classification structure-activity relationship (CSAR) model and to predict the genotoxicity property of 140 thiophene derivatives with the information derived from the compounds’ mol. structures. The seven descriptors selected by linear discriminant anal. (LDA) were used as the inputs to develop the GS-SVM model. Using the Grid Search method, a satisfactory model with a good predictive capability was obtained. The quality of the models was evaluated by the number of right classified compounds The total accuracy of the LDA model was 81.4% and 85.2% for the training set and test set, resp., and to the GS-SVM model was 92.9% and 92.6%, resp. It was proved that the GS-SVM method was a very useful modeling approach with good classification ability for the genotoxicity of the thiophene derivatives This work also provides a new idea and an alternative method to investigate the genotoxicity of the similar structures with thiophene derivatives, and can be extended to other toxicity studies. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Electric Literature of 92-36-4

The Article related to thiophene derivative genotoxicity classification structure activity, Toxicology: Carcinogens, Mutagens, and Teratogens and other aspects.Electric Literature of 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica