Lu, Dong-Dong et al. published their research in Journal of Organic Chemistry in 2017 | CAS: 615-20-3

2-Chlorobenzothiazole (cas: 615-20-3) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Recommanded Product: 615-20-3

Bulky Yet Flexible Pd-PEPPSI-IPentAn for the Synthesis of Sterically Hindered Biaryls in Air was written by Lu, Dong-Dong;He, Xu-Xian;Liu, Feng-Shou. And the article was included in Journal of Organic Chemistry in 2017.Recommanded Product: 615-20-3 This article mentions the following:

In this report, a type of moisture and air stable Pd-PEPPSI-IPentAn complex with the combination of acenaphthyl on the backbone and isopentyl groups on N-aryl moieties, I, was described and applied in the Suzuki-Miyaura cross-coupling reaction in air. The reaction conditions were optimized, and the structure-reactivity relationships between I and other classical efficient Pd-PEPPSI complexes were investigated intensively. Our study demonstrated that both the backbone and N-aryl moieties gave rise to a significant effect on this transformation when exposed to air. A wide range of sterically hindered (hetero)aryl chlorides with (hetero)arylboronic acids were compatible, giving good to excellent isolated yields of sterically hindered bi(hetero)aryls. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzothiazole (cas: 615-20-3Recommanded Product: 615-20-3).

2-Chlorobenzothiazole (cas: 615-20-3) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Recommanded Product: 615-20-3

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Gadekar, Sachin P. et al. published their research in Research on Chemical Intermediates in 2021 | CAS: 16112-21-3

2-(4-Methylphenyl)benzothiazole (cas: 16112-21-3) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Recommanded Product: 2-(4-Methylphenyl)benzothiazole

Ruthenium silicate (RS-1) zeolite: novel heterogeneous efficient catalyst for synthesis of 2-arylbenzothiazole derivatives was written by Gadekar, Sachin P.;Lande, Machhindra K.. And the article was included in Research on Chemical Intermediates in 2021.Recommanded Product: 2-(4-Methylphenyl)benzothiazole This article mentions the following:

Mesoporous silicate and transition metal (Ru+3) containing mesoporous silicate materials or ruthenium silicate Ru+3/Si+4 where synthesis by using hydrothermal process. Mesoporous ruthenium silicate (RS-1) and zeolite catalyst have been successfully synthesized with variable molar ratio such as (a) Ru:Si 1:100, (b) Ru:Si 1:150, (c) Ru:Si 1:200. The elemental composition, structural morphol., crystal phase and properties and various parameters of the catalyst were examined by Fourier transform IR spectroscopy, SEM, powder X-ray diffraction. Energy dispersive X-ray pattern/spectroscopy anal. EDX/EDS, where as the activity of obtained catalysts was tested in the Willgerodt-Kindler synthesis between 2-aminothiophenol and substituted aryl aldehyde (1:1 mol) to form a 2-arylbenzothiazole. The novelty of the presented work was the ruthenium (Ru+3) metal impregnations in silicate framework for the synthesis of novel ruthenium silicate (RS-1) zeolite as a catalyst and the investigation of the various parameters, role, its stability and catalytic activity in the Willgerodt-Kindler (combined both Knovenagel and Maichel addition reaction) synthesis. The developed protocol has several benefits such as short reaction time, mild reaction condition, and good reusability of catalyst. Graphic abstract: [graphic not available: see fulltext]. In the experiment, the researchers used many compounds, for example, 2-(4-Methylphenyl)benzothiazole (cas: 16112-21-3Recommanded Product: 2-(4-Methylphenyl)benzothiazole).

2-(4-Methylphenyl)benzothiazole (cas: 16112-21-3) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Recommanded Product: 2-(4-Methylphenyl)benzothiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Vree, T. B. et al. published their research in European Journal of Clinical Pharmacology in 1981 | CAS: 127-76-4

N-(4-(N-(Thiazol-2-yl)sulfamoyl)phenyl)acetamide (cas: 127-76-4) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Computed Properties of C11H11N3O3S2

Pharmacokinetics and mechanism of renal excretion of short acting sulfonamides and N4-acetylsulfonamide derivatives in man. Structural requirements of sulfonamides for active tubular secretion was written by Vree, T. B.;Hekster, Y. A.;Damsma, J. E.;Tijhuis, M.;Friesen, W. T.. And the article was included in European Journal of Clinical Pharmacology in 1981.Computed Properties of C11H11N3O3S2 This article mentions the following:

The pharmacokinetics of short acting sulfonamides and a series of N4-acetylsulfonamides was investigated. Sulfonamides with a S atom 2 at. bond distances from the N1-atom are excreted by active tubular secretion, e.g. sulfamethizole  [144-82-1], sulfaethidole  [94-19-9], and sulfathiazole  [72-14-0]. When the S atom is replaced by an O or N, active renal excretion no longer occurs. N4-Acetylsulfonamides are excreted by active tubular secretion. The renal clearance value of the N4-acetylsulfonamides are not influenced by the substituent at the N1 position. Two groups of N4-acetylsulfonamides can be distinguished. One has a T1/2 of 4-6 h and a renal clearance value of 20-60 mL/min and the second has a T1/2 of 10-20 h and a renal clearance of <10 mL/min. N4-Acetylsulfonamides are deacetylated ∼5%. In the experiment, the researchers used many compounds, for example, N-(4-(N-(Thiazol-2-yl)sulfamoyl)phenyl)acetamide (cas: 127-76-4Computed Properties of C11H11N3O3S2).

N-(4-(N-(Thiazol-2-yl)sulfamoyl)phenyl)acetamide (cas: 127-76-4) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Computed Properties of C11H11N3O3S2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Abou-Seri, Sahar M. et al. published their research in European Journal of Medicinal Chemistry in 2016 | CAS: 2103-99-3

4-(4-Chlorophenyl)thiazol-2-amine (cas: 2103-99-3) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Recommanded Product: 2103-99-3

1-Piperazinylphthalazines as potential VEGFR-2 inhibitors and anticancer agents: Synthesis and in vitro biological evaluation was written by Abou-Seri, Sahar M.;Eldehna, Wagdy M.;Ali, Mamdouh M.;Abou El Ella, Dalal A.. And the article was included in European Journal of Medicinal Chemistry in 2016.Recommanded Product: 2103-99-3 This article mentions the following:

In our endeavor towards the development of effective VEGFR-2 inhibitors, three novel series of phthalazine derivatives based on 1-piperazinyl-4-arylphthalazine scaffold were synthesized. All the newly prepared phthalazines were evaluated in vitro for their inhibitory activity against VEGFR-2. In particular, compounds I and II potently inhibited VEGFR-2 at sub-micromolar IC50 values 0.35 ± 0.03 and 0.40 ± 0.04 μM, resp. Moreover, seventeen selected compounds were evaluated for their in vitro anticancer activity according to US-NCI protocol, where compounds I and II proved to be the most potent anticancer agents. While, compound I exhibited potent broad spectrum anticancer activity with full panel GI50 (MG-MID) value of 3.62 μM, compound II showed high selectivity toward leukemia and prostate cancer subpanels [subpanel GI50 (MG-MID) 3.51 and 5.15 μM, resp.]. Mol. docking of compounds I and II into VEGFR-2 active site was performed to explore their potential binding mode. In the experiment, the researchers used many compounds, for example, 4-(4-Chlorophenyl)thiazol-2-amine (cas: 2103-99-3Recommanded Product: 2103-99-3).

4-(4-Chlorophenyl)thiazol-2-amine (cas: 2103-99-3) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Recommanded Product: 2103-99-3

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Roostaei Firozabad, Amirreza et al. published their research in BMC Infectious Diseases in 2021 | CAS: 14769-73-4

(S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole (cas: 14769-73-4) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at 未 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.HPLC of Formula: 14769-73-4

Efficacy and safety of Levamisole treatment in clinical presentations of non-hospitalized patients with COVID-19: a double-blind, randomized, controlled trial was written by Roostaei Firozabad, Amirreza;Meybodi, Zohreh Akhoundi;Mousavinasab, Seyed Ruhollah;Sahebnasagh, Adeleh;Jelodar, Mohsen Gholinataj;Karimzadeh, Iman;Habtemariam, Solomon;Saghafi, Fatemeh. And the article was included in BMC Infectious Diseases in 2021.HPLC of Formula: 14769-73-4 This article mentions the following:

Abstract: Background: Levamisole has shown clin. benefits in the management of COVID-19 via its immunomodulatory effect. However, the exact role of Levamisole effect in clin. status of COVID-19 patients is unknown. We aimed to evaluate the efficacy of Levamisole on clin. status of patients with COVID-19 during their course of the disease. Methods: This prospective, double-blind, randomized controlled clin. trial was performed in adult patients with mild to moderate COVID-19 (room-air oxygen saturation > 94%) from late Apr. 2020 to mid-August 2020. Patients were randomly assigned to receive a 3-day course of Levamisole or placebo in combination with routine standard of care. Results: With 25 patients in each arm, 50 patients with COVID-19 were enrolled in the study. Most of the study participants were men (60%). On days 3 and 14, patients in Levamisole group had significantly better cough status distribution when compared to the placebo group (P-value = 0.034 and 0.005, resp.). Moreover, there was significant differences between the two groups in dyspnea at follow-up intervals of 7 (P-value = 0.015) and 14 (P-value = 0.010) days after receiving the interventions. However, no significant difference in fever status was observed on days 1, 3, 7, and 14 in both groups (P-value > 0.05). Conclusion: The results of the current study suggest that Levamisole may improve most of clin. status of patients with COVID-19. The patients receiving Levamisole had significantly better chance of clin. status including cough and dyspnea on day 14 when compared to the placebo. However, the effect-size of this finding has uncertain clin. importance. Trial registration: The trial was registered as IRCT20190810044500N7 (19/09/2020). In the experiment, the researchers used many compounds, for example, (S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole (cas: 14769-73-4HPLC of Formula: 14769-73-4).

(S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole (cas: 14769-73-4) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at 未 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.HPLC of Formula: 14769-73-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Smith, Nicholas D. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2004 | CAS: 3364-80-5

Thiazole-4-carbaldehyde (cas: 3364-80-5) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Recommanded Product: 3364-80-5

Discovery of highly potent, selective, orally bioavailable, metabotropic glutamate subtype 5 (mGlu5) receptor antagonists devoid of cytochrome P450 1A2 inhibitory activity was written by Smith, Nicholas D.;Poon, Steve F.;Huang, Dehua;Green, Mitchell;King, Christopher;Tehrani, Lida;Roppe, Jeffrey R.;Chung, Janice;Chapman, Deborah P.;Cramer, Merryl;Cosford, Nicholas D. P.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2004.Recommanded Product: 3364-80-5 This article mentions the following:

Structure-activity relationship studies focused on bio-isosteric replacements of 2-pyridyl resulted in mGlu5 receptor antagonists with reduced inhibition of cytochrome P 450 1A2. This led to highly potent, selective and orally bioavailable 2-imidazolyl tetrazoles such as I that are devoid of cytochrome P 450 inhibitory activity. In the experiment, the researchers used many compounds, for example, Thiazole-4-carbaldehyde (cas: 3364-80-5Recommanded Product: 3364-80-5).

Thiazole-4-carbaldehyde (cas: 3364-80-5) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Recommanded Product: 3364-80-5

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Peyron, Corinne et al. published their research in Bioorganic Chemistry in 2005 | CAS: 121359-48-6

2-(Tributylstannyl)thiazole (cas: 121359-48-6) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Category: thiazole

Synthesis and in vitro antileishmanial activity of 5-substituted-2′-deoxyuridine derivatives was written by Peyron, Corinne;Benhida, Rachid;Bories, Christian;Loiseau, Philippe M.. And the article was included in Bioorganic Chemistry in 2005.Category: thiazole This article mentions the following:

We report herein the synthesis and the in vitro antileishmanial evaluation of 5-substituted-2′-deoxyuridine nucleosides. The most active compound against Leishmania donovani promastigotes was Thia-dU (3a) with an IC50 = 3 渭M. This compound exhibited the same activity as zidovudine (3′-azido-2′-deoxythymidine) used as nucleoside reference compound Considering the cytotoxicity of synthetic compounds on peritoneal murine macrophages, the most toxic compound was MeThio-dU (3d) with a MTC at 10 渭M. Only Methia-dU (3b) was active against intra-macrophagic amastigotes with an IC50 = 6.5 渭M. This latter can now be evaluated in vivo, for further investigations through structure-based drug design. In the experiment, the researchers used many compounds, for example, 2-(Tributylstannyl)thiazole (cas: 121359-48-6Category: thiazole).

2-(Tributylstannyl)thiazole (cas: 121359-48-6) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Wang, Xie et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2017 | CAS: 3034-53-5

2-Bromothiazole (cas: 3034-53-5) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Product Details of 3034-53-5

Nickel-catalysed direct alkylation of thiophenes via double C(sp3)-H/C(sp2)-H bond cleavage: the importance of KH2PO4 was written by Wang, Xie;Xie, Peipei;Qiu, Renhua;Zhu, Longzhi;Liu, Ting;Li, You;Iwasaki, Takanori;Au, Chak-Tong;Xu, Xinhua;Xia, Yuanzhi;Yin, Shuang-Feng;Kambe, Nobuaki. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.Product Details of 3034-53-5 This article mentions the following:

The efficient Ni-catalyzed oxidative C(sp3)-H/C(sp2)-H cross-dehydrogenative coupling reaction was developed for synthesis of highly functionalized alkyl (aryl)-substituted thiophenes such as I [R1 = Me, Et, Ph; R2 = Me, Ph, Bn, 2-naphthyl; R1 = R2 = Me, Ph; R1R2 = (CH2)5, Ph, 2-H3CC6H4; R3 = 2-thienyl, benzothien-2-yl, 4-Br-2-thienyl, etc.] from thiophenes and aliphatic (aromatic) amides that contain an 8-aminoquinoline as a removable directing group in the presence of a silver oxidant. The approach enabled the facile one-step synthesis of substituted thiophenes I with high functional group compatibility via double C(sp3)-H/C(sp2)-H bond cleavage without affecting C-Br and C-I bonds and formation of C(alkyl)-C(heteroaryl) bonds. DFT calculations verified the importance of KH2PO4 as an additive for promoting C-H bond cleavage and supported the involvement of a Ni(III) species for efficient C(sp2)-H cleavage and C-C coupling. In the experiment, the researchers used many compounds, for example, 2-Bromothiazole (cas: 3034-53-5Product Details of 3034-53-5).

2-Bromothiazole (cas: 3034-53-5) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Product Details of 3034-53-5

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Sharma, Alok et al. published their research in Indian Journal of Experimental Biology in 1994 | CAS: 36085-73-1

6-Allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-amine dihydrochloride (cas: 36085-73-1) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Reference of 36085-73-1

Dopamine receptor mediated antidepressant action of B-HT 920 in mice was written by Sharma, Alok;Kulkarni, S K.. And the article was included in Indian Journal of Experimental Biology in 1994.Reference of 36085-73-1 This article mentions the following:

Possible involvement of dopaminergic (DAergic) system in forced swimming-induced immobility (despair behavior) was investigated in mice. B-HT 920 (0.05 and 0.1 mg/kg), a post-synaptic DAergic agonist, produced a dose dependent reduction in immobility period, which was sensitive to blockade by haloperidol (0.5 mg/kg) and sulpiride (100 mg/kg). This effect was also blocked by 伪2 antagonist yohimbine (5 mg/kg). SKF 38393 (5 mg/kg), a D1-DA agonist potentiated the action of B-HT 920. Reserpinization (2 mg/kg, 24 h prior) produced despair immobility in mice. When a low dose of B-HT 920 (0.05 mg/kg) was given to reserpinized animals, the duration of immobility period was further increased. But on the other hand, a higher dose (0.1 mg/kg) of it reduced reserpine-induced immobility. Desipramine (5 and 10 mg/kg), elicited a dose dependent reduction in the immobility period, which was sensitive to blockade by sulpiride (100 mg/kg). Desipramine (10 mg/kg) showed a biphasic response in combination with B-HT 920, i.e., a potentiation of the response due to a low dose of B-HT 920 (0.05 mg/kg) and an antagonism of the response due to a higher dose of B-HT 920 (0.1 mg/kg), resp. SKF 38393 (5 mg/kg), potentiated the action of desipramine (5 mg/kg). SKF 38393 (5 mg/kg) further potentiated the action of desipramine (5 mg/kg) and B-HT 920 (0.05 mg/kg). These observations suggests that B-HT 920 reduces behavioral immobility by DAergic mechanism and desipramine also modulates D2-DA receptors in its anti-depressant action. In the experiment, the researchers used many compounds, for example, 6-Allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-amine dihydrochloride (cas: 36085-73-1Reference of 36085-73-1).

6-Allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-amine dihydrochloride (cas: 36085-73-1) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Reference of 36085-73-1

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Nandi, Ganesh C. et al. published their research in Tetrahedron Letters in 2013 | CAS: 1452-16-0

2-Cyanothiazole (cas: 1452-16-0) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at 未 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 掳C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Name: 2-Cyanothiazole

Schmidt reaction in ionic liquids: highly efficient and selective conversion of aromatic and heteroaromatic aldehydes to nitriles with [BMIM(SO3H)][OTf] as catalyst and [BMIM][PF6] as solvent was written by Nandi, Ganesh C.;Laali, Kenneth K.. And the article was included in Tetrahedron Letters in 2013.Name: 2-Cyanothiazole This article mentions the following:

A mild and selective method is presented for the conversion of aromatic and heteroaromatic aldehydes to nitriles via the Schmidt reaction with TMSN3 by using [BMIM(SO3H)][OTf] as catalyst and [BMIM][PF6] as solvent. E.g., in the presence of this catalyst in [BMIM][PF6], reaction of 2-MeOC6H4CHO with TMSN3 gave 100% 2-MeOC6H4CN. The method offers high yields and simple product isolation, and avoids the use of liquid superacids or corrosive Lewis acids commonly employed for this transformation. It also offers some potential for recycling/reuse of the IL solvent. In the experiment, the researchers used many compounds, for example, 2-Cyanothiazole (cas: 1452-16-0Name: 2-Cyanothiazole).

2-Cyanothiazole (cas: 1452-16-0) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at 未 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 掳C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Name: 2-Cyanothiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica