Heterocyclic Building Blocks-Thiazole

Dihydropyrimidinone-derived selenoesters efficacy and safety in an in vivo model of A尾 aggregation was written by Pereira, Flavia Suelen de Oliveira;Barbosa, Flavio Augusto Rocha;Canto, Romulo Farias Santos;Lucchese, Cristiane;Pinton, Simone;Braga, Antonio Luiz;Azeredo, Juliano Braun de;Quines, Caroline Brandao;Avila, Daiana Silva. And the article was included in NeuroToxicology in 2022.Quality Control of (S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole This article mentions the following:

In a previous in vitro study, dihydropyrimidinone-derived selenoesteres demonstrated antioxidant properties, metal chelators and inhibitory acetylcholinesterase (AChE) activity, making these compounds promising candidates for Alzheimers Disease (AD) treatment. However, these effects have yet to be demonstrated in an in vivo animal model; therefore, this study aimed to evaluate the safety and efficacy of eight selenoester compounds in a Caenorhabditis elegans model using transgenic strains for amyloid-beta peptide (A尾) aggregation. The L1 stage worms were acutely exposed (30 min) to the compounds at concentrations ranging from 5 to 200渭M and after 48 h the maintenance temp was increased to 25掳 C for A尾 expression and aggregation. After 48 h, several parameters related to phenotypic manifestations of A尾 toxicity and mechanistic elucidation were analyzed. At the concentrations tested no significant toxicity of the compounds was found. The selenoester compound FA90 significantly reduced the rate of paralyzed worms and increased the number of swimming movements compared to the untreated worms. In addition, FA90 and FA130 improved egg-laying induced by levamisole and pos. modulated HSP-6 and HSP-4 expression, thereby increasing reticular and mitochondrial protein folding response in C. elegans, which could attenuate A尾 aggregation in early exposure. Therefore, our initial screening using an alternative model demonstrated that FA90, among the eight selenoesters evaluated, was the most promising compound for AD evaluation screening in more complex animals. In the experiment, the researchers used many compounds, for example, (S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole (cas: 14769-73-4Quality Control of (S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole).

(S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole (cas: 14769-73-4) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at 未 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Quality Control of (S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Quantitative Analysis of the Interaction of Constitutive Androstane Receptor with Chemicals and Steroid Receptor Coactivator 1 Using Surface Plasmon Resonance Biosensor Systems: A Case Study of the Baikal Seal (Pusa sibirica) and the Mouse was written by Dau, Pham Thi;Sakai, Hiroki;Hirano, Masashi;Ishibashi, Hiroshi;Tanaka, Yuki;Kameda, Kenji;Fujino, Takahiro;Kim, Eun-Young;Iwata, Hisato. And the article was included in Toxicological Sciences in 2013.Quality Control of 6-(4-Chlorophenyl)imidazo[2,1-b]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl) oxime This article mentions the following:

The constitutive androstane receptor (CAR) not only displays a high basal transcriptional activity but also acts as a ligand-dependent transcriptional factor. It is known that CAR exhibits different ligand profiles across species. However, the mechanisms underlying CAR activation by chems. and the species-specific responses are not fully understood. The objectives of this study are to establish a high-throughput tool to screen CAR ligands and to clarify how CAR proteins from the Baikal seal (bsCAR) and the mouse (mCAR) interact with chems. and steroid receptor coactivator 1 (SRC1). The authors developed the surface plasmon resonance (SPR) system to assess quant. the interaction of CAR with potential ligands and SRC1. The ligand-binding domain (LBD) of bsCAR and mCAR was synthesized in a wheat germ cell-free system. The purified CAR LBD was then immobilized on the sensor chip for the SPR assay, and the kinetics of direct interaction of CARs with ligand candidates was measured. Androstanol and androstenol, estrone, 17尾-estradiol, TCPOBOP, and CITCO showed compound-specific but similar affinities for both CARs. The CAR-SRC1 interaction was ligand dependent but exhibited a different ligand profile between the seal and the mouse. The results of SRC1 interaction assay accounted for those of the authors’ previous in vitro CAR-mediated transactivation assay. In silico analyses also supported the results of CAR-SRC1 interaction; there is little structural difference in the ligand-binding pocket of bsCAR and mCAR, but there is a distinct discrimination in the helix 11 and 12 of these receptors, suggesting that the interaction of ligand-bound CAR and SRC1 is critical for determining species-specific and ligand-dependent transactivation over the basal activity. The SPR assays demonstrated a potential as a high-throughput screening tool of CAR ligands. In the experiment, the researchers used many compounds, for example, 6-(4-Chlorophenyl)imidazo[2,1-b]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl) oxime (cas: 338404-52-7Quality Control of 6-(4-Chlorophenyl)imidazo[2,1-b]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl) oxime).

6-(4-Chlorophenyl)imidazo[2,1-b]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl) oxime (cas: 338404-52-7) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Quality Control of 6-(4-Chlorophenyl)imidazo[2,1-b]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl) oxime

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

An overview of levamisole hydrochloride with immuno-stimulant activity was written by Biswajit, Das;Suvakanta, Dash;Chandra, Choudhury Ramesh;Jashabir, Chakraborty. And the article was included in American Journal of Pharmacy and Health Research in 2014.Reference of 16595-80-5 This article mentions the following:

Levamisole, marketed as the hydrochloride salt under the trade name Ergamisol (R12564), is an anti helminthic and immunomodulator belonging to a class of synthetic imidazo-thiazole derivatives It was discovered in 1966 at Belgium’s Janssen pharmaceutica, where it was prepared initially in the form of its racemate called tetramisole. The two stereoisomers of tetramisole were subsequently synthesized, and the levorotatory isomer was given the name levamisole. Levamisole has been used in humans to treat parasitic worm infections, and has been studied in combination with other forms of chemotherapy for colon cancer, melanoma, and head and neck cancer. In some of the leukemic cell line studies, both levamisole and tetramisole showed similar effect. Effective studies need to be undertaken to study the full potential of levamisole in Immunostimulation activities and immuno synergestic effect of Levamisole with combination to natural polysaccharides. In the experiment, the researchers used many compounds, for example, (S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride (cas: 16595-80-5Reference of 16595-80-5).

(S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride (cas: 16595-80-5) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at 未 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 掳C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Reference of 16595-80-5

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Lack of Detection of the Analgesic Properties of PF-05089771, a Selective Na_v1.7 Inhibitor, Using a Battery of Pain Models in Healthy Subjects was written by Siebenga, Pieter;van Amerongen, Guido;Hay, Justin L.;McDonnell, Aoibhinn;Gorman, Donal;Butt, Richard;Groeneveld, Geert Jan. And the article was included in Clinical and Translational Science in 2020.Computed Properties of C18H12Cl2FN5O3S2 This article mentions the following:

The aim was to demonstrate analgesic properties of a potent selective Na_v1.7 sodium channel blocker, PF-05089771, alone and concomitantly with pregabalin in healthy subjects using a battery of human evoked pain models. This was a double-blind, double-dummy, randomized, placebo-controlled, five-period cross-over study with PF-05089771 alone and PF-05089771 concomitantly with pregabalin as treatment arms with pregabalin, ibuprofen, and placebo as control arms (NCT02349607). A battery of human evoked pain models was used to investigate analgesic properties of PF-05089771. Twenty-five subjects were enrolled in the study of which 23 subjects completed all five periods. PF-05089771 alone did not differ from placebo on the primary pain end points. The same holds when comparing PF-05089771 concomitantly with pregabalin and pregabalin alone. Pregabalin showed significant effects relative to placebo on thermal pain on the normal skin and UVB skin (least squares means with 90% confidence interval: 0.63 (0.32-0.93) and 0.53 (0.11-0.96)), pressure stimulation (1.10 (1.04-1.18)), and cold pressor (1.22 (1.14-1.32)). Ibuprofen demonstrated significant effects on thermal pain UVB skin (1.26 (0.82-1.70)) and pressure stimulation assessment (1.08 (1.01-1.15)), consistent with historical results. This study did not demonstrate analgesic properties of PF-05089771 alone or concomitantly with pregabalin in a battery of pain models. In the experiment, the researchers used many compounds, for example, 4-(2-(3-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide (cas: 1235403-62-9Computed Properties of C18H12Cl2FN5O3S2).

4-(2-(3-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide (cas: 1235403-62-9) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1).Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Computed Properties of C18H12Cl2FN5O3S2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Genomic landscape of drug response reveals mediators of anthelmintic resistance was written by Doyle, Stephen R.;Laing, Roz;Bartley, David;Morrison, Alison;Holroyd, Nancy;Maitland, Kirsty;Antonopoulos, Alistair;Chaudhry, Umer;Flis, Ilona;Howell, Sue;McIntyre, Jennifer;Gilleard, John S.;Tait, Andy;Mable, Barbara;Kaplan, Ray;Sargison, Neil;Britton, Collette;Berriman, Matthew;Devaney, Eileen;Cotton, James A.. And the article was included in Cell Reports in 2022.Recommanded Product: (S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole This article mentions the following:

Like other pathogens, parasitic helminths can rapidly evolve resistance to drug treatment. Understanding the genetic basis of anthelmintic drug resistance in parasitic nematodes is key to tracking its spread and improving the efficacy and sustainability of parasite control. Here, we use an in vivo genetic cross between drug-susceptible and multi-drug-resistant strains of Haemonchus contortus in a natural host-parasite system to simultaneously map resistance loci for the three major classes of anthelmintics. This approach identifies new alleles for resistance to benzimidazoles and levamisole and implicates the transcription factor cky-1 in ivermectin resistance. This gene is within a locus under selection in ivermectin-resistant populations worldwide; expression analyses and functional validation using knockdown experiments support that cky-1 is associated with ivermectin survival. Our work demonstrates the feasibility of high-resolution forward genetics in a parasitic nematode and identifies variants for the development of mol. diagnostics to combat drug resistance in the field. In the experiment, the researchers used many compounds, for example, (S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole (cas: 14769-73-4Recommanded Product: (S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole).

(S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole (cas: 14769-73-4) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Recommanded Product: (S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Synthesis of N-Substituted Methyl 4H-Thieno[3,2-b]pyrrole-5-carboxylates was written by Torosyan, S. A.;Gimalova, F. A.;Zagitov, V. V.;Erastov, A. S.;Miftakhov, M. S.. And the article was included in Russian Journal of Organic Chemistry in 2018.Formula: C8H7NO2S This article mentions the following:

The alkylation of Me 4H-thieno[3,2-b]pyrrole-5-carboxylate with Me iodide and allyl, propargyl and benzyl bromides in the presence of sodium hydride in THF afforded the corresponding N-substituted derivatives I (R = Me, CH₂=CHCH₂, CH鈮CH₂, Bn). Some reactions of the alkylation products were studied. In the experiment, the researchers used many compounds, for example, Methyl 4H-thieno[3,2-b]pyrrole-5-carboxylate (cas: 82782-85-2Formula: C8H7NO2S).

Methyl 4H-thieno[3,2-b]pyrrole-5-carboxylate (cas: 82782-85-2) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, 蟺-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Formula: C8H7NO2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Direct C-H Bond Activation of Benzoxazole and Benzothiazole with Aryl Bromides Catalyzed by Palladium(II)-N-heterocyclic Carbene Complexes was written by Kaloglu, Murat;Kaloglur, Nazan;Oezdemir, Ismail. And the article was included in Chinese Journal of Chemistry in 2018.Computed Properties of C14H11NS This article mentions the following:

Herein, a series of novel palladium(II)-NHC complexes (NHC=N-heterocyclic carbene) were synthesized. The structures of all novel complexes were characterized by ¹H NMR, ¹³C NMR, FT-IR spectroscopy and elemental anal. techniques. These palladium(II)-NHC complexes were tested as efficient catalysts in the direct C-H bond activation of benzoxazole and benzothiazole with aryl bromides in the presence of 1 mol% catalyst loading at 150 掳C for 4 h. Under the given conditions, various aryl bromides were successfully applied as the arylating reagents to achieve the 2-arylbenzoxazoles and 2-arylbenzothiazoles in acceptable to high yields. In the experiment, the researchers used many compounds, for example, 2-(4-Methylphenyl)benzothiazole (cas: 16112-21-3Computed Properties of C14H11NS).

2-(4-Methylphenyl)benzothiazole (cas: 16112-21-3) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at 未 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Computed Properties of C14H11NS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Identification and Categorization of Volatile Sulfur Flavor Compounds in Roasted Malts and Barley was written by Parr, Hebe;Bolat, Irina;Cook, David. And the article was included in Journal of the American Society of Brewing Chemists.Recommanded Product: 2-Ethoxythiazole This article mentions the following:

We report for the first time the application of HS-SPME-GC coupled with sulfur-specific pulsed flame photometric detection to sensitively analyze the volatile sulfur compounds (VSC鈥瞫) present in drum roasted malt and barley samples typically used in brewing. Twenty-five VSC鈥瞫 were identified across a range of 9 roasted products produced from barley/malt. Thiophenes (n = 10) were a major class of heterocyclic sulfur compounds identified, along with thiazoles (n = 4), and thiofurans (n = 2). Quant. (n = 18) and semi-quant. (n = 6) data are reported for VSC鈥瞫 across this product range. Principal Component Anal. (PCA) of data clearly identified (PC1) that heterocyclic sulfur compounds were formed in products processed at high temperatures (>170 掳C) under dry conditions (roasted barley, chocolate and black malts). Whereas compounds such as Me dithiolane and Me Pr sulfide were associated primarily with lower temperature finished products (crystal, amber and cara malts). Pathways for the generation of observed VSC鈥瞫 are considered alongside typical roasting conditions employed in the manufacture of these products. Concentrations of VSC鈥瞫 identified will certainly contribute characteristic aromas to the roasted products themselves. The transfer of VSC鈥瞫 from the grist into finished beer, and their sensory impact in a range of beer styles, remains to be determined In the experiment, the researchers used many compounds, for example, 2-Ethoxythiazole (cas: 15679-19-3Recommanded Product: 2-Ethoxythiazole).

2-Ethoxythiazole (cas: 15679-19-3) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Recommanded Product: 2-Ethoxythiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Modulation of ligand responses by coupling of 伪_2A-adrenoceptors to diverse G_伪-proteins was written by Pauwels, P. J.;Tardif, S.;Colpaert, F. C.;Wurch, T.. And the article was included in Biochemical Pharmacology in 2001.Application In Synthesis of 6-Allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-amine dihydrochloride This article mentions the following:

The hypothesis that different signaling may be mediated via a single 伪_2A-adrenoceptor (伪_2A AR) subtype was investigated by challenging 伪₂ AR ligands in combination with diverse recombinant weight, mutant, and chimeric G_伪-proteins. Possible coupling of 伪_2A AR to endogenous G_伪i/o-proteins in CHO-K1 cells was excluded by measuring pertussis toxin (PTX)-resistant [³⁵S]GTP纬S-binding responses as a common functional response to 伪_2A AR activation. (-)-Adrenaline (10 渭M) displayed the highest magnitude of [³⁵S]GTP纬S-binding response in the co-presence of a PTX-resistant G_伪oCys³⁵¹Ile protein, whereas a decreased response was obtained with the mutant G_伪i1/2-proteins. Replacement of the last six amino acids at the C-terminal portion of the G_伪o-protein by the corresponding amino acid region of either the G_伪z-, G_伪s-, G_伪q-, or G_伪15-protein and co-expression with the 伪_2A AR resulted in similar maximal (-)-adrenaline-mediated [³⁵S]GTP纬S-binding responses with these chimeric G_伪o-proteins. The ligands D-medetomidine, BHT 920 (6-allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-ylamine) and (+)-RX 811059 (2-(2-ethoxy-2,3-dihydro-benzo[1,4]dioxin-2-yl)-4,5-dihydro-1H-imidazole) were weakly active or virtually inactive at the chimeric G_伪o/s-, G_伪o/q-, and G_伪o/15-proteins in contrast to the G_伪o/z-protein. Furthermore, combining the constitutively active mutant Thr³⁷³Lys 伪_2A AR with these chimeric G_伪o-proteins enhanced the apparent intrinsic activity of D-medetomidine and BHT 920. A similar observation was made using the corresponding fusion proteins, where the stoichiometry of the mutant 伪_2A AR to the chimeric G_伪o-protein was fixed at 1.0. These data indicate that a single ligand may display different magnitudes of activation at the 伪_2A AR subtype coupled to chimeric G_伪o proteins under controlled conditions of 伪_2A AR: G_伪o-protein expression. In the experiment, the researchers used many compounds, for example, 6-Allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-amine dihydrochloride (cas: 36085-73-1Application In Synthesis of 6-Allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-amine dihydrochloride).

6-Allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-amine dihydrochloride (cas: 36085-73-1) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Application In Synthesis of 6-Allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-amine dihydrochloride

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

MNPs@SiO₂-Pr-AP: A new catalyst for the synthesis of 2-amino-4-aryl thiazole derivatives was written by Ghorbani-Vaghei, Ramin;Alavinia, Sedigheh;Merati, Zohreh;Izadkhah, Vida. And the article was included in Applied Organometallic Chemistry in 2018.Formula: C9H8N2OS This article mentions the following:

Magnetically recoverable nano-magnetic catalyst supported with functionalized (n-propyl)-4-amino-pyridine silica (MNPs@SiO₂-Pr-AP) was synthesized and characterized using different techniques. A simple and efficient synthesis of 2-amino-4-aryl thiazoles I [R = H, 4-Cl, 3-NO₂, etc, X = CH, N] was described via condensation of acetophenones and thiourea using three different types of catalytic systems including N,N,N’,N’-tetrabromobenzene-1,3-disulfonamide [TBBDA], poly(N,N’-dibromo-N-ethylbenzene-1,3-disulfonamide) [PBBS] and a combination of TBBDA and MNPs@SiO₂-Pr-AP. The results showed that, the use of TBBDA along with the MNPs@SiO₂-Pr-AP gains the highest yields of the products in the shortest reaction time. In the experiment, the researchers used many compounds, for example, 4-(2-Amino-4-thiazolyl)phenol (cas: 57634-55-6Formula: C9H8N2OS).

4-(2-Amino-4-thiazolyl)phenol (cas: 57634-55-6) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at 未 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Formula: C9H8N2OS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica