Heterocyclic Building Blocks-Thiazole

Akerfeldt, Stig published the artcileIn vivo antiviral effects of benzothiazole derivatives against various influenza A2 strains, Application In Synthesis of 92-36-4, the publication is Journal of Medicinal Chemistry (1970), 13(5), 1012-13, database is CAplus and MEDLINE.

Seventeen derivatives of benzothiazole were investigated for antiviral activity against various influenza A2 strains in mice. Aminoadamantane was used as an internal standard in the experiments 2-Aminobenzothiazole and 2-amino-4-chlorobenzothiazole gave a protective effect comparable to, or better than, that found for aminoadamantane. Small variations in the structure of these 2 compounds caused a complete disappearance of the antiviral effect. To be effective the active compounds had to be administered in near-toxic doses. All 17 compounds were also tested for antiviral effect against rhino virus 33342, adeno virus 3, and herpes simplex virus. Significant antiviral effect could not be demonstrated for any compound in vitro.

Journal of Medicinal Chemistry published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Application In Synthesis of 92-36-4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Abdel Azzem, M. published the artcileElectroactive film of polyaniline substituted with the benzothiazole ring, Application In Synthesis of 92-36-4, the publication is Delta Journal of Science (1993), 17(3), 127-140, database is CAplus.

Voltammetric studies of ring-substituted aniline with a heterocyclic ring , i.e., 2-(4-aminophenyl)-6-methylbenzothiazole (ABT), were carried out in acetonitrile and acidic aqueous solutions Potential sweep electrolysis of 0.05M ABT at a glassy carbon electrode in CH₃CN containing 0.1M LiC10₄ and 0.05M pyridine produced a polymeric film. The film-coated electrode showed an electrochem. response in acidic aqueous solution The elec. conductivity measurement on pressed pellets of PABT prepared by constant current electrolysis was 3.8 × 10 S/cm. Based on IR spectroscopic characterization and elec. conductivity measurement, a polymerization mechanism was proposed.

Delta Journal of Science published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Application In Synthesis of 92-36-4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Zhang, Peng published the artcileStructure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5, COA of Formula: C14H18BNO2S, the publication is Bioorganic & Medicinal Chemistry (2010), 18(9), 3026-3035, database is CAplus and MEDLINE.

The metabotropic glutamate receptor subtype 5 (mGluR5) has been implicated in numerous neuropsychiatric disorders including addiction. We have discovered that the rigid diaryl alkyne template, derived from the potent and selective noncompetitive mGluR5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP), can serve to guide the design of novel quinoline analogs and pharmacophore optimization has resulted in potent mGluR5 noncompetitive antagonists (EC₅₀ range 60-100 nM) in the quinoline series.

Bioorganic & Medicinal Chemistry published new progress about 791614-90-9. 791614-90-9 belongs to thiazole, auxiliary class Boronate Esters,Boronic acid and ester,Boronic acid and ester, name is 2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]thiazole, and the molecular formula is C65H82N2O18S2, COA of Formula: C14H18BNO2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Berry, Craig R. published the artcileCycloaddition Reactions of Thiazolium Azomethine Ylides: Application to Pyrrolo[2,1-b]thiazoles, Formula: C4H5NS2, the publication is Organic Letters (2007), 9(21), 4099-4102, database is CAplus and MEDLINE.

Thiazolium azomethine ylides, generated from 1,3-thiazoles equipped with a C-2 methanethiol group, participated in an efficient [3+2] cycloaddition reaction with acetylene derivatives to yield unique pyrrolo[2,1-b]thiazoles. The elimination of the methanethiol leaving group from the cycloadduct replaced the need for a sep. oxidation step and suppressed ring-opening side reactions. Products were obtained in short synthetic sequences to demonstrate their use as a scaffold for compound libraries.

Organic Letters published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C4H5NS2, Formula: C4H5NS2.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Wang, Jie published the artcileProcess improvement on the synthesis of 3-mercapto-1-(1, 3-thiazolin-2-yl) azetidine hydrochloride, Quality Control of 5053-24-7, the publication is Hecheng Huaxue (2013), 21(3), 367-369, database is CAplus.

A key intermediate of Tebipenem pivoxil, 3-mercapto-1-(1, 3-thiazolin-2-yl) azetidine hydrochloride, was synthesized from benzylamine by N-alkylation, cyclization, catalytic hydrogenation, N-protection, mesylation, S_N2 substitution, hydrolysis, and condensation. The overall yield was 40%. The structure was confirmed by ¹H NMR, IR and MS.

Hecheng Huaxue published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C12H19BrS, Quality Control of 5053-24-7.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Zhang, Caiyang published the artcileCesium carbonate-promoted synthesis of aryl methyl sulfides using S-methylisothiourea sulfate under transition-metal-free conditions, Product Details of C4H5NS2, the publication is Organic & Biomolecular Chemistry (2018), 16(34), 6316-6321, database is CAplus and MEDLINE.

In the presence of cesium carbonate, an efficient synthesis of aryl Me sulfides by the reactions of aryl halides with com. available S-methylisothiourea sulfate was developed. This odourless and highly crystalline solid was used as the substitute for malodorous methanethiol. The gram-scale reaction also proceeded smoothly without the use of column chromatog. separation Similarly, 2-(dimethylamino)ethylthio and cyclopropylmethylthio groups were easily introduced into the aromatic rings from the corresponding S-[2-(dimethylamino)ethyl]isothiourea dihydrochloride and S-cyclopropylmethylisothiourea hydrobromide. The possible reaction mechanism was proposed. It was believed that this route to aryl alkyl sulfides were well competitive with currently known methods due to its wide substrate scope, excellent yields, easy operation and transition-metal-free conditions.

Organic & Biomolecular Chemistry published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C7H3Cl2F3O2S, Product Details of C4H5NS2.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Yin, Qiang published the artcileThe first fungal laccase with an alkaline pH optimum obtained by directed evolution and its application in indigo dye decolorization, Recommanded Product: Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), the publication is AMB Express (2019), 9(1), 1-13, database is CAplus and MEDLINE.

Engineering of fungal laccases with optimum catalytic activity at alk. pH has been a long-lasting challenge. In this study, a mutant library containing 3000 clones was obtained by error-prone PCR to adapt the optimum pH of a fungal laccase Lcc9 from the basidiomycete Coprinopsis cinerea. After three rounds of functional screening, a mutant with three amino acid changes (E116K, N229D, I393T) named PIE5 was selected. PIE5 showed an optimum pH of 8.5 and 8.0 against guaiacol and 2,6-DMP when expressed in Pichia pastoris, representing the first fungal laccase that possesses an optimum pH at an alk. condition. Site directed mutagenesis disclosed that N229D contributed the most to the optimum pH increment. A single N229D mutation caused an increase in optimum pH by 1.5 units. When used in indigo dye decolorization, PIE5 efficiently decolorized 87.1 ± 1.1% and 90.9 ± 0.3% indigo dye at the optimum conditions of pH 7.0-7.5 and 60°C, and with either Me 3,5-dimethoxy-4-hydroxybenzoate or 2,2′-azino-bis(3-ethylbenzothazoline-6-sulfonate) as the mediator. In comparison, the com. available fungal laccase TvLac from Trametes villosa decolorized 84.3 ± 1.8% of indigo dye under its optimum conditions (opt. pH 5.0 and 60°C). The properties of an alk.-dependent activity and the high indigo dye decolorization ability (1.3-fold better than the parental Lcc9) make the new fungal laccase PIE5 an alternative for specific industrial applications.

AMB Express published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C12H9NO, Recommanded Product: Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate).

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Amanor-Atiemoh, Robert published the artcileEffect of simultaneous dual-frequency ultrasound aided ethanolic pretreatment on drying kinetics, bioactive compounds, antioxidant activity, and physicochemical properties of apple slices using pulsed vacuum dryer, Computed Properties of 30931-67-0, the publication is Journal of Food Process Engineering (2020), 43(11), e13535, database is CAplus.

This work aims at investigating effect of different pretreatments and varied temperature on the drying kinetics, bioactive compounds, antioxidant activity, microstructure and functional group of apple slices using pulsed vacuum dryer. Pretreated apple slices (Ethanol, US + W, and US + E) dried at varied temperature (60, 70, and 80°C) were analyzed to determine total phenolic content (TPC), total flavonoid content (TFC), 1,1-diphenyl-2-picrylhydrazyl (DPPH⁺), 2,2-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid color, microstructure and FT-IR spectroscopy. The findings revealed that US + E pretreatment significantly decreased drying time. US + E pretreatment retained TPC, TFC, DPPH⁺ and ABTS⁺ than Ethanol, US + W, and control and was further corroborated by the observed peaks as revealed by the FT-IR spectroscopy. However, drying often leads to a reduction in quality parameters as well as degradation of nutritional components of the apple. Novel pretreatment techniques like ultrasonic aided ethanolic pretreatment preceding to apple drying provides an added advantage over conventional drying methods in that it reduces dehydration time as a result of faster moisture removal, lowers energy consumption, improves process efficiency leading to industrial competiveness and it also preserves the nutritional and sensorial parameters of dried apple slices.

Journal of Food Process Engineering published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, Computed Properties of 30931-67-0.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Tang, Yunlian published the artcileBioinformatic analysis of differentially expressed genes and identification of key genes in EBV-transformed lymphoblasts, Application In Synthesis of 95-24-9, the publication is Biomedicine & Pharmacotherapy (2019), 108984, database is CAplus and MEDLINE.

Although the Epstein-Barr virus (EBV) is a well-known human oncogenic virus, its mol. mechanisms involved in the transformation of healthy human cells remain poorly understood. In this study, human lymphocytes were isolated from the peripheral blood of healthy adults, and lymphocytes were transformed in vitro by EBV. Agilent human whole genome microarrays were used to detect the differential gene expression profiles of EBV-transformed lymphoblasts and healthy peripheral blood lymphocytes (PBLs). By constructing the gene functional network of EBV-induced lymphocyte transformation, we screened out candidate key genes in this process and verified their expression levels by real-time quant. polymerase chain reaction (RT-qPCR) and Western blot. In the EBV-transformed lymphoblasts, 2335 differentially expressed genes, including 1328 up-regulated and 1007 down-regulated, were screened out. Five candidate key genes, namely, PLK1, E2F1, PTPN11, BIRC5 and FYN were mainly screened out according to the results of LIMMA, String, Cytoscape software anal. RT-qPCR and Western blot showed that PLK1, E2F1, PTPN11, BIRC5 genes had increased expression levels, and FYN gene was down-regulated in EBV-transformed lymphoblasts. Silencing of PLK1 gene in Raji cells could inhibit cell proliferation and invasion, and induce cell cycle arrest and apoptosis. In conclusion, PLK1, E2F1, PTPN11, BIRC5 and FYN are the candidate key mols. of EBV-transformed lymphocytes.

Biomedicine & Pharmacotherapy published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C13H26N2, Application In Synthesis of 95-24-9.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Wang, Hefei published the artcileRole of Pyrogenic Carbon in Parallel Microbial Reduction of Nitrobenzene in the Liquid and Sorbed Phases, Category: thiazole, the publication is Environmental Science & Technology (2020), 54(14), 8760-8769, database is CAplus and MEDLINE.

Surface functional groups and graphitic C comprise the electroactive components of pyrogenic C. The role of pyrogenic C with different electroactive components content in mediating electron transfer in biochem. reactions has not been systematically studied. The authors determined the pyrogenic C electron exchange capacity was 0.067-0.120 mmol e^–/g pyrogenic C with maximum elec. conductivity (EC) of 4.85 S/cm. Nitrobenzene was simultaneously reduced in liquid and sorbed phases by Shewanella oneidensis strain MR-1 in the presence of pyrogenic C. Pyrogenic C did not affect aqueous nitrobenzene reduction; reduction of sorbed nitrobenzene was much slower than that of the aqueous species. Enhancing the pyrogenic C oxygenated functional moiety content by HNO₃ oxidation elevated bio-reduction rates of aqueous and sorbed species. Anthraquinone groups were deemed the most likely oxygenated functional redox compounds based on voltammetric curve tests and spectroscopic anal. Pyrogenic C reactivity for mediating sorbed nitrobenzene reduction was pos. correlated with its EC, which was demonstrated to be related to condensed aromatic structures. This work elucidated the mechanism for pyrogenic C-mediated biotransformation of nitrobenzene and helped properly evaluate the pyrogenic C role in biogeochem. redox processes occurring in nature.

Environmental Science & Technology published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C14H21BO2, Category: thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica