Heterocyclic Building Blocks-Thiazole

4175-76-2,4175-76-2, 2,4-Dichlorothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2,4-Dichlorothiazole (10 g, 64.9 mmol) was dissolved in acetic acid (50.0 ml) and heated to 60 C. Bromine (15.05 ml, 292 mmol) was added dropwise and the reaction mixture then stirred at 90 C. for 5.5 hours. The reaction was cooled to room temperature and made basic by slow addition of solid sodium carbonate, then diluted with water (100 mL) and extracted with Et2O (3*150 ml). The combined organic extracts were washed with sat.aq. sodium thiosulfate (50 ml) dried over sodium sulfate evaporated under reduced pressure to afford the title compound as a pale yellow oil. LC-MS Rt 1.43 min [M+H]+ 275.9/277.9/279.9/281.9 (Method 2minLowpHv03)

The synthetic route of 4175-76-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; AHMED, Mahbub; ASHALL-KELLY, Alexander; BLOOMFIELD, Graham Charles; GUERITZ, Louisa; MCKENNA, Jeffrey; MCKENNA, Joseph; MUTTON, Simon; PARMAR, Rakesh; SHEPERD, Jon; WRIGHT, Paul; US2014/171412; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

14542-16-6, 4-Methylthiazole-2-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 4-methylthiazole-2-carboxylic acid (50.0 mg, 0.349 mmol) and CDI (84.9 mg,0.524 mmol) in THF (5.0 mL) was stirred at room temperature for 1 h, 2-amino-6-methylpyridine (37.7 mg, 0.349 mmol) was added. The mixture was stirred at room temperature for 2 h. The subsequent mixture was concentrated under reduced pressure and extracted with H2O/ethyl acetate. The combined organic layer was dried over Na2SO4, concentrated under reduced pressure and purified by column chromatography on silica gel (hexane/ethyl acetate = 10:1) to afford the title compound 6ae (55 mg, 57 %) as white solid; 1H-NMR (400MHz, CDCl3) delta 9.61(s, 1H), 8.12 (d, J = 8 Hz, 1H), 7.63(t, J = 8 Hz, 1H), 7.18 (d, J = 0.8, 1H), 6.93 (d, J = 7.2, 1H), 2.49 (d, J = 1.2, 1H). 13C-NMR (100MHz, CDCl3) delta 162.0, 157.7, 157.2, 154.4, 150.0, 138.7,120.4, 119.6, 110.9, 24.1, 17.0. LC/MS (ESI-) 234.1 (M+H)+., 14542-16-6

The synthetic route of 14542-16-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Vu, Hoang Nam; Kim, Ji Young; Hassan, Ahmed H.E.; Choi, Kihang; Park, Jong-Hyun; Park, Ki Duk; Lee, Jae Kyun; Pae, Ae Nim; Choo, Hyunah; Min, Sun-Joon; Cho, Yong Seo; Bioorganic and Medicinal Chemistry Letters; vol. 26; 1; (2016); p. 140 – 144;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.121-66-4,5-Nitrothiazol-2-amine,as a common compound, the synthetic route is as follows.,121-66-4

Example 1 Preparation of N-(5-Nitro-thiazol-2-yl)-2-pyridin-3-yl-acetamide (compound 13) To a solution of 3-Pyridylacetic acid hydrochloride (2.076 g, 12 mmol) in anhydrous THF, 1.5 equivalents of CDI (18 mmol, 2.916 g) in anhydrous THF and 1 equivalent of NEt3 (1.66 mL) are added. The resulting mixture is allowed to stir at room temperature for 4 hours. Then, 2-amino-5-nitro-thiazol (12 mmol, 1.740 g) in THF is added to the reaction mixture and this is stirred at room temperature for 10 h. When the reaction is completed, the solvent is evaporated and the resulting brown crude is dissolved in CH2Cl2 and water. This mixture produces a yellow precipitate, which is filtered and washed with water to obtain the desired compound as a yellow solid (2.300 g, yield: 73 %, 265 M+). 1H-NMR (DMSO): 3.95 (s, 2H); 7.38 (dd, 1H); 7.74 (d, 1H); 8.50 (d, 1H); 8.52 (s, 1H); 8.63 (s, 1H) 13C-NMR (DMSO): 38.52; 123.4; 129.7; 137.1; 141.7; 142.6; 148.1; 150.3; 161.8; 170.7

As the paragraph descriping shows that 121-66-4 is playing an increasingly important role.

Reference£º
Patent; Neuropharma, S.A.; EP1849785; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4175-66-0,2,5-Dimethylthiazole,as a common compound, the synthetic route is as follows.

To a solution of 2, 5-dimethylthiazole (0.730 g, 5.10 mmol) in benzene (80 mL). add N-bromosuccinimide (0.908 g, 5.10 mmol) and a catalytic amount of benzoyl peroxide. Heat the solution at reflux for 2 hours and stir overnight at room temperature. Cool the mixture, dilute with diethyl ether, wash with saturated NA2*S03 (75 mL), followed by saturated sodium hydrogencarbonate (75 mL), dry (NA2SO4), filter, and concentrate. Perform flash chromatography on silica gel eluting with 100% diethyl ether to afford 390 mg of the title compound. IN NMR (CDCL3) 67. 39 (s, 1H), 4.70 (s, 2H), 2.48 (s, 3H)., 4175-66-0

The synthetic route of 4175-66-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2005/9941; (2005); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

40283-46-3, 2-Aminothiazole-5-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 14: 2-(tert-Butoxycarbonylamino)thiazole-5-carboxylic acid BocHN [0111] A mixture of 2-aminothiazole-5-carboxylic acid (2.2 kg, 15.33 mol), aqueous 2 M NaOH (0.674 kg in 8.39 L of DI water), DI water (17.68 L), and THF (17.68 L) was cooled to about 0C. A solution of Boc-anhydride (4.02 kg, 1.20 equiv) in THF (2.21 L) was added to the mixture while maintaining an internal temperature below 5C. When the addition was complete, the reaction mixture was warmed to an internal temperature of 25C and was stirred for 24 hours. The reaction mixture was cooled to about 0C and diluted with DI water (22.1 L). While maintaining an internal temperature below 5C, the pH of the mixture was adjusted to 4.9 by slowly adding acetic acid (5.30 L). After 1 hour a precipitate formed, which was collected by filtration, and rinsed successively with DI water (6.63 L) and MTBE (4.42 L). The filter cake was held under nitrogen for 1 hour and then dried under reduced pressure at 25C to afford the title compound (5.14 kg).

40283-46-3, The synthetic route of 40283-46-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; MATTHEWS, Christopher; O’BRYAN, Colin; PROVENCAL, David Paul; WO2012/51450; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

432047-36-4, 1-(2-Thiazolyl)ethylamine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,432047-36-4

Example 84: N-[4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-(trifluoromethyl)phenyl]-N’-[(1S)-1-(1,3-thiazol-2-yl)ethyl]urea 4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-(trifluoromethyl)aniline (30 mg) was dissolved in chloroform (1 ml) and triethylamine (0.1 ml) to prepare a solution. A solution of triphosgene (35 mg) in chloroform (0.2 ml) was then added to the solution, and the mixture was stirred at room temperature for one hr. Next, a solution of (1S)-1-(1,3-thiazol-2-yl)-1-ethylamine (35 mg) in chloroform (0.2 ml) was added thereto, and the mixture was stirred at room temperature for 10 hr. The stirred mixture was purified by chromatography on silica gel using chloroform/methanol for development to give the title compound (29 mg, yield 68%). 1H-NMR (CDCl3, 400 MHz): delta 1.70 (d, J = 6.8 Hz, 3H), 4.07 (s, 3H), 4.10 (s, 3H), 5.34 – 5.41 (m, 1H), 6.26 (d, J = 6.8 Hz, 1H), 6.58 (d, J = 5.9 Hz, 1H), 7.16 (s, 1H), 7.30 (d, J = 3.2 Hz, 1H), 7.37 (dd, J = 2.9, 9.0 Hz, 1H), 7.44 (d, J = 2.7 Hz, 1H), 7.55 (s, 1H), 7.72 (d, J = 3.4 Hz, 1H), 7.75 (br, 1H), 8.23 (d, J = 9.0 Hz, 1H), 8.51 (d, J = 5.9 Hz, 1H)

The synthetic route of 432047-36-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; KIRIN BEER KABUSHIKI KAISHA; EP1535910; (2005); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22900-83-0,Ethyl 2-bromo-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

Weigh tert-butyl ((R)-2-hydroxy-2-phenylethyl) (4-((S)-pyrrolidine-2-carboxamido)phenethyl)carbamate (500 mg, 1.10 Mm),Ethyl 2-bromo-4-methyl-thiazole-5-carboxylate(330 mg, 1.32 mmol),Potassium carbonate (461 mg, 3.30 mmol) in a 100 mL single-mouth bottle,Add acetonitrile (15 mL) and start to reflux at 90 ¡ã C, and stop the reaction for 10 hours.The reaction mixture was concentrated, and the residue was purified by column chromatography ( petroleum ether/ethyl acetate (v/v) = 2/1)The title compound was obtained as a white solid(430 mg, 63percent).

22900-83-0, 22900-83-0 Ethyl 2-bromo-4-methylthiazole-5-carboxylate 2824057, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Zhong Wenhe; Jin Chuanfei; Xu Tengfei; (45 pag.)CN109734712; (2019); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

34272-64-5, 2-(4-Methyl-2-thioxo-2,3-dihydrothiazol-5-yl)acetic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Each resin from Step 3 was distributed into 24 fritted syringes (Torvig, 50 mg each, 50 mumol), for a total of 96 syringes, and was swelled in NMP (1 mL) for 30 min. The solvent was removed by filtration. Twenty-four solutions of the building blocks listed below (10 mmol each) and DIBA (3.5 mL, 20 mmol) in NMP (10 mL) were prepared. 3 mL of the 24 solutions was added to the 24 syringes for each resin from Step 3, accordingly. The suspensions were then shaken for 20 h on a Titer Plate Shaker. The reaction mixture was filtered and washed 5 times with methylene chloride (5 mL), 3 times with THF (5 mL), 3 times THF/H2O (3/1 v/v, 5 mL), and 3 times with THF (5 mL). The resins were then dried overnight under vacuum., 34272-64-5

The synthetic route of 34272-64-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Kong, Xianqi; Wu, Xinfu; Valade, Isabelle; Gervais, Francine; US2006/167057; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53572-98-8,Imidazo[2,1-b]thiazole-6-carboxylic acid,as a common compound, the synthetic route is as follows.

To a solution of the respective carboxylic acid (0.030 mmol, 1.8 eq) in DMF (0.25 mL) is added successively a solution of DIPEA (0.075 mmol, 4.4 eq) in DMF (0.15 mL) and a solution of TBTU (0.030 mmol, 1.8 eq) in DMF (0.15 mL). The obtained mixture is treated with a solution of the respective 3-aza-bicyclo[3.1.0]hexane derivative (0.017 mmol, 1.0 eq, free base) in DMF (0.15 mL). The mixture is shaken over night and purified by prep. HPLC to give the respective amide derivatives. prepared by reaction of [(1R*,2S*,5S*)-2-aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl]-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone with imidazo[2,1-b]thiazole-6-carboxylic acid. LC-MS: tR=0.84 min; [M+H]+=478.1., 53572-98-8

The synthetic route of 53572-98-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Actelion Phamaceuticals Ltd.; US2010/16401; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.383865-57-4,4-Methoxy-7-morpholinobenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

EXAMPLE 4 (4-Methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-carbamic acid isobutyl ester Using 4-methoxy-7-morpholin-4-yl-benzothiazol-2-ylamine and isobutanol, the title compound was obtained as yellow crystals (12% yield). MS: m/e=366(M+H+), mp 164-168 C.

383865-57-4, The synthetic route of 383865-57-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Flohr, Alexander; Jakob-Roetne, Roland; Norcross, Roger David; Riemer, Claus; US2004/235842; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica