Heterocyclic Building Blocks-Thiazole

88982-82-5,88982-82-5, 4-Bromo-1,3-thiazole-2-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 4-Bromothiazole-2-carboxylic acid (compound 1, 1 eq) and boronic acid derivatives (compound 2a-g, 1.5 eq) were suspended in dimethoxy ethane (DME)/H2O (16 volume, 3:1). Then, Pd(PPh3)4 (0.05 eq) and K2CO3 (1.5 eq) were added to the suspension. The obtained mixture was heated to about 100 C and stirred for about 24 h under nitrogen atmosphere. The solution was cooled to room temperature and acidified with concentrated hydrochloric acid. Then, the precipitate was filtered and washed with water. The obtained wet cake was redissolved in dichloromethane. The organic phase was washed with saturated sodium bicarbonate (NaHCO3) aqueous solution for 30 min. Then, the aqueous phase was acidified again with concentrated hydrochloric acid, and the precipitate was filtered to obtained compounds 3a-g.

The synthetic route of 88982-82-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wang, Haibo; Cai, Zhengjiang; Zheng, Shan; Ma, Huidan; Lin, Haiming; Zheng, Xiaohe; Letters in drug design and discovery; vol. 15; 4; (2018); p. 388 – 397;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.61296-22-8,2-Amino-5-bromothiazole monohydrobromide,as a common compound, the synthetic route is as follows.,61296-22-8

5-(4-Methoxy-2-methyl-phenyl)-4-methyl-thiophene-2-sulfonyl chloride (95 mg, 0.30 mmol, 1.5 equiv.) was dissolved in 0.3 ml MeCN, followed by the addition of sodium cyanate (28.6 mg, 0.44 mmol, 2.2 equiv.). Under strong stirring, pyridine (0.055 ml, 0.68 mmol, 3.4 equiv.) was added dropwise to the reaction mixture which was further stirred for 4 hrs at rt. 2-Amino-5-bromothiazole. HBr (52 mg, 0.20 mmol, 1.0 equiv.), was added and the reaction stirred for 1 hour. Water (20 ml) and 70% acetic acid (2 ml) were added to the suspension which was filtered, washed with water and cold MeOH. The crude solid was dissolved in MeCN-DMSO and chromatographed on a HPLC 75*30 mm RP 18 5 mum column, with A=0.1% HCOOH and B=MeCN and with a gradient of 40% to 90% B in 10 min. The desired fractions were lyophilized to give N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxy-2-methylphenyl)-4-methylthiophene-2-sulfonamide, 16 mg, m/e 499.9 (MH-).

61296-22-8 2-Amino-5-bromothiazole monohydrobromide 2723848, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Gubler, Marcel; Haap, Wolfgang; Hebeisen, Paul; Kitas, Eric A.; Kuhn, Bernd; Minder, Rudolf E.; Schott, Brigitte; Wessel, Hans P.; US2007/281979; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

62266-82-4, 6-Bromobenzo[d]thiazol-2(3H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: One equivalent of appropriate heterocyclic derivative was dissolved in DMF. Three equivalents of potassium carbonate and 1.2 equivalent of the appropriate 3-chloropropan-1-amine derivative were added. The resulting mixture was heated at 70C until disappearance of the starting material. The reaction was monitored by TLC. After 24-96 h, the solvent was removed under reduced pressure, and water added to the residue. The crude product was extracted with dichloromethane. The combined organic fractions were washed with water and dried over magnesium sulphate. Purification by thick layer chromatography or column chromatography was performed.

62266-82-4, 62266-82-4 6-Bromobenzo[d]thiazol-2(3H)-one 188444, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Donnier-Marechal, Marion; Carato, Pascal; Le Broc, Delphine; Furman, Christophe; Melnyk, Patricia; European Journal of Medicinal Chemistry; vol. 92; (2015); p. 575 – 582;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161798-03-4,Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

172.8 g of formic acid and16.0 g of ethyl 2-(3-formyl-4-isobutoxy-phenyl)-4-methyl-thiazole-5-carboxylate (FBT-1) prepared in Example 1 were added to a 500 ml round bottom flask, 4.2g hydroxylamine hydrochloride and 4.1g sodium formate were added, and stirred at 105 ~ 110 C for 2h. After completion of the reaction, cooled to 20 ~ 30 C, heat crystallization was carried out for 1h, filtered, filter cake was washed with 25.3g ethanol, filtered, dried and 14.2 g of ethyl 2-(3-cyano-4-isobutoxy-phenyl)-4-methyl-thiazole-5-carboxylate (FBT-2) was obtained in a yield of 89.5%., 161798-03-4

The synthetic route of 161798-03-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hunan Fangsheng Pharmaceutical Co., Ltd.; Zhang Qinghua; Chen Bo; Yan Zhiyong; (6 pag.)CN109912531; (2019); A;,
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Thiazole | chemical compound | Britannica

71224-95-8, 2-Aminobenzo[d]thiazole-7-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

71224-95-8, Example 116, 2-amino-N-(5-(2,3-dihvdrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)benzo[d]thiazole-7-carboxamide[00153] HATU (0.201 g, 0.53 mmol) and DIPEA (0.230 mL, 1 .32 mmol) were added to a solution of 2-aminobenzo[d]thiazole-7-carboxylic acid (102 mg, 0.53 mmol) in DMA (3 mL) under an inert atmosphere and the reaction allowed to stir for 15 minutes. Compound 2 (0.125 g, 0.440 mmol) was added and the reaction stirred at ambient temperature for approximately 24 hours and then at 40 C overnight. No product was observed. Additional 2-aminobenzo[d]thiazole-7-carboxylic acid (102 mg, 0.53 mmol) was converted to the acid chloride by treatment with oxalyl chloride (approximately 1 .2 equivalents) and DMF (a few drops) in DCM and the acid chloride added to the reaction mixture. The reaction was diluted with water and the solids filtered. The solids were dissolved in DMF and purified by preparative HPLC. Fractions containing the desired compound were evaporated to dryness to afford the desired material as a white solid (0.043 g, 21 %).1H NMR (400 MHz, DMSO) delta 10.05 (s, 1 H), 10.04 (s, 1 H), 7.87 (d, J = 7.1 Hz, 1 H), 7.82 (d, J = 2.2 Hz, 1 H), 7.62 (dd, J = 2.2, 8.3 Hz, 1 H), 7.49 – 7.56 (m, 3H), 7.47 (s, 2H), 7.39 (t, J = 7.8 Hz, 1 H), 7.25 (d, J = 8.5 Hz, 1 H), 6.98 (d, J = 8.4 Hz, 1 H), 4.28 – 4.35 (m, 4H), 2.21 (s, 3H). m/z (ES+), (M+H)+ = 461 .

The synthetic route of 71224-95-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; JONES, Keith; RYE, Carl; CHESSUM, Nicola; CHEESEMAN, Matthew; PASQUA, Adele Elisa; PIKE, Kurt Gordon; FAULDER, Paul Frank; WO2015/49535; (2015); A1;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.693-95-8,4-Methylthiazole,as a common compound, the synthetic route is as follows.,693-95-8

General procedure: Aniline ligand (10.0mmol) and palladium dichloride (0.886g, 5.0mmol) were dissolved in 15mL of DMAc at room temperature. After the mixture was stirred for 0.5hat 80C, the methanol (50mL) was added and the precipitation was formed. The precipitate of palladium complexes was then dissolved in 5mL dichloromethane, then 20mL hexane was added. After crystallized from the mixture of ethanol and dichloromethylene, the palladium complex was obtained as light yellow crystals.

As the paragraph descriping shows that 693-95-8 is playing an increasingly important role.

Reference£º
Article; He, Xiao-Xi; Li, Yan-Fang; Huang, Ju; Shen, Dong-Sheng; Liu, Feng-Shou; Journal of Organometallic Chemistry; vol. 803; (2016); p. 58 – 66;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.348-40-3,6-Fluorobenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

6-Fluoro-2-hydrazinobenzothiazole (2). Hydrochloric acid (10 mL) was added dropwise to hydrazine hydrate 99% (10 g, 0.2 mol) at 5-10 C, followed by addition of a solution of 2-amino-6-fluorobenzothiazole (1) (3.364 g, 0.02 mol) in ethylene glycol (40 mL). The mixture was heated at reflux temperature for 5 h. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from ethanol. Yield 89%, m.p. 194-196 C [1].

348-40-3, The synthetic route of 348-40-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Gabr, Moustafa T.; El-Gohary, Nadia S.; El-Bendary, Eman R.; El-Kerdawy, Mohamed M.; Ni, Nanting; Shaaban, Mona I.; Chinese Chemical Letters; vol. 26; 12; (2015); p. 1522 – 1528;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6436-59-5,Ethyl 2-methylthiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

6436-59-5, Production Example 49; To a solution of ethyl 2-methyl-1,3-thiazole-4-carboxylate (14.53 g) in MeCN (150 mL) was added NBS (22.66 g), followed by heating under reflux for 3 hours. To the reaction mixture was added NBS (7.55 g), followed by heating under reflux for 2 hours. Under ice-cooling, to the reaction mixture was added a saturated aqueous NaHCO3 solution, followed by stirring for 5 minutes, and then extraction with EtOAc. The organic layer was dried over MgSO4 and then concentrated under reduced pressure. The residue obtained was purified by silica gel column chromatography (hexane:EtOAc = from 100:0 to 60:40) to obtain ethyl 5-bromo-2-methyl-1,3-thiazole-4-carboxylate (8.52 g) as a yellow solid.

As the paragraph descriping shows that 6436-59-5 is playing an increasingly important role.

Reference£º
Patent; Astellas Pharma Inc.; EP2119716; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2786-51-8,5-Chlorobenzo[d]thiazole,as a common compound, the synthetic route is as follows.

2786-51-8, General procedure: 1 mL Xylene was added into the flask charged with 0.25 mmol 4-quinolinonyl triflate, 0.75 mmol benzothiazole, 5 mol% Pd(TFA)2 (4.1 mg), 20 mol% PCy (14 mg), 0.25 mmol K2CO3, 10 mol% CuI (4.7 mg). The mixture was stirred at 140oC under Ar for 12 hours, then cooled down to room temperature, diluted with 20 mL ethyl acetate and washed with 10 mL H2O. The aqueous layer was extracted twice with ethyl acetate (5 mL) and the combined organic phase was dried over Na2SO4. After evaporation of the solvents the residue was purified by flash column chromatography (silica gel, PE/EtOAc) to afford the desired products 3 and 5.

2786-51-8 5-Chlorobenzo[d]thiazole 14388566, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Guo, Tao; Tetrahedron Letters; vol. 57; 51; (2016); p. 5837 – 5840;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63139-97-9,(2-Methylthiazol-5-yl)methanamine,as a common compound, the synthetic route is as follows.

63139-97-9, To the solution of 4-bromo-2-methyl-6-(((1S,2S)-2-(1-methyl-1H-pyrazol-3-yl)cyclopropyl)methoxy)pyridazin-3(2H)-one (made according to Example 1, by replacing ((1S,2S)-2-( 5-methylpyridin-2-yl)cyclopropyl)methanol with ((I S,2S)-2-(1-methyl-1H -pyrazol-3-yl)cyclopropyl)methanol, 27 mg, 0.08 mmol) in toluene (2 mL) under N2, (2-methylthiazol-5-yl)methanamine (13 mg, 0.096 mmol), Pd2(dba)3 (7 mg, 0.008 mmol), BINAP (7 mg, 0.012mmol) and Na01Bu (9 mg, 0.096 mmol) were added. After the reaction mixture was stirred at 85C for 4 h, 15 mL water was added. The mixture was extracted with EtOAc (3 x 10 mL). Thecombined organics were dried over MgS04, filtered and concentrated in vacuo. The residue was5 purified by reverse phase chromatography (X bridge Prep C180BD, 40-60% acetonitrile inwater with 10 mmol NH4HC03 modifier) to afford the title compound as an oil. 1H NMR (400MHz, MeOD) o 7.56 (s, 1H),7.42 (d, 1H), 5.96 (d, 1H), 5.89 (s, 1H), 4.59 (s, 2H), 4.15-5.11(m, 1H), 4.04-4.01 (m, 1H), 3.81 (s, 3H), 3.63 (s, 3H), 2.66 (s, 3H), 1.95- 1.89 (m, 1H), 1.61-1.53 (m, 1H), 1.01-0.95 (m, 2H); LRMS m/z (M+H) 387.1 found, 387.15 required.

The synthetic route of 63139-97-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott D.; MCCOMAS, Casey C.; REGER, Thomas S.; QI, Changhe; WO2014/139150; (2014); A1;,
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Thiazole | chemical compound | Britannica