Heterocyclic Building Blocks-Thiazole

173979-01-6, 4-(Tributylstannyl)thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of ethyl 3-(2-(6-chioro-3-cvano- 4-methyipyridin-2-yi)-5-fluoro- I ,2,3,4-tetrahydroisoquinolin-6-yI)propanoate (50 mg, 0.124 mrnol) and 4-(tributylstannyi)thiazoie (51.2 mg, 0.137 mrnol) in dioxane (3 ml) was added (i2 XPhos (979mg. 0.012 mmol). The mixture was stirred at 110 c for 12 h, then quenched with 10% aqueous KF (10 ml), filtered and extracted with ethyl acetate (8 niL x 3). The organic layers were combined and washed with water (15 mL), brine (10 mL), dried over Na2SO4,filtered and concentrated under reduced pressure to afford the title compound, which was used directly without further purification., 173979-01-6

173979-01-6 4-(Tributylstannyl)thiazole 2763258, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; ADAMS, Gregory, L.; COX, Jason, M.; DEBENHAM, John, S.; EDMONDSON, Scott; GILBERT, Eric, J.; GUO, Yan; JIANG, Yu; JOSIEN, Hubert; KIM, Hyunjin, M.; LAN, Ping; MIAO, Shouwu; PLUMMER, Christopher, W.; RAJAGOPALAN, Murali; SHAH, Unmesh; SUN, Zhongxiang; TRUONG, Quang, T.; UJJAINWALLA, Feroze; VELAZQUEZ, Francisco; VENKATRAMAN, Srikanth; SUZUKI, Takao; WANG, Nengxue; (182 pag.)WO2017/205193; (2017); A1;,
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10200-59-6, 2-Thiazolecarboxaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 2-amino-5-bromobenzenethiol (3) (10 g, 48.9 mmol) with thiazole-2-carbaldehyde (4) (4.3 mL, 48.9 mmol) and ZnO NPs (362 mg, 4.44 mmol) in absolute ethanol (40 mL) was stirred at room temperature for 8 min. After completion of the reaction (TLC), the solvent was evaporated in vacuum and the crude solid product was purified by column chromatography (ethyl acetate?hexane, 1 : 1) to give pure compound 5. Yield 93percent. 1H NMR spectrum, delta, ppm: 7.49 d (1H, J = 8.09 Hz), 7.68 d (1H, J = 8.10 Hz), 7.75 d (1H, J = 8.09 Hz), 7.84 d (1H, J = 8.10 Hz), 7.93 s (1H). MS (FAB): 298 [M]+.

10200-59-6, The synthetic route of 10200-59-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Pragathi; Sreenivasulu; Veronica; Madhavi; Raju; Russian Journal of General Chemistry; vol. 89; 5; (2019); p. 1009 – 1014; Zh. Obshch. Khim.; vol. 89; 5; (2019); p. 1009 – 1014,6;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5464-79-9,2-Amino-4-methoxybenzothiazole,as a common compound, the synthetic route is as follows.

5464-79-9, 2-Amino-4-methoxy-benzothiazole (1. 00 g, 5.54 mmol) was added to a stirred solution of polyphosphoric acid (85%, 40 ml) at 60 C. The resulting mixture was stirred at 60 C until all the benzothiazole had dissolved. The resulting solution was then cooled to-10 C and a solution of sodium nitrite (2.3 g, 33.3 mmol) in water (5 ml) was added so as to keep the internal temperature BELOW-4 C. After complete addition the resulting solution was added to a solution of hypophosphoric acid (50%, 15 ml) at 0 C. After the evolution of gas had ceased the mixture was diluted with water and basified with NAHC03 (sat). The aqueous solution was extracted with CHC13 (3 x 200 ML) with the combined organic extracts dried (MGSO4) and the solvent removed in vacuo. The resulting solid was recrystallised from EtOH: H20 to give an orange solid (300 mg). The liquor was concentrated and purified by flash chromatography eluting silica gel with hexane: EtOAc [4: 1] to hexane: EtOAc [1: 1] to give a further 210mg of product. RF = 0. 38 in hexane : ether [1 : 1] ; ON (300 MHz, CDC13) 8.91 (1H, s, CH), 7.53 (1H, d, Ar), 7.39 (1H, T, Ar), 6.93 (1H, d, Ar), 4.07 (3H, s, OCH3)

5464-79-9 2-Amino-4-methoxybenzothiazole 21622, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2004/43931; (2004); A1;,
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541-58-2, 2,4-Dimethylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The light source was a medium-pressure mercury lamp (500W) in a glass cooling water jacket to cut off light of wavelengths shorter than 300nm. The solution of phthalimide (2mmol, 0.025M) and N-vinyllactams or methylthiazoles (10mmol) in dichloromethane (80ml) was purged with argon(Ar) for 15min and then irradiated under continuous Ar purging. The reaction course was monitored by TLC. After the reaction, the solvent was removed under reduced pressure and the residue was purified by flash chromatography on a silica gel column with petroleum ether/ethyl acetate as eluents (gradient elution)., 541-58-2

541-58-2 2,4-Dimethylthiazole 10934, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Shen, Yong-Miao; Grampp, Guenter; Tao, Fei-Fei; He, Ning-De; Chen, Da-Qing; Ye, Miao; Journal of Photochemistry and Photobiology A: Chemistry; vol. 271; (2013); p. 85 – 92;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1452-15-9,4-Cyanothiazole,as a common compound, the synthetic route is as follows.

General procedure: Trifluoroacetic acid (4 mL) was added to a mixture of nitrile(1.0 mmol) and thiosemicarbazide (1.1 mmol). The reaction mixturewas stirred and refluxed for 6 h. Then, it was cooled to roomtemperature and aqueous ammonia was added. The precipitatedsolidwas filtered,washed with hot water and air-dried. It should benoted that the compounds f1-f35 were directly used for the nextreaction without further purification., 1452-15-9

1452-15-9 4-Cyanothiazole 15069, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Chen, Ya; Kirchmair, Johannes; Li, Xueyao; Ma, Guixing; Wu, Song; Xia, Jie; Xue, Wenjie; Zhang, Hongmin; European Journal of Medicinal Chemistry; vol. 188; (2020);,
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556-90-1, 2-aminothiazol-4(5H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of cyclohexyl-2-(phenylimino)-4-thiazolidineione,3-methyl-2-(phenylimino) thiazolidine-4-one, thiazolidine-2,4-dione, 3-methyl thiazolidine-2,4-dione or imidazolidine-2,4-dione (1.0 equiv) in absolute ethanol (15 mL) was added theappropriate 2,5-dimethyl-1-aryl -3-formylpyrrole (1.1 equiv),piperidine (1.2 equiv) and 3 molecular sieves. The mixture washeated to reflux at 90 C for 8e10 h, cooled, filtered and concentratedin vacuo. The residue was purified by column chromatographyon a silica gel column (ethylacetate/hexane ordichloromethane/hexane) and in some cases recrystallized frommethanol to give 20e54 as generally yellowish solids.

556-90-1, 556-90-1 2-aminothiazol-4(5H)-one 11175, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Mital, Alka; Murugesan, Dinakaran; Kaiser, Marcel; Yeates, Clive; Gilbert, Ian H.; European Journal of Medicinal Chemistry; vol. 103; (2015); p. 530 – 538;,
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1123-99-5, 2-Iodobenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under a nitrogen atmosphere, in 25 ml substrate is added into the test tube reactor 3dfm (0.2mmol, 52.0 mg), 1-chloro-butane (3.0mmol, 276.0 mg), PdCl2(dppf) (0.02mmol, 14.6 mg), DPPF (0.01mmol, 5.6 mg), Cs2CO3(0.3mmol, 195.0 mg), Na2S2O35H2O (0.5mmol, 248.0 mg), DMSO (4.0 ml) and glycol (0.1 ml). Heating the reaction system to 120 C for reaction. TLC detection after the reaction is ended, the system is cooled to room temperature. Hydrosolvent quenching reaction with saturated ammonium chloride, extracted with ethyl acetate (3*10 ml), column chromatography purification to obtain the product 3df (62%)., 1123-99-5

1123-99-5 2-Iodobenzo[d]thiazole 827981, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; East China Normal University; JIANG, XUE FENG; QIAO, ZONG JUN; (33 pag.)CN103848767; (2016); B;,
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24295-03-2, 2-Acetylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Ketone (20 mmol) (2-acetylpyridine, 2-acetylthiazole or 2-acetylpyrazine)was added to a solution of aldehyde (10 mmol) (4-methoxybenzaldehyde,4-methoxy-1-naphthaldehyde or 6-methoxy-2-naphthaldehyde) in EtOH (75 mL). KOH (1.54 g, 27.5 mmol) and NH3(aq)(35 mL) were then added. The solution was stirred at room temp. for 24 h. The solid was collected by filtration and washed with H2O. Recrystallization from ethanol (L1,L4, L7) or toluene (L2, L3, L5, L6, L8,L9) afforded a crystalline solid.

24295-03-2, The synthetic route of 24295-03-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Klemens, Tomasz; ?witlicka, Anna; Machura, Barbara; Kula, S?awomir; Krompiec, Stanis?aw; ?aba, Katarzyna; Korzec, Mateusz; Siwy, Mariola; Janeczek, Henryk; Schab-Balcerzak, Ewa; Szalkowski, Marcin; Grzelak, Justyna; Ma?kowski, Sebastian; Dyes and Pigments; vol. 163; (2019); p. 86 – 101;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.911466-96-1,2-(Ethoxycarbonyl)thiazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.

Isobutyl chloroformate (1.16 ml, 8.95 mmol) was added to an ice-cooled (0C) suspension of 2- (ethoxycarbonyl)-1 ,3-thiazole-4-carboxylic acid (216) (1.5 g, 7.46 mmol) and TEA (1 .25 ml, 8.95 mmol) in THF (60 ml). The reaction was stirred at 0C for 1 h. The reaction was filtered through a plug of Celite and NaBH4 (0.705 g, 18.64 mmol) was added to the filtrate and stirred for 2h. The reaction was diluted with sat. aq. Na2C03 solution and stirred for 10 mins, then extracted with EtOAc. The combined organic layers were washed with brine, dried (Na2S04), filtered and the solvent evaporated. Purification by flash column chromatography (eluting with a gradient of 40-50% EtOAc-Heptane) gave the titled compound (0.734 g, 52.6%) as a crystalline solid. 1 H-NMR (DMSO-d6, 500 MHz) d[ppm]= 7.85 (s, 1 H), 5.50 (t, J = 5.8 Hz, 1 H), 4.63 (dd, J = 5.8, 0.8 Hz, 2H), 4.37 (q, J = 7.1 Hz, 2H), 1.33 (d, J = 7.1 Hz, 3H) HPLCMS (ESI+): [m/z]: 187.90 [M+H], 911466-96-1

911466-96-1 2-(Ethoxycarbonyl)thiazole-4-carboxylic acid 53487863, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; VIFOR (INTERNATIONAL) AG; DUeRRENBERGER, Franz; BUHR, Wilm; BURCKHARDT, Susanna; BURGERT, Michael; KALOGERAKIS, Aris; REIM, Stefan; MANOLOVA, Vania; BOYCE, Susan; YARNOLD, Christopher John; PENA, Paula; SHEPHERD, Jon; LECCI, Cristina; JARJES-PIKE, Richard; SCOTT, John; (416 pag.)WO2017/68089; (2017); A2;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.117724-63-7,2-Methyl-4-(trifluoromethyl)thiazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.,117724-63-7

9-Dichloromethylidene-5-amino-benzonorbomene (175 mg, 0.73 mmol), 2- methyl-4-trifluoromethyl-thiazole-5-carboxylic acid (162 mg, 0.77 mmol, 1.05 eq.) and triethylamine (184 mg, 1.8 mmol, 2.5 eq.) were reacted with bis-(2-oxo-3-oxazolidinyl)- phosphinic acid chloride (278 mg, 1.09 mmol, 1.5 eq.) in dichloromethane (10 ml) at 25 0C for 20 hours. The reaction mixture in ethyl acetate was washed successively with water and saturated. Sodium chloride solution, dried over sodium sulphate, evaporated and purified on silica gel (ethyl acetate-hexane-(l:2) to give 250 mg colourless crystals (m.p. 136-139 0C).

The synthetic route of 117724-63-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SYNGENTA PARTICIPATIONS AG; WO2007/48556; (2007); A1;,
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Thiazole | chemical compound | Britannica