Heterocyclic Building Blocks-Thiazole

383865-57-4, 4-Methoxy-7-morpholinobenzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-Benzyl-3-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-urea Using 4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine and benzylamine the title compound was obtained as an off-white solid (99%), MS: m/e=399 (M+H+).

383865-57-4, 383865-57-4 4-Methoxy-7-morpholinobenzo[d]thiazol-2-amine 11402861, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Alanine, Alexander; Flohr, Alexander; Miller, Aubry Kern; Norcross, Roger David; Riemer, Claus; US2002/45615; (2002); A1;,
Thiazole | C3H3NS – PubChem
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2634-33-5,1,2-Benzothiazol-3-one,as a common compound, the synthetic route is as follows.

General procedure: A solution of 1,2-benzisothiazol-3-one 1 (151 mg, 1 mmol), inTHF (10 ml), K2CO3 (276 mg, 2 mmol) was added at room temperaturefor 30 min, then t-butyl bromoacetate 10 (195 mg, 1 mmol)was added. After the reaction was stirred at room temperaturefor 3 h, the solvent was removed under vacuum. The residualwas isolated by column chromatography (ethyl acetate/petroleumether, 15:1) to yield 11. The intermediate 11 (265 mg, 1 mmol) indry CH2Cl2 (10 ml) was treated with trifluoroacetic acid (TFA,3.3 ml) for 5 h at room temperature and the solvent was removedunder vacuum. The residue washed with ethyl ether (2 25 ml) toyield the desired product 12 as white solid. A solution of compound 12 (209 mg, 1 mmol) in dry THF(10 ml) was added portion wise to a suspension of carbonyldiimidazole(162 mg, 1 mmol) in THF (5 ml) and the mixture was stirredat room temperature for 20 min and then refluxed for 10 min.A solution of primary amine (1 mmol) in THF (5 ml) was addedand the reaction mixture was stirred at room temperature overnight.A white precipitate formed, which was collected by suctionfiltration.

2634-33-5, The synthetic route of 2634-33-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wu, Lixin; Lu, Meiqi; Yan, Zhihui; Tang, Xiaobin; Sun, Bo; Liu, Wei; Zhou, Honggang; Yang, Cheng; Bioorganic and Medicinal Chemistry; vol. 22; 8; (2014); p. 2416 – 2426;,
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Thiazole | chemical compound | Britannica

7504-44-1,7504-44-1, 2-(4-Thiazolyl)acetic Acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

HATU (2.12 g, 5.58 mmol) was added to a mixture containing of 2-((lr, 4r)-4-((5 -amino-i -(phenyl sulfonyl)- 1H-pyrrolo[2,3 -b]pyridin-4- yl)amino)cyclohexyl)acetonitrile (Intermediate 2, 1.14 g, 2.78 mmol), 2-(thiazol-4-yl)acetic acid(400 mg, 2.79 mmol), DIPEA (722 mg, 5.59 mmol)and DMF (10 mL) at 0 C (ice / water) and was stirred at room-temperature for 2 hours. The reaction was partitioned between EtOAc (100 mL) and water (100 mL), the aqueous phase was extracted with ethyl acetate (50 mL x 3) and the combined organic extracts were dried over anhydrous Na2504, filtered, and concentrated to dryness. The residue was purified by flash column chromatography to provide the titlecompound (1.5 g, 95% yield) as a yellow solid. MS (ESI): mass calcd. for C26H26N60352,534.65; m/z found, 534.9 [M+H]t

7504-44-1 2-(4-Thiazolyl)acetic Acid 236262, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BACANI, Genesis M.; CHAI, Wenying; KOUDRIAKOVA, Tatiana; KRAWCZUK, Paul J.; KREUTTER, Kevin D.; LEONARD, Kristi; RIZZOLIO, Michele C.; SEIERSTAD, Mark; SMITH, Russel C.; TICHENOR, Mark S.; VENABLE, Jennifer D.; WANG, Aihua; (452 pag.)WO2018/112382; (2018); A1;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.69812-29-9,2-Acetamido-4-methylthiazole-5-sulfonyl chloride,as a common compound, the synthetic route is as follows.

69812-29-9, General procedure: To a solution of 1 (0.5g, 2mmol) in CH2Cl2 (30mL), K2CO3 (1.8g, 6mmol) and the substituted benzoyl chloride (2mmol) were added and stirred at 0C untill the TLC analysis showed completion of the reaction, then filterd. The filtrate was washed with water, brine, dried, filtered and concentrated. Then the residue was purified by flash column chromatography on silica gel with CH2Cl2/CH3OH as the eluent to give the title compounds.

69812-29-9 2-Acetamido-4-methylthiazole-5-sulfonyl chloride 96951, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Zhang, Xin; Lv, Xiao-Qin; Tang, Sheng; Mei, Lin; Li, Ying-Hong; Zhang, JingPu; Jiang, Jian-Dong; Peng, Zong-Gen; Song, Dan-Qing; European Journal of Medicinal Chemistry; vol. 143; (2018); p. 1053 – 1065;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

777-12-8, 6-(Trifluoromethyl)benzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

777-12-8, To a stirred solution of methyl 5-chloro-3-cyano-2-methoxybenzoate (86mg, 0.382mmo1) in MeOH (3m1) was added 2.0 ml iN KOH solution. The resulting mixture was stirred at 60¡ãC overnight. The solvent was evaporated out and 4N HC1 in dioxane (lml) was added to the residue. The mixture was stirred for another 10mm before it was concentrated and dried under vacumn. To this residue was added HBTU (172mg, 0.456mmo1), DMF (3m1) and DIPEA (330u1, 1.9 mmol). The mixture was stirred for lOmins and then 6-(trifluoromethyl)benzo[d]thiazol-2-amine (83mg, 0.3 8mmol) was added. The resulting reaction was heated at 120 ¡ãC for 24hs. After cooled to rt, the mixture was separated between EA and water. The organic layer was washed with brine, dried over Na2SO4 and concentrated in vacuo. Purification by column chromatography gave the 5-chloro-3-cyano-2- hydroxy-N-(6-(trifluoromethyl)benzo[d]thiazol-2-yl)b enzamide as a yellow solid (62mg, 42percent). ?H NMR (300 IVIHz, Acetone-d6) 8.31 (dt, J = 1.6, 0.9 Hz, 1H), 7.85 (d, J = 3.0 Hz, 1H), 7.79 -7.65 (m, 2H), 7.14 (d, J = 3.0 Hz, 1H). MS (ESI) [M+H] requires m/z 398.00, found m/z 397.95.

The synthetic route of 777-12-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JIN, Shengkan; AUGERI, David J.; CAO, Bin; TAO, Hanlin; (126 pag.)WO2017/201313; (2017); A1;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.90533-23-6,4-(3-Chlorophenyl)thiazol-2-amine,as a common compound, the synthetic route is as follows.,90533-23-6

Step 3:; To a solution of 4-(3-chlorophenyl)thiazol-2-amine (1 g) in tetrahydrofuran (20 mL) was added NBS (0.88 g). After stirring at room temperature overnight, the mixture was partitioned between ethyl acetate (30 mL) and water (20 mL). The organic phase was washed with water (20 mL x 2), dried and concentrated to give 5-bromo-4-(3-chlorophenyl)thiazol-2-amine (1.05 g) as a red liquid. MS(ES ) m/z 289 (MH ).

90533-23-6 4-(3-Chlorophenyl)thiazol-2-amine 675261, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXO GROUP LIMITED; WANG, Yonghui; YANG, Ting; WO2012/100734; (2012); A1;,
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Thiazole | chemical compound | Britannica

5398-36-7, Ethyl 2-aminothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of compound 1 (7.8 g, 45.3mmol), Boc2O (9.9 g, 45.3 mmol), DMAP (0.1 g, 0.82mmol) in CH2Cl2 (50 mL) was stirred at room temperature for 4 h. After completion of the reaction, the mixture was washed with H2O (30mL), brine (30 mL), the organic layer was dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The crude product was purified by column chromatograph on silica gel (200-300 mesh) by ethyl acetate and petroleum ether (v/v = 1:2) as eluent to afford 2 as a light yellow solid (11.5 g, yield 93.5%).

5398-36-7, The synthetic route of 5398-36-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Li, Feng-Yun; Guo, Xiao-Feng; Fan, Zhi-Jin; Zhang, Yu-Qing; Zong, Guang-Ning; Qian, Xiao-Lin; Ma, Liu-Yong; Chen, Lai; Zhu, Yu-Jie; Tatiana, Kalinina; Morzherin, Yury Yu.; Belskaya, Nataliya P.; Chinese Chemical Letters; vol. 26; 10; (2015); p. 1315 – 1318;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

39136-63-5, 5-Phenylthiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step A: (3-hydroxy-3-((3-(5-phenylthiazol-2-yl)thioureido)methyl)-1-ammoniobicyclo[2.2.2]octan-1-yl)trihydroborate To 5-phenylthiazol-2-amine (0.52 g, 2.9 mmol) in acetonitrile (6 mL) was added Iota, Gamma-thiocarbonyldiimidazole (0.68 g, 3.8 mmol). The reaction mixture was stirred at 65 C for 2 hours. The precipitate was filtered and washed with acetonitrile (2 x 20 mL) to yield intermediate N-(5-phenylthiazol-2-yl)- ^-imidazole-l- carbothioamide. The intermediate was taken up in N,N-dimethylformamide (30 mL) and treated with (3-(aminomethyl)-3-hydroxy-l-ammoniobicyclo[2.2.2]octan-l- yl)trihydroborate (0.5 g, 2.9 mmol). The reaction mixture was stirred for 5 hours at 65 C. The reaction was concentrated in vacuo and purified via silica gel chromatography (30-100% ethyl acetate/hexane). The product fractions were combined and concentrated in vacuo to yield (3-hydroxy-3-((3-(5-phenylthiazol-2- yl)thioureido)methyl)-l-ammoniobicyclo[2.2.2]octan-l-yl)trihydroborate (.85 g, 2.19 mmol, 74.4 % yield) as a white powder. LC/MS confirmed product with loss of BH3 in the LC/MS conditions: retention time 3.26 (M+1-BH3= 375.33)., 39136-63-5

39136-63-5 5-Phenylthiazol-2-amine 873119, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; COOK II, James H.; MCDONALD, Ivar, M.; KING, Dalton; OLSON, Richard, E.; WANG, Nenghui; IWUAGWU, Christiana, I.; ZUSI, Christopher, F.; MACOR, John, E.; WO2011/53292; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10200-59-6,2-Thiazolecarboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: Method A [31]: To a solution of the starting aldehyde (1.5 mmol) and ketone (0.75 mmol) in methanol (10 mL) was added the solution of sodium methoxide in methanol (5.4 M, 0.14 mL,0.75 mmol), and the mixture was stirred for 4-18 h and monitored with TLC. When the reaction was completed, the following two work-up procedures were applied. Procedure 1: if precipitate was observed, the precipitate was filtered and rinsed with cold methanol. Procedure 2: if no precipitate was observed, then saturated solution of ammonium chloride was added, and the subsequent mixture was extracted with dichloromethane. The organic layer was dried over anhydrous MgSO4. The solvent was evaporated under vacuum to give a crude product, which was purified by preparative TLC (3e5percent methanol in dichloromethane) or column chromatography (2percent methanol in dichloromethane)., 10200-59-6

As the paragraph descriping shows that 10200-59-6 is playing an increasingly important role.

Reference£º
Article; Samaan, Nawras; Zhong, Qiu; Fernandez, Jayjoel; Chen, Guanglin; Hussain, Ali M.; Zheng, Shilong; Wang, Guangdi; Chen, Qiao-Hong; European Journal of Medicinal Chemistry; vol. 75; (2014); p. 123 – 131;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

121-66-4, 5-Nitrothiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General Procedure: Dry sodium nitrite (1.04 g, 15 mmol) was slowly added with stirring to cold concentrated sulphuric acid (10 ml) and warmed to 50 C on water bath. The solution was then cooled to 0 C and a mixture of glacial acetic acid/propionic acid (30 ml, 5:1) was added dropwise with stirring so as to maintain the temperature below 15 C. The resulting solution was then cooled below 0 C and to this, 2-amino-5-nitrothiazole (2.17 g, 15 mmol) was added in small portions while stirring. The stirring was further continued at this temperature for 2 h. The resulting diazonium salt solution was slowly added to resorcinol (1.65 g, 15 mmol) dissolved in 50 ml of 10% sodium hydroxide solution with the reaction temperature was maintained below 0 C. The solution was stirred for 2 h and stood for 30 min to allow the precipitate to settle. The precipitate was filtered and washed several times with water until the filtrate was neutral. The product was finally purified by column chromatography over SiO2 with benzene and ethyl acetate (1:1) as an eluate to give 1.75 g (45% yield) of a., 121-66-4

As the paragraph descriping shows that 121-66-4 is playing an increasingly important role.

Reference£º
Article; Kariduraganavar; Tambe; Tasaganva; Kittur; Kulkarni; Inamdar; Journal of Molecular Structure; vol. 987; 1-3; (2011); p. 158 – 165;,
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Thiazole | chemical compound | Britannica