Heterocyclic Building Blocks-Thiazole

3364-80-5, Thiazole-4-carboxaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 4-formaldehyde thiazole (113 mg, 1mmol) dissolved in 2 ml methanol, by adding 2-hydroxypropanedinitrile acetic acid solution (0.4 ml, 5mol/L), then rapidly added to 4-dimethyl aminopyridine (12 mg), 50 ¡ãC stirring under 40 minutes. After concentrating the reaction solution through the column chromatography separation to obtain 4 – (hydroxy-a)-thiazole acetic acid methyl ester (144 mg, 83percent)., 3364-80-5

As the paragraph descriping shows that 3364-80-5 is playing an increasingly important role.

Reference£º
Patent; Shanghai Syn-The-All Pharmaceutical Co. Ltd.; Zhang, ZhiLiu; Lin, XiaoJuan; Yu, Haiyu; Wu, Chengde; Ma, RuJian; Chen, ShuHui; (8 pag.)CN103086881; (2016); B;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4175-66-0,2,5-Dimethylthiazole,as a common compound, the synthetic route is as follows.

To a solution of 2, 5-dimethylthiazole (0.730 g, 5.10 mmol) in benzene (80 mL). add N-bromosuccinimide (0.908 g, 5.10 mmol) and a catalytic amount of benzoyl peroxide. Heat the solution at reflux for 2 hours and stir overnight at room temperature. Cool the mixture, dilute with diethyl ether, wash with saturated NA2*S03 (75 mL), followed by saturated sodium hydrogencarbonate (75 mL), dry (NA2SO4), filter, and concentrate. Perform flash chromatography on silica gel eluting with 100% diethyl ether to afford 390 mg of the title compound. IN NMR (CDCL3) 67. 39 (s, 1H), 4.70 (s, 2H), 2.48 (s, 3H).

4175-66-0, As the paragraph descriping shows that 4175-66-0 is playing an increasingly important role.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2005/9941; (2005); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.302964-24-5,2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide,as a common compound, the synthetic route is as follows.

Add 2-amino-N- (2-chloro-6-methylphenyl) thiazole-5-carboxamide A (4mmol, 1071mg), compound N1 (4mmol, 601mg) to the flask, add no 150ml of water toluene was installed on the water separator device, and the reaction was heated and refluxed for 24h. After the reaction was completed, toluene was distilled off under reduced pressure to obtain crude intermediate O1., 302964-24-5

302964-24-5 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide 21911644, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Guangdong Medical University; Zhao Jinwu; Xu Jingxiu; Zuo Changqing; (12 pag.)CN111039890; (2020); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.324579-90-0,4-Cyclopropylthiazol-2-amine,as a common compound, the synthetic route is as follows.

To a stirred solution of Compound J (5.6 g, 40 mmol) and CuBr (8.5 g, 60 mmol) in CH3CN (100 mL) was added dropwise t-BuONO (6.2 g, 7.2 mL, 60 mmol) at 0 ¡ãC. Then the reaction mixture was warmed to room temperature and further stirred for additional 30 mins. After that, the precipitate was filtered and the solvent was removed under reduced pressure. The residue was purified by column chromatography (eluent: 100percent petroleum ether) to afford the desired product K (3.5 g, 43 percent) as a light yellow oil containing small amount of petroleum ether. 1H NMR (400 MHz, CDC13): delta 6.77 (s, 1H), 2.00-1.95 (m, 1H), 0.94-0.85 (m, 4H)., 324579-90-0

The synthetic route of 324579-90-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GUO, Lei; HU, Taishan; HU, Yimin; KOCER, Buelent; LIN, Xianfeng; LIU, Haixia; MAYWEG, Alexander V.; QIU, Zongxing; SHEN, Hong; TANG, Guozhi; WANG, Lisha; WU, Guolong; YAN, Shixiang; ZHANG, Weixing; ZHOU, Mingwei; ZHU, Wei; WO2014/37480; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161798-01-2,Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

b) Preparation of Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate [Compound of formula IV1.350.0gm of Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl-5-thiazolecarboxylate, [Compound of formula III] 332. Ogm of potassium carbonate and 330.0gm of isobutyl bromide were added to 1.751tr of DMF. Reaction mixture was heated to 90 +/- 3C and stirred for 4 hr. Reaction mixture was cooled to 25C and slowly added 10.50 ltr of water. Slurry of the product formed was stirred for 2.0hr, filtered, washed and dried under vacuum to give 389 gm of titled compound.Analytical Data- ¡¤ ^NMR (CDC13, 400 MHz) : delta 1.079-1.101 (doublet, 6H); delta 1.366-1.413 (triplet,3H); delta 2.185-2.230 (multiplet, 1H); delta 2.769 (singlet, 3H); delta 3.914-3.935 (doublet, 2H); delta 4.316-4.387 (quartet, 2H); delta 7.045-7.074 (doublet, 1H); delta 8.188-8.225 (doublet of doublet, 1H); delta 8.353-8.361 (doublet, 1H).? Mass (m/e): 348.3

161798-01-2, The synthetic route of 161798-01-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SANDOZ AG; LUTHRA, Parven, Kumar; KHAN, Rashid; SALUNKHE, Dadasaheb; NASIR ALI, Shafakat, Ali; WO2012/131590; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.69812-29-9,2-Acetamido-4-methylthiazole-5-sulfonyl chloride,as a common compound, the synthetic route is as follows.

[00217] A solution of 3-(10,l l-dihydro-5H-dibenzo[?/]azepin-5-yl)propan-l-amine hydrochloride (0.075 g, 0.259 mmol) in DMF (0.85 mL) was cooled to 0 C, treated with Et3N (0.144 mL, 1.03 mmol), and 2-acetamido-4-methylthiazole-5-sulfonyl chloride (0.073 g, 0.285 mmol). The mixture was warmed to 25 C and stirred for 2 h. The mixture was partitioned between water (50 mL) and CH2CI2 (50 mL). The organic layer was washed with saturated aqueous NaCl (5 x 30 mL), dried (Na2S04), and concentrated in vacuo. The residue was dissolved in a minimal amount of CH2CI2 and purified by flash chromatography (S1O2, 2-5% ethyl acetate -hexanes) to afford the title compound (0.032 g, 26%) as a white solid. 1H NMR (600 MHz, CD3OD) delta 7.10- 7.01 (6H, m), 6.88-6.85 (2H, m), 3.71 (2H, t, J= 6.6 Hz), 3.02 (3H, br s), 2.99 (2H, J = 6.6 Hz), 2.36 (3H, s), 2.23 (3H, s), 1.71 (2H, quintet, J= 6.6 Hz); 13C NMR (150 MHz, CD3OD) delta 169.8, 159.2, 151.7, 148.2, 134.2, 129.5, 126.1, 12.4, 119.6, 119.5, 46.9, 40.5, 31.9, 27.2, 21.2, 15.0; LCMS m/z 471.2135 ([M + H+], C23H27N4O3S2 requires 471.1519).

69812-29-9, As the paragraph descriping shows that 69812-29-9 is playing an increasingly important role.

Reference£º
Patent; MT. SINAI SCHOOL OF MEDICINE; OHLMEYER, Michael; NARLA, Goutham; DHAWAN, Neil; KASTRINSKY, David; WO2013/25882; (2013); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

18903-18-9, Ethyl 5-aminothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5-Amino-thiazole-4-carboxylic acid ethyl ester (460 mg) obtained in the same manner as in Chem. Pharm. Bull, 19(1) 119-123 (1971) was dissolved in ethanol (7 ml). Hydrazine monohydrate (1.3 ml) was added to this solution and the mixture was refluxed at 100C for 22 hr. The reaction mixture was cooled to room temperature and the obtained solid was collected by filtration and washed with ethanol. This solid was dried in vacuo to give the title compound (280 mg).1H-NMR(?, 300MHz, DMSO-d6) 4.26(2H,s),7.07(2H,s),8.00(1H,s),8.83(1H,s)., 18903-18-9

The synthetic route of 18903-18-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Japan Tobacco Inc.; EP1452526; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14542-12-2,Thiazol-2-ylmethanol,as a common compound, the synthetic route is as follows.,14542-12-2

This material (3.4 g, 29.6 mmol, 1 eq) was treated with TBDPSCI (8.94 g, 1.1 eq),imidazole (4.0 g, 2 eq) in 20 mL DCM. The mixture was stirred for 14 h. After removalof solvent, extraction with EtOAc and drying the organic layer with Na2C03,evaporation of the solvent afforded 10.5 g of the desired product quantitavely.1HNMR(CDCI35): 1.1 (s, 9 H) 4.90.(s, 2H) 7.30-7.40 (m, 7 H) 7.60-7.70 Patent; SCHERING CORPORATION; WO2006/19957; (2006); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

78364-55-3, 6-Fluoro-2-hydrazinylbenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,78364-55-3

General procedure: A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 ¡ãC for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized to give compounds 3-29.

78364-55-3 6-Fluoro-2-hydrazinylbenzo[d]thiazole 2049844, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Gabr, Moustafa T.; El-Gohary, Nadia S.; El-Bendary, Eman R.; El-Kerdawy, Mohamed M.; Ni, Nanting; Chinese Chemical Letters; vol. 27; 3; (2016); p. 380 – 386;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

848841-68-9, 4-(4-Chlorothiazol-2-yl)morpholine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,848841-68-9

Method B; N- { 4-Chloro-5-[8-( 1 -ethyl-propyl)-2,6-dimethyl-imidazo [1,2- b]pyridazin-3-yl]-thiazol-2-yl } -morpholine.; A 20L reactor flask under nitrogen is charged with 2900 ml of dry and degassed DMF then with 8-(1-ethyl-propyl)-3-iodo-2,6-dimethyl-imidazo[1,2-b]pyridazine (287 g, 0.836 mol), 2-morpholino-4-chlorothiazole (205.4 g, 1.01 mol, 1.2 equv.), Pd(OAc)2 (3.74 g, 7.91 mmol, 0.01 equiv.), triphenylphosphine (8.77g, 33.1 mmol, 0.04 equiv.), Copper iodide (8 g, 41.59 mmol, 0.05 equiv.) and cesium carbonate (544.9 g, 1.65 mol). The reaction mixture is heated at 120C. After 16 h at 120C, 1.87 g of Pd(OAc)2 and 4.38 g of triphenylphosphine more is added. After 1 h, the mixture is cooled, quenched with NH4CI solution (4300 mL) and extracted with MTBE (2900 mL), the aqueous phase is extracted twice more with 2000 ml of MTBE. The organic phases are washed with sat NaCl aq (2000 mL), then treated with charcoal 72 g in flask bottle and filtered on Celite. The filtrate is concentrated under vacuum to afford 373.8 g (79.3%) of the title compound which is 81.4%-area HPLC analysis the rest being solvent and with no detectable Example 200 by-product.

The synthetic route of 848841-68-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2006/102194; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica