Heterocyclic Building Blocks-Thiazole

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10200-59-6,2-Thiazolecarboxaldehyde,as a common compound, the synthetic route is as follows.

Manufacturing Example 88-1-1 Thiazole-2-yl-methanol; To a mixture of 2-formylthiazole (300 mg, 2.65 mmol) and methanol (30 mL) was added sodium borohydride (201.0 mg, 5.30 mmol) at 0 C., which was stirred for 1 hour at room temperature. Water was added to this reaction mixture, which was then extracted with ethyl acetate. The organic layer was separated, washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, and filtered. The filtrate was concentrated under a reduced pressure, and the residue was purified by NH silica gel column chromatography (diethyl ether) to obtain the title compound (251.2 mg, 82%).1H-NMR Spectrum (DMSO-d6) delta (ppm): 4.74 (2H, d, J=6.0 Hz), 6.04 (1H, t, J=6.0 Hz), 7.63-7.65 (1H, m), 7.73-7.75 (1H, m)., 10200-59-6

As the paragraph descriping shows that 10200-59-6 is playing an increasingly important role.

Reference£º
Patent; Tanaka, Keigo; Yamamoto, Eiichi; Watanabe, Naoaki; US2009/82403; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

19759-66-1, 2-Aminobenzothiazole-6-carbonitrile is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

0.88g (0.005 mol) 2-amino-6-cyanobenzothiazole was dissolved in 10 mL of N,N-dimethylformamide, 0.4 g (0.01 mol) of sodium hydroxide was added with stirring, After 10 minutes, 1.26 g (0.005 mol) of 2,6-dichloro-3,5-dinitrotoluene was added thereto, The reaction was continued at room temperature for 5 hours. After completion of the TLC monitoring reaction, the reaction solution was poured into 50 mL of saturated brine and extracted with ethyl acetate. The organic phase was extracted with anhydrous magnesium sulfate and evaporated under reduced pressure. The residue was subjected to column chromatography (eluent ethyl acetate and petroleum ether (Boiling range 60-90 C) in a volume ratio of 1:10) to give 0.40 g of compound 4405, Yellow solid. Melting point 229-231 C., 19759-66-1

The synthetic route of 19759-66-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SINOCHEM CORP; Shenyang Research Institute Of Chemical Industry Co., Ltd .; GUAN, AIYING; LI, HUICHAO; SUN, QIN; LIU, CHANGLING; WANG, JUNFENG; SUN, XUFENG; YANG, FAN; (21 pag.)CN104177310; (2016); B;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2933-29-1,2-Amino-4,5,6,7-tetrahydrobenzothiazole,as a common compound, the synthetic route is as follows.

30 mg (0.19 mmol) of 4,5,6,7-tetrahydrobenzo [d] thiazol-2-amine 53 mg (0.19 mmol) of 2, 4′-dibromoacetophenone was dissolved in 3 ml of ethanol and stirred in a microwave reactor at 150 C for 20 minutes. The residue was concentrated under reduced pressure and subjected to column chromatography (EtOAc: Hex = 1: 5) to obtain Compound 2c (14 mg, 22%)., 2933-29-1

2933-29-1 2-Amino-4,5,6,7-tetrahydrobenzothiazole 18046, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Chung-Ang University Industry-Academic Cooperation Foundation; Min, Kyung Hoon; Kwon, Ahra; Song, Ji Ho; (22 pag.)KR2017/23387; (2017); A;,
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Thiazole | chemical compound | Britannica

62266-82-4, 6-Bromobenzo[d]thiazol-2(3H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

62266-82-4, Example 12A 2-amino-5-bromothiophenol and its disulfide A mixture of 6-bromobenzothiazolone (CAS number 62266-82-4, Aldrich Chemical Company (12.9 g, 56.1 mmol), NaOH (33 g, 0.825 mol) and water (90 mL) was heated to 100 C. for 15 hours under nitrogen. The mixture was cooled to 0 C. and pH was adjusted to pH 5 using 5N acetic acid at 0-10 C. under nitrogen. The precipitate was filtered, washed with water and vac. dried at 45 C. to give the product as a mixture of 2-amino-5-bromothiophenol and its disulfide (11.47 g, 100%).

62266-82-4 6-Bromobenzo[d]thiazol-2(3H)-one 188444, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Cowart, Marlon D.; Ku, Yi-Yin; Chang, Sou-Jen; Fernando, Dilinie P.; Grieme, Timothy A.; Altenbach, Robert J.; US2004/224953; (2004); A1;,
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Thiazole | chemical compound | Britannica

2516-40-7, 2-Bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The corresponding halide reagent (1mmol) was added to a mixture of thiourea (1.1mmol) (compounds a) or selenourea (compounds b) in absolute ethanol or dry methanol (20mL) for compound 1b. The mixture was stirred at reflux for 0.5?15h. The product was isolated by filtration or by rotatory evaporation of the solvent under vacuum and purified by recrystallization, washing or column chromatography., 2516-40-7

As the paragraph descriping shows that 2516-40-7 is playing an increasingly important role.

Reference£º
Article; Alcolea, Veronica; Plano, Daniel; Encio, Ignacio; Palop, Juan Antonio; Sharma, Arun K.; Sanmartin, Carmen; European Journal of Medicinal Chemistry; vol. 123; (2016); p. 407 – 418;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

848841-68-9,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.848841-68-9,4-(4-Chlorothiazol-2-yl)morpholine,as a common compound, the synthetic route is as follows.

Part F: Title compound; A Teflon screw-cap via) is charged with 100 mg (0.40 mmol, 1.0 equiv) of crude 3-chloro-2,5-dimethyI-7-(pentan-3-yI)-5H-pyrrolo[2,3-b]rhoyrazine and 2 mL of DMF. To the solution is added 98 mg (0.48 mmol, 1.2 equiv) of 4-(4-chlorothiazol-2-yI)morphoIine, 21 mg (0.08 mmol, 0.20 equiv) of tripbenylphosphine, 19 mg (0.1 mmol, 0.25 equiv) of copper(I) iodide, 261 mg (0.8 mmoi, 2.0 equiv) of cesium carbonate, and lastly 5 rag (0.02 mmol, 0.05 equiv) of palladium acetate. The reaction vial is evacuated and purged with nitrogen three times before being tightly capped and heated overnight at 1 10 C, The reaction mixture is cooled to it, diluted with water and extracted with EtOAc (3 X 10 mL). The combined organic extracts are washed with brine, dried over NaiSO^ and concentrated under reduced pressure. The resulting residue is purified by preparative thin layer chromatography using 30% EtOAc in hexanes to give the desired compound as a yellow solid (26 mg, 15% yield). MS = 420.08 (M +1). 1H NMR (300 MHz, CDC13) delta 7.22 (IH, s), 3.82-3.85 (4H, m), 3.84 (3H, s), 3.44-3.56 (4H, m), 2.96 (IH, m) 2.70 (3 H, s), 1.73-1 .85 (4H, m), 0.86 (6H, q, J = 7.5 Hz).

The synthetic route of 848841-68-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NEUROGEN CORPORATION; WO2008/83070; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.80945-86-4,6-Bromo-2-chlorobenzothiazole,as a common compound, the synthetic route is as follows.,80945-86-4

Intermediate 86:N-{6-[bis(ethyloxy)methyl]-2-[(phenylmethyl)thio]-4-pyrimidinyl}-6-bromo-1,3-benzothiazol-2-amineIn an atmosphere of nitrogen, an ice-cooled solution of a mixture of 6-[bis(ethyloxy)methyl]-2-[(phenylmethyl)thio]-4-pyrimidinamine (10.8g, 33.8mmol) and 6-bromo-2-chloro-1,3-benzothiazole (8.82g, 35.5mmol) in dry dimethylformamide (20OmL) was treated portionwise over 5 minutes with sodium hydride (60% w/w in oil) (2.7Og,67.6mmol) and the mixture stirred with cooling for 3 hours. The mixture was treated with aqueous ammonium chloride (5%, 20OmL) and ethyl acetate (40OmL). The organic phase was dried over magnesium sulfate, filtered and evaporated to dryness to afford the title compound (17.82g, 33.5mmol, 99% yield). LCMS (Method A): Rt 1.53 minutes; m/z531 ,533 (MH+).

As the paragraph descriping shows that 80945-86-4 is playing an increasingly important role.

Reference£º
Patent; GLAXO GROUP LIMITED; ALDER, Catherine, Mary; BALDWIN, Ian, Robert; BARTON, Nicholas, Paul; CAMPBELL, Amanda, Jennifer; CHAMPIGNY, Aurelie, Cecile; HARLING, John, David; MAXWELL, Aoife, Caitriona; SIMPSON, Juliet, Kay; SMITH, Ian, Edward, David; TAME, Christopher, John; WILSON, Caroline; WOOLVEN, James, Michael; WO2010/106016; (2010); A1;,
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Thiazole | chemical compound | Britannica

94284-66-9, 1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

94284-66-9, General procedure: 1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone (1 mol) in methanol (4.0-4.1 l), was added dropwise to a cooled solution of corresponding aromatic aldehydes (1 mol) in 10% NaOH (600-650 ml). The solution was maintained at 0 C for 1.5 h and then was allowed to stir at room temperature. After some time (5-12 h) solid started separating out. The solid was filtered under vacuum and recrystallized from dioxane or ethanol to give the title chalcones. The yield range after recrystallization of chalcones was 32-84%.

The synthetic route of 94284-66-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Liaras; Geronikaki; Glamo?lija; ?iri?; Sokovi?; Bioorganic and Medicinal Chemistry; vol. 19; 10; (2011); p. 3135 – 3140;,
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Thiazole | chemical compound | Britannica

7709-58-2, 4-(Chloromethyl)thiazole hydrochloride is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Part 8; Independently during this time, 4-(chloromethyl)-1,3-thiazole hydrochloride (59.84 g, 352 mmol) was freshly converted to the free base as follows: The hydrochloride was mixed with dichloromethane (750 mL) and water (300 mL) and the pH of the aqueous layer was adjusted to pH 9 with solid sodium bicarbonate. The organic layer was separated, dried over sodium sulfate and carefully evaporated at 80 torr to give the free base., 7709-58-2

7709-58-2 4-(Chloromethyl)thiazole hydrochloride 2763289, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2005/103045; (2005); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

38585-74-9, Thiazol-5-ylmethanol is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

D. ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate A solution of 3.11 g (27 mmol) of 5-(hydroxymethyl)thiazole and excess N-methyl morpholine in 100 ml of methylene chloride was cooled to 0 C. and treated with 8.2 g (41 mmol) of 4-nitrophenyl chloroformate. After being stirred for 1 h, the reaction mixture was diluted with CHCl3, washed successively with 1N HCl, saturated aqueous NaHCO3, and saturated brine, dried over NaSO4, and concentrated in vacuo. The residue was purified by silica gel chromatography (SiO2, 1-2% MeOH/CHCl3, Rf=0.5 in 4% MeOH/CHCl3) to yield 5.9 g (78%) of the desired compound as a yellow solid. NMR (CDCl3) delta5.53 (s, 2H), 7.39 (dt, J=9, 3 Hz, 2H), 8.01 (s, 1H), 8.29 (dt, J=9, 3 Hz, 2H), 8.90 (s, 1H). Mass spectrum: (M+H)+ =281.

38585-74-9, As the paragraph descriping shows that 38585-74-9 is playing an increasingly important role.

Reference£º
Patent; Abbott Laboratories; US5914332; (1999); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica