Heterocyclic Building Blocks-Thiazole

Zhang, Guohua published the artcileEthanol extracts from Cinnamomum camphora seed kernel: Potential bioactivities as affected by alkaline hydrolysis and simulated gastrointestinal digestion, COA of Formula: C18H24N6O6S4, the publication is Food Research International (2020), 109363, database is CAplus and MEDLINE.

The aim of the study was to evaluate the changes of potential bioactivities of ethanol extracts (EE) from Cinnamomum camphora seed kernel (CCSK) after alk. hydrolysis and simulated gastrointestinal digestion. The total phenolic and total flavonoid contents in EE decreased by 30.6%, 1%, 33% and 11.8% after hydrolysis and digestion, resp. The total saponins content decreased by 17% after hydrolysis while increased by 48% after digestion. The total condensed tannin contents increased by 70.3% and 17.2% after hydrolysis and digestion, resp. The 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), cupric ion reducing activity (CUPRAC), ferric reducing antioxidant power (FRAP) and metal chelating activity (MCA) were used to determine antioxidant activity. Overall, the changes of antioxidant activities by hydrolysis and digestion were consistent with the changes of their total phenolic and flavonoid contents. The α-amylase and α-glucosidase inhibitory activities in EE increased by 817% and 33.3% after digestion while decreased by 12.3% and 19% after hydrolysis, resp. Although the inhibitory activities of cholinesterase, tyrosinase and xanthine oxidase were decreased by hydrolysis and digestion, most of these activities were retained. These results showed that CCSK ethanol extracts had strong bioactivities and were reasonably stable to alkali and digestive enzymes.

Food Research International published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C20H17FO4S, COA of Formula: C18H24N6O6S4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Zou, Yuke published the artcileNIR-Responsive Polyurethane Nanocomposites Based on PDA@FA Nanoparticles with Synergistic Antibacterial Effect, Recommanded Product: Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), the publication is Macromolecular Chemistry and Physics, database is CAplus.

At present, high-performance antibacterial polymer materials have attracted widespread attention, possessing huge application prospects in the fields of medical and biol. science, and packaging. In this work, polydopamine nanoparticles (PDA NPs) with photothermal ability and active sites are designed to adsorb fusidic acid (FA) mols. with targeted antibacterial capability; then, polydopamine@fusidic acid (PDA@FA) is introduced into the polyurethane (PU) to obtain multifunctional and antibacterial PU materials (PUDA@FA). The structures and morphologies of PDA NPs and PDA@FA are successfully characterized by Fourier transform-IR spectroscopy and SEM. With the introduction of PDA@FA, the nano-sized reinforcement not only greatly improves the mech. properties (tensile strength 19.31 MPa and toughness 10.6 MJ m^-3) of PU film but also due to the photothermal effect of PDA NPs and the antibacterial of FA, the scavenging activities of DPPH and ABTS reach 70-85% and 55-70%, resp. The antibacterial rate of Staphylococcus aureus reaches more than 99.9% and presents long-term antibacterial ability. In this way, this work provides new guidance for the preparation of high-performance PU materials with both antibacterial and anti-oxidation properties, broadening the application scope of antibacterial materials.

Macromolecular Chemistry and Physics published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C10H14O2, Recommanded Product: Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate).

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Khan, Takallum published the artcileSilica-Supported P₂O₅ as an Efficient Heterogeneous Catalyst for the One Pot Synthesis of 3-Amino-imidazo[2,1-b](1,3)benzothiazole under Green Conditions, HPLC of Formula: 95-24-9, the publication is Journal of Heterocyclic Chemistry (2019), 56(1), 11-17, database is CAplus.

The new approach involving the solid supported catalyst for the formation of C-N bond followed by cyclization has been reported. In this work we have reported a facile, efficient, and environment-friendly protocol for the synthesis of some new 3-amino-imidazo[2,1-b](1,3)benzothiazole derivatives by one-pot condensation of 2-aminobenzothiazole, indole-3-carbaldehyde, and aryl isocyanide in the presence of silica-supported P2O5 as a heterogeneous solid acid catalyst. The reaction was performed using conventional method under green conditions. The present approach offers the advantages of simple methodol., inexpensive acid catalyst, short reaction time, easy work up with excellent yield, simple purification and use of green solvent. All the newly synthesized compounds were characterized in details using phys. and chem. techniques such as m.p., 1H NMR, 13C NMR, and FTIR spectroscopy.

Journal of Heterocyclic Chemistry published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, HPLC of Formula: 95-24-9.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Li, Hui published the artcileSingle-Solution Doping Enabling Dominant Integer Charge Transfer for Synergistically Improved Carrier Concentration and Mobility in Donor-Acceptor Polymers, Related Products of thiazole, the publication is Advanced Functional Materials (2022), 32(14), 2110047, database is CAplus.

Chem. doping of donor-acceptor (D-A) polymers is essential for their usage in highly efficient optoelectronic devices. The crucial challenge remains to synergistically improve the carrier concentration and mobility of these polymers via a single solution doping method. Here, a D-A polymer, Pg₃2T-OTz is designed and synthesized, containing a weak-acceptor-strong-donor backbone with nonpolar (alkoxy) and polar (ethylene glycol) side chains. Pure integer charge transfer (ICT) is shown to occur in 2,3,5,6-tetrafluoro-tetracyanoquinodimethane (F4TCNQ)-doped D-A polymer at a low doping level. It is shown that the ordered edge-on orientations of ICT structures overcome the Coulomb interactions and endow a long-range hole delocalization, while few charge transfer complex states form in amorphous regions and bridge the crystalline ICT structures at high doping level, creating a network that sustains efficient charge transport. As a result, simultaneously high carrier concentration and high mobility are realized for F4TCNQ-doped Pg₃2T-OTz and thus a high elec. conductivity up to 550 S cm^-1 is approached, which is the highest value among any doped polymers via a single-solution doping process. This work demonstrates that the modulation of the acceptor strength combined with side-chain engineering is an effective mol. design strategy to promote both the doping efficiency and carrier transport property of D-A polymers.

Advanced Functional Materials published new progress about 2215018-37-2. 2215018-37-2 belongs to thiazole, auxiliary class Thiazoles, name is 4,4′-Bis(octyloxy)-2,2′-bis(trimethylstannyl)-5,5′-bithiazole, and the molecular formula is C28H52N2O2S2Sn2, Related Products of thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Ding, Hongyan published the artcileSKA3 promotes the proliferation, migration and invasion of endometrial carcinoma cells, Application of 6-Chlorobenzothiazol-2-ylamine, the publication is Chengdu Yixueyuan Xuebao (2021), 16(3), 293-298, database is CAplus.

Objective To investigate the effects of spindle and kinetochore associated complex subunit 3 (SKA3) on the proliferation, migration and invasion of endometrial carcinoma cells. Methods Real-time quant. polymerasechain reaction (RT-qPCR) and Western blotting were used to detect the levels of SKA3 mRNA and protein expression in endometrial epithelial cells HEECs and endometrial carcinoma cells KLE, JEC and Ishikawa cells. And the Ishikawa cells with the highest expression level were selected for subsequent research. Ishikawa cells were divided into three groups. In the control group, Ishikawa cells were cultured normally. In the si-SKA3 group, 50 nmol/L siRNA-SKA3 was transfected into Ishikawa cells according to liposome 2000 instructions. In the NC group, 50 nmol/L siRNA-NC was transfected into Ishikawa cells according to liposome 2000 instructions. Cell proliferation was detected by cell counting kit-8 (CCK8) and clonal formation assay. Cell invasion and migration were detected by Transwell and scratch assay. And protein expression of CyclinD1, MMP-2, AKT, and p-AKT were detected by Western blotting. Results Compared with the HEECs of endometrial epithelial cells, the expression levels of SKA3 mRNA and protein in each endometrial carcinoma cell line were significantly increased (P<0.05). After interference with SKA3 expression, the proliferation and invasion ability of Ishikawa cells were decreased, the width of scratches were enlarged, and the protein expression of CyclinD1 and MMP-2 were significantly decreased (P<0.05). Compared with the control group and the NC group, the expression of AKT protein in si-SKA3 group was not significantly changed (P>0.05), while the expression of p-AKT protein decreased (P<0.05). Conclusion Interference with SKA3 can inhibit the proliferation, migration and invasion of Ishikawa cells of endometrial carcinoma, of which the mechanism may be related to the inhibition of SKA3 on PI3K/AKT signaling pathway.

Chengdu Yixueyuan Xuebao published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, Application of 6-Chlorobenzothiazol-2-ylamine.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Sun, Mimi published the artcileA Bendable Biofuel Cell-Based Fully Integrated Biomedical Nanodevice for Point-of-Care Diagnosis of Scurvy, COA of Formula: C18H24N6O6S4, the publication is ACS Sensors (2021), 6(1), 275-284, database is CAplus and MEDLINE.

Fully integrated nanodevices that allow the complete functional implementation without an external accessory or equipment are deemed to be one of the most ideal and ultimate goals for modern nanodevice design and construction. In this work, we demonstrate the first example of a bendable biofuel cell (BFC)-based fully integrated biomedical nanodevice with simple, palm-sized, easy-to-carry, pump-free, cost-saving, and easy-to-use features for the point-of-care (POC) diagnosis of scurvy from a single drop of untreated human serum (down to 0.2μL) by integrating a bendable and disposable vitamin C/air microfluidic BFC (micro-BFC) (named iezCard) for self-powered vitamin C biosensing with a custom mini digital LED voltmeter (named iezBox) for signal processing and transmission, along with a ”built-in” biocomputing BUFFER gate for intelligent diagnosis. Under the simplicity- and practicability-oriented idea, a cost-effective strategy (e.g., biomass-derived hierarchical micro-mesoporous carbon aerogels, screen-printed technique, a single piece of Kimwipes paper, LED display, and universal components) was implemented for nanodevice design rather than any top-end or pricey method (e.g., photolithog./electron-beam evaporation, peristaltic pump, wireless system, and 3D printing technique), which enormously reduces the cost of feedstock down to ~USD 2.55 per integrated kit including a disposal iezCard (~USD 0.08 per test) and a reusable iezBox (~USD 2.47 for large-scale tests). These distinctive and attractive features allow such a fully integrated biomedical nanodevice to fully satisfy the basic requirements for POC diagnosis of scurvy from a single drop of raw human serum and make it particularly appropriate for resource-poor settings, where there is a lack of medical facilities, funds, and qualified personnel.

ACS Sensors published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C10H12F6N4O6PdS2, COA of Formula: C18H24N6O6S4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Ma, Dawei published the artcileEfficient and economical access to substituted benzothiazoles: copper-catalyzed coupling of 2-haloanilides with metal sulfides and subsequent condensation, Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole, the publication is Angewandte Chemie, International Edition (2009), 48(23), 4222-4225, S4222/1-S4222/18, database is CAplus and MEDLINE.

The first metal-catalyzed direct coupling of metal sulfides with aryl halides and subsequent intramol. condensation provided substituted benzothiazoles. A wide range of functional groups are tolerated under the reaction conditions.

Angewandte Chemie, International Edition published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Shang, Yuhao published the artcilePolyphenol Profiles and Antioxidant Activities of Non-centrifugal Sugars Derived from Different Varieties of Membrane-Clarified Sugarcane Juice, Safety of Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), the publication is Sugar Tech (2022), 24(2), 614-625, database is CAplus.

The objectives of this research were to determine the sugar compositions, polyphenol contents and antioxidant effects of non-centrifugal sugars (NCS) of different sugarcane varieties. The polyphenols contents and compounds of nine NCSs obtained from the juices of different sugarcane varieties clarified with a 50 nm ceramic membrane (M-NCSs) were measured via ultraperformance liquid chromatog.-mass spectrometry (UPLC-MS). Their antioxidant activities were investigated via 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging, 2, 2′-azino-bis-(3-Et benzothia-zoline-6-sulfonic acid) (ABTS) assay, β-carotene-linoleate assays, and ferrous and cupric ion chelating assays. Results showed that the phenolic compound with the highest content was gallic acid, and all samples were abundant in phenolics, including flavonoids, with high antioxidative activities. The content of phenolics and flavonoids, ranged from 17.24 to 21.14 mg/mL and from 203.55 to 350.37μg/mL, resp. Among these M-NCSs, Funong 41 (G) genotype had the best DPPH free radical scavenging activity. The GUC 23-2 (A1) genotype showed the best ABTS free radical scavenging activity. β-Carotene-linoleate assays revealed that the 15-6013 (B2) genotype exhibited the best antioxidant activity. The Guitang 42 (E) genotype displayed the best ferrous ion chelating activity. The Zhongzhe 9 (F) genotype presented the best cupric ion chelating activity. In summary, sugarcane variety influenced the polyphenols contents and antioxidant effects of M-NCSs. This study lays a foundation for the further study of M-NCSs.

Sugar Tech published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C22H23ClN4, Safety of Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate).

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Lin, Derong published the artcileComparison of apple polyphenol-gelatin binary complex and apple polyphenol-gelatin-pectin ternary complex: Antioxidant and structural characterization, HPLC of Formula: 30931-67-0, the publication is LWT–Food Science and Technology (2021), 111740, database is CAplus.

Polyphenol-gelatin binary complex and polyphenol-gelatin-pectin ternary complex were synthesized. The differences in antioxidant activity between the binary complex and ternary complex were evaluated by using ABTS, DPPH, and reducing power assays. The differences in structural characterization between the binary complex and ternary complex were investigated by SEM (SEM), NMR (¹H and ¹³C NMR), and Fourier transform IR (FT-IR) spectroscopy. The reducing power assays of the ternary complex was greater than that of the binary complex. The maximum of ABTS•+ scavenging activity of the binary complex and the ternary complex was 98.1% and 99.3%, resp., and the maximum DPPH• scavenging activity was 84.7% and 87.6%, resp. The results of structural characterization showed that they were very similar in structure. Both complexes are mainly composed of hydrogen bonds and hydrophobic interactions, but the ternary complex is more tightly bound. In addition, the surface is smoother, and the gap is smaller.

LWT–Food Science and Technology published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C18H24N6O6S4, HPLC of Formula: 30931-67-0.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Zhou, Huaxi published the artcileRole of NOM in the Photolysis of Chlorine and the Formation of Reactive Species in the Solar/Chlorine System, COA of Formula: C18H24N6O6S4, the publication is ACS Omega (2022), 7(9), 7769-7776, database is CAplus and MEDLINE.

The solar/chlorine system has been proposed as a novel advanced oxidation process (AOP) for efficient pollutant degradation and water disinfection by producing a series of reactive species including hydroxyl radicals (HO^•), chlorine radicals (Cl^•), and so forth. In this study, the role of natural organic matter (NOM) in the photolysis of free available chlorine (FAC) and the formation of HO^• and Cl^• in the solar/chlorine system was investigated employing nitrobenzene and benzoic acid as selective chem. probes. The decay rate of FAC was significantly accelerated in the presence of NOM at pH 5.5 under simulated solar irradiation, likely due to the photoreaction between FAC and the photoexcited NOM. The decay rate of FAC increased upon increasing the electron-donating capacity of NOM, which indicated that phenolic components play a significant role in the photodegradation of FAC. This acceleration mechanism was further verified using 4-nitrophenol as a model phenolic compound NOM promoted Cl^• formation and quenched HO^• in the solar/chlorine system. The proposed reaction mechanism included the reaction of excited singlet phenolic compounds in NOM with FAC, which yielded Cl^•. This study provides a useful insight into future applications for using the solar/chlorine system as a novel AOP for wastewater treatment or disinfection.

ACS Omega published new progress about 30931-67-0. 30931-67-0 belongs to thiazole, auxiliary class Salt,Hydrazine,Amine,Benzothiazole, name is Ammonium 2,2′-(hydrazine-1,2-diylidene)bis(3-ethyl-2,3-dihydrobenzo[d]thiazole-6-sulfonate), and the molecular formula is C11H15NO2, COA of Formula: C18H24N6O6S4.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica