Heterocyclic Building Blocks-Thiazole

16582-58-4,16582-58-4, 6-Iodobenzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Chloroacetyl chloride (0.06 mol) was added dropwise to a mixture of the appropriate 2-amino-6-Substituted benzothiazole, 3a-k (0.05 mol) and K2CO3 (0.06 mol) in benzene (50 mL) at room temperature. The reaction mixture was refluxed for 6-12 h, then, after cooling to room temperature, it was slowly poured into 100 mL of ice water. A solid was formed thereafter. The precipitate was separated by filtration and washed successively with water. The product was dried under vacuum to obtain 4a-k. The progress of the reaction was monitored by Thin Layer Chromatography using toluene: acetone (8:2) solvent system.

The synthetic route of 16582-58-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Patel, Rahul V.; Patel, Paresh K.; Kumari, Premlata; Rajani, Dhanji P.; Chikhalia, Kishor H.; European Journal of Medicinal Chemistry; vol. 53; (2012); p. 41 – 51;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

5398-36-7, Ethyl 2-aminothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1 Preparation of ethyl 2-chlorothiazol-4-carboxylate 17 g (100 mmol) ethyl 2-aminothiazol-4-carboxylate (Example 30, step 1) was added to 150 ml acetonitrile, and 18.5 g (110 mmol) dihydrated cupric chloride was added, and then, with mechanical stirring, 18.5 ml (130 mmol) isoamyl nitrite was slowly added dropwise, followed by continuing the reaction for 4 hr after complete of addition. To the resulting mixture, ethyl acetate and water were added, filtered to remove insoluble solids, and the layers were separated. The aqueous phase was further extracted with ethyl acetate, the resultant organic phases were combined, dried over anhydrous sodium sulfate, filtered, and concentrated to obtain 16 g of an oily liquid 1H NMR (CDCl3) 1.39-1.43(3H,t, J=7.0Hz); 4.40-4.44(2H,m, J=7.0Hz); 8.08(1H, s).

5398-36-7, 5398-36-7 Ethyl 2-aminothiazole-4-carboxylate 73216, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Beijing Molecule Science and Technology Co., Ltd.; EP2039686; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6633-61-0,Methyl 2-aminothiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

6633-61-0, To a preheated (50 C.) slurry of copper (II) chloride (932 mg), 10 mL of acetonitrile was added, along with the thiazole aminoester (1 g) and amyl nitrite (737 mg). The mixture was heated at 50 C. for 2 h. The resulting mixture was concentrated and purified by Biotage (5-10% ethyl acetate in hexane) to give the chloride as a brown solid.

As the paragraph descriping shows that 6633-61-0 is playing an increasingly important role.

Reference£º
Patent; Raghavan, Subharekha; Colletti, Steven L.; Ding, Fa-Xiang; Shen, Hong; Tata, James R.; Lins, Ashley Rouse; Smenton, Abigail Lee; Chen, Weichun; Schmidt, Darby Rye; Tria, George Scott; US2006/293364; (2006); A1;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.32137-76-1,Ethyl 1,3-benzothiazole-2-carboxylate,as a common compound, the synthetic route is as follows.

To a 250 mL round bottom flask was added ethyl benzothiazole-2-carboxylate (1.0363 g, 5.0 mmol). 20 mL ethanol and 2 mL hydrazine hydrate were added followed by heating the solution to reflux for 6 hours. The reaction mixture was cooled to room temperature and solid precipitate was filtered, collected, and recrystallized in ethanol to yield benzo[d]thiazole-2-carbohydrazide (943.4 mg, 89.1% yield).

32137-76-1, The synthetic route of 32137-76-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY; Hagen, Timothy J.; Thompson, Michael; Troxell, Jeremy R.; Hartnett, Brian E.; (69 pag.)US2018/271098; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

19952-47-7, 2-Amino-4-chlorobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

19952-47-7, General procedure: All microwave irradiation experiments were carried out in CEM-Discover monomode microwavedevice, operating at a frequency of 2.45 GHz. Substituted aminobenzothiazole, equimolar amount ofsubstituted benzaldehyde (1.5 mmol) and mercaptoacetic acid in absolut ethanol (3 mL) were placed ina 10 mL reaction vial containing a stirring bar. The vial was sealed with a Teflon septum and placedinto the microwave cavity. It was irradiated at 100 C using 100 W as maximum power for 30 min.at the end of the reaction the mixture was rapidly cooled with gas jet cooling to room temperature.The clean product was obtained after filter under reduced pressure.

The synthetic route of 19952-47-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Petrou, Anthi; Eleftheriou, Phaedra; Geronikaki, Athina; Akrivou, Melpomeni G.; Vizirianakis, Ioannis; Molecules; vol. 24; 21; (2019);,
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Thiazole | chemical compound | Britannica

173979-01-6, 4-(Tributylstannyl)thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 63 (3-Chloro-5-thiazol-4-yl-phenyl)-(1 H-imidazol-2-yl)-methanoneA solution of Example 53 (50 mg, 0.15 mmol) in 1 ,4-dioxane (3 ml_) was stirred in a microwave reaction tube. 4-Tributylstannanyl-thiazole (62 mg, 0.165 mmol) followed by Pd(PPh3)4 (10 mg, 8.6 mumol) was added to the stirred mixture. The tube was sealed and the reaction was heated at 1200C for 30 mins. The mixture was then diluted with EtOAc (20 ml.) and washed with brine. The organic phase was then dried over Na2SO4, filtered and the solvent evaporated. The crude was triturated in dichloromethane and the collected precipitate was purified further by SiO2 chromatography (Hexanes/ EtOAc; 9:1 to 2:1 ) to give the title compound as a beige solid (10 mg, 23%). MS(ESI) m/z 289.9 (M+H)+. 1H NMR (400 MHz, DMSO-d6): 13.62 (1 H, s), 9.28 (1 H, d), 8.97 (1 H, t), 8.58 (1 H, t), 8.46 (1 H, d), 8.34 (1 H, t), 7.58 (1 H, s), 7.39 (1 H, s).

173979-01-6, The synthetic route of 173979-01-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; ASTEX THERAPEUTICS LIMITED; HOWARD, Steven; MORTENSON, Paul Neil; HISCOCK, Steven Douglas; WOOLFORD, Alison Jo-Anne; WOODHEAD, Andrew James; CHESSARI, Gianni; O’REILLY, Marc; CONGREVE, Miles Stuart; DAGOSTIN, Claudio; CHO, Young Shin; YANG, Fan; CHEN, Christine Hiu-Tung; BRAIN, Christopher Thomas; LAGU, Bharat; WANG, Yaping; KIM, Sunkyu; GRIALDES, John; LUZZIO, Michael Joseph; PEREZ, Lawrence Blas; WO2010/125402; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

79836-78-5, Ethyl 2-methylthiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1: Intermediate 15-a To a solution of ethyl 2-methylthiazole-5-carboxylate (5.82 g, 34.0 mmol) in THF (170 ml), cooled to 0 C, was added a 1.0M solution of LiAIH4 in THF (34.0 ml, 34.0 mmol) and the reaction was slowly warmed to room temperature and stirred overnight. Water (1.3 ml) was slowly added, followed by 15% NaOH (1.3 ml_). The solution was stirred for 2 hours at room temperature then filtered over celite. The filtrate was concentrated under reduced pressure to provide intermediate 15-a as a yellow oil., 79836-78-5

The synthetic route of 79836-78-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PHARMASCIENCE, INC.; LAURENT, Alain; ROSE, Yannick; JAQUITH, James B.; WO2013/177668; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13623-11-5,2,4,5-Trimethylthiazole,as a common compound, the synthetic route is as follows.

2,4,5-trismethyl thiazole (2.5 g, 19.65 mmol), N-bromosuccinimide(10.49 g, 58.96 mmol) and benzoyl peroxide (30 mg) were dissolved in 150 ml of CCl4. Resulting mixture was stirred at 70 C for 5 h. After cooling, succinimide salt was removed by water washing and product was extracted by DCM (50 ml ¡Á 2).To this organic layer washed with brine solution and dried over Na2SO4. This product was also not stable at room temperature for long time and it was stable only at below 15 C in DCMsolvent. This crude product was also used for further synthesiswithout purification.

13623-11-5, The synthetic route of 13623-11-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Mahesh; Karpagam; Journal of Fluorescence; vol. 26; 4; (2016); p. 1457 – 1466;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.67899-00-7,2-Amino-4-methylthiazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.

To a suspension of 6 (500mg, 3.20mmol) in tetrahydrofuran (20mL) were added pyridine (1.30mL, 16.0mmol) and acetyl chloride (0.60ml, 7.90mmol) at 0C, and the reaction mixture was stirred for 21h at room temperature. After the volatiles of the mixture were removed in vacuo, water was poured into the residue, and the suspension was stirred for 1h. The resulting precipitate was collected by filtration, washed with water and dried in vacuo to yield 7 (585mg, 91%) as a colorless powder. 1H NMR (200MHz, DMSO-d6) delta 2.15 (s, 3H), 2.52 (s, 3H), 12.35 (br s, 1H); MS (ESI): m/z 201 [M+H]+, 223 [M+Na]+, 199 [M-H]-., 67899-00-7

As the paragraph descriping shows that 67899-00-7 is playing an increasingly important role.

Reference£º
Article; Oka, Yusuke; Yabuuchi, Tetsuya; Oi, Takahiro; Kuroda, Shoichi; Fujii, Yasuyuki; Ohtake, Hidenori; Inoue, Tomoyuki; Wakahara, Shunichi; Kimura, Kayo; Fujita, Kiyoko; Endo, Mayumi; Taguchi, Kyoko; Sekiguchi, Yoshinori; Bioorganic and Medicinal Chemistry; vol. 21; 24; (2013); p. 7578 – 7583;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.247037-82-7,Thiazole-2-carboximidamide hydrochloride,as a common compound, the synthetic route is as follows.

A mixture of ethyl 3-oxobutanoate (0.4 g, 3 mmol), cyclohexanecarbaldehyde (0.34 g, 3 mmol), 1,3-thiazole-2-carboximidamide HCl salt (0.49 g, 3 mmol) and KOAc (0.59 g, 6 mmol) in CF3CH2OH (10 mL) was stirred for 24 hours at 90 C. After being cooled, it was partitioned (EtO Ac-brine). The organic was dried (Na2SO4), filtered and concentrated. The residue was chromatographed (silica, ethyl acetate/petroleum ether) to give the desired compound as a yellow solid (0.35 g, 34%). ESIMS m/z = 334.1 [M+H]+.

247037-82-7, The synthetic route of 247037-82-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ENANTA PHARMACEUTICALS, INC.; QIU, Yao-Ling; CAO, Hui; LI, Wei; PENG, Xiaowen; JIN, Meizhong; KASS, Jorden; GAO, Xuri; OR, Yat, Sun; (99 pag.)WO2017/11552; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica