Heterocyclic Building Blocks-Thiazole

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34259-99-9,4-Bromothiazole,as a common compound, the synthetic route is as follows.

Step 1 : Na (0.69 g, 30 mmol) was added to a solution of ^-butylthiol(3.38 mL, 30 mmol) at room temperature portionwise and stirred for 0.5 h. Then, 4- bromothiazole 1 (0.49 g, 3.0 mmol) was added and the mixture was heated to reflux overnight. LC-MS indicate desired product formed and the reaction was concentrated. The residue was dissolved in EA, filtered through silica gel and the filtrate was concentrated again. The residue was used for the next step directly., 34259-99-9

34259-99-9 4-Bromothiazole 2763218, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; ACHAOGEN, INC.; WO2009/55696; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42182-65-0,Benzo[d]thiazol-2-ylmethanamine,as a common compound, the synthetic route is as follows.,42182-65-0

A solution of 4-(3-chloro-1,2,4-triazin-5-yl)-3-methylphenol (60 mg, 0.27 mmol), benzothiazol-2-yl-methylamine (89 mg, 0.54 mmol), pyridine (28 muL, 0.32 mmol) in anhydrous acetonitrile (0.4 mL) was stirred at 85C overnight. The solution was then concentrated and the residue was purified by preparative TLC (silica gel, dichloromethane/methanol 92/8) to give 4-{3-[(1,3-benzothiazol-2-ylmethyl)amino]-1,2,4-triazin-5-yl}-3-methylphenol (33.8 mg, 36%) as a yellow oil. ESI-MS m/z 350 (M+H)+. 1H NMR (CDCl3), delta (ppm): 8.78 (s, 1H), 7.97 (d, J = 8.1 Hz, 1H), 7.83 (d, J = 8.1 Hz, 1H), 7.48 (t, J = 7.5 Hz, 1H), 7.39-7.31 (m, 2H), 6.77-6.75 (m, 2H), 6.56 (br s, 1H), 5.16 (s, 2H), 2.30 (s, 3H).

42182-65-0 Benzo[d]thiazol-2-ylmethanamine 350414, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Mutabilis; EP2141164; (2010); A1;,
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Thiazole | chemical compound | Britannica

7709-58-2, 4-(Chloromethyl)thiazole hydrochloride is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

20 ml (0.29 mol) of cyclopropylamine was added to a solution of 4.9 g (29.0 mmol) of 4- (chloromethyl)-thiazole hydrochloride in 45 ml ethanol and 45 ml of saturated aqueous sodium hydrogen carbonate. The reaction mixture was stirred for 20 hrs at ambient temperature and extracted with ethyl acetate (3 x 100 ml). The combined organic layers were dried over magnesium sulphate and concentrated in vacuum. Column chromatography (gradient n- pentane/ethyl acetate) yielded 1.5 g (32% yield) of N-(1 ,3-thiazol-4-ylmethyl)cyclopropylamine. At ambient temperature a solution of 0.28g (1.4 mmol) of 3-(difluoromethyl)-1-methyl-pyrazole- 4-carbonyl chloride in 2 ml of tetrahydrofurane was added drop wise to a solution of 0.20 g (1.3 mmol) of N-(1 ,3-thiazol-4-ylmethyl)-cyclopropylamine and 0.6 ml triethylamine in 4 ml tetrahydrofurane. The reaction mixture was stirred for 16 hrs at ambient temperature and quenched with water. The watery layer was extracted three times with ethyl acetate (3 x 20 ml), the combined organic layers were dried over magnesium sulphate and concentrated in vacuum. Column chromatography (gradient n-pentane/ethyl acetate) yielded 0.13 mg (51 % yield) of N- cyclopropyl-N-(1 ,3-thiazol-4-yl-methyl)-1-methyl-3-difluoromethyl-pyrazole-4-carboxamide (M+1 = 313)., 7709-58-2

7709-58-2 4-(Chloromethyl)thiazole hydrochloride 2763289, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; BAYER CROPSCIENCE SA; WO2008/15189; (2008); A2;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23056-10-2,5-Thiocyanatothiazol-2-amine,as a common compound, the synthetic route is as follows.

To a solution of Part A thiocyanate (800 mg, 5.09 mmol) and Example 1D (1.51 g, 5.09 mmol) in THF (20 mL) was added DEPBT (3.05 g, 10.18 mmol) and iPr2NEt (1.8 mL, 10.18 mmol). The reaction mixture was stirred at RT for 18 h, then was concentrated in vacuo. The residue was taken up in EtOAc and brine, and extracted with EtOAc (3¡Á). The combined organic extracts were washed with 1N aqueous HCl, H2O, 5% aqueous NaHCO3, H2O, and brine, dried (MgSO4), and concentrated in vacuo. The residue was chromatographed (SiO2; continuous gradient 10% EtOAc/Hex to 100% EtOAc/Hexane) to give Part B compound (927 mg, 42%) as an orange solid.

23056-10-2, As the paragraph descriping shows that 23056-10-2 is playing an increasingly important role.

Reference£º
Patent; Bristol-Myers Squibb Company; US2008/9465; (2008); A1;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5304-21-2,6-Bromo-2-methylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.,5304-21-2

Compound 11 (114 mg, 0.500 mmol)Was dissolved in methanol (5.00 mL), And benzaldehyde (51.0 muL, 0.500 mmol),Sodium hydroxide (60.0 mg, 1.50 mmol) was added,And heated under reflux for 14 hours under stirring.Precipitated crystals were collected by filtration,And washed with methanol and purified water to obtain Compound 12 in a yield of 50.0 mg (31.8percent).

As the paragraph descriping shows that 5304-21-2 is playing an increasingly important role.

Reference£º
Patent; Kyoto University; Nihon Medi-Physics Co.,Ltd.; Saji, Hideo; Ono, Masahiro; Inohara, Tadashi; Seki, Ikuya; (24 pag.)JP2016/79108; (2016); A;,
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1003-32-3, Thiazole-5-carboxyaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-(5-thiazolyl)-3-cyclohexylpropan-1-ol A solution of thiazole-5-carboxaldehyde (2.31 g, 20.4 mmol) in 20 mL of in THF was added to a cold (0 C.) solution of 2-cyclohexylethylmagnesium bromide (prepared from 2-bromoethylcyclohexane (7.88 g) and magnesium turnings (1.22 g)) in 30 mL of ethyl ether and the mixture stirred 30 minutes. The cold bath was removed and the mixture stirred for 2 hours more and then quenched by the addition of 3N aqueous HCl. The solution was stirred until 2 clear phases resulted and then the layers were separated. The pH of the aqueous phase was adjusted to 4 with 2M aqueous sodium carbonate and then extracted with 3 portions of ethyl acetate. All the organic phases were combined and washed with brine, dried, filtered and concentrated. The residue was purified by column chromatography on silica gel (125 g, 50% ethyl acetate/hexanes) to provide 2.69 g (58%) of the title compound. MS (DCI, NH3): 226 (MH+); 243 (M+NH4)+.

1003-32-3, As the paragraph descriping shows that 1003-32-3 is playing an increasingly important role.

Reference£º
Patent; University of Pittsburgh; US6204293; (2001); B1;,
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Thiazole | chemical compound | Britannica

911466-96-1,911466-96-1, 2-(Ethoxycarbonyl)thiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of Compound 3A (0.300 g, 1.49 mmol) was dissolved in N,N- dimethylformamide (2.98 mL), and then treated successively with PYBOP (0.854 g, 1.64 mmol), 4-methylmorpholine (0.492 mL, 4.47 mmol) and 1,2,3,4- tetrahydroquinoline (0.218 mL, 1.64 mmol). The reaction was stirred overnight at room temperature and was then slowly added to 15 mL of water, The aqueous layer was extracted with CH2CI2 (3 x 15 mL). The combined organic layer was washed with saturated aqueous NaHCO3 solution (25 mL) and brine (25 mL). The organic layer was dried over Na2SO4, filtered and concentrated. The product was purified by flash chromatography using a gradient of 0-40% ethyl acetate-hexanes to provide compound 4A (0.121 g, 26% yield).

The synthetic route of 911466-96-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SCHERING CORPORATION; WO2009/58730; (2009); A1;,
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Thiazole | chemical compound | Britannica

72605-86-8, Methyl 2-chlorothiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

72605-86-8, General procedure: A mixture of compounds 12a-c (6.5 mmol, 1.0 eq), methyl2-chlorothiazole-5-carboxylate (1.2 g, 6.5 mmol, 1.0 eq),and K2CO3 (904.0 mg, 6.5 mmol, 1.0 eq) in CH3CN(10.0 mL) was stirred at 82 C for 16 h. The mixture wasconcentrated to give the crude compounds 13-15, whichwas put into next step without further purification.

As the paragraph descriping shows that 72605-86-8 is playing an increasingly important role.

Reference£º
Article; Zhang, Jiankang; Xi, Jianjun; He, Ruoyu; Zhuang, Rangxiao; Kong, Limin; Fu, Liping; Zhao, Yanmei; Zhang, Chong; Zeng, Linghui; Lu, Jingyi; Tao, Rujia; Liu, Zhengmengtong; Zhu, Huajian; Liu, Shourong; Medicinal Chemistry Research; vol. 28; 10; (2019); p. 1633 – 1647;,
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Thiazole | chemical compound | Britannica

89281-44-7, 2-Methylthiazol-5-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

89281-44-7, Compound 3 was dissolved in methanol (10 mL), and then a solution of the corresponding thiazole amine in methanol (5 mL) was added to the solution. The reaction mixture was stirred at 45 C for 12 h. After the reaction was completed, which was monitored with TLC, the mixture was concentrated and extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated. Crude product was purified by column chromatography (ethyl acetate/petroleum ether = 8:1) to give compound 7a and 7b.

As the paragraph descriping shows that 89281-44-7 is playing an increasingly important role.

Reference£º
Article; Zheng, Min; Yao, Ting-Ting; Xu, Xiao-Jun; Cheng, Jing-Li; Zhao, Jin-Hao; Zhu, Guo-Nian; Bioorganic and Medicinal Chemistry Letters; vol. 24; 15; (2014); p. 3565 – 3568;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.139670-03-4,2-Bromo-4-chlorothiazole,as a common compound, the synthetic route is as follows.

Isopropylmagnesium chloride lithium chloride complex solution (4.58 mL, 5.95 mmol) was added slowly to a suspension of 3-(5-(3-cyanophenyl)-1,3-dimethyl-2,4-dioxo-3,4-dihydro-1H-pyrrolo[3,4-d]pyrimidin-6(2H)-yl)-N-methoxy-N-methylpropanamide (784 mg, 1.983 mmol) and 2-bromo-4-chlorothiazole (Intermediate Q, step 2) (394 mg, 1.983 mmol) in THF (30 mL). The mixture was stirred at room temperature for 40 mins. The reaction mixture was quenched with saturated NH4Cl(aq) and extracted with EtOAc (2¡Á). The combined organic extracts were washed with brine, dried over sodium sulphate and evaporated under vacuum. Purification by chromatography on silica, eluting with 10-60% EtOAc/hexane afforded the title compound. [1181] 1H NMR (400 MHz, CDCl3) delta 7.79-7.59 (4H, mult), 7.51 (1H, s), 6.51 (1H, s), 4.41 (2H, t), 3.50 (2H, t), 3.41 (3H, s), 3.35 (3H, s) [1182] LC-MS Rt 1.20 mins [M+H]+ 454.0 (Method 2minLowpHv03)

139670-03-4, As the paragraph descriping shows that 139670-03-4 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; AHMED, Mahbub; ASHALL-KELLY, Alexander; GUERITZ, Louisa; MCKENNA, Jeffrey; MCKENNA, Joseph; MUTTON, Simon; PARMAR, Rakesh; SHEPHERD, Jon; WRIGHT, Paul; US2014/171417; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica