Heterocyclic Building Blocks-Thiazole

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20949-81-9,2-Phenylthiazole-4-carbaldehyde,as a common compound, the synthetic route is as follows.

A solution of aldehyde 5 (10 mmol), benzoylacetone 6(10 mmol), concentrated H2SO4 (0.1 mL), thiourea andmethanol (50 mL) was refluxed for 24 h. The mixture wascooled and the precipitates were collected and crystallizedfrom methanol to produce compound 7.Yield: 74%. mp:148-151C , 1HNMR (DMSO-d6) : 1.69(s,3H,CH3), 5.45 (s,1H,H4), 7.35 (s, 1H,H-thiazol), 7.45-7.82 (m, 10H, phenyl), 7.89 (bs,1H, NH), 9.20 (bs,1H, NH),13CNMR (DMSO-d6) : 16.3 (CH3-C6), 55.2 (C4-tetrahydropyrimidine), 110.3, 113.4, 127.1, 127.3, 128.1,128.2, 129.3, 129.5, 130.1, 130.3, 131.4, 133.4, 133.7, 137.8,155.2, 162.3, 170.1, 175.3, 188.4, IR (KBr) cm-1: 3317,3114, 2924, 1713, 1674, 1180. Anal. Calcd. for C21H17N3OS2: C, 64.42; H, 4.38; N, 10.73. Found: C, 64.39; H, 4.46;N,10.56.

20949-81-9, The synthetic route of 20949-81-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Sharifzadeh, Mohammad; Khademi, Hamid Reza; Almasirad, Ali; Rezayan, Zahra; Ghayahbashi, Mohsen Rezayan; Amini, Mohsen; Letters in drug design and discovery; vol. 10; 9; (2013); p. 900 – 905;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

61830-21-5, Ethyl 2-amino-5-bromothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,61830-21-5

General procedure: A mixture of 2-aminothiazole derivatives 2a-h and 3a-e (1.0 mmol) and K2CO3 (4.0 mmol) was stirred at room temperature with drop-wise addition of 4-chlorobutyryl chloride (4.0 mmol) in chloroform for 48 h. The reaction mixture was monitored by TLC (using chloroform/ethyl acetate 9:1). Ammoniated water was added, and the organic layer was separated and dried over anhydrous Na2SO4, and the solvent was removed in vacuum. The resulting precipitate was crystallized from ethanol to give crystals of pure N-(thiazole-2-yl)-4-chlorobutanamide derivatives.

The synthetic route of 61830-21-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ghabbour, Hazem A.; Kadi, Adnan A.; Eltahir, Kamal E. H.; Angawi, Rihab F.; El-Subbagh, Hussein I.; Medicinal Chemistry Research; vol. 24; 8; (2015); p. 3194 – 3211;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1003-32-3, Thiazole-5-carboxyaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A. Hydrazone of 5-thiazolecarboxaldehyde and t-butylcarbazate Using the procedure of Example 1D, but replacing benzaldehyde with 5-thiazolecarboxaldehyde (Dondoni, et. al., Synthesis, 998(1987)), provided the desired compound., 1003-32-3

The synthetic route of 1003-32-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Abbott Laboratories; US5461067; (1995); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.394223-37-1,Benzo[d]thiazol-5-ylmethanol,as a common compound, the synthetic route is as follows.

To a mixture of compound B-188 (2.8 g, 17 mmol) in anhydrous dichloromethane (20 mL) was added manganese dioxide (14 g, 0.16 mol) at room temperature. The mixture was stirred at room temperature for 16 hours. On completion, the reaction was filtered, and the filtrate was concentrated in vacuo to give compound B-189 (2.5 g, 93% yield) as a yellow solid.

394223-37-1, As the paragraph descriping shows that 394223-37-1 is playing an increasingly important role.

Reference£º
Patent; FORUM PHARMACEUTICALS, INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66371; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-34-9,Benzothiazolone,as a common compound, the synthetic route is as follows.

General procedure: K2CO3 9.2 g, 66.6 mmol) and 1,4-dibromobutane (21.0 mL, 177.6 mmol) were added, under stirring, to a solution of benzo[d]oxazol-2(3H)-one (3.0 g, 22.2 mmol) in anhydrous DMF (30 mL). The reaction mixture was heated at 60 C for 3 h. After cooling, the reaction mixture was poured into 100 mL water and extracted with ethyl acetate (3 x 70 mL). The combined organic layers were washed with saturated aqueous NaCl and dried over sodium sulfate. The solvent was removed in vacuo, and the residue was purified by flash column chromatography (SiO2) using hexane/ethyl acetate (8:2) as eluent to give 3.6 g (62%) of 2e as a white solid. 4.2.1.3 3-(2-Bromoethyl)benzo[d]thaizol-2(3H)-one (2b) General procedure A, yield 57%, white solid. 1H NMR (400 MHz, CDCl3) delta 7.64-6.99 (m, 4H), 4.37 (t, J = 6.2, 2H), 3.82 (t, J = 6.1, 2H). 13C NMR (101 MHz, CDCl3) delta 166.07, 154.40, 142.70, 135.83, 134.62, 122.03, 120.40, 55.74, 39.59. MS (EI) m/z 258 (M++1).

934-34-9, The synthetic route of 934-34-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Abdelazeem, Ahmed H.; Khan, Shabana I.; White, Stephen W.; Sufka, Kenneth J.; McCurdy, Christopher R.; Bioorganic and Medicinal Chemistry; vol. 23; 13; (2015); p. 3248 – 3259;,
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Thiazole | chemical compound | Britannica

170961-15-6, tert-Butyl thiazol-2-ylcarbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To tetrahydrofuran solution (100 ml) of 47 (10.0 g, 49.9 mmol), t-butoxy potassium (6.72 g, 59.9 mmol) was added at 0C while stirring, stirred for 10 min at the same temperature, added iodomethane (4.66 ml, 74.9 mmol), and stirred for 16 hours at room temperature. The insolubles were removed by filtering the reaction mixture, and the filtrate was evaporated to dryness under reduced pressure. The residue was purified by silica gel column chromatography (solvent: n-hexane/ethyl acetate = 9/1), to obtain 48 (6.53 g, 61%) of colorless solid substance. mp 51?52 C, 1H NMR(500MHz, DMSO-D6)delta 1.53(9H,s),3.47(3H,s),7.25(1H,d,J=3.5Hz),7.45(1H,d,J=3.5Hz) ,IR(Neat)1734cm-1, APCI-MS m/z 215[M+H]+, 170961-15-6

The synthetic route of 170961-15-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Tohoku University; EP2103611; (2009); A1;,
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Thiazole | chemical compound | Britannica

72850-52-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.72850-52-3,Ethyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

2-Chloro-4-trifluoromethyl-thiazole-5-carboxylic acid ethyl ester (259 mg, 1.0mmol), sodium ethoxide (23% by weight in ethanol) (0.33 ml, 1.1 mmol) and ethanol (2ml) were heated under reflux for 2 hours. The mixture was partitioned between water andethyl acetate. The organic phase was dried over magnesium sulfate and concentrated togive the product as a yellow gum (187 mg, 70% yield). ^-NMR (400 MHz, CDC13):1.36 (3H, t, Me), 1.45 (3H, t, Me), 4.35 (2H, q, CH2), 4.55 (2H, q, CH2).

As the paragraph descriping shows that 72850-52-3 is playing an increasingly important role.

Reference£º
Patent; SYNGENTA LIMITED; WO2006/24820; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3292-77-1, 2-Bromo-1-(thiazol-2-yl)ethanone is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 2-bromo-1-(thiazol-2-yl)ethanone (2.5 g; 12 mmol), acetonitrile (70 ml) and imidazole (1.65 g; 24 mmol) was stirred at ambient temperature for 1 hour. The mixture was evaporated to dryness and the residue partitioned between dichloromethane and water. The organic phase was separated, washed with saturated brine and evaporated to give 2-(imidazol-1-yl)-1-(thiazol-2-yl)-ethanone as a brown solid (1.17 g; 50%). MP: 109-112 C. 1H NMR (DMSO d6, 400 MHz) delta: 5.6 (2H,s); 6.85-8.1 (5H,m).

3292-77-1, 3292-77-1 2-Bromo-1-(thiazol-2-yl)ethanone 2795212, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; AstraZeneca UK Limited; Zeneca-Pharma SA; US6342765; (2002); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

348-40-3, 6-Fluorobenzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 1,1?-Carbonyldiimidazole (12 mmol)was added to a solution of 6-(substituted)benzo[d]thiazol-2-amine (10 mmol) in dry dichloromethane (50 mL) and the reaction was stirred for 20 h at reflux conditions. The reaction mixture was cooled down to 2-8 C, filtered and washed with cold dichloromethane. The crude product was dried under reduced pressure to yield N-(6-(substituted)benzo[d]thiazol-2-yl)-1H-imidazole-1-carboxamide as a white solid (90-95%) and used in next reaction without further purification.

348-40-3, The synthetic route of 348-40-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Hroch, Lukas; Benek, Ondrej; Guest, Patrick; Aitken, Laura; Soukup, Ondrej; Janockova, Jana; Musil, Karel; Dohnal, Vlastimil; Dolezal, Rafael; Kuca, Kamil; Smith, Terry K; Gunn-Moore, Frank; Musilek, Kamil; Bioorganic and Medicinal Chemistry Letters; vol. 26; 15; (2016); p. 3675 – 3678;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

18903-18-9, Ethyl 5-aminothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 24 Intermediate 25 (1.12g, 5.84mmol) and 5-aminothiazole-4-carboxylic acid ethyl ester (0.9g, 5.84mmol) were combined in toluene (25ml_). The mixture was stirred under a nitrogen atmosphere at 60C for 1 hour and then at room temperature for 18 hours. The mixture was partitioned between 1 M hydrochloric acid and ethyl acetate and the layers separated. The aqueous layer was extracted with ethyl acetate and the combined organic layers dried with Na2S04, filtered and concentrated in vacuo to dryness. The residue was purified by chromatography on silica eluting with 0-70% ethyl acetate/cyclohexane. The fractions containing the desired product were combined and the solvents removed by evaporation in vacuo to give Intermediate 24 (298mg) as a cream solid. LCMS (Method 2) Rt 3.09 min; m/z(M+H)+ 328, 18903-18-9

As the paragraph descriping shows that 18903-18-9 is playing an increasingly important role.

Reference£º
Patent; ANTABIO SAS; LEMONNIER, Marc; DAVIES, David; PALLIN, David; WO2014/198849; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica