Heterocyclic Building Blocks-Thiazole

53266-94-7, Ethyl 2-(2-aminothiazol-4-yl)acetate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

53266-94-7, EXAMPLE 65; Step A; A neat mixture of 54 g (0.29 mole) ethyl (2-aminothiazol-4-yl)acetate and 50 g (0.276 mole) benzophenone imine was stirred at 190¡ã C. for 5 h and then cooled at RT and diluted with 100 mL of CH2Cl2. The entire mixture was transferred onto a silica gel column and eluted with 20percent EtOAc/Hexane. The title compound was obtained as light-yellow solid (70 g, 69percent yield). 1H NMR (300 MHz, CDCl3): 1.26 (t, 3H), 3.74 (s, 2H), 4.15 (q, 2H), 6.87 (s, 1H), 77.25-7.86 (m, 10H); MassSpectrum (NH3-Cl): m/z 351 (M+1).

The synthetic route of 53266-94-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Butora, Gabor; Goble, Stephen D.; Pastemak, Alexander; Yang, Lihu; Zhou, Changyou; Moyes, Christopher R.; US2008/81803; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

20485-41-0, 4-Methylthiazole-5-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 69 (250 mg, 0.81 mmol), HATU (460 mg, 1.2 mmol), dry N,N-dimethylformamide (5 mL), diisopropylethylamine (0.4 mL) and trimethylacetic acid (165 mg, 1.62 mmol) was stirred at room temperature for 12 h. The reaction mixture was poured into water (40 mL), extracted with ethyl acetate (3 x 30 mL), organic phases combined, washed with water (3 x 50 mL), a saturated aqueous solution of brine (20 mL), dried (magnesium sulfate), filtered and concentrated. The crude material was purified by Flashmaster II chromatography (eluent 0-90 percent ethyl acetate/dichloromethane). The purified material was taken up in diethyl ether (10 mL), washed with water (2 x 10 mL) to remove any trace N,N-dimethylformamide, dried (magnesium sulfate), filtered and concentrated to give 1-{4-[(4-Chloro-2-fluorophenyl)(pyridin-3-yl)methyl]piperazin-1-yl}-2,2-dimethylpropan-1-one (13) (53 mg, 17 percent) as a yellow oil.#10;, 20485-41-0

As the paragraph descriping shows that 20485-41-0 is playing an increasingly important role.

Reference£º
Article; Keenan, Martine; Alexander, Paul W.; Diao, Hugo; Best, Wayne M.; Khong, Andrea; Kerfoot, Maria; Thompson, R. C. Andrew; White, Karen L.; Shackleford, David M.; Ryan, Eileen; Gregg, Alison D.; Charman, Susan A.; Von Geldern, Thomas W.; Scandale, Ivan; Chatelain, Eric; Bioorganic and Medicinal Chemistry; vol. 21; 7; (2013); p. 1756 – 1763;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

533-30-2, 6-Aminobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

533-30-2, General procedure: Dialkyl/diaryl phosphite (1.0 mmol) was added portion wise over a period of 5 min to the stirred mixture of heterocyclic aldehyde (1.0 mmol) and benzothiazole amine (1.0 mmol) at room temperature. Further 5 mol percent of TNT was added to the reaction mixture and the stirring was continued for 15 min. After the completion of the reaction as monitored through TLC, the reaction mixture was dissolved in EtOAc (2 mL) and the catalyst was separated by centrifugation followed by subsequent washings with EtOAc. The recovered catalyst was reused for the next cycle. The filtrate was washed with brine, dried over anhydrous Na2SO4, filtered, and concentrated on a rotary evaporator and the resulting residue was purified by silica gel column chromatography (70:30, hexane/EtOAc) to afford the corresponding pure alpha-aminophosphonate. The novel alpha-aminophosphonates were structurally assigned by their IR, NMR (1H, 13C & 31P), and mass spectral (HRMS) analyses.

As the paragraph descriping shows that 533-30-2 is playing an increasingly important role.

Reference£º
Article; Reddy, Bhoomireddy Rajendra Prasad; Reddy, Motakatla Venkata Krishna; Reddy, Peddiahgari Vasu Govardhana; Kumar, Dharani Praveen; Shankar, Muthukonda V.; Tetrahedron Letters; vol. 57; 6; (2016); p. 696 – 702;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

944804-88-0, tert-Butyl 4-bromothiazol-2-ylcarbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

944804-88-0, A mixture of 48 (3.61g, 12.9mmol) and 70 Na2CO3 (3.4g, 32.3mmol) in DME/H2O/dioxane (240/48/48mL) was exchanged with N2 twice, and 5-chloro-2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (45a) (6.6g, 25.9mmol) and Pd(PPh3)4 (1.45g, 1.25mmol) were added to the mixture. The reaction mixture was heated to 100C and stirred for 6h under N2 atmosphere. The solid was removed by centrifugation at 3000rpm, 25C for 20min. The supernatant was concentrated and the crude product was purified by silica gel flash chromatography (eluting with ethyl acetate in petroleum ether 2-5%) to give 11 as a white solid (1.57g, yield=37%). 1H NMR (400MHz, DMSO-d6) delta 11.79 (s, 1H), 8.44 (s, 1H), 8.11 (s, 1H), 7.61 (s, 1H), 1.50 (s, 9H); LC/MS (ESI, m/z) 274.05 [M+H]+.

The synthetic route of 944804-88-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wang, Beilei; Wu, Jiaxin; Wu, Yun; Chen, Cheng; Zou, Fengming; Wang, Aoli; Wu, Hong; Hu, Zhenquan; Jiang, Zongru; Liu, Qingwang; Wang, Wei; Zhang, Yicong; Liu, Feiyang; Zhao, Ming; Hu, Jie; Huang, Tao; Ge, Juan; Wang, Li; Ren, Tao; Wang, Yuxin; Liu, Jing; Liu, Qingsong; European Journal of Medicinal Chemistry; vol. 158; (2018); p. 896 – 916;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22900-83-0,Ethyl 2-bromo-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

Tert-Butyl 4- (2-benzyl) -4 (trifluoromethyl) phenyl) piperazine-1-carboxylate(0. 52 g, 1.50 mmol),Bromo-4-methylthiocono-5-carboxylate (0.39 g, 1. 58 mmol) and potassium carbonate(0.42 g, 3. OO mmol) was addedDMSO (10 mL), and the reaction was allowed to warm to 110 ¡ã C for 20 hours.After completion of the reaction, the reaction solution was cooled to room temperature,And water (20 mL) was added thereto, followed by extraction with ethyl acetate (20 mLX3). The combined organic phases were dried over anhydrous sodium sulphateDried, filtered and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate (v / v) = 2/1)Afforded the title compound as a light yellow solid (0.35 g, 45.2percent)., 22900-83-0

The synthetic route of 22900-83-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ru yuan yaozu zizhixian dazhong yaopin maoyi youxian co ltd/Ru yuan yaozu zizhixian dazhong yaopin maoyi youxian gongci; Jin, chuan Fei; Liang, Haiping; zhang, yingjun; Zhang, Ji; Kang, Ning; Li, Yong; Liu, Yan Ping; (38 pag.)CN105294554; (2016); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2933-29-1,2-Amino-4,5,6,7-tetrahydrobenzothiazole,as a common compound, the synthetic route is as follows.

General procedure: The solution of (15) (1 mmol) in anhydrous dichloromethane (10 mL) was supplemented with the appropriate isocyanate or isothiocyanate (1.1 mmol) and refluxed for 5 h. The solid product was washed with water and purified by re-crystallizationfrom aqueous ethanol, and air-dried to give the corresponding urea or thiourea compounds (16a-h). 5.3.2.2.2 1-isopropyl-3-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)urea (16b) 60% yield; mp = 92-94 C. IR (KBr) (numax/cm-1): 3294, 3070, 2927, 1679, 1569, 1234. 1H NMR (DMSO) (delta/ppm): 1.09 (d, J = 6.6 Hz, 6H, (CH3)2), 1.73 (br s, 4H, CH2), 2.47 (br s, 2H, CH2), 2.56 (br s, 2H, CH2), 3.75 (m, 1H, CH), 6.41 (d, J = 7.3 Hz, 1H, NH), 9.83 (br s, 1H, NH). 13C NMR (DMSO) (delta/ppm): (CH3): 22.76; (CH2): 22.04, 22.63, 22.98, 25.94; (CH): 41.23; (Cq): 141.45, 142.74, 151.97, 167.83. Anal. (C11H17N3OS) theoretical: 55.20% C, 7.16% H, 17.56% N, 13.39% S; found: 55.55% C, 7.21% H, 17.30% N, 12.99% S.

2933-29-1, 2933-29-1 2-Amino-4,5,6,7-tetrahydrobenzothiazole 18046, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Harrouche, Kamel; Renard, Jean-Francois; Bouider, Nafila; De Tullio, Pascal; Goffin, Eric; Lebrun, Philippe; Faury, Gilles; Pirotte, Bernard; Khelili, Smail; European Journal of Medicinal Chemistry; vol. 115; (2016); p. 352 – 360;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20358-02-5,4-Bromobenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

In the reaction vessel 4-bromobenzo[20358-02-5

The synthetic route of 20358-02-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; MANDAL, Mihir; TANG, Haifeng; XIAO, Li; SU, Jing; LI, Guoqing; YANG, Shu-Wei; PAN, Weidong; TANG, Haiqun; DEJESUS, Reynalda; HICKS, Jacqueline; LOMBARDO, Matthew; CHU, Hong; HAGMANN, William; PASTERNAK, Alex; GU, Xin; JIANG, Jinlong; DONG, Shuzhi; DING, Fa-Xiang; LONDON, Clare; BISWAS, Dipshikha; YOUNG, Katherine; HUNTER, David, N.; ZHAO, Zhiqiang; YANG, Dexi; WO2015/112441; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

41731-52-6, Ethyl 2-chlorothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Sodium borohydride (690 mg, 18 mmol) was added as a single portion to a solution of ethyl 2-chloro-4-thiazolecarboxylate (1.6 g, 9 mmol) in ethanol (70 ml) at 0 C., then the mix was allowed to warm to room temperature with stirring overnight. The reaction was acidified to pH 5 with IN HCl and concentrated under vacuum, then the white residue was partitioned between water (125 ml) and ethyl acetate (3*300 ml). The organic phase was washed with brine and dried (Na2SO4), then the solvents were removed. Chromatography of the residue on silica gel (15 g, eluent 15%/-30% hexane/ethyl acetate) gave 2-chloro-4-hydroxymethylthiazole (850 mg, 5.5 mmol) in 63% yield as a clear oil, 1H nmr, 4.72 (s, 2H), 7.11 (s, 1H)., 41731-52-6

The synthetic route of 41731-52-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Biota Scientific Management Pty Ltd.; US7078403; (2006); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55661-33-1,Thiazol-2-ylmethanamine,as a common compound, the synthetic route is as follows.

Example 1286-Chloro-2-oxo-8-(2-oxo-2-((thiazol-2-ylmethyl)amino)ethyl)-1 ,2-dihydroquinoline- 3-carboxylic acid a) Methyl 6-chloro-2-methoxy-8-(2-oxo-2-(thiazol-2-ylmethylamino)ethyl)- quinoline-3-carboxylate[00366] Thiazol-2-yl-methylamine (104 muIota, 1 .10 mmol, 2.0 equiv.) is added to a suspension of (CO)sMoCINEt (220 mg, 0.55 mmol) in ethanol (5 mL). The resulting mixture is stirred under a nitrogen atmosphere for 2 h. Diglyme (5 mL) is added to the mixture and heated to 120 C with evaporation of ethanol. Tributylamine (144 muIota, 0.60 mmol, 1 .10 equiv.) and methyl 8-(bromomethyl)-6-chloro-2-methoxyquinoline-3- carboxylate (170 mg, 0.49 mmol, 0.9 equiv.) are added and the mixture is heated at 130 C for 2 h. The reaction mixture is filtered over kieselguhr and the filtrate is concentrated in vacuo. The residue is taken on hydromatrix and purified by flash column chromatography (silica, 1 -10% MeOH in DCM) to afford 89 mg (44%) of the title compound as a solid. 1H NMR (400 MHz, CDCI3), delta (ppm) 3.90 (s, 3H), 3.96 (s, 3H), 4.08 (s, 2H), 4.36 (d, 2H), 6.56 (br s, 1 H), 7.07-7.13 (m, 2H), 7.22-7.29 (m, 3H), 7.72 (s, 2H), 8.54 (s, 1 H). LC-MS: 399 [M+H] [35CI]., 55661-33-1

The synthetic route of 55661-33-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Merz Pharma GmbH & Co. KGaA; ABEL, Ulrich; HANSEN, Angela; WOLTER, Falko Ernst; KRUEGER, Bjoern; KAUSS, Valerjans; ROZHKOVS, Jevgenijs; SEMENIHINA, Valentina; PISKUNOVA, Irena; PELSS, Juris; WO2012/164085; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

934-34-9, Benzothiazolone is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Intermediates 19-26 were prepared following literature procedures, with slight modifications [50]. A solution of 10-14 (6.6mmol) in acetone (20mL) was mixed with K2CO3 (10mmol) and stirred at room temperature for 10min. After addition of the appropriate 1-bromo-omega-chloroalkane or 1,omega-dibromoalkane (7.3mmol), the mixture was stirred for further 24h. Inorganic materials was removed by filtration, then the solvent was removed in vacuum to obtain a residue which was used without any further purification for the next step. For analytical purpose, crude 23-26 were purified by flash chromatography or by recrystallization.

934-34-9, As the paragraph descriping shows that 934-34-9 is playing an increasingly important role.

Reference£º
Article; Salerno, Loredana; Pittala, Valeria; Romeo, Giuseppe; Modica, Maria N.; Marrazzo, Agostino; Siracusa, Maria A.; Sorrenti, Valeria; Di Giacomo, Claudia; Vanella, Luca; Parayath, Neha N.; Greish, Khaled; European Journal of Medicinal Chemistry; vol. 96; (2015); p. 162 – 172;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica