Heterocyclic Building Blocks-Thiazole

1452-16-0, 2-Cyanothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A 2.5 M solution of nBuLi (2.0 eq) in hexane was added under argon to a solution of 2,2-dimethoxyethanamine (2.0 eq) in THF at -78C. After stirring for 30 min, thiazole-2-carbonitrile (2-Im-2, 3.0 g, 1.0 eq) was added and the resulting solution was stirred at 0 C for 2h, then quenched with 20 mL of 5% MeOH in water. The volatiles were removed and 6N HC1 was added to adjust to pH=l. The acidic solution was refluxed overnight, cooled to rt then poured into a mixture of ice and aqueous a2C03. This was extracted with EtOAc and the organic layer was concentrated to give Imadazole 2. LCMS (0.01% Ammonia): 152.1 m/z (M+H)+; ?-NMR (DMSO-d6, 500MHz): delta: 13.19 (bs, 1H), 7.98 (d, 1H, J=3.0Hz), 7.82 (d, 1H, J=3.0Hz), 7.36 (s, 1H), 7.14 (s, 1H)., 1452-16-0

As the paragraph descriping shows that 1452-16-0 is playing an increasingly important role.

Reference£º
Patent; ELAN PHARMACEUTICALS, INC.; GALEMMO, Robert, A., Jr.; ARTIS, Dean, Richard; YE, Xiaocong, Michael; AUBELE, Danielle, L.; TRUONG, Anh, P.; BOWERS, Simeon; HOM, Roy, K.; ZHU, Yong-Liang; NEITZ, R., Jeffrey; SEALY, Jennifer; ADLER, Marc; BEROZA, Paul; ANDERSON, John, P.; WO2011/79114; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.88982-82-5,4-Bromo-1,3-thiazole-2-carboxylic acid,as a common compound, the synthetic route is as follows.

Step A:4-bromothiazole-2-carboxylic acid (1,1.0 g, 4.8 mmol)Dissolved in ethylene glycol dimethyl ether (12mL)And water (4mL),Add 4-fluorophenylboronic acid (17, 1.0 g, 7.2 mmol)And anhydrous potassium carbonate (994 mg, 7.2 mmol),Then tetrakis(triphenylphosphine)palladium (277 mg, 0.24 mmol) was added.The resulting mixture was heated to 98 C under nitrogen for 24 hours.TLC analysis indicated the end of the reaction.The reaction solution was cooled to room temperature.Then add water (40 mL),The pH was adjusted to 2-3 with 6M hydrochloric acid.Filtered, the filter cake was dissolved in 20 mL of dichloromethane.The dichloromethane layer was washed with a saturated sodium bicarbonate solution.Divide the water layer,Adjust the pH of the water layer to 2-3,Filter the suspension,The filter cake was dried to give compound 18 (906 mg).Yield: 84.7%.

88982-82-5, 88982-82-5 4-Bromo-1,3-thiazole-2-carboxylic acid 15122065, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Zhejiang Haizheng Pharmaceutical Co., Ltd.; Wang Haibo; Zheng Xiaohe; Cai Zhengjiang; Zheng Shan; Ye Zhengchun; Ma Huidan; Lin Haiming; (54 pag.)CN108623532; (2018); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.41731-83-3,Ethyl 2-bromothiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

Step 1: 2-Bromo-1,3-thiazole-5-carboxamide Into a 2 L round-bottom flask was added ethyl 2-bromothiazole-5-carboxylate (50.0 g, 212 mmol), THF (500 mL) and MeOH (250 mL). To this was added concentrated ammonium hydroxide in water (590 mL) and the reaction mixture was stirred at room temperature for 4 h. The solvents were removed under reduced pressure and the crude mixture poured into a separatory funnel containing brine (1 L). The aqueous layer was extracted with EtOAc (4*500 mL) and the combined organic layers were washed with brine, dried over Na2SO4, filtered and concentrated under reduced pressure.

41731-83-3, The synthetic route of 41731-83-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Isabel, Elise; Lachance, Nicolas; Leclerc, Jean-Philippe; Leger, Serge; Oballa, Renata M.; Powell, David; Ramtohul, Yeeman K.; Roy, Patrick; Tranmer, Geoffrey K.; Aspiotis, Renee; Li, Lianhai; Martins, Evelyn; US2011/301143; (2011); A1;,
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440100-94-7,440100-94-7, 2-Bromothiazole-5-carbonitrile is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 2-bromothiazole-5-carbonitrile (200 mg, 1.05 mmol), tert-butylpiperazine-1-carboxylate (800 mg, 4.3 mmol), potassium phosphate tribasic (260 mg, 1.22mmol), palladium acetate trimer (40 mg, 0.06 mmol), tri-tert-butylphosphinetetrafluoroborate (20 mg, 0.06 mmol) in toluene (4 mL), taken in a microwave vial underargon atmosphere was irradiated for 30 min at 80 C (TLC indicated complete consumptionof starting material). The reaction mixture was diluted with water (10 mL) and extracted withEtOAc (3 x 30 mL). The combined organic extracts were washed with brine (10 mL), driedover N a2S04 and concentrated under reduced pressure. The crude product obtained waspurified by column chromatography (100-200 silica gel, 20 g, 10-30% EtOAc-Hexane) toafford tert-butyl 4-(5-cyanothiazol-2-yl)piperazine-1-carboxylate (200 mg, 64%) as a whitesolid LCMS (ESI+): m/z: 295.60 [M+Ht.

The synthetic route of 440100-94-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MITOBRIDGE, INC.; TAKAHASHI, Taisuke; KLUGE, Arthur; LAGU, Bharat; JI, Nan; (162 pag.)WO2018/125961; (2018); A1;,
Thiazole | C3H3NS – PubChem
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.615-21-4,2-Hydrazinylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.

615-21-4, In a 4-neck reactor equipped with a thermometer, 10.0 g (60.5 mmol) of 2-hydrazinobenzothiazole was dissolved in 100 ml of DMF in a nitrogen stream.To this solution, 41.8 g (304 mmol) of potassium carbonate and 10.34 g (60.6 mmol) of 5-bromovaleronitrile were added and the whole of the mixture was stirred at 60 C. for 8 hours.After completion of the reaction, the reaction solution was cooled to 20 C., poured into 1000 ml of water, and extracted with 1000 ml of ethyl acetate.After drying the ethyl acetate layer with anhydrous sodium sulfate, sodium sulfate was filtered off. Ethyl acetate was distilled off under reduced pressure from the filtrate by a rotary evaporator to obtain a yellow solid.This yellow solid was purified by silica gel column chromatography (n-hexane: ethyl acetate = 60: 40)As a white solid, 6.82 g of Intermediate T was obtained (yield: 45.7%).

The synthetic route of 615-21-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ZEON CORPORATION; SAKAMOTO, KEI; OKUYAMA, KUMI; SANUKI, KANAKO; (77 pag.)JP6191793; (2017); B1;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51640-36-9,2-Chlorothiazole-5-carbonitrile,as a common compound, the synthetic route is as follows.

2-(6-Piperidin-1-yl-pyrimidin-4-ylamino)-thiazole-5-carbonitrile (22-10) A flame dried flask under Ar was charged with sodium hydride (35 mg, 60% dispersion, 0.86 mmol) and 2 mL anhydrous THF. 6-Piperidin-1-yl-pyrimidin-4-ylamine (70 mg, 0.39 mmol) was added slowly followed after 10 minutes by the addition of 2-chloro-thiazole-5-carbonitrile (68 mg, 0.47 mmol). After 1 hour at room temperature the reaction was heated to reflux. After 4 hours, the reaction was cooled, diluted with water and adjusted to pH 7 with 1M HCl (aq). The resulting precipitate was filtered washed with water and air dried. The resulting solid triturated with ether, sonucated, filtered and washed with ether. 1H-NMR (400 MHz, DMSO-6) 11.99 (s, 1H), 8.39 (1H,s), 8.24 (1H,s), 6.20 (1H,s), 3.57-3.54 (m, 4H), 1.64-1.53 (m, 6H). M+1=287.3. mp>250.

51640-36-9, The synthetic route of 51640-36-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bilodeau, Mark T.; Hartman, George D.; Hoffman JR., Jacob M.; Sisko, John T.; Manley, Peter J.; Smith, Anthony M.; Tucker, Thomas J.; Lumma JR., William C.; Rodman, Leonard; US2002/137755; (2002); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161798-03-4,Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

c) Preparation of Ethyl 2-(3-cvano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate [Compound of formula V]. 350.0gm of Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate, [Compound of formula IV] 123.0gm of sodium formate followed by 84.0gm of hydroxylamine hydrochloride were added to 1.4 ltr of formic acid. Reaction mixture was heated to reflux and stirred for 5hr to complete the reaction. Reaction solution was cooled to 25C. Slowly added 2.8 ltr of water at 25C. Slurry formed was stirred for about l.Ohr, filtered, washed with water and dried under vacuum to give 321.0gm of titled compound.Analytical Data- ¡¤ ^NMR (CDC13, 400 MHz) : delta 1.053-1.104 (doublet, 6H); delta 1.368-1.416 (triplet,3H); delta 2.164-2.253 (multiplet, 1H); delta 2.768 (singlet, 3H); delta 3.890-3.911 (doublet, 2H); delta 4.324-4.395 (quartet, 2H); delta 6.998-7.027 (doublet, 1H); delta 8.075-8.112 (doublet of doublet, 1H); delta 8.175-8.182 (doublet, 1H).? Mass (m/e) : 345.2, 161798-03-4

The synthetic route of 161798-03-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SANDOZ AG; LUTHRA, Parven, Kumar; KHAN, Rashid; SALUNKHE, Dadasaheb; NASIR ALI, Shafakat, Ali; WO2012/131590; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.41731-83-3,Ethyl 2-bromothiazole-5-carboxylate,as a common compound, the synthetic route is as follows.,41731-83-3

Step 1: ethyl 2-pyridin-2-yl-1,3-thiazole-5-carboxylate A mixture of bromo(pyridine-2-yl)zinc (0.5 M in THF, 1.27 mL), ethyl 2-bromo-1,3-thiazole-5-carboxylate (0.063 mL, 0.42 mmol) and tetrakis(triphenylphosphine)palladium(0) (0.02 g, 0.02 mmol) in 1,4-dioxane (3 mL) and water (0.03 mL) was subjected to MWI at 120 C. for 10 min. The reaction mixture was diluted with water and extracted with EtOAc. The organic solutions were combined, dried over Na2SO4, filtered, and concentrated to give ethyl 2-pyridin-2-yl-1,3-thiazole-5-carboxylate (0.12 g) which was used without further purification. LCMS: (FA) ES+235.

As the paragraph descriping shows that 41731-83-3 is playing an increasingly important role.

Reference£º
Patent; Millennium Pharmaceuticals, Inc.; US2008/171754; (2008); A1;,
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Thiazole | chemical compound | Britannica

1235406-42-4, tert-Butyl thiazol-4-ylcarbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1. Preparation of thiazol-4-amine hydrochloride To a mixture of tert-butyl thiazol-4-ylcarbamate (34.0 g, 169.8 mmol) in dichloromethane (150 mL) was added 4.0 M hydrochloric acid in anhydrous dioxane (180 mL). The reaction mixture was stirred at ambient temperature for 3 hours and then filtered. The residue rinsed with diethyl ether (80 mL) to afford the title compound as a colorless solid (22.99 g, 99% yield): MS (ES+) m/z 101 (M+1).

1235406-42-4, 1235406-42-4 tert-Butyl thiazol-4-ylcarbamate 53241636, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Xenon Pharmaceuticals Inc.; Andrez, Jean-Christophe; Burford, Kristen Nicole; Dehnhardt, Christoph Martin; Focken, Thilo; Grimwood, Michael Edward; Jia, Qi; Lofstrand, Verner Alexander; Wesolowski, Steven Sigmund; Wilson, Michael Scott; US2020/71313; (2020); A1;,
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1452-15-9, 4-Cyanothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1452-15-9, Preparation of Products; To a mixture of nitrile (60 mg) and substituted aniline (leq) was added AlCl3 (leq). The mixture was heated up to 2000C and stirred for 20 min under N2. The mixture was cooled and the product purified by preparative HPLC.

As the paragraph descriping shows that 1452-15-9 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME LIMITED; WO2007/138343; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica