Heterocyclic Building Blocks-Thiazole

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161797-99-5,Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

a) Preparation of Ethyl 2-(3-formyl-4-hvdroxyphenyl)-4-methyl-5-thiazolecarboxylate[Compound of formula lO.Ogm of Ethyl 2-(4-hydroxyphenyl)-4-methyl-5-thiazole carboxylate, [Compound of formula II] and 5.86gm of hexamethylenetetramine was added to 100.0ml of trifluoroacetic acid. Reaction mixture was heated to reflux under stirring for 40 hr. Trifluoroacetic acid was distilled out at 80 +/- 3¡ãC. Residue obtained was cooled to 25¡ãC and slowly added 100 ml of water. Slurry formed was stirred for 2.0hr. Slurry of the product was filtered, washed and dried under vacuum to give 9.6 gm of titled compound., 161797-99-5

As the paragraph descriping shows that 161797-99-5 is playing an increasingly important role.

Reference£º
Patent; SANDOZ AG; LUTHRA, Parven, Kumar; KHAN, Rashid; SALUNKHE, Dadasaheb; NASIR ALI, Shafakat, Ali; WO2012/131590; (2012); A1;,
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5398-36-7, Ethyl 2-aminothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5398-36-7

To 40 ml of an aqueous solution of 4.00 g (23.2 mmol) of ethyl 2-aminothiazole-4-carboxylate was added 1.86 g (46.5 mmol) of sodium hydroxide, followed by stirring at room temperature for 5 hours. The reaction liquid was adjusted to pH 1 by the addition of concentrated hydrochloric acid, and the precipitated crystals were collected by filtration to prepare 2.84 g (yield 85%) of a target compound. 1H-NMR (CDCl3, ppm) delta 7.18 (2H, broad-s), 7.38 (1H, s). The proton of the carboxylic acid was not detected.

5398-36-7 Ethyl 2-aminothiazole-4-carboxylate 73216, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Mitsui Chemicals Agro, Inc.; EP2319830; (2011); A1;,
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1452-16-0, 2-Cyanothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of thiazole-2-carbonitrile (1.5 g, 14 mmol) in 5 mL of dry MeOH was added dropwise a solution of sodium methoxide (0.74 g, 14 mmol) in 10 mL of dry methanol. The reaction mixture was stirred at room temperature until the disappearance of starting material monitored by LC/MS. After that, ammonium chloride (1.5 g, 28 mmol) was added in one portion and the reaction mixture was stirred overnight. The undissolved material was removed by filtration and the filtrate was concentrated to afford thiazole-2-carboxamidine hydrochloride (Compound A) as a grey solid which was used directly in the next step without further purification. MS: calc’d 128 (MH+), measured 128 (MH+).

1452-16-0, The synthetic route of 1452-16-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; HOFFMANN-LA ROCHE INC.; Guo, Lei; Hu, Taishan; Hu, Yimin; Kocer, Buelent; Kou, Buyu; Li, Gangqin; Lin, Xianfeng; Liu, Haixia; Shen, Hong; Shi, Houguang; Wu, Guolong; Zhang, Zhisen; Zhou, Mingwei; Zhu, Wei; US2014/343032; (2014); A1;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63788-62-5,2-Acetylamino-4-methylthiazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.

63788-62-5, A mixture of 10j (0.23g, 1.14mmol), 7 (0.23g, 1.14mmol), and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC¡¤HCl) (0.26g, 1.37mmol) in dimethylformamide (3mL) was stirred at room temperature for 15h. The reaction mixture was then allowed to heat at 100C for 3h and was evaporated in vacuo. The residue was purified using silica gel column chromatography (methanol/chloroform) to yield 13 (69.0mg, 17%) as a yellow oil.

As the paragraph descriping shows that 63788-62-5 is playing an increasingly important role.

Reference£º
Article; Oka, Yusuke; Yabuuchi, Tetsuya; Oi, Takahiro; Kuroda, Shoichi; Fujii, Yasuyuki; Ohtake, Hidenori; Inoue, Tomoyuki; Wakahara, Shunichi; Kimura, Kayo; Fujita, Kiyoko; Endo, Mayumi; Taguchi, Kyoko; Sekiguchi, Yoshinori; Bioorganic and Medicinal Chemistry; vol. 21; 24; (2013); p. 7578 – 7583;,
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Thiazole | chemical compound | Britannica

7305-71-7, 2-Amino-5-methylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7305-71-7, Example 21 (E)-2-(3-Chloro-4-methanesulfonyl-phenyl)-2-cyclopentyloxyimino-N-(5-methyl-thiazol-2-yl)-acetamide (E)-(3-Chloro-4-methanesulfonyl-phenyl)-cyclopentyloxyimino-acetic acid (prepared as in Example 1, 84 mg, 0.24 mmol), 5-methyl-thiazol-2-ylamine (28 mg, 0.24 mmol) and N,N-diisopropylethylamine (127 muL, 0.73 mmol) were combined in methylene chloride (2 mL) and cooled in an ice bath. O-(7-Azabenzotriazole-1-yl)-N,N,N’N’-tetramethyluronium hexafluorophosphate (92 mg, 0.24 mmol) was added and the ice bath was removed. After stirring 2 h, the reaction mixture was evaporated in vacuo. The residue was treated with saturated aqueous sodium bicarbonate solution (1 mL) and extracted with chloroform (2*3 mL). The combined organic phases were dried over sodium sulfate and evaporated in vacuo. The residue was purified by flash column chromatography (Merck silica gel 60, 40-63 mum; 40percent ethyl acetate/hexanes) to afford (E)-2-(3-chloro-4-methanesulfonyl-phenyl)-2-cyclopentyloxyimino-N-(5-methyl-thiazol-2-yl)-acetamide (74 mg, 69percent) as a white solid after lyophilization from aqueous acetonitrile: LC-MS (ESI) m/e calcd for C18H20ClN3O4S2 [M+] 441.06, found 442 [M+H+]; H1-NMR (400 MHz, CDCl3) delta ppm 1.66 (m, 4 H, 2*CH2), 1.89 (m, 4 H, 2*CH2), 2.45 (d, J=1.2 Hz, 3 H, ArCH3), 3.31 (s, 3 H, SO2CH3), 4.93 (m, 1 H, OCH), 7.15 (brq, 1 H, Ar), 7.59 (dd, Jo=8.2, Jm=1.5 Hz, 1 H, Ar), 7.70 (d, Jm=1.5 Hz, 1 H, Ar), 8.21 (d, Jo=8.2 Hz, 1 H, Ar), 10.03 (s, 1 H, NH).

The synthetic route of 7305-71-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Berthel, Steven Joseph; Kester, Robert Francis; Murphy, Douglas Eric; Prins, Thomas Jay; Ruebsam, Frank; Tran, Chinh Viet; Vourloumis, Dionisios; US2008/146625; (2008); A1;,
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78364-55-3, 6-Fluoro-2-hydrazinylbenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,78364-55-3

General procedure: 2-(2-Arylidenehydrazino)-6-fluorobenzothiazoles 6a-r. General Procedure D. A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 ¡ãC for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from the appropriate solvent to give the desired compounds 6a-r.

78364-55-3 6-Fluoro-2-hydrazinylbenzo[d]thiazole 2049844, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Gabr, Moustafa T.; El-Gohary, Nadia S.; El-Bendary, Eman R.; El-Kerdawy, Mohamed M.; Ni, Nanting; Shaaban, Mona I.; Chinese Chemical Letters; vol. 26; 12; (2015); p. 1522 – 1528;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35272-15-2,2-Methylthiazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.

1.00 g (6.99 mmol) of 2-methyl-1,3-thiazole-4-carboxylic acid was added to 3.62 g of polyphosphoricacid. 0.64 g (6.99 mmol) of hydrazinecarbothioamide was added portionwise. It was stirred for 1 h at140 ¡ãC. After cooling down to 70 ¡ãC, water (10 mL) was added dropwise. After cooling to 0 ¡ãC,aqueous ammonium hydroxide solution (25percent, 8 mL) was added till a pH value of 12 was achieved. The precipitate was collected by filtration, washed with water and dried under reduced pressure at 50 ¡ãC affording 821 mg (59percent of theory) of the title compound.?H-NMR (400MHz, DMSO-d6): 6 [ppm]= 2.69 (s, 3H), 7.33 (s, 2H), 7.96 (s, 1H). LC-MS (Method 4): R = 0.65 mm; MS (ESIpos): m/z = 199 [M+H].

35272-15-2, The synthetic route of 35272-15-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; THEDE, Kai; BENDER, Eckhard; SCOTT, William; RICHTER, Anja; ZORN, Ludwig; LIU, Ningshu; MOeNNING, Ursula; SIEGEL, Franziska; GOLZ, Stefan; HAeGEBARTH, Andrea; LIENAU, Philip; PUEHLER, Florian; BASTING, Daniel; SCHNEIDER, Dirk; MOeWES, Manfred; GEISLER, Jens; WO2015/140195; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18903-18-9,Ethyl 5-aminothiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

18903-18-9, To a solution of 2,4-dichloro-1,3,5-triazine (330.5 mg, 2.2 mmol) in dichloromethane (15 mL) at 0 C., ethyl 5-aminothiazole-4-carboxylate (345 mg, 2 mmol) was added, followed by N,N-Diisopropylethylamine (0.523 mL, 3 mmol). The reaction mixture was stirred at 0 C. for 30 minutes. Then more 2,4-dichloro-1,3,5-triazine (300 mg, 2 mmol) was added and the reaction mixture was stirred at room temperature overnight. After this time, the reaction was quenched with saturated sodium bicarbonate solution (PH?8) and extracted with dichloromethane for three times. The combined extracts were washed once with saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The crude residue was purified by flash chromatography (silica gel) to give the desired product as white solid. LCMS-ESI+ (m/z): [M+H]+ calcd for C9H9ClN5O2S: 286.7. found: 286.1.

As the paragraph descriping shows that 18903-18-9 is playing an increasingly important role.

Reference£º
Patent; Gilead Sciences, Inc.; Du, Zhimin; Guerrero, Juan A.; Kaplan, Joshua A.; Knox, JR., John E.; Lo, Jennifer R.; Mitchell, Scott A.; Naduthambi, Devan; Phillips, Barton W.; Venkataramani, Chandrasekar; Wang, Peiyuan; Watkins, William J.; Zhao, Zhongdong; (593 pag.)US2016/96827; (2016); A1;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34259-99-9,4-Bromothiazole,as a common compound, the synthetic route is as follows.

a) 6- (Thiazol-4-yl)- 8-((2- (trimethylsilyl)ethoxy)methoxy)-3- ((2- (trimethylsilyl)ethoxy)methyl)guinazolin-4(3H)-oneA suspension of 4-bromo-thiazole (0.02 g, 0.1 mmol), (6-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)-8- ((2- (trimethylsilyl)ethoxy)methoxy)-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one (0.05 g, 0.08 mmol, example 28), bis (diphenylphosphino)feffocene-palladium(II)dichloride (0.01 g, 0.01 mmol), potassium carbonate (0.03 g, 0.25 mmol) and water (0.2 ml) in dimethylformamide (1 ml) was stirred in a sealed tube at 100 ¡ãC for 2 hours and then at 80 ¡ãC overnight. Filtration and chromatography (C18 reverse phase HPLC, methanol / water (0.1percent formic acid) = 40:60 to 100:0) yielded thetitle compound as white solid (0.01 g, 18 percent). MS: mle = 506.7 [M+Hf?., 34259-99-9

34259-99-9 4-Bromothiazole 2763218, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BISSANTZ, Caterina; BONNAFOUS, Rene; BUETTELMANN, Bernd; JAKOB-ROETNE, Roland; LERNER, Christian; RUDOLPH, Markus; WO2014/102233; (2014); A1;,
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Thiazole | chemical compound | Britannica

298694-30-1, 4-Bromo-2-methylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

step 2: A mixture of 4-(8-(3-(tert-butoxycarbonylamino)propyl)-2-(methylthio)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)-3-chlorophenylboronic acid (688 mg, crude), 4-bromo-2-methylthiazole (254 mg, 1.4 mmol), Pd(PPh3)4 (71 mg, 0.061 mmol) and Na2CO3 (0.5 M in water, 4 mL) in MeCN (4 mL) was stirred at 90 C. under N2 overnight. After cooling to RT, the reaction mixture was diluted with EtOAc (200 mL) and washed with aq. NaCl solution (100 mL). The organic layer was dried (MgSO4) and concentrated under reduced pressure. The residue was purified by SiO2 chromatography eluting with a PE/DCM/EtOAc gradient (3:3:2 to 1:1:2) to afford tert-butyl 3-(6-(2-chloro-4-(2-methylthiazol-4-yl)phenyl)-2-(methylthio)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)propylcarbamate as yellow oil (137 mg, 63% from two steps). LCMS (ESI): m/z=503.1 [M-55]+.

298694-30-1, The synthetic route of 298694-30-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GENENTECH, INC.; Rudolph, Joachim; Gazzard, Lewis J.; Crawford, James J.; Ndubaku, Chudi; Drobnick, Joy; Lee, Wendy; US2015/31674; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica