Heterocyclic Building Blocks-Thiazole

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.111600-83-0,5-Bromo-4-methylthiazole,as a common compound, the synthetic route is as follows.

Compound 47b (300 mg, 1.69 mmol) under nitrogen,B2pin2 (861 mg, 3.39 mmol), Pd(dppf)Cl2 (30 mg, 0.04 mmol) and KOAc (332 mg, 3.39 mmol) were placed in a reaction flask.Add 20mL of ethylene glycol dimethyl ether,Heat to 80 C for 8 h.After the reaction was cooled to room temperature, filtered and the filtrate washed with water, EtOAc. The combined organic phase was dried over anhydrous sodium sulfate, filtered and the solvent was distilled off under reduced pressure, purified by silica gel column chromatography to give compound 47c (400mg).

111600-83-0, As the paragraph descriping shows that 111600-83-0 is playing an increasingly important role.

Reference£º
Patent; Sichuan Kelun Botai Bio-pharmaceutical Co., Ltd.; Zhu Jiawang; Cai Jiaqiang; Li Guiying; You Zejin; Wu Yongyong; Han Runfeng; Ge Yong; Wang Lichun; Wang Jingyi; (49 pag.)CN109928979; (2019); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

777-12-8, 6-(Trifluoromethyl)benzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6-(Trifluoromethyl)benzo[d]thiazol-2-amine (6.8 g, 31.16 mmol)was dissolved in THF (60 mL) under N2. Isoamyl nitrite (8.03 g,68.55 mmol) was added dropwise and the mixture was refluxed for1.5 h. Then the mixture was poured into ice-H2O (60 mL) andextracted with EtOAc. The organic layer was washed by saturatedaqueous NaCl and dried over Na2SO4. It was then concentrated andpurified via flash chromatography on silica gel to get 6 g (Yield43.2%) of 6-(trifluoromethyl)benzo[d]thiazole (21n) as a yellow oil.ES-LCMS m/z: 204.0 (MH).

777-12-8, The synthetic route of 777-12-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Cao, Hengyi; Zhu, Guangya; Sun, Lin; Chen, Ge; Ma, Xinxin; Luo, Xiao; Zhu, Jidong; European Journal of Medicinal Chemistry; vol. 183; (2019);,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.56012-38-5,(2-Methylthiazol-5-yl)methanol,as a common compound, the synthetic route is as follows.

Step 6: Intermediate 5-h: To a solution of intermediate 5-g (1.0 g, 105.0 mmol) and intermediate 5-d (352 mg, 2.73 mmol) in THF (20 ml) were sequentially added triphenylphosphine (1.07 g, 4.1 mmol) and DIAD (796 p1, 4.1 mmol) at room temperature and the reaction was then stirred at room temperature for 1 hour. Volatiles were removed under reduced pressure. Purification by silica gel chromatography provided intermediate 5-h as yellow oil., 56012-38-5

56012-38-5 (2-Methylthiazol-5-yl)methanol 12808792, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; PHARMASCIENCE, INC.; LAURENT, Alain; ROSE, Yannick; WO2014/29007; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

62266-82-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62266-82-4,6-Bromobenzo[d]thiazol-2(3H)-one,as a common compound, the synthetic route is as follows.

tert-butyl 4-[(6-bromo-2-oxo-l ,3-benzothiazol-3(2H)-yl)methyl]piperidine-l- carboxylate (11-1) , ,To a round bottom flask was added 6-bromo-l,3-benzothiazol-2(3H)-one (0.300 g, 1.304 mmol), tert-butyl 4-(hydroxymethyl)piperidine-l -carboxylate (0.365 g, 1.695 mmol), triphenylphosphine (0.455 g, 1.695 mmol), diisopropyl (E)-diazene-l,2-dicarboxylate (DIAD) (0.330 mL, 1.695 mmol), and NMP (5 mL). The reaction mixture was then permitted to stir at room temperature for two hours. The crude reaction mixture was then diluted with methanol, filtered and concentrated. Purification of crude reaction mixture by reverse phasechromatography (Waters Sunfire MSC18, 30% acetonitrile / 0.1% trifluoroacetic acid / water? 100% acetonitrile / 0.1 % trifluoroacetic acid / water) fer/-butyl 4-[(6-bromo-2-oxo-l,3- benzothiazol-3(2H)-yl)methyl]piperidine-l -carboxylate (11-1) as a tan solid. HRMS (M+H)+: observed = 427.0691 , calculated – 427.0686.

62266-82-4 6-Bromobenzo[d]thiazol-2(3H)-one 188444, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; LAYTON, Mark, E.; KELLY, Michael, J.; WO2011/137046; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6436-59-5,Ethyl 2-methylthiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

6436-59-5, 476 ml of a 1.2 molar solution of DIBAH in toluene is slowly added in drops at -75 C. under nitrogen to a solution that consists of 60 g of 2-methylthiazole-4-carboxylic acid ethyl ester in 1070 ml of methylene chloride. It is stirred for 2 more hours. Then, 150 ml of isopropanol, and then 230 ml of water are slowly added in drops to it, the cold bath is removed and stirred vigorously at 25 C. for 2 more hours. The precipitate that is produced is suctioned off and rewashed with ethyl acetate. The filtrate is concentrated by evaporation in a vacuum, and the residue that is thus obtained is purified by chromatography on silica gel. 35.6 g of the title compound is obtained with hexane/ether 1:1 as a colorless oil.1H-NMR (CDCl3): delta=2.8 (3H), 8.05 (1H), 10.0 (1H) ppm.

6436-59-5 Ethyl 2-methylthiazole-4-carboxylate 293353, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Schering, AG; US7001916; (2006); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

913836-22-3, Methyl 5-bromothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

913836-22-3, To a stirred solution of methyl 5-bromo-1 ,3-thiazole-4-carboxylate (5.00 g, 22.52 mmol) in THF (80 mL) was added an aq. solution of LiOH.H20 (2.70 g, 1 12.58 mmol) in H20 (20 mL). The reaction mixture was stirred at room temperature for 18 h. DCM (50 mL) and H2O (20 mL) were then added and the reaction mixture acidified to pH~2 with 2 M aqueous HCI, followed by extraction with DCM (3 chi 20 mL). The combined organic extracts were washed with brine (20 mL), dried over MgSCU, filtered and concentrated under reduced pressure to give 5-bromo-1 ,3-thiazole-4-carboxylic acid (3.09 g, 66 % yield) as a yellow solid, which was used without further purification. LC-MS (Method D) 208.3/210.3 [M+H]+; RT 1.36 min

The synthetic route of 913836-22-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; REDX PHARMA PLC; STOKES, Neil; (163 pag.)WO2017/46603; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

121-66-4, 5-Nitrothiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

121-66-4, 5-Nitro-2-aminothiazole (1 eq)And triethylamine (1.2 eq) were dissolved in CH 2 Cl 2,Chloroacetyl chloride (1.2 eq) was added dropwise at 0 C,After the addition was completed, the reaction was continued for 5h,The reaction was checked by TLC, leaving no residue of the starting material and stopping the reaction.To the reaction mixture were added 100 ml of distilled water, the aqueous phase was extracted three times with CH 2 Cl 2 (3 ¡Á 100 ml), the organic phase was washed twice with saturated NaCl (2 ¡Á 100 ml), dried over anhydrous magnesium sulfate and then concentrated by evaporation to obtain a crude product. The crude product was purified by column chromatography on silica gel (methylene chloride: methanol = 150: 1, v: v) to give pure yellow solid in 82% yield.

As the paragraph descriping shows that 121-66-4 is playing an increasingly important role.

Reference£º
Patent; Shandong University; Hu Wei; Li Xun; Wang Chuandong; Li Xing; Wang Yan; Wu Yibo; Lu Di; Wu Hao; Zhang Yunxi; (8 pag.)CN106588813; (2017); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.440100-94-7,2-Bromothiazole-5-carbonitrile,as a common compound, the synthetic route is as follows.

2) 2-Bmothiazole-5-carbonitrile (955 mg, 5.05 mmol) obtained in (1) and diisopropylethylamine (1.80 mL, 10.1 mmol) were dissolved in 1,4-dioxane (20 mL). To the solution was added 1,2-amino-2-methylpropane (1.10 mL, 10.1 mmol) under ice-cooling, and the mixture was allowed to react at room temperature overnight. After the reaction mixture was concentrated, the residue was purified by silica gel column chromatography (chloroform/methanol=10/1) to obtain the title compound (895 mg, 4.57 mmol).yield: 90%<1>H NMR (CDCl3) delta (ppm): 7.64 (1H, s), 3.15 (2H, s), 1.21 (6H, s).APCIMS (m/z): 197 (M + H)<+>

440100-94-7, The synthetic route of 440100-94-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; KYOWA HAKKO KOGYO CO., LTD.; EP1354882; (2003); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

7210-76-6, Ethyl 2-amino-4-methylthiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,7210-76-6

An aqueous solution of 1M-sodium hydroxide (50 ml) was added to an ethanol solution (100 ml) of ethyl 2-amino-4-methylthiazole-5-carboxylate (3.0 g) and the mixture was stirred at room temperature for 26 hours. After distilling off the solvent, acetic acid was added thereto under ice cooling (pH=5). Water was added thereto, the resultant mixture was stirred, and the crystal was collected by filtration. The crystal was washed with water, thereby obtaining 2-amino-4-methyl-thiazole-5-carboxylic acid (2.5 g) as a colorless solid.

7210-76-6 Ethyl 2-amino-4-methylthiazole-5-carboxylate 343747, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; TAISHO PHARMACEUTICAL CO., LTD.; US2012/220767; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

78502-71-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78502-71-3,Ethyl 2-(bromomethyl)thiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

Example 7; 2-{(3-phenyl-1H-indazol-1-yl)methyl}thiazole-4-carboxylic acidSodium hydride (added with 40% mineral oil, 9 mg, manufactured by Kanto Chemical Co., Inc.) was added to a solution of 3-phenyl-1H-indazole (40 mg), which had been synthesized according to the literature (T. Edward, C., et al., Tetrahedron, 1991, 47, 9599-9620), in N,N-dimethylformamide (1 mL, manufactured by Kanto Chemical Co., Inc.) under ice cooling, and the mixture was stirred for 5 minutes at the same temperature. Subsequently, ethyl 2-bromomethylthiazole-4-carboxylate (51 mg) synthesized according to the method of the literature (K. Benno, et al., Leibigs. Ann. Chem., 1981, 4, 623-632) was added thereto, and the mixture was stirred overnight at room temperature. Water (1 mL) was added to the reaction solution, and the mixture was extracted with ethyl acetate (3¡Á2 mL), washed with brine (10 mL), and dried (MgSO4). The solvent was then evaporated. The resulting residue was purified by PTLC (hexane:ethyl acetate=2:1), to give 7.2 mg of the title compound. LC-MS: HPLC retention time 4.08 minutes, m/z 336 (M+H), condition A-1.

The synthetic route of 78502-71-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASAHI KASEI PHARMA CORPORATION; US2010/29733; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica