Heterocyclic Building Blocks-Thiazole

2634-33-5, 1,2-Benzothiazol-3-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The acid 4 (5 mmol), EDC (1.2 g, 6.26 mmol), HOBt (0.9 g,5.88 mmol), NMM (1.2 mL, 10.74 mmol), and dichloromethane (10 mL) were mixed at ice-bath and stirred at 0 C for half an hour. 1,2-Benzisothiazol-3-one 1 (800 mg, 5.3 mmol) was added to NMM (1.6 mL, 14.32 mmol) in 10 mL of dichloromethane at 0 Ct hen the above mixture was added and stirred at room temperature overnight. After stirring overnight, the mixture was diluted with CH2Cl2, and then successively through washed with water, 5% KHSO4 solution, saturated NaHCO3 solution, and brine, the extract was dried with anhydrous Na2SO4 and evaporated under vacuum. The product was isolated by column chromatography (petroleum ether/CH2Cl2, 10:1) to yield the final compound. 4.2.8 2-(2-(2-Fluorophenyl)acetyl)benzo[d]isothiazol-3(2H)-one (12) Compound 12 was prepared through 2-fluorophenylacetic acid, obtained a white solid in 75% yield. Mp 154.3-155.5 C. 1H NMR (400 MHz, DMSO-d6) delta 7.99 (d, J = 8.0 Hz, 2H), 7.82 (td, J = 8.0, 1.2 Hz, 1H), 7.50 (t, J = 8.0 Hz, 1H), 7.42-7.34 (m, 2H), 7.23-7.17 (m, 2H), 4.52 (s, 2H). 13C NMR (101 MHz, DMSO-d6) delta 170.4, 163.8, 161.3 (d, J = 243 Hz), 141.5, 135.2, 132.7 (d, J = 4.0 Hz), 129.8 (d, J = 8.0 Hz), 127.5, 126.7, 125.5, 124.8 (d, J = 3.0 Hz), 122.7, 121.6 (d, J = 16 Hz), 115.5 (d, J = 21 Hz), 37.5. IR (KBr, cm-1): 1705, 1690. HRMS-ESI (m/z) calcd for C15H10FNO2S [M+H+] 288.0494, found 288.0495., 2634-33-5

As the paragraph descriping shows that 2634-33-5 is playing an increasingly important role.

Reference£º
Article; Li, Zhenghui; Pan, Yang; Zhong, Weilong; Zhu, Yunpeng; Zhao, Yongle; Li, Lixin; Liu, Wei; Zhou, Honggang; Yang, Cheng; Bioorganic and Medicinal Chemistry; vol. 22; 24; (2014); p. 6735 – 6745;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3034-55-7, 5-Bromothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5-Bromothiazole (1.55 g, 9.0 mmol), piperidine (2.7 mL, 27.0 mmol), sodium tert-butoxide (1.78 g, 18.0 mmol), Rh(cod)2BF4 (73 mg, 2.0 mol %), 1,3-diisopropylimidazolium chloride (70 mg, 4.0 mol %) and 1,2-dimethoxyethane (9 mL) were mixed under argon atmosphere. The reaction mixture was vigorously stirred at 80 C overnight, then it was cooled down to room temperature and diluted with AcOEt. The crude reaction was filtered through a pad of silica gel, the organic solvents were evaporated and the residue was purified by flash chromatography on silica gel using as eluent CH2Cl2/AcOEt 10:0.5, then 10:1, to afford a slightly yellow oil (1.40 g; 92%). Found: C 57.49, H 6.92, N 16.48. C8H12N2S requires C 57.11, H 7.19, N 16.65%. IR (Nujol, cm-1): 1651 (CN), 1558 (CC), 1539 (CC). 1H NMR (400 MHz, CDCl3): delta 8.16 (s, 1H), 7.01 (s, 1H), 3.15-3.05 (m, 4H), 1.75-1.68 (m, 4H), 1.60-1.53 (m, 2H). 13C NMR (75 MHz, CDCl3): delta 156.0, 140.5, 122.3, 53.5, 25.1, 23.5. HRMS (ESI+): found 169.0789 [M+H]+. C8H13N2S requires 169.0794., 3034-55-7

As the paragraph descriping shows that 3034-55-7 is playing an increasingly important role.

Reference£º
Article; Galan, Elena; Andreu, Raquel; Garin, Javier; Mosteo, Laura; Orduna, Jesus; Villacampa, Belen; Diosdado, Beatriz E.; Tetrahedron; vol. 68; 32; (2012); p. 6427 – 6437;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

16629-15-5, 2-Bromo-5-chlorothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2-bromo-5-chlorothiazole (0.068 g, 0.34 mmol, 1.0 eq) in 1,4-dioxane (2.0 mL) was added compound 199.3 (0.10 g, 0.41mmol, 1.2eq) followed by addition of 1M aq. Na2C03 (0.68 mL, 0.68 mmol, 2.0 eq). Reaction mixture was degassed with argon for 10 min and Pd(PPh3)4 (0.037g, 0.034mmol, O. leq) was added. Reaction mixture was stirred at 100 C for 16 h. After completion of reaction was quenched with water and extracted with EtOAc. Organic layers were combined, washed with brine, dried over Na2S04 and concentrated under reduced pressure to obtain crude material. The crude was purified by column chromatography to furnish 1.4. (0.025 g, 23.0 %). MS(ES): m/z 314.4 [M]+

16629-15-5, The synthetic route of 16629-15-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NIMBUS LAKSHMI, INC.; GREENWOOD, Jeremy Robert; HARRIMAN, Geraldine C.; LEIT DE MORADEI, Silvana Marcel; MASSE, Craig E.; MCLEAN, Thomas H.; MONDAL, Sayan; (401 pag.)WO2018/71794; (2018); A1;,
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Thiazole | chemical compound | Britannica

556-90-1, 2-aminothiazol-4(5H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,556-90-1

2a (1 g, 8.62 mmol) was added to 15 mL of 20% dilute hydrochloric acid and refluxed for 10h. It was concentrated and cooled giving a white solid precipitate. It was filtered, washed, and recystallized with 70% ethanol. Dried to obtain 0.78 g of white needle-like crystals, yield 77.2%.

The synthetic route of 556-90-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; China Pharmaceutical University; Lai, Yisheng; Wang, Hui; Sun, Qirui; Zhang, Yingyi; Li, Yuezhen; Zhang, Yihua; (22 pag.)CN105884712; (2016); A;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78364-55-3,6-Fluoro-2-hydrazinylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 2-hydrazinobenzothiazole 1a (0.825 g, 5 mmol)and alpha-cyanoacetophenone 2a (0.73 g, 5 mmol) was refluxed in ethanol containing acetic acid (3ml) for 5-6 h. Excess solvent was removed by distillation. The crude product so obtained was recrystallized from ethanol to give 5a (1.09 g, 75percent), Mp 201 ¡ã C (lit.[20], 202 ¡ã C). Other compounds (5b-d) of this type were prepared similarly.

78364-55-3, The synthetic route of 78364-55-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Aggarwal, Ranjana; Kumar, Virender; Bansal, Anshul; Sanz, Dionisia; Claramunt, Rosa M.; Journal of Fluorine Chemistry; vol. 140; (2012); p. 31 – 37;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

615-21-4, 2-Hydrazinylbenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

615-21-4, 2.00 g of the compound represented by the formula (C-3-1) and 20 mL of tetrahydrofuran were placed in a reaction vessel under a nitrogen atmosphere.While cooling with ice, 0.69 g of sodium methoxide was added, and the mixture was stirred at room temperature for 2 hours.A solution obtained by dissolving 3.17 g of the compound represented by the formula (C-3-2) in 5 mL of tetrahydrofuran was added dropwise.After stirring at room temperature for 5 hours, it was diluted with 100 mL of dichloromethane and poured into water.The organic layer was washed with brine and dried over sodium sulfate, and the solvent was evaporated.By subjecting column chromatography (ruthenium gel, dichloromethane) and recrystallization (dichloromethane/hexane), 2.67 g of the compound of formula (C-3) was obtained.The yield of the compound represented by the formula (C-3-1) was 80%. The reaction solution after the reaction showed a light coloration.

As the paragraph descriping shows that 615-21-4 is playing an increasingly important role.

Reference£º
Patent; DIC CORPORATION; HORIGUCHI, MASAHIRO; MAMIYA, JUNICHI; (100 pag.)TW2019/14995; (2019); A;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1235406-28-6,3-Cyano-4-fluoro-N-(thiazol-2-yl)benzenesulfonamide,as a common compound, the synthetic route is as follows.

General procedure: A 0.2M solution in DMSO of the compound of formula (IV) (500 muL, 100 mumol) was added to a 0.2M solution in DMSO of the compound of formula (II) (500 muL, 100 mumol) followed by anhydrous potassium phosphate (64 mg, 300 mumol). The reaction mixture was heated to 80 C. for 16 hours before concentrating in vacuo. The residue was dissolved in DMSO (1 mL) and purified using preparative HPLC as described below to afford the desired compound of formula (I). The compounds of the Examples in the table belowwere prepared from the appropriate sulphonamide and: (a)3-cyano-4-fluorophenol; (b) 3,4-difluorophenol or (c)3-chioro-4-cyanophenol; according to Library Protocol 3.1., 1235406-28-6

1235406-28-6 3-Cyano-4-fluoro-N-(thiazol-2-yl)benzenesulfonamide 58042268, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; PFIZER LIMITED; Owen, Robert McKenzie; Storer, Robert Ian; US2014/315933; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1003-32-3,Thiazole-5-carboxyaldehyde,as a common compound, the synthetic route is as follows.

A solution of (2,6-di-tert-butyl-4H-pyran-4yl)tributylphosphonium perchlorate 1b (607 mg, 1.23 mmol) in anhydrous THF (10 mL) was prepared, purged with argon and cooled to -78 C. To this solution, n-BuLi (1.6 M in hexanes) (0.77 mL, 1.59 mmol) was added dropwise and the resulting mixture was stirred for 15 min. Then thiazole-5-carbaldehyde 4 (86 mg, 0.94 mmol) in anhydrous THF (7 mL) was added dropwise and the mixture was progressively heated to reach 0 C during 4 h. Saturated NH4Cl solution was added to quench the reaction and the solvent was evaporated under reduce pressure. The organic layer was extracted with dichloromethane, washed with water and dried over anhydrous MgSO4. After removal of the solvent, the product was purified by alumina column chromatography (30% ethyl acetate in hexanes). Yield: orange solid (219 mg, 0.75 mmol; 88%). Mp 60-61 C. IR (KBr): cm-1 1577 (C=C). 1H NMR (300 MHz, CD2Cl2): delta (ppm) 8.52 (s, 1H), 7.63 (s, 1H), 6.23 (d, J = 2.0 Hz, 1H), 5.81 (s, 1H), 5.69 (d, J = 2.0 Hz, 1H), 1.24 (s, 9H), 1.20 (s, 9H). 13C NMR (75 MHz, CD2Cl2): delta (ppm) 165.7, 163.2, 148.8, 140.2, 137.2, 131.9, 104.6, 99.9, 98.9, 36.2, 35.7, 28.2, 28.1. HRMS (ESI+): m/z calcd for [C17H24NOS]+: 290.1573, found: 290.1577., 1003-32-3

The synthetic route of 1003-32-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Perez Tejada, Raquel; Pelleja, Laia; Palomares, Emilio; Franco, Santiago; Orduna, Jesus; Garin, Javier; Andreu, Raquel; Organic electronics; vol. 15; 11; (2014); p. 3237 – 3250;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.133046-46-5,Ethyl 2-(trifluoromethyl)thiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

Ethyl 2-(trifluoromethyl)-1,3-thiazole-4-carboxylate (80 mg) in ethanol (1 ml) was treated with 2N sodium hydroxide (0.706 ml) and the solution stirred at room temperature for 18 h. 2M Hydrochloric acid (0.54 ml) was added and the mixture blown down to dryness. The residue was dried under vacuum over phosphorous pentoxide and was then suspended in dry dichloromethane (1 ml) and treated at room temperature with oxalyl chloride (0.032 ml) and DMF (1 drop). The mixture was stirred at room temperature for 30 mins and then added dropwise to a solution of Intermediate 16 (98 mg) in acetonitrile (2 ml) and the mixture was stirred at room temperature for 22 h. The mixture was diluted with dichloromethane (15 ml), washed with brine (2¡Á15 ml) and blown down to dryness. The residue was purified by mass directed autoprep HPLC followed by SPE cartridge (5 g, aminopropyl) eluting with methanol. The eluent was blown down to dryness to give Example 339 as a brown gum (96 mg). LCMS showed MH+=483; TRET=2.57 min.

133046-46-5, The synthetic route of 133046-46-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Edlin, Christopher David; Holman, Stuart; Jones, Paul Spencer; Keeling, Suzanne Elaine; Lindvall, Mika Kristian; Mitchell, Charlotte Jane; Trivedi, Naimisha; US2009/131431; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.541-58-2,2,4-Dimethylthiazole,as a common compound, the synthetic route is as follows.,541-58-2

General procedure: Aniline ligand (10.0mmol) and palladium dichloride (0.886g, 5.0mmol) were dissolved in 15mL of DMAc at room temperature. After the mixture was stirred for 0.5hat 80C, the methanol (50mL) was added and the precipitation was formed. The precipitate of palladium complexes was then dissolved in 5mL dichloromethane, then 20mL hexane was added. After crystallized from the mixture of ethanol and dichloromethylene, the palladium complex was obtained as light yellow crystals.

The synthetic route of 541-58-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; He, Xiao-Xi; Li, Yan-Fang; Huang, Ju; Shen, Dong-Sheng; Liu, Feng-Shou; Journal of Organometallic Chemistry; vol. 803; (2016); p. 58 – 66;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica