New learning discoveries about 349-49-5

As the paragraph descriping shows that 349-49-5 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.349-49-5,4-(Trifluoromethyl)thiazol-2-amine,as a common compound, the synthetic route is as follows.

(Example 48) 4-Hydroxy-4-(trifluoromethyl)-3-{1-[4-(trifluoromethyl)1,3-thiazol-2-yl]piperidin-4-yl}-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-b]pyridin-6-one (hereinafter, referred to as compound 48-a)[0476] Copper(II) chloride (2.90 g, 21.57 mmol) was added to a solution of 2-amino-4-(trifluoromethyl)thiazole (3.05 g, 18.14 mmol) in acetonitrile (80 mL), then isoamyl nitrite (3.60 mL, 27.04 mmol) was added dropwise thereto at 0¡ãC, and the mixture was stirred at room temperature for 1 hour and at 50¡ãC for 2 hours. Then, the solvent in the reaction solution was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography [elute: hexane/ethyl acetate = 100/0 – 70/30 (gradient)] to obtain an oil (1.12 g)._: [0478] 4-Hydroxy-3-(piperidin-4-yl)-4-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-b]pyridin-6-one (62 mg, 0.18 mmol) produced in Reference Example 60 and N,N-diisopropylethylamine (40 muL, 0.24 mmol) were added to a solution of the obtained oil (55 mg) in dimethyl sulfoxide (2 mL), and the mixture was stirred at room temperature for 5 hours and further at 0¡ãC for 2 hours and 30 minutes. The reaction solution was diluted with ethyl acetate, washed with water and brine, and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography [elute: hexane/ethyl acetate = 70/30 – 10/90 (gradient)] to obtain the title compound 48-a (6 mg, yield: 6percent) and compound 48-b (18 mg, yield: 16percent). Compound 48-a 1H-NMR (400 MHz, DMSO-d6) delta: 12.29 (1H, s), 10.53 (1H, s), 7.54 (1H, s), 6.79 (1H, s), 4.05-3.96 (2H, m), 3.40-3.20 (1H, m), 3.14 (2H, t, J = 12 Hz), 2.90 (1H, d, J = 16 Hz), 2.73 (1H, d, J = 16 Hz), 1.94-1.74 (4H, m); MS (ESI) m/z: 456 (M+H)+.Compound 48-b 1H-NMR (400 MHz, DMSO-d6) delta: 12.27 (1H, s), 10.54 (1H, s), 8.61 (1H, s), 6.80 (9H, s), 4.10 (2H, d, J = 13 Hz), 3.33-3.18 (3H, m), 2.90 (1H, d, J = 16 Hz), 2.73 (1H, d, J = 16 Hz), 1.99-1.74 (4H, m); MS (ESI) m/z: 607 (M+H)+., 349-49-5

As the paragraph descriping shows that 349-49-5 is playing an increasingly important role.

Reference£º
Patent; Daiichi Sankyo Company, Limited; KOBAYASHI, Hideki; OHKAWA, Nobuyuki; TAKANO, Daisuke; KUBOTA, Hideki; ONODA, Toshio; KANEKO, Toshio; ARAI, Masami; TERASAKA, Naoki; EP2862861; (2015); A1;,
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Some tips on 53266-94-7

The synthetic route of 53266-94-7 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53266-94-7,Ethyl 2-(2-aminothiazol-4-yl)acetate,as a common compound, the synthetic route is as follows.,53266-94-7

A neat mixture of 54 g (0.29 mole) ethyl (2-aminothiazol-4-yl) acetate and 50 g (0.276 mole) benzophenone imine was stirred at 190 ¡ãC for 5 h and then cooled at RT and diluted with 100 mL of CH2CL2. The entire mixture was transferred onto a silica gel column and eluted with 20percent EtOAc/Hexane. The title compound was obtained as light-yellow solid (70 g, 69percent yield). 1H NMR (300 MHz, CDC13) : 81. 26 (t, 3H), 3.74 (s, 2H), 4.15 (q, 2H), 6.87 (s, 1H), 77.25-7. 86 (m, 10 H) ; Mass Spectrum (NH3-CI): m/z 351 (M+1).

The synthetic route of 53266-94-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK & CO., INC.; WO2005/14537; (2005); A2;,
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New learning discoveries about 35272-15-2

As the paragraph descriping shows that 35272-15-2 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35272-15-2,2-Methylthiazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.

To 2-methyl-1 ,3-thiazole-4-carboxylic acid (1 g) was added thionyl chloride (5 ml). The mixture was heated at 80 ¡ãC for 8 h. Thionyl chloride (5 ml) was added and the mixture heated for 2 h at 80 ¡ãC. Further thionyl chloride (5 ml) was added and the mixture heated for 2 h. The mixture was concentrated in vacuo and azeotroped with toluene to give the title compound, 1 .12 g.1H NMR (DSMO) delta 8.34 (s, 1 H), 2.80 (s, 3H), 35272-15-2

As the paragraph descriping shows that 35272-15-2 is playing an increasingly important role.

Reference£º
Patent; GLAXO GROUP LIMITED; BALDWIN, Ian Robert; DOWN, Kenneth David; FAULDER, Paul; GAINES, Simon; HAMBLIN, Julie Nicole; JONES, Katherine Louise; LE, Joelle; LUNNISS, Christopher James; PARR, Nigel James; RITCHIE, Timothy John; ROBINSON, John Edward; SMETHURST, Christian Alan Paul; WO2011/67366; (2011); A1;,
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Brief introduction of 348-40-3

348-40-3, As the paragraph descriping shows that 348-40-3 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.348-40-3,6-Fluorobenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

Hydrochloric acid (10 mL) was added dropwise to hydrazine hydrate 99% (10 g, 0.2 mol) at 5-10 C, followed by addition of a solution of 2-amino-6-fluorobenzothiazole (1) (3.364 g, 0.02 mol) in ethylene glycol (40 mL). The mixture was heated at reflux temperature for 5 h. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from ethanol. Yield 89%, m.p. 194-196 C [1].

348-40-3, As the paragraph descriping shows that 348-40-3 is playing an increasingly important role.

Reference£º
Article; Gabr, Moustafa T.; El-Gohary, Nadia S.; El-Bendary, Eman R.; El-Kerdawy, Mohamed M.; Ni, Nanting; Chinese Chemical Letters; vol. 27; 3; (2016); p. 380 – 386;,
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Downstream synthetic route of 5398-36-7

The synthetic route of 5398-36-7 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5398-36-7,Ethyl 2-aminothiazole-4-carboxylate,as a common compound, the synthetic route is as follows.,5398-36-7

Thiazole 4b (0.439 g 2.5 mmol) was dissolved in a mixture ofCH2Cl2:THF (1:1) (10 mL). (Boc)2O (0.577 g, 2.65 mmol) and TEA (0.744 g, 7.36 mmol) were added. The mixture was refluxed for 72 h and then concentrated under reduced pressure. The residue was disolved in AcOEt, washed with HCl 5% v/v (3 x 15 mL), dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by silica flash cromatography AcOEt:EP (3:7). White solid. Yield 74%. 1H NMR ((CD3)2CO, 400 MHz): delta 1.33 (t, 3H,J =7.2 Hz), 1.54 (s, 9H), 4.30 (q, 2H, J = 7.2 Hz), 7.22 (s, 1H), 10.33 (s,1H). 13C NMR ((CD3)2CO, 100 MHz): delta 14.6, 28.2, 61.1, 82.2, 122.4,143.0, 160.4, 161.8.

The synthetic route of 5398-36-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Franco, Jaime; Medeiros, Andrea; Benitez, Diego; Perelmuter, Karen; Serra, Gloria; Comini, Marcelo A.; Scarone, Laura; European Journal of Medicinal Chemistry; vol. 126; (2017); p. 776 – 788;,
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New learning discoveries about 53332-78-8

The synthetic route of 53332-78-8 has been constantly updated, and we look forward to future research findings.

53332-78-8, Thiazol-2-ylmethanamine dihydrochloride is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

53332-78-8, Step 2.5-(methylthio)-N-(thiazol-2-ylmethyl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7- amine A mixture of crude 5-(methylthio)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl trifluoromethanesulfonate (130 mg, 0.43 mmol), 2-(aminomethyl)thiazole dihydrochloride (99 mg, 0.529 mmol) and DIPEA (0.33 mL, 1.89 mmol) in 1,4-dioxane (2.0 mL) was stirred at room temperature 16.5 h. All volatiles were removed by rotary evaporation, and the crude residue was purified by chromatography on silica gel (gradient 0-20% methanol in DCM) to afford the title compound (22 mg, 18% over 2 steps) as an off-white solid: ESI MS m/z 280 [M + H]+; 1H NMR (500 MHz, DMSO-d6) G 9.99 (t, J = 6.0 Hz, 1H), 8.45 (s, 1H), 7.76 (d, J = 3.3 Hz, 1H), 7.67 (d, J = 3.3 Hz, 1H), 4.97 (d, J = 6.1 Hz, 2H), 2.50 (s, 3H).

The synthetic route of 53332-78-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; THE GENERAL HOSPITAL CORPORATION; UNITED STATES DEPARTMENT OF HEALTH AND HUMAN SERVICES; SLAUGENHAUPT, Susan, A.; JOHNSON, Graham; PAQUETTE, William, D.; ZHANG, Wei; MARUGAN, Juan; (306 pag.)WO2016/115434; (2016); A1;,
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Some tips on 1003-32-3

The synthetic route of 1003-32-3 has been constantly updated, and we look forward to future research findings.

1003-32-3, Thiazole-5-carboxyaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3:Ammonium formate (8.75 g), thiazole-5-carbaldehyde (5.23 g), and isonitrile 3 (12.0 g) were dissolved in MeOH (100 mL) and heated to reflux for 4 h. The solution was concentrated to approximately 20 mL of MeOH and EtOAc (200 mL) was added. The mixture was filtered and the solvent evaporated to yield a light brown solid. Trituration with ether provided a white solid (5.70 g), which was used without further purification in the following step. MS (ESI) 350 (M+H)., 1003-32-3

The synthetic route of 1003-32-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SCHERING CORPORATION; N. V. ORGANON; HO, Ginny, D.; SEGANISH, William, M.; TULSHIAN, Deen, B.; TIMMERS, Cornelis Marius; RIJN, Rachel Deborah Van; LOOZEN, Hubert Jan Jozef; WO2011/8597; (2011); A1;,
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New learning discoveries about 31699-14-6

The synthetic route of 31699-14-6 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31699-14-6,2-Amino-4-(4-iodophenyl)thiazole,as a common compound, the synthetic route is as follows.

General procedure: The general protocol followed by us in obtaining 2-(2,4-dioxo-1,3-thiazolidin-5-yl)acetamide compounds 4a-o is illustrated for the synthesis of N-(4-phenyl-1,3-thiazol-2-yl)-2-(2,4-dioxo-1,3-thiazolidin-5-yl)acetamide (4a) as an example. A solution of compound 1 (0.4 g, 2.55 mmol) in DCM (10 mL) is cooled to 0 C and then charged with HOBT (0.36 g, 2.4 mmol), followed by HBTU (0.90 g, 2.4 mmol). The reaction mixture is stirred at 0 C for 45 min. After that, a solution of 4-phenylthiazol-2-amine, 3a (0.29 g,1.70 mmol) and DIEA (0.8 mL, 5.1 mmol) in a mixture of DCM (5 mL) and DMF (2.5 mL) is added drop wise over 5 min. The reaction temperature is initially maintained at 0 C for 1 h and later at RT for 10 h. Completion of reaction is evidenced by TLC analysis. After evaporating the DCM solvent on rotavapor, the reaction mixture is diluted with 40 mL of distilled water and extracted with (3 15 mL) of ethyl acetate. The combined organic layer is washed with saturated aqueous sodium bicarbonate solution (2 10 mL), followed by saturated aqueous sodium chloride solution (2 20 mL). After drying over anhydrous sodium sulfate, the organic layer is filtered and the filtrate is stripped off the solvent. The crude product thus obtained is purified by column chromatography over silica gel. The rest of the 2-(thiazolidinedion-5-yl)acetamide derivatives (4b-o) are prepared similarly by reacting 2,4-dioxo-1,3-thiazolidine-5-acetic acid (1) with the appropriate amine (3b-o)., 31699-14-6

The synthetic route of 31699-14-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Koppireddi, Satish; Komsani, Jayaram Reddy; Avula, Sreenivas; Pombala, Sujitha; Vasamsetti, Satishbabu; Kotamraju, Srigiridhar; Yadla, Rambabu; European Journal of Medicinal Chemistry; vol. 66; (2013); p. 305 – 313;,
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Simple exploration of 63837-11-6

The synthetic route of 63837-11-6 has been constantly updated, and we look forward to future research findings.

63837-11-6,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63837-11-6,5-Bromo-2-methylbenzothiazole,as a common compound, the synthetic route is as follows.

EXAMPLE 17A 4-(2-methyl-1,3-benzothiazol-5-yl)benzoic acid The desired product was prepared by substituting 5-bromo-2-methyl-1,3-benzothiazole for 6-bromoindole in Example 4A. MS (DCI) m/e 270 (M+H)+.

The synthetic route of 63837-11-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Augeri, David J.; Baumeister, Steven A.; Bruncko, Milan; Dickman, Daniel A.; Ding, Hong; Dinges, Jurgen; Fesik, Stephen W.; Hajduk, Philip J.; Kunzer, Aaron R.; McClellan, William; Nettesheim, David G.; Oost, Thorsten; Petros, Andrew M.; Rosenberg, Saul H.; Shen, Wang; Thomas, Sheela A.; Wang, Xilu; Wendt, Michael D.; US2002/55631; (2002); A1;,
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Thiazole | chemical compound | Britannica

New learning discoveries about 199475-45-1

199475-45-1, 199475-45-1 5-Bromobenzo[d]thiazol-2(3H)-one 2801273, athiazole compound, is more and more widely used in various fields.

199475-45-1, 5-Bromobenzo[d]thiazol-2(3H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 5-bromo-3H-1,3-benzothiazol-2-one (94.4 mg,0.410 mmol)in water(2.1 mL)was added NaOH (16.4 mg,0.410 mmol)and then dimethyl sulfate (62.1 mg,0.492mmol). After stirring at room temperature for 3 h,the resulting precipitate was filtered,washedwith water,and dried under reduced pressure to give the title compound (89.3 mg,89%)as awhite powder that required no further purification. 1H NMR (400 MHz,CDCl3)8 7.32- 7.2915 (m,2H),7.20 (dd,J = 1.5,0.6 Hz,1H),3.45 (s,3H).

199475-45-1, 199475-45-1 5-Bromobenzo[d]thiazol-2(3H)-one 2801273, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; CYR, Patrick; BRONNER, Sarah; ROMERO, F. Anthony; MAGNUSON, Steven; TSUI, Vickie Hsiao-Wei; WAI, John; LAI, Kwong Wah; WANG, Fei; (251 pag.)WO2017/205536; (2017); A2;,
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Thiazole | chemical compound | Britannica