Heterocyclic Building Blocks-Thiazole

2289-75-0, 4,5-Dimethylthiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 1N-(4,5-dimethylthiazol-2-yl)-2-[5-(6,7-dimethoxyquinazolin-4-yloxy)pyridin-2- yl]acetamideTriethylamine (0.245 ml) and 2-(7-azabenzotriazol-l-yl)-l,l,3,3-tetramethyluronium hexafluoropliosphate(V) (0.236 g) were added in turn to a stirred mixture of2-[5-(6,7-dimethoxyquinazolin-4-yloxy)pyridin-2-yl]acetic acid (0.2 g), 2-amino- 4,5-dimethylthiazole (0.083 g) and DMF (2 ml) and the resultant mixture was stirred at ambient temperature for 40 minutes. A mixture of a saturated aqueous sodium bicarbonate solution (5 ml) and a saturated aqueous sodium carbonate solution (5 ml) was added and the resultant mixture was stirred at ambient temperature for 1 hour. The precipitate was isolated and triturated under diethyl ether. The resultant solid was dried under vacuum at 400C for 16 hours. There was thus obtained the title compound as a solid (0.185 g); 1H NMR: (DMSOd6) 2.1 (s, 3H), 2.2 (s, 3H), 4.0 (m, 8H), 7.4 (s, IH), 7.5 (d, IH), 7.6 (s, IH), 7.8 (m, IH), 8.5 (m, IH), 8.55 (s, IH): Mass Spectrum: M-H’ 450., 2289-75-0

The synthetic route of 2289-75-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/99317; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.133840-96-7,2-Chloro-6-(trifluoromethoxy)benzo[d]thiazole,as a common compound, the synthetic route is as follows.

General procedure: 2-Chloro-6-trifluoromethoxy-benzothiazole (1.27 g, 5 mmol)was dissolved in 10 mL ethylamine aqueous solution. Theresultant mixture was stirred at room temperature overnight.The solvent was removed under reduced pressure. Theresidue was dissolved in CH2Cl2 and washed three timeswith water, dried over anhydrous Na2SO4, filtered and thesolvent completely removed. The crude material was purifiedby column chromatography over silica used dichloromethaneas eluent to give compound 4a as a whiteamorphous powder (1.11 g, 84.7%). Compounds 4b-4iwere also prepared by the same procedure from compound3 with n-butylamine, diaethylamin, cyclohexylamine, pyrrolidine,piperidine, morpholine, and 4-methylpiperidine,respectively. Spectroscopic data of N-alkylated derivativesof riluzole were given as follow., 133840-96-7

133840-96-7 2-Chloro-6-(trifluoromethoxy)benzo[d]thiazole 10037924, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Wu, Xiang-Long; Liu, Liu; Li, You-Jia; Luo, Jie; Gai, Dong-Wei; Lu, Ting-Li; Mei, Qi-Bing; Medicinal Chemistry Research; vol. 27; 5; (2018); p. 1374 – 1383;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

247037-82-7, Thiazole-2-carboximidamide hydrochloride is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of thiazole-2-carboximidamide hydrochloride (5.49 g, 33.6 mmol) and sodium bicarbonate (5.64 g, 67.1 mmol) in NMP (46 ml) at 120 C. was added a solution of the compound from Step 2-2a (8.80 g, 33.6 mmol) in NMP (20 ml). The mixture was heated at 120 C. under N2 for 2.5 h before being allowed to cool down and diluted with MTBE and water. The organic layer was washed with water (*1), brine (*1), dried over Na2SO4 (s), filtered and concentrated. The residue was purified by flash column chromatography (silica, hexanes/EtOAc) to afford the desired compound as yellow oil (5.10 g, 41%). ESI MS m/z=372.13 [M+H]+., 247037-82-7

As the paragraph descriping shows that 247037-82-7 is playing an increasingly important role.

Reference£º
Patent; ENANTA PHARMACEUTICALS, INC.; Qiu, Yao-Ling; Cao, Hui; Peng, Xiaowen; Li, Wei; Kass, Jorden; Gao, Xuri; Jin, Meizhong; Or, Yat Sun; (49 pag.)US2017/355701; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109113-98-6,6-(Trifluoromethyl)imidazo[2,1-b]thiazole,as a common compound, the synthetic route is as follows.

At 00C POCl3 (17.1 mmol) is added dropwise to a solution of DMF (20.6 mmol) in chloroform (5.0 mL). A solution of 6-trifluoromethyl-imidazo[2,l-b]thiazole (3.17 mmol) in chloroform (15 mL) is added dropwise at 00C and the mixture is stirred for 3h at RT. After heating for 2.5d to reflux the mixture is poured into ice, extracted three times with DCM, dried over MgSO4 and concentrated under reduced pressure. DCM is added, the obtained precipitate is filtered off and the filtrate is concentrated in vacuo to give a crude product which is dissolved in tert.-butanol (19.5 mL). A solution of sodium chlorite (23.0 mmol) and sodium dihydrogen phosphate dihydrate (17.6 mmol) in water (19.5 mL) is added dropwise and the mixture is stirred for 90 min at RT. The solvents are partially removed in vacuo and the obtained precipitate is filtered off to give the desired product as a white solid. LC-MS: tR = 0.73 min; [M+H]+ = 237.2.

109113-98-6, 109113-98-6 6-(Trifluoromethyl)imidazo[2,1-b]thiazole 11084696, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; WO2009/16560; (2009); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2786-51-8, 5-Chlorobenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,2786-51-8

General procedure: A mixture of benzothiazole 1a (67.5 mg, 0.5 mmol), cyclohexane-1,3-dione 2b (112 mg, 1 mmol), KH2PO4 (136 mg, 1 mmol), DMSO (2 mL) and water (2 mL) were placed into a 15 mL flask under air. The reaction mixture was stirred in oil bath for 3 days at 80 C. The progress of the reaction was monitored by TLC. When the reaction was complete, it was neutralised with a saturated KHCO3 aqueous solution, and extracted with ethyl acetate (3 ¡Á10 mL). The extract was washed with water (3 ¡Á 5 mL) and dried over anhydrous Na2SO4. After drying, it was concentrated under reduced pressure to give the crude product, which was further purified by silica-gel column chromatography to afford 2,3-dihydro-10H-phenothiazin-4 (1H)-ones 3b (93.2 mg, yield: 86%).

As the paragraph descriping shows that 2786-51-8 is playing an increasingly important role.

Reference£º
Article; Suliman, Ayman Mohammed Yousif; Li, Yanjun; Zhang, Shaonan; Yuan, Yu; Journal of Chemical Research; vol. 39; 11; (2015); p. 657 – 660;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

886361-30-4, Methyl 2-amino-5-(4-fluorophenyl)thiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In an inert atmosphere, copper(II)bromide (47.3 mmol, 1.0 eq) was suspended in MeCN (200 mL) and cooled to 5-10 C. followed by the addition of 3-methylbutylnitrite (71 mmol, 1.45 eq) over 15 min. To this reaction mixture the respective 2-aminothiazole derivative (47.3 mmol, 1 eq) was added in portions over 35 min at 5-10 C. The reaction mixture was then carefully heated to 65 C. and stirring continued for 2 h. The volatiles were removed under reduced pressure and the black residue was purified by FC (heptane/EtOAc, as the appropriate mixture) to give the products as slightly yellow oils or solids

886361-30-4, 886361-30-4 Methyl 2-amino-5-(4-fluorophenyl)thiazole-4-carboxylate 2782963, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Aissaoui, Hamed; Boss, Christoph; Gude, Markus; Koberstein, Ralf; Sifferlen, Thierry; US2010/222328; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

56012-38-5,56012-38-5, (2-Methylthiazol-5-yl)methanol is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Methanesulfonyl chloride (0.066 mL, 0.85 mmol) was added to (2-methylthiazol-5-yl)methanol (100mg, 0.77 mmol) and triethylamine (0.215 mL, 1.55 mmol) in DCM (3mL) at 0C over a period of 1 minute under nitrogen. The resulting solution was stirred at 0 C for 1 hour, then evaporated, redissolved in DCM (5m1) and washed with water (5m1). The organic phase was dried using a phase separator cartridge, evaporated and dried under vacuum to give (2-methylthiazol-5 -yl)methyl methanesulfonate (124 mg, 77 %) as animpure colourless gum which was used crude in the next stage. m/z: ES+ [M+H]+ not seen.

56012-38-5 (2-Methylthiazol-5-yl)methanol 12808792, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; WARD, Richard, Andrew; GRAHAM, Mark, Andrew; SWALLOW, Steven; JONES, Clifford, David; (282 pag.)WO2016/162325; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

80945-86-4,80945-86-4, 6-Bromo-2-chlorobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

intermediate 69:6-bromo-W-[2-chloro-6-{4-morpholinylmeth^amineIn an atmosphere of nitrogen, an ice-cooled solution of a mixture of 2-ch.oro-6-(4- morpholinylmethyl)-4-pyrimidinamine (1.356 g, 5.93 mmol) and 6-bromo-2-chloro-1 ,3- benzothiazo.e (1 ,474 g, 5.93 mmol) in dry A/,A/-dimethy.forrnamide (30 mL) was treated portionwise over 5 minutes with sodium hydride (60% w/w in mineral oil, 0.474 g, 1 1.86 mmol). The reaction mixture was stirred with cooling for 1 hour and at ambient temperature for a further 1 hour. The mixture was treated cautiously with saturated ammonium chloride (7.5 mL). Saturated aqueous sodium carbonate was added (aqueous pH=11 ) and the product was extracted with dichloromethane (2 x 100 mL). The organic layers were combined, dried using a hydrophobic frit and evaporated to dryness. The residue was purified by chromatography on silica using a gradient elution from 0 to 100 % ethyl acetate in cyciohexane followed by 0 to 30 % methanol in dichloromethane to afford the title compound (1.7 g, 3.86 mmol, 65 % yield). LCMS (Method D): Rt 1.19 minutes; m/z 440, 442 (MH+).

The synthetic route of 80945-86-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; BARTON, Nicholas Paul; CAMPOS, Sebastien Andre; CARR, Robin Arthur; HARLING, John David; SMITH, Ian Edward David; WO2012/35055; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2634-33-5, 1,2-Benzothiazol-3-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The acid 4 (5 mmol), EDC (1.2 g, 6.26 mmol), HOBt (0.9 g,5.88 mmol), NMM (1.2 mL, 10.74 mmol), and dichloromethane (10 mL) were mixed at ice-bath and stirred at 0 C for half an hour. 1,2-Benzisothiazol-3-one 1 (800 mg, 5.3 mmol) was added to NMM (1.6 mL, 14.32 mmol) in 10 mL of dichloromethane at 0 Ct hen the above mixture was added and stirred at room temperature overnight. After stirring overnight, the mixture was diluted with CH2Cl2, and then successively through washed with water, 5% KHSO4 solution, saturated NaHCO3 solution, and brine, the extract was dried with anhydrous Na2SO4 and evaporated under vacuum. The product was isolated by column chromatography (petroleum ether/CH2Cl2, 10:1) to yield the final compound. 4.2.11 2-(2-(2-Chlorophenyl)acetyl)benzo[d]isothiazol-3(2H)-one (15) Compound 15 was prepared through 2-chlorophenylacetic acid, obtained a white solid in 79% yield. Mp 171.3-172.5 C. 1H NMR (400 MHz, DMSO-d6) delta 8.00 (dd, J = 8.0, 3.6 Hz, 2H), 7.83 (t, J = 8.0 Hz, 1H), 7.53-7.45 (m, 3H), 7.38-7.34 (m, 2H), 4.62 (s, 2H). 13C NMR (101 MHz, DMSO-d6) delta 170.3, 163.8, 141.5, 135.2, 134.3, 132.79, 132.77, 129.6, 129.5, 127.7, 127.6, 126.7, 125.5, 122.7, 41.8. IR (KBr, cm-1): 1700, 1685. HRMS-ESI (m/z) calcd for C15H10ClNO2S [M+H+] 304.0199, found 304.0197., 2634-33-5

2634-33-5 1,2-Benzothiazol-3-one 17520, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Li, Zhenghui; Pan, Yang; Zhong, Weilong; Zhu, Yunpeng; Zhao, Yongle; Li, Lixin; Liu, Wei; Zhou, Honggang; Yang, Cheng; Bioorganic and Medicinal Chemistry; vol. 22; 24; (2014); p. 6735 – 6745;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3034-55-7,5-Bromothiazole,as a common compound, the synthetic route is as follows.

A mixture of 5-bromothiazole (200 mg, 1.2 mmol), (2-nitrophenyl)boronic acid (306 mg, 1.8 mmol), Na2CO3 (259 mg, 2.4 mmol) and Pd(PPh3)4(141 mg, 0.1 mmol) in DMA (5 mL) was degassed with nitrogen, heated to 150 C. and stirred for 2 hours under nitrogen atmosphere and microwave. The reaction was cooled to r.t, filtered and concentrated in vacuo. The residue was diluted with water, extracted with EA. The combined organic layer was washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue was purified by column chromatography to give 5-(2-nitrophenyl)thiazole (130 mg, 52% yield) as a yellow solid. LC/MS (ESI, m/z): [M+1]+=207.2

3034-55-7, 3034-55-7 5-Bromothiazole 546059, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Kymera Therapeutics, Inc.; Ji, Nan; Kluge, Arthur F.; Weiss, Matthew M.; Zhang, Yi; (180 pag.)US2020/10468; (2020); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica