Downstream synthetic route of 1024583-33-2

1024583-33-2, The synthetic route of 1024583-33-2 has been constantly updated, and we look forward to future research findings.

1024583-33-2, Methyl 2-bromobenzo[d]thiazole-6-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-((((1R,3s,5S)-9-azabicyclo[3.3.1]decan-3-yl)oxy)methyl)-5-cyclopropyl-3-(2,6 -dichlorophenyl)isoxazole trifluoroacetate (500 mg, crude), methyl 2-bromobenzo[d]thiazole-6-carboxylate(272 mg, 1.0 mmol) and cesium carbonate (1.0 g, 3 mmol of) was added to the DMA (5 mL), the reaction microwave 120 0.5 hours, and pouredinto water (20mL), filtered (filter cake was purified by silica gel column chromatography in dichloromethane: methanol = 20: 1) to give the desired product ( 200 mg,two-step yield 49.2%).

1024583-33-2, The synthetic route of 1024583-33-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hainan Xuanzhu Pharmaceutical Technology Co., Ltd.; Fang Wenkui; Chen Bo; (66 pag.)CN109265471; (2019); A;,
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Brief introduction of 72850-52-3

As the paragraph descriping shows that 72850-52-3 is playing an increasingly important role.

72850-52-3, Ethyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

72850-52-3, EXAMPLE 49 STR65 Ethyl 2[(diphenylmethyl)amino]-4-(trifluoromethyl)-5thiazolecarboxylate A reaction vessel was charged with 120 ml of toluene and 11.0 g (42.4 mmol) of ethyl 2-chloro-4-trifluoromethyl-5-thiazolecarboxylate (prepared as described in U.S. Pat. No. 4,199,506). Then, 15.5 g (86 mmol) of aminodiphenylmethane was added in one portion. The resulting yellowish-orange solution was refluxed under nitrogen for 9 days. Then, solvent was removed from the mixture under reduced pressure to yield a yellowish-orange solid material, which was flash chromatographed (~38 ml/min) on silica gel using 10% ethyl acetate in hexane solvent. There was obtained 13.2 g of a thick yellow oil which solidified upon standing to a yellow solid product (m.p.=92-95 C.) identified in Table I.

As the paragraph descriping shows that 72850-52-3 is playing an increasingly important role.

Reference£º
Patent; Monsanto Company; US5000775; (1991); A;,
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Some tips on 38205-60-6

38205-60-6, As the paragraph descriping shows that 38205-60-6 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.38205-60-6,1-(2,4-Dimethylthiazol-5-yl)ethanone,as a common compound, the synthetic route is as follows.

EXAMPLE 23 1-(2,4-Dimethyl-5-thiazolyl)-1-(3-pyridyl)ethanol 5-Acetyl-2,4-dimethylthiazole (2.5 g) in dry diethylether (10 ml) was added dropwise to a stirred solution of 3-lithiopyridine (from 3.5 g 3-bromopyridine) in diethylether at -70 C. After 3 hours the mixture was allowed to warm to room temperature. After a further 1 hour, aqueous sodium hydrogen carbonate was added and the organic layer was separated. The aqueous layer was extracted with diethylether. The material obtained from the combined organic layers was purified by flash chromatography to give the title compound, m.p. 107.5-109 C. 13 C Nmr (CDCl3) 16.3, 18.7, 32.7, 71.9, 123.1, 133.5, 137.9, 142.4, 146.9, 148.0 and 162.2 ppm.

38205-60-6, As the paragraph descriping shows that 38205-60-6 is playing an increasingly important role.

Reference£º
Patent; Astra Aktiebolag; US5607956; (1997); A;,
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Some tips on 41731-39-9

41731-39-9, 41731-39-9 2-Bromo-4-(trifluoromethyl)thiazole 23149887, athiazole compound, is more and more widely used in various.

41731-39-9, 2-Bromo-4-(trifluoromethyl)thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of oxetan-3-yl 4-(1-(phenylsulfonyl)-2-(tributylstannyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)piperazine-1-carboxylate (250 mg, 342 mupiiotaomicron), 2-bromo-4- (trifluoromethyl)thiazole (120 mg, 513 muiotaetaomicron), Cul (65 mg, 342 mmol), and Pd(PPh3)4 (197 mg, 171 muetaiotaomicron) in toluene (10 mL) was degassed with N2, and then stirred at 100C for 16 h under N2. The mixture was cooled to room temperature and concentrated. The residue was directly purified by silica gel chromatography (ethyl acetaterpetroleum ether = 3: 10) to give the title product (70 mg, yield 35%) as a light yellow solid. MS (ES+) C25H22F3N5O5S2 requires: 593, found: 594 [M+H]+.

41731-39-9, 41731-39-9 2-Bromo-4-(trifluoromethyl)thiazole 23149887, athiazole compound, is more and more widely used in various.

Reference£º
Patent; BLUEPRINT MEDICINES CORPORATION; BRUBAKER, Jason D.; FLEMING, Paul E.; KIM, Joseph L.; WILLIAMS, Brett; HODOUS, Brian L.; (238 pag.)WO2019/79649; (2019); A1;,
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New learning discoveries about 533-30-2

The synthetic route of 533-30-2 has been constantly updated, and we look forward to future research findings.

533-30-2,533-30-2, 6-Aminobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[00405] Step 2: A mixture of 6-chloro-4-((lS,2S)-2,3-dihydroxy-l- phenylpropylamino)nicotinonitrile (0.108 g, 0.356 mmol), benzo[d]thiazol-6-amine (0.187 g, 1.244 mmol) and NMP (1.422 mL) was stirred at 150 ¡ãC for 1 hour in a microwave reactor. The vessel was cooled to room temperature, diluted with water and filtered. Following drying on a buchner funnel, 6-(benzo[d]thiazol-6-ylamino)-4- ((lS,2S)-2,3-dihydroxy-l-phenylpropylamino)nicotinonitrile (0.122 g, 0.292 mmol, 82 percent yield) was collected as a yellowish solid. LC-MS (m/z, M+l= 418), Waters sunfire 4.6x50mm C18 5um 4 min/1 min hold time 0-100percent (A-B) A=10percent MeOH-90percent water – 0.1percentTFA, B=90percent MeOH-10percent water – 0.1percentTFA RT= 2.06.

The synthetic route of 533-30-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; DODD, Dharmpal, S.; MUSSARI, Christopher, P.; BHIDE, Rajeev, S.; NAIR, Satheesh Kesavan; PAIDI, Venkatram Reddy; KUMAR, Sreekantha Ratna; BANERJEE, Abhisek; SISTLA, Ramesh; PITTS, William, J.; HYNES, John; WO2013/106614; (2013); A1;,
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Simple exploration of 682342-65-0

682342-65-0 5-Iodo-4-(trifluoromethyl)thiazol-2-amine 22717671, athiazole compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.682342-65-0,5-Iodo-4-(trifluoromethyl)thiazol-2-amine,as a common compound, the synthetic route is as follows.,682342-65-0

2-Amino-5-iodo-4-trifluoromethylthiazole (1.2 g) was dissolved in pyridine (2 ml) and thiophene-2-carbonyl chloride (0.80 g) was added at room temperature with stirring. The mixture was stirred for 6 hr at room temperature. The mixture was poured into ice water and acidified with aqueous hydrochloric acid then extracted with chloroform. The chloroform layer was dried over magnesium sulfate and the solvent was removed under reduced pressure. The solid thus obtained was recrystallized from methanol to give N-(5-iodo-4-trifluoromethylthiazol-2-yl)thiophene-2-carboxamide (1.2 g), m. p. 184-185 C.

682342-65-0 5-Iodo-4-(trifluoromethyl)thiazol-2-amine 22717671, athiazole compound, is more and more widely used in various.

Reference£º
Patent; Nippon Soda Co., Ltd.; US2004/82629; (2004); A1;,
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New learning discoveries about 66947-92-0

The synthetic route of 66947-92-0 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.66947-92-0,Methyl 2-amino-1,3-benzothiazole-6-carboxylate,as a common compound, the synthetic route is as follows.

2-Bromo-benzothiazole-6-carboxylic acid; [00105] To a solution of 2-bromo-benzothiazole-6-carboxylic acid methyl ester (1.256 g, 4.39 mmol) in THF (60 mL) and H2O (20 mL) is added lithium hydroxide monohydrate (920 mg, 21.9 mmol) at 0 0C. The mixture is stirred at rt overnight. The mixture is treated with IN HCl solution to adjust pH to 2 and extracted with ethyl acetate. The organic phase is washed with brine. The solvent is removed in vacuo and the crude product is used for next step without further purification. MS(ESI) m/z: 257.9 (M+l) +., 66947-92-0

The synthetic route of 66947-92-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; IRM LLC; WO2008/124393; (2008); A1;,
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Analyzing the synthesis route of 55690-60-3

55690-60-3 5-Methoxybenzo[d]thiazole-2-thiol 2830679, athiazole compound, is more and more widely used in various.

55690-60-3, 5-Methoxybenzo[d]thiazole-2-thiol is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55690-60-3, Sulfuryl chloride (10 mL) was added to 5-methoxy-2- mercaptobenzothiazole at 0 0C. After complete addition, the reaction mixture was allowed to warm to it. After 2 h, the reaction mixture was poured into ice water (100 mL). This was allowed to warm to rt and was extracted with EtOAc (3 x). The combined organics were dried over Na2SO4, filtered, and concentrated under reduced pressure. The material was used without further purification. LC-MS: RT = 9.08 min., [M+H]+ = 234.0.

55690-60-3 5-Methoxybenzo[d]thiazole-2-thiol 2830679, athiazole compound, is more and more widely used in various.

Reference£º
Patent; CRITICAL THERAPEUTICS, INC.; WO2007/146066; (2007); A2;,
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Analyzing the synthesis route of 106092-09-5

106092-09-5, 106092-09-5 (S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole 11521153, athiazole compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.106092-09-5,(S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole,as a common compound, the synthetic route is as follows.

A solution of (S)-4,5,6,7-tetrahydrobenzo[1,2-d]thiazole-2,6-diamine (0.200 g, 1.18 mmol) and Na2CO3 (1.18 mmol) in N,N-dimethylformamide (10 mL) was stirred at room temperature for 15 min. Then 2,2,2-trichloro-1-(4,5-dibromo-1H-pyrrol-2-yl)ethan-1-one (0.438 g, 1.18 mmol) was added and the mixture stirred at 40 C for 2.5 h. Solvent was removed under reduced pressure and purified by column chromatography using dichloromethane/methanol (20:1) as eluent. Yield: 340 mg (68%); white crystals; mp 129-130C; [alpha]D -23.0 (c 0.18, MeOH); 1H NMR (400 MHz, DMSO-d6) delta 1.73-1.83 (m, 1H, HA-7), 1.89-1.96 (m, 1H, HB-7), 2.43-2.54 (m, 3H, signal overlapped with DMSO-d5, H-5, HA-4), 2.79 (dd, 1H, J = 5.5, 14.7 Hz, HB-4), 4.08-4.17 (m, 1H, CHNH), 6.69 (s, 2H, 2-NH2), 7.00 (s, 1H, Ar-H-3), 8.07 (d, 1H, J = 7.8 Hz, NH-C=O), 12.69 (s, 1H, Ar-NH) ppm; 13C NMR (101 MHz, DMSO-d6) delta 24.9, 28.7, 28.8, 45.5, 97.8, 104.5, 112.3, 112.9, 128.1, 144.2, 158.3, 166.2 ppm.

106092-09-5, 106092-09-5 (S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole 11521153, athiazole compound, is more and more widely used in various.

Reference£º
Article; Campos, Ludmila E.; Garibotto, Francisco M.; Angelina, Emilio; Kos, Jiri; Toma?i?, Tihomir; Zidar, Nace; Kikelj, Danijel; Gonec; Marvanova, Pavlina; Mokry, Petr; Jampilek; Alvarez, Sergio E.; Enriz, Ricardo D.; Bioorganic Chemistry; vol. 91; (2019);,
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Brief introduction of 3364-80-5

3364-80-5 Thiazole-4-carboxaldehyde 2763214, athiazole compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3364-80-5,Thiazole-4-carboxaldehyde,as a common compound, the synthetic route is as follows.

A stirred mixture of 2-amino-4-methyl-pentanoic acid tert-butyl ester, hydrochloride (2. 1G, 9.38 mmol), 1, 3-thiazole-4-carboxaldehyde (Intermediate b) (1. 06 g, 9.38 MMOL) and triethylamine (1.31 mL, 9.38 MMOL) in dichloromethane (25 mL) was heated under reflux under nitrogen for 20 hours. The reaction mixture was allowed to cool to room temperature, washed twice with water, dried over NA2SO4 and evaporated to give the title compound as an oil. ‘H NMR (CDCI3) : 5 8.84 (s, 1H), 8.49 (d, 1 H), 8.01 (s, 1H), 4.00 (dd, 1 H), 1.90-1. 70 (m, 2H), 1.64-1. 56 (m, 1H), 1.47 (s, 9H), 0.96 (d, 3H) and 0.91 (d, 3H)., 3364-80-5

3364-80-5 Thiazole-4-carboxaldehyde 2763214, athiazole compound, is more and more widely used in various.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/60889; (2004); A1;,
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