Heterocyclic Building Blocks-Thiazole

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29927-08-0,5,6-Dimethylbenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

General procedure: To the solution of beta-naphthol (1mmol) in methanol were added respective substituted 2-aminobenzothiazole (1mmol) and the synthesized pyrazole aldehyde31 (1mmol). The reaction mixture was refluxed for 5h. The reaction was monitored by TLC and the advantage of this method is that a solid product (white ppt) was formed in the round bottom flask after completion of the reaction. The solid compound was collected by filtration and purified by column chromatography to obtain pure pyrazole linked benzothiazole-beta-naphthol derivatives in good to excellent yields., 29927-08-0

The synthetic route of 29927-08-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Nagaraju, Burri; Kovvuri, Jeshma; Kumar, C. Ganesh; Routhu, Sunitha Rani; Shareef, Md. Adil; Kadagathur, Manasa; Adiyala, Praveen Reddy; Alavala, Sateesh; Nagesh, Narayana; Kamal, Ahmed; Bioorganic and Medicinal Chemistry; vol. 27; 5; (2019); p. 708 – 720;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

55661-33-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55661-33-1,Thiazol-2-ylmethanamine,as a common compound, the synthetic route is as follows.

Example 3; 2-(2-oxo-3,3-diphenylpyrrolidin-l-yl)-7V-(l,3-thiazol-2-ylmethyl)acetamide; N1-((ethylimino)methylene)-Lambda/3,Lambda/3-dimethylpropane-l ,3-diamine hydrochloride(0.049 g, 0.254 mmol) , 2-(2-oxo-3,3-diphenylpyrrolidin-l-yl)acetic acid (Example 1C, 0.050 g, 0.169 mmol) and thiazol-2-ylmethanamine (0.021 g, 0.186 mmol) were combined and stirred together in dichloromethane (0.5 mL) at room temperature. After stirring overnight, the reaction was loaded directly onto a SF 15- 12 silica gel column (Analogix, Burlington, WI), and the title compound was eluted using a gradient of 5% to 100% ethyl acetate/hexanes over 20 minutes (flow = 30 mL/minute). 1H NMR (300 MHz, CDCl3) delta ppm 7.69 (d, J= 3.3 Hz, 1 H), 7.19-7.38 (m, 11 H), 6.77 (t, J= 5.8 Hz, 1 H), 4.67 (d, J= 5.8 Hz, 2 H), 4.09 (s, 2 H), 3.53 (t, J= 6.5 Hz, 2 H), 2.84 (t, J= 6.5 Hz, 2H); MS (ESI+) m/z 392 (M+H)+.

55661-33-1 Thiazol-2-ylmethanamine 2756507, athiazole compound, is more and more widely used in various.

Reference£º
Patent; ABBOTT LABORATORIES; BHATIA, Pramila, A.; DOHERTY, George, A.; DRIZIN, Irene; MACK, Helmut; PERNER, Richard, J.; STEWART, Andrew, O.; ZHANG, Qing Wei; WO2010/39947; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2942-23-6,2,7-Dichlorobenzo[d]thiazole,as a common compound, the synthetic route is as follows.

In a nitrogen atmosphere 2,7-dichlorobenzo[d]thiazole (10.0 g, 49.3mmol) and (9-phenyl-9H-carbazol-3-yl)boronic acid(28.3 g, 98.6 mmol) was added to 300 ml of dioxane, stirred and refluxed. Then potassium carbonate (27.2 g, 197.1 mmol)Was dissolved in 50 ml of water and stirred sufficiently, followed by bis(tri-tertiary-butylphosphine)palladium (1.0 g, 4 mol%) Was added. After the reaction for 12 hours, the temperature was reduced to room temperature, the organic layer and the water layer were separated, and then the organic layer was distilled under reduced pressure.After distillate was extracted with chloroform and water, the organic layer was dried using magnesium sulfate. After drying the organic layer, compound 1 (13.4 g, 44%) was prepared through recrystallization of ethyl acetate., 2942-23-6

The synthetic route of 2942-23-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; LG Chem, Ltd.; Jeong Min-u; Lee Dong-hun; Jang Bun-jae; Lee Jeong-ha; Han Su-jin; Park Seul-chan; Hwang Seong-hyeon; (37 pag.)KR2020/6503; (2020); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55661-33-1,Thiazol-2-ylmethanamine,as a common compound, the synthetic route is as follows.

General procedure: 5.1.5 2-(1-(4-Fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide (7a) To a solution of 6a (2.00 g, 5.98 mmol), EDCI (1.50 g, 7.82 mmol) and iPr2NEt (2.67 mL, 15.64 mmol) in N,N-dimethylformamide (80 mL) was added HOBt (1.00 g, 7.40 mmol). The reaction mixture was stirred at ambient temperature for 15 min, followed by addition of 3-(aminomethyl)pyridine (0.73 mL, 7.16 mmol). After stirring for 17 h at ambient temperature, the reaction mixture was diluted with ethyl acetate (300 mL) and sequentially washed with water, saturated NaHCO3 solution, water and brine. The organic solution was dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated in vacuo, and the residue was crystallized from ethyl acetate and hexanes to yield 7a as an off-white solid (1.93 g, 76%), mp 178-180 C (ethyl acetate/hexanes); By a similar procedure as described for 7a, 7h was obtained as an off-white solid (0.17g, 66%). Mp 189-190C (ethyl acetate/hexanes); 1H NMR (300MHz, CDCl3) delta 8.25 (s, 1H), 7.74 (br s, 1H), 7.40-7.31 (m, 3H), 7.06-6.97 (m, 2H), 6.78 (t, J=5.4Hz, 1H), 4.97 (s, 2H), 4.92 (d, J=5.4Hz, 2H), 2.67 (s, 3H); MS (ES+) m/z 431.1 (M+1), 55661-33-1

55661-33-1 Thiazol-2-ylmethanamine 2756507, athiazole compound, is more and more widely used in various.

Reference£º
Article; Sun, Shaoyi; Zhang, Zaihui; Pokrovskaia, Natalia; Chowdhury, Sultan; Jia, Qi; Chang, Elaine; Khakh, Kuldip; Kwan, Rainbow; McLaren, David G.; Radomski, Chris C.; Ratkay, Leslie G.; Fu, Jianmin; Dales, Natalie A.; Winther, Michael D.; Bioorganic and Medicinal Chemistry; vol. 23; 3; (2015); p. 455 – 465;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

41731-52-6, Ethyl 2-chlorothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 3-tert-butyl phenol (100 mg, 0.65 mmol) in dry THF (5 ml) was added potassium tert-butoxide (75 mg, 0.65 mmol) and the mixture was heated to reflux for 1 h. Upon cooling, the volatiles were removed in vacuo before the residue was taken up into dimethylsulf oxide (DMSO; 20 ml). Ethyl 2-chiorothiazole-4-carboxylate (prepared according to the procedure of T. R. Kelly and F. Lang, J. Org. Chem., 1996, 61 , 4623-4633; however in our EPO hands the material produced by this synthesis was a 2:1 mixture of the 2- chloro- and 5-chloro-thiazole-4-carboxylates; 130 mg, 0.67 mmol) was then added before the mixture was heated to 85 G for 16 h. Upon cooling the reaction mixture was partitioned between ethyl acetate (25 ml) and water (25 ml) and after rigorous shaking the aqueous later was separated and extracted further with ethyl acetate (3 x 25 ml). The combined organic phase was washed with brine (50 ml) and dried (MgSO4) before being concentrated in vacuo. The crude product was then purified by column chromatography (SiO2; 49:1 light petroleum-ethyl acetate to 19:1) to afford the title compound as a pale yellow oil (100 mg, 50 %). 1H NMR delta 8.20 (1 H, s), 7.20-7.27 (3 H, m), 7.01-7.05 (1 H, m), 4.31 (2 H, q), 1.31 (3 H, t) and 1.26 (9 H, s).

41731-52-6, As the paragraph descriping shows that 41731-52-6 is playing an increasingly important role.

Reference£º
Patent; PARADIGM THERAPEUTICS LTD.; WO2007/582; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1003-60-7,2-Methylthiazole-5-carbaldehyde,as a common compound, the synthetic route is as follows.

(a) An aqueous solution of 2% sodium hydroxide (3 ml) was added to a solution of 2-methyl-thiazole-5-carboxaldehyde (2.5 g) in acetone (20 ml) and water (10 ml). The mixture was stirred for 24 hours at ambient temperature, diluted with water (150 ml) and extracted with chloroform (2*50 ml). The organic layer was washed with water then dried over anhydrous magnesium sulphate and filtered. Evaporation of the solvent gave 1-(2-methyl-5-thiazolyl)but-1-en-3-one as a low-melting point solid (1.4 g, 43%). Pmr spectrum (CDCl3; delta in ppm): 2.30 (3H,s); 2.72 (3H,s); 6.36 (1H,d); 7.56 (1H,d); 7.74 (1H,s).

1003-60-7, 1003-60-7 2-Methylthiazole-5-carbaldehyde 13934728, athiazole compound, is more and more widely used in various.

Reference£º
Patent; ICI Australia Limited; US4604132; (1986); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19654-14-9,2-(3-Bromophenyl)benzothiazole,as a common compound, the synthetic route is as follows.

Intermediate 6 (10.4 g, 35.8 mmol), intermediate 7 (9.20 g, 39.3 mmol), a mixed solution of toluene / ethanol (2: 1, 195 mL), aqueous tripotassium phosphate (2.0 M, ) Were sequentially added, and nitrogen bubbling was carried out for 30 minutes.Pd (PPh 3) 4 (1.00 g, 0.87 mmol) was added thereto, and the mixture was stirred for 3 hours while heating under reflux. After returning to room temperature, distilled water was added and extraction was carried out using toluene.The organic layer was washed with a saturated aqueous sodium chloride solution, dried over magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was subjected to silica gel column chromatography to give Intermediate 8 (13.6 g, yield 95%). Intermediate 6 was synthesized by referring to the method described in International Publication No. 2015/087961., 19654-14-9

As the paragraph descriping shows that 19654-14-9 is playing an increasingly important role.

Reference£º
Patent; MITSUBISHI CHEMICAL CORPORATION; KOMATSU, HIDEJI; ISHIBASHI, KOICHI; NAGAYAMA, KAZUHIRO; (41 pag.)JP2018/58797; (2018); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2289-75-0,4,5-Dimethylthiazol-2-amine,as a common compound, the synthetic route is as follows.

A mixture of 4,5-dimethylthiazol-2-ylamine (1.0 g, 7.8 mmol) and (2-bromo-ethoxy)benzene (1.9 g, 9.4 mmol) were heated neat to 85 0C for 19 hours. The mixture was cooled to ambient temperature and the residue was crystallized from isopropanol. The solid was collected by filtration and dried under vacuum to afford 1.3 g (50%) of the title compound. MS (DCIZNH3) mZz 249 (M+H)+, 2289-75-0

2289-75-0 4,5-Dimethylthiazol-2-amine 73238, athiazole compound, is more and more widely used in various.

Reference£º
Patent; ABBOTT LABORATORIES; WO2009/67613; (2009); A1;,
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Thiazole | chemical compound | Britannica

61296-22-8, 2-Amino-5-bromothiazole monohydrobromide is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

61296-22-8, 5-Thiocyanatothiazol-2-amine (Compound 0107) A mixture of 2-amino-5-bromothiazole hydrobromide (0106, 53.0 g, 0.204 mol) and potassium thiocyanate (78.5 g, 0.808 mol) in methanol (1.4 L) was stirred at room temperature for 20 h. Methanol was evaporated and water (180 ml) was added. The pH of the aqueous solution was adjusted to pH=12 with 10% NaOH and precipitate formed. The solid was collected by filtration to yield compound 0107 (14.0 g, 44%) as a brownish solid: LCMS: 157 [M+l]+.

As the paragraph descriping shows that 61296-22-8 is playing an increasingly important role.

Reference£º
Patent; CURIS, INC.; QIAN, Changgeng; CAI, Xiong; ZHAI, Haixiao; WO2010/75542; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

24295-03-2, 2-Acetylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 7 2-(2-Thiazolyl)-1,8-naphthyridine 2-Aminonicotinaldehyde (1.5 g, 12.3 mmol) and 2-acetylthiazole (1.64 g, 12.9 mmol) are dissolved in 12 ml of MeOH and the mixture is treated with 1.5 ml of 40% KOH. After 3 h, the reaction is complete and the mixture is poured onto water. The solid which is deposited is filtered off with suction, washed and dried. 1.22 g (yield 46%) of the desired product are obtained. M.p. 160-165 C., 24295-03-2

The synthetic route of 24295-03-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BASF Aktiengesellschaft; US5723413; (1998); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica