Simple exploration of 170232-69-6

170232-69-6, As the paragraph descriping shows that 170232-69-6 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.170232-69-6,(2,4-Dichlorothiazol-5-yl)methanol,as a common compound, the synthetic route is as follows.

To a solution of (2,4-dichloro-l,3-thiazol-5-yl)methanol (850 mg, 4.6 mmol) in anhydrous dichloromethane (40 mL) was added dropwise phosphorus tribromide (850 muL, 9.2 mmol). The mixture was stirred at room temperature for 3 hours. The solvent was evaporated. The residue was dried in vacuo, affording 5-(bromomethyl)-2,4- dichloro-l,3-thiazole. The product was used without further purification.

170232-69-6, As the paragraph descriping shows that 170232-69-6 is playing an increasingly important role.

Reference£º
Patent; CHLORION PHARMA, INC.; UNIVERSITE LAVAL; ATTARDO, Giorgio; TRIPATHY, Sasmita; WO2010/132999; (2010); A1;,
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Some tips on 687636-93-7

687636-93-7 2-Bromothiazole-5-methanol 7213124, athiazole compound, is more and more widely used in various.

687636-93-7, 2-Bromothiazole-5-methanol is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of N-(5-{[(2-chlorophenyl)oxy]methyl}-1 ,3,4-thiadiazol-2-yl)-1 ,2,3,4- tetrahydro-6-isoquinolinecarboxamide (Example 1 ) (218 mg, 0.5 mmol), DBU (0.224 ml_, 1.5 mmol) and (2-bromo-1 ,3-thiazol-5-yl)methanol (97 mg, 0.5 mmol) in THF (10 ml.) was stirred overnight at 8O0C. Then extra amounts of DBU (0.075 ml_, 0.5 mmol) and (2-bromo-1 ,3-thiazol-5-yl)methanol (97 mg, 0.5 mmol) were added and the mixture was stirred overnight at 600C. The THF was evaporated under reduced pressure and the residue was dissolved in DCM. The organic phase was washed with water then dried over sodium sulphate. After filtration and evaporation under reduced pressure, the residue was purified by flash column chromatography eluting with a gradient DCIWMeOH: 99/1 to DCM/MeOH: 95/5 to give after trituration in cold DCM and drying the title compound as white solid (15 mg, 6%).HRMS calculated for C23H20CIN5O3S2 (M+H)+ 514.0775, found: 514.0770, Rt: 2.70 min MP: 237-239C, 687636-93-7

687636-93-7 2-Bromothiazole-5-methanol 7213124, athiazole compound, is more and more widely used in various.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/104524; (2008); A1;,
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Analyzing the synthesis route of 29927-08-0

29927-08-0, Big data shows that 29927-08-0 is playing an increasingly important role.

29927-08-0, 5,6-Dimethylbenzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 2-Aminobenzothiazole (0.30 g, 2.0 mmol) was dissolved in hot glacial acetic acid/propionic acid mixture (2:1, 6.0 ml) and was rapidly cooled in an ice-salt bath to -5 C. The mixture was then stirred for 2 h. at 0-5 C. The liquor was then added in portions during 30 min to a cold solution of nitrosyl sulfuric acid [prepared from sodium nitrite (0.15 g) and concentrated sulfuric acid (3 ml at 50 C)]. The mixture was stirred for an additional 2 h at 0 C. Excess nitrous acid was destroyed by the addition of urea. The resulting diazonium salt was cooled in salt/ice mixture. 2-methlyindole(0.26 g, 2.0 mmol) was dissolved in mixture of acetic acid/propionic acid solution (3:1, 8.0 ml) and cooled in salt/ice bath and then cold diazonium solution was added to this cooled solution by stirring in a dropwise manner. The solution was stirred at 0-5 C for 2 h. and pH of the reaction mixture was maintained at 4-6 by simultaneous addition of saturated sodium carbonate solution.The mixture was stirred for a further 1 h at 5 C. The resulting product was filtered, washed with water, dried and crystallized from ethanol mixture gave brown powder (yield: 0.29 g, 51%; m.p: 168-170 C), FT-IR (KBr) numax: 3345 (indole -NH), 3059 (aromatic C-H), 2969, 2920 (aliphatic C-H), 1605 (C=C) cm-1; 1HNMR (DMSO-d6/CDCl3): d 9.71 (b, indole -NH), 7.98 (1H,m), 7.37(1H,m), 7.30-7.15 (4H,m), 6.82 (2H,m), 2.36 (3H,s).Anal. Calcd. For C16H12N4S: C, 65.73; H, 4.14; N, 19.16; S, 10.97Found: C, 65.68; H, 4.19; N, 19.11; S, 10.92%.MS (m/z, 70 eV): 292.0 (M+), 277.0, 158.0, 130.0.

29927-08-0, Big data shows that 29927-08-0 is playing an increasingly important role.

Reference£º
Article; Sefero?lu, Zeynel; Kaynak, Filiz Betul; Ertan, Nermin; Ozbey, Suheyla; Journal of Molecular Structure; vol. 1047; (2013); p. 22 – 30;,
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Simple exploration of 432047-36-4

432047-36-4 1-(2-Thiazolyl)ethylamine 19896985, athiazole compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.432047-36-4,1-(2-Thiazolyl)ethylamine,as a common compound, the synthetic route is as follows.

Example 78: N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl}-N’-[(1S)-1-(1,3-thiazol-2-yl)ethyl]urea 4-[(6,7-Dimethoxy-4-quinolyl)oxy]aniline (30 mg) was dissolved in chloroform (1 ml) and triethylamine (0.1 ml) to prepare a solution. A solution of triphosgene (35 mg) in chloroform (0.2 ml) was then added to the solution, and the mixture was stirred at room temperature for one hr. Next, a solution of (1S)-1-(1,3-thiazol-2-yl)-1-ethylamine (35 mg) in chloroform (0.2 ml) was added thereto, and the mixture was stirred at room temperature for 10 hr. The stirred mixture was purified by chromatography on silica gel using chloroform/methanol for development to give the title compound (31 mg, yield 68%). 1H-NMR (CDCl3, 400 MHz): delta 1.68 (d, J = 6.8 Hz, 3H), 4.09 (s, 3H), 4.10 (s, 3H), 5.32 – 5.38 (m, 1H), 6.51 (d, J = 6.3 Hz, 1H), 6.55 (br, 1H), 7.06 (d, J = 8.8 Hz, 1H), 7.22 (d, J = 3.2 Hz, 1H), 7.64 (d, J = 1.2 Hz, 1H), 7.66 (d, J = 3.4 Hz, 1H), 7.67 (s, 1H), 7.79 (s, 1H), 8.31 (d, J = 6.3 Hz, 1H), 8.59 (s, 1H), 432047-36-4

432047-36-4 1-(2-Thiazolyl)ethylamine 19896985, athiazole compound, is more and more widely used in various.

Reference£º
Patent; KIRIN BEER KABUSHIKI KAISHA; EP1535910; (2005); A1;,
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Brief introduction of 556-90-1

556-90-1 2-aminothiazol-4(5H)-one 11175, athiazole compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.556-90-1,2-aminothiazol-4(5H)-one,as a common compound, the synthetic route is as follows.,556-90-1

General procedure: Synthesis of Compounds 120 to 122, which are (Z)-5-(substituted benzylidene)-2-iminothiazolidin-4-one analogs, was performed as follows. In detail, in an acetic acid (4 mL/1 g sodium acetate) solvent, a mixture including a substituted benzaldhehyde (300 mg), pseudothiohydantoin (1.1 eq.), and sodium acetate (3.0 eq.) was refluxed for 3 to 7 hours. After cooling, water was added thereto, and the produced precipitate was filtered, and in consideration of physical characteristics of the used starting materials, the resultant precipitate was washed with water and methylene chloride and/or ethyl acetate to obtain a solid target product.

556-90-1 2-aminothiazol-4(5H)-one 11175, athiazole compound, is more and more widely used in various.

Reference£º
Patent; Pusan National University Industry University Cooperation Foundation; Jung, Hae Young; Moon, Hyung Ryong; Park, Min Hwe; Ha, Young Mi; Park, Yoon Jung; Park, Ji Young; Kim, Jin-a; Lee, Ji Yeon; Lee, Kyung Jin; (57 pag.)KR101677122; (2016); B1;,
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Simple exploration of 5198-88-9

The synthetic route of 5198-88-9 has been constantly updated, and we look forward to future research findings.

5198-88-9,5198-88-9, 2-Bromothiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 5Preparation of Compound 5To a solution of 2-bromo-thiazole-5-carboxylic acid (0.050 mmol, 10 mg), lambda/,lambda/-diisopropylethylamine (0.20 mmol, 26 mg) and HATU (0.050 mmol, 19 mg) in DMF (1 ml_) was added 4-(2-aminophenyl)-piperazine-1-carboxylic acid tert-butyl ester (0.10 mmol, 28 mg). The resulting reaction was heated to 80 0C and allowed to stir at this temperature for 15 hours, after which time the reaction mixture was cooled to room temperature and concentrated in vacuo. The resulting residue was reacted with TFA (0.5 ml_) for 10 minutes. The TFA solution was then concentrated in vacuo Xo provide a crude residue which was purified using reverse phase HPLC to provide Compound 5.

The synthetic route of 5198-88-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SCHERING CORPORATION; WO2008/54702; (2008); A1;,
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Analyzing the synthesis route of 161798-01-2

161798-01-2 Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate 135404723, athiazole compound, is more and more widely used in various.

161798-01-2, Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example-2 Preparation of Ethyl-2-(3-cyano-4-hydroxyphenyl)-4-methyl thiozole-5-carboxylate A mixture of 10.0 g of Ethyl-2-(3-formyl-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate and 2.85 g of hydroxylamine hydrochloride were stirred for 30 minutes in 30 g of Dimethylformamide. To this reaction mixture 3.3 grams of acetyl chloride was added and stirred at 90¡ã C. for 2-3 hours. Reaction mass was cooled to room temperature and diluted with 100 ml of water and stir for 2 hours. The reaction mass was filtered and washed with purified water to give 10.0 g of Ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate (yield 99.0percent)., 161798-01-2

161798-01-2 Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate 135404723, athiazole compound, is more and more widely used in various.

Reference£º
Patent; Vellanki, Siva Rama Prasad; Sahu, Arabinda; Raavi, Satyanarayana; Nuchu, Ravi; Dandala, Ramesh; US2013/303780; (2013); A1;,
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Some tips on 3034-55-7

3034-55-7, As the paragraph descriping shows that 3034-55-7 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3034-55-7,5-Bromothiazole,as a common compound, the synthetic route is as follows.

A solution containing 300 mg of 16h, 180 mul of 5-Br-thiazole, 350 mul of diisopropyl amine, 21mg of PdCl2(benzonitrile)2, 250 mul of IM tri-te/t-butyl phosphine (in toluene), 12 mg of CuI in 2 ml of degassed dioxane was stirred overnight at RT under a N2 atmosphere. The mixture was poured onto 5% aq. NH4CI and extracted with ethyl acetate. The extract was dried, concentrated and the crude material was purified by chromatography over silica gel, using a gradient of heptane/ethyl acetate as eluent. This afforded 320 mg 16i as a colorless oil. Rf 0.45 (heptane/ethyl acetate 1/1). MS-ESI: [M+l] 337.17NMR (CDCl3) delta 8.64 and 7.88 (2x s, 2, thiazole H), 1.40 (m, 2, CH2), 1.48 (s, 9, tertC49), 1.64 (m, 4, 2x CH2), 2.46 (t, 2, CH2), 3.20 (m, 2, CH2), 3.83 (s, 3, OCH3).

3034-55-7, As the paragraph descriping shows that 3034-55-7 is playing an increasingly important role.

Reference£º
Patent; N.V. ORGANON; LOOZEN, Hubert, Jan, Jozef; TIMMERS, Cornelis, Marius; STOCK, Herman, Thijs; WO2011/12600; (2011); A1;,
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Analyzing the synthesis route of 160844-75-7

160844-75-7 Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate 9884549, athiazole compound, is more and more widely used in various.

160844-75-7, Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 5:Preparation of febuxostat2-(3-Cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester (100 gm) was dissolved in ethanol (500 ml) at room temperature and then added a solution of sodium hydroxide (13 gm) in water. (250 ml) slowly for 30 minutes. The contents were heated to 65C and maintained for 1 hour. The reaction mass was then cooled to 50C and pH of the reaction mass was adjusted to 2.0 with hydrochloric acid solution (15%). The reaction mass was stirred for 15 minutes at 50C and then cooled to room temperature. The contents were maintained for 3 hours at room temperature and filtered. The solid thus obtained was dissolved in ethanol (500 ml) and then heated to 60C. The reaction mass was treated with carbon at 60C and filtered. The filtrate obtained was then cooled to room temperature and stirred for 2 hours. The reaction mass was further cooled to 10C and maintained for 1 hour. The solid obtained was collected by filtration and washed with chilled ethanol to obtain a wet solid. To the wet solid was added a mixture of ethanol and water (9: 1 ; 500 ml) at room temperature and then heated to 60C to obtain a solution. The solution was stirred for 30 minutes at 60C and then cooled to 25C. The reaction mass was maintained for 1 hour at 25C and the mass was further cooled to 10C. The solid obtained was collected by filtration and dried with vacuum sucking for 15 minutes to obtain 65 gm of febuxostat., 160844-75-7

160844-75-7 Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate 9884549, athiazole compound, is more and more widely used in various.

Reference£º
Patent; HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; MURALIDHARA REDDY, Dasari; RAMAKRISHNA REDDY, Matta; VAMSI KRISHNA, Bandi; WO2012/168948; (2012); A2;,
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Analyzing the synthesis route of 21344-90-1

21344-90-1, As the paragraph descriping shows that 21344-90-1 is playing an increasingly important role.

21344-90-1, 4-(2-Chlorophenyl)thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

276A N-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]-4-propylbenzenesulfonamide The title compound was prepared from 4-(2-chlorophenyl)-1,3-thiazol-2-amine and 4-n-propylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (30.9 mg) with purity >90percent. MS (pos) m/z 393.1.

21344-90-1, As the paragraph descriping shows that 21344-90-1 is playing an increasingly important role.

Reference£º
Patent; Kurz, Guido; Nilsson, Marianne; US2003/166689; (2003); A1;,
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