Heterocyclic Building Blocks-Thiazole

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.67899-00-7,2-Amino-4-methylthiazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: The suspension of acid (2.00 mmol) in DMF (10 mL) was cooled to 0 C in an ice bath. N-methylmorpholine (0.49 mL, 4.40 mmol) and TBTU (0.84 g, 2.60 mmol) were added, and the reaction mixture was stirred at 0 C for 0.5 h. Then it was allowed to reach room temperature, and amine (2.00 mmol) was added to the solution.The reaction mixture was stirred overnight at room temperature, after which the solvent was evaporated under reduced pressure.The residue was dissolved in ethyl acetate (40 mL) and washed witha saturated aqueous solution of NaHCO3 (3 x 20 mL), 10% citric acid(3 x 20 mL) and brine (20 mL). The organic phase was dried over Na2SO4, and filtered, and the solvent was removed under reduced pressure. The crude product was purified by crystallization or flash column chromatography., 67899-00-7

67899-00-7 2-Amino-4-methylthiazole-5-carboxylic acid 832243, athiazole compound, is more and more widely used in various.

Reference£º
Article; ?kedelj, Veronika; Perdih, Andrej; Brvar, Matja?; Krofli?, Ana; Dubbee, Vincent; Savage, Victoria; O’Neill, Alex J.; Solmajer, Tom; Be?ter-Roga?, Marija; Blanot, Didier; Hugonnet, Jean-Emmanuel; Magnet, Sophie; Arthur, Michel; Mainardi, Jean-Luc; Stojan, Jure; Zega, Anamarija; European Journal of Medicinal Chemistry; vol. 67; (2013); p. 208 – 220;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34272-64-5,2-(4-Methyl-2-thioxo-2,3-dihydrothiazol-5-yl)acetic acid,as a common compound, the synthetic route is as follows.

EXAMPLE 172 7-beta-Amino-3-(5-carboxymethyl-4-methyl-1,3-thiazol-2-yl-thiomethyl)-ceph-3-em-4-carboxylic acid 2.7 g (0.01 mole) of 7-aminocephalosporanic acid and 1.9 g (0.01 mole) of 5-carboxymethyl-2-mercapto-4-methyl-1,3-thiazole are suspended in 250 ml of water. Sodium bicarbonate is added until a clear solution has formed. The reaction solution is heated to 50 C. for 4 hours, whilst keeping the pH value constant at the neutral point. The solution is allowed to cool and is extracted several times with ethyl acetate and the aqueous phase is adjusted to a pH value of 2 with 2 N HCl. The precipitate is filtered off, washed several times with alcohol and ether and dried. 3.7 g of the title compound of melting point 195-196 C. (decomposition) are obtained. NMR (d6 -DMSO, 60 MHz): delta=2.17 ppm (s, 3H, =C–CH3), delta=3.52 ppm (AB, 2H, 2–CH2 –), delta=3.68 ppm (s, 2H, =C–CH2 –COO–) delta=4.31 ppm (AB, 2H, 3–CH2 –S–) and delta=4.80 ppm (m, 2H, 6–CH–+7–CH–)., 34272-64-5

As the paragraph descriping shows that 34272-64-5 is playing an increasingly important role.

Reference£º
Patent; Hoechst Aktiengesellschaft; US4278793; (1981); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5198-88-9,2-Bromothiazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.,5198-88-9

a) Preparation of Intermediate V.1 N-[2-(Aminocarbonyl)phenyl]-2-bromo-4-thiazolecarboxamide (Intermediate V.1) 2-Bromo-4-thiazolecarboxylic acid (1 g), HATU (2.01 g) and 2-aminobenz-amide (0.65 g) are introduced into N,N-dimethylformamide (DMF) (20 ml). The mixture is cooled with an ice bath, and N,N-diisopropylethylamine (0.90 ml) is added. The reaction mixture is stirred at room temperature for 6 days, poured into ice-water and allowed to thaw with stirring, and the precipitated solid is filtered off with suction, washed twice with water, twice with diethyl ether and dried in vacuo. Intermediate V.1 is obtained as a solid (1.4 g). C11H8BrN3O2S, M=326.2. 1H-NMR (300 MHz, D6-DMSO): delta=7.20 (m, 1H), 7.56 (m, 1H), 7.79 (s, 1H), 7.84 (m, 1H), 8.30 (s, 1H), 8.47 (m, 1H), 8.67 (m, 1H), 12.9 (s, 1H).

As the paragraph descriping shows that 5198-88-9 is playing an increasingly important role.

Reference£º
Patent; Ulrich, BOTHE; Arne, Von Bonin; Duy, Nguyen; Ulf, Bomer; Judith, Guenther; US2009/163486; (2009); A1;,
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Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.80945-83-1,2-Chlorobenzothiazole-6-carbonitrile,as a common compound, the synthetic route is as follows.

80945-83-1, Step 1 : 2-(4-(2-chloro-4-((5-cvclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-4- hvdroxypiperidin-1-yl)benzo[d]thiazole-6-carbonitrile To a sealed tube equipped with a magnetic stirring bar, 4-(2-chloro-4-((5-cyclopropyl-3-(2,6- dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)piperidin-4-ol hydrochloride (General synthesis 4, step 2) (100 mg, 0.19 mmol), 2-chlorobenzo[d]thiazole-6-carbonitrile (54.1 mg, 0.23 mmol), potassium carbonate (234 mg, 3.8 mmol) and DMF ( 2 mL) were added. The tube was sealed and the mixture was heated at 80 ¡ãC for 40 minutes. Water (20 mL) was added and the resulting mixture was extracted with EtOAc (50 mL X 3), the combined organic phases were washed with brine (20 mL), dried over Na2S04, filtered, and concentrated in vacuo. Silica gel column chromatography gave the desired product (37 mg, 30percent yield).

The synthetic route of 80945-83-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GILEAD SCIENCES, INC.; KINZEL, Olaf; KREMOSER, Claus; BLOMGREN, Peter, A.; CURRIE, Kevin, S.; KROPF, Jeffrey, E.; SCHMITT, Aaron; WATKINS, William, J.; XU, Jianjun; GEGE, Christian; (92 pag.)WO2016/96116; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1452-15-9, 4-Cyanothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The mixture was heated to distill off 130 ml of 1-butanol+water. When the pot temperature reached about 70 C., all of the o-phenylenediamine monohydrochloride salt was in solution. When half (~65 ml) of the 1-butanol+water has been distilled, 55 g (0.5 mole) of 4-cyanothiazole were added to the reaction flask and a water scrubber (200 ml of water) was added to the exit of the condenser. After a total of 130 ml of 1-butanol+water was distilled, which took about 40 minutes, the Dean-Stark trap was removed from the system. During the removal of 1-butanol+water, the temperature of the reaction mixture rose to 115 C. As the reaction progressed the reflux temperature gradually decreased to 110 C. from an initial reflux temperature of 115 C. Thiabendazole formed during refluxing as a precipitate., 1452-15-9

1452-15-9 4-Cyanothiazole 15069, athiazole compound, is more and more widely used in various.

Reference£º
Patent; E. I. Du Pont de Nemours and Company; US5310923; (1994); A;,
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Thiazole | chemical compound | Britannica

74531-15-0, 4,5-Dimethylthiazole-2-carbaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Representative procedure for the conversion of thiazole-2-carbaldehyde derivatives into (1,3-thiazol-2-yl)methylamine derivatives. Under argon, a solution of 4,5-dimethyl-1,3-thiazole-2-carbaldehyde (644.9 mg, 4.57 mmol), hydroxylamine hydrochloride (648.1 mg, 9.143 mmol) and sodium methoxide (493.7 mg, 9.14 mmol) in ethanol (9 mL) was stirred at room temperature overnight. The white solid was filtered off, rinsed with methanol and the solution was evaporated. The crude oxime was dissolved in acetic acid (25 mL), zinc dust (1.8 g, 27.5 mmol) was added portionwise at room temperature and the reaction mixture was stirred at room temperature for 3 hours. The mixture was then filtered over a pad of celite and rinsed with methanol. Toluene was added and the filtrate was concentrated. An aqueous solution of ammonium chloride was added, the solution was acidified to pH = 2 with hydrochloric acid 1N and extracted with diethyl ether and ethyl acetate. These organic layers were discarded. The aqueous layer was basified with aqueous sodium hydroxide to pH = 10, and then extracted with diethyl ether and ethyl acetate. Combined organic extracts were dried over sodium sulfate, filtered and evaporated to give crude (4,5-dimethyl-1,3-thiazol-2-yl)methylamine (321.7 mg, 49%) as a pale yellow oil which was used in the next steps without purification. ESI-MS m/z 143 (M+ H)+., 74531-15-0

As the paragraph descriping shows that 74531-15-0 is playing an increasingly important role.

Reference£º
Patent; Mutabilis; EP2141164; (2010); A1;,
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Thiazole | chemical compound | Britannica

185613-91-6, 4-(Benzo[d][1,3]dioxol-5-yl)thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-(Benzo[d][1,3]dioxol-5-yl)thiazol-2-amine(2) (1.00 g, 4.54 mmol) and NaH (0.164 g, 6.82 mmol) to THF (15 ml) todissolved and then allowed to react at room temperature for 1 hour under a nitrogen stream. After dropwise addition of 2-chlorobenzylbromide (1.40 g, 6.82 mmol) slowly at room temperature and reacted for 10 minutes. After the reaction wasfinished, it was concentrated under reduced pressure and extracted three times into a saturated solution of NaHCO3 isdissolved in ethyl acetate. The ethyl acetate layer was separated and dried with anhydrous Na2SO4, then purified by columnchromatography (Ethyl acetate: Hexane = 1: 5) to give the compound 1e to give. Yield 17.6%, 185613-91-6

As the paragraph descriping shows that 185613-91-6 is playing an increasingly important role.

Reference£º
Patent; Chungbuk National University Industry-Academic Cooperation Foundation; Jung, Jae Kyung; Kim, Young Soo; Lee, Hee Sun; (27 pag.)KR101651208; (2016); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

34272-64-5, 2-(4-Methyl-2-thioxo-2,3-dihydrothiazol-5-yl)acetic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Each resin from Step 3 was distributed into 24 fritted syringes (Torvig, 50 mg each, 50 mumol), for a total of 96 syringes, and was swelled in NMP (1 mL) for 30 min. The solvent was removed by filtration. Twenty-four solutions of the building blocks listed below (10 mmol each) and DIBA (3.5 mL, 20 mmol) in NMP (10 mL) were prepared. 3 mL of the 24 solutions was added to the 24 syringes for each resin from Step 3, accordingly. The suspensions were then shaken for 20 h on a Titer Plate Shaker. The reaction mixture was filtered and washed 5 times with methylene chloride (5 mL), 3 times with THF (5 mL), 3 times THF/H2O (3/1 v/v, 5 mL), and 3 times with THF (5 mL). The resins were then dried overnight under vacuum., 34272-64-5

34272-64-5 2-(4-Methyl-2-thioxo-2,3-dihydrothiazol-5-yl)acetic acid 3035180, athiazole compound, is more and more widely used in various.

Reference£º
Patent; Kong, Xianqi; Wu, Xinfu; Valade, Isabelle; Gervais, Francine; US2006/167057; (2006); A1;,
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Thiazole | chemical compound | Britannica

78364-55-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78364-55-3,6-Fluoro-2-hydrazinylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.

General procedure: The mixture of 6-fluoro-2-hydrazinylbenzo[d]thiazole (2) (0.01 mol) and benzalde-hyde/substituted benzaldehyde (0.01 mol) was reuxed in ethanol (15 ml) at 70?80 ¡ãC for 3 h. The separated product obtained was ltered off, washed withdistilled water and recrystallized from methanol to give the correspondinghydrazone. The product obtained was further dissolved in acetic acid (20 ml) atroom temperature followed by the addition of sodium acetate (0.5 g). Bromine(2 mmol) in acetic acid (10 ml) was added dropwise to the reuxing reactionmixture. After 1 h, the mixture was poured onto crushed ice (100 g). The precipitateobtained was ltered off and crystallized from ethanol-dimethylformamide (1:1) togive crystals of (3a?3t).

As the paragraph descriping shows that 78364-55-3 is playing an increasingly important role.

Reference£º
Article; Kukreja, Sharu; Sidhu, Anjali; Sharma, Vineet K.; Research on Chemical Intermediates; vol. 42; 12; (2016); p. 8329 – 8344;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2289-75-0,4,5-Dimethylthiazol-2-amine,as a common compound, the synthetic route is as follows.

A mixture of 2-amino-4,5-dimethylthiazole (1 ,0 g, 7 8 mmol) and (bromomethyl)cyclobutane (0.88 mL, 7.8 mmol) was warmed to 85 0C and stirred for 18 hours. The mixture was cooled to ambient temperature and the residue was purified via column chromatography (SiO2, 10% methanol in ethyl acetate then 9:1:0.1 CH2Cl2 : methanol : NH4OH) to afford the title compound. MS (DCI/NH3) m/z l97 (M+H)+, 2289-75-0

As the paragraph descriping shows that 2289-75-0 is playing an increasingly important role.

Reference£º
Patent; ABBOTT LABORATORIES; WO2007/140439; (2007); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica