Downstream synthetic route of 2516-40-7

As the paragraph descriping shows that 2516-40-7 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2516-40-7,2-Bromobenzothiazole,as a common compound, the synthetic route is as follows.

9-Ethyl-3- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) -9H-carbazole (1 g, 3.1 mmol) is dissolved in the THF (20 mL). 2-bromobenzothiazole (0.663 g, 3.1 mmol), Pd (PPh3) 4 (0.179 g, 0.155 mmol), Na2CO3 (0.985 g, 9.3 mmol) and distilled water (4 mL) was added a After 15 hours the 70 degree in a nitrogen atmosphere heated at. After the reaction mixture was poured into distilled water (300 mL) Separate the organic layer with ethyl acetate, dry over MgSO4 and evaporate solvents. Column with ethyl acetate / hexane: separate the compound (3) by the (1 2) as a developing solvent to obtain the compound (2) to 65percent.

As the paragraph descriping shows that 2516-40-7 is playing an increasingly important role.

Reference£º
Patent; Pusan National University Industry-Academic Cooperation Foundation; Jin, Sung Ho; Park, Jin Soo; (26 pag.)KR101481147; (2015); B1;,
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Downstream synthetic route of 34259-99-9

As the paragraph descriping shows that 34259-99-9 is playing an increasingly important role.

34259-99-9, 4-Bromothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1. 4-Neopentylthiazole. 4-Bromothiazole (1.98 g, 12.1 mmol) was covered with a 0.5 M solution of neopentylzinc iodide in THF (96 mL, 48.2 mmol). Pd2dba3.CHCI3 (624 mg, 0.603 mmol) and 2(-di-te/t-butylphosphine)biphenyl (720 mg, 2.41 mmol) were added and the reaction mixture was placed in an oil bath pre-heated to 70 ¡ãC. The resulting solution was allowed to stir for 24 h at 70 ¡ãC. The resulting mixture was cooled to room temperature and concentrated under vacuum and the residue was dissolved in ethyl acetate (100 mL) and subsequently washed with aqueous NaOH (2 x 40 mL, 3N). The organic phase was then dried (Na2SO4), filtered, concentrated under vacuum and the residue was purified on a silica gel column (eluant hexane to hexane/ethyl acetate 8/2) to give 4-neopentylthiazole (1.42 g, 75percent), retention time (min) = 1.198, method [1], MS(ESI) 156.1 (M+H).

As the paragraph descriping shows that 34259-99-9 is playing an increasingly important role.

Reference£º
Patent; ELAN PHARMACEUTICALS, INC.; WO2007/47306; (2007); A1;,
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Analyzing the synthesis route of 10200-59-6

10200-59-6 2-Thiazolecarboxaldehyde 2734903, athiazole compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10200-59-6,2-Thiazolecarboxaldehyde,as a common compound, the synthetic route is as follows.

To a solution of n-BuLi (8.4 ml, 1.6 mol/l, 13.4 mmol) in THF (30 mL) was added 2-bromothiazole (377 mg, 2.12 mmol) dropwise under nitrogen atmosphere at -70¡ã C., and the mixture was stirred at the temperature for 1 h. Then DMF (1.4 ml, 18.3 mmol) was added into the solution dropwise under nitrogen atmosphere at -70¡ã C. The resulting mixture was stirred at the temperature for 1 h. Then the mixture was quenched with aqueous saturated ammonium chloride, diluted with ethyl acetate and water, and the phases were separated. The organic phase was washed with brine, dried over sodium sulfate, filtered and concentrated to give yellow oil. The yellow oil was dissolved in methanol (15 ml), cooled to -60¡ã C., and sodium borohydride (463 mg, 12.2 mmol) was added portionwise under nitrogen atmosphere. The mixture was stirred at the temperature for 1 h. The reaction was quenched with acetone and concentrated. The residue was diluted with ethyl acetate and water, and the phases were separated. The organic layer was dried over sodium sulfate, filtered and concentrated, then purified by silica gel chromatography eluting with petroleum/ethyl acetate=3:1 to give thiazol-2-ylmethanol (230 mg, 16.4percent yield) as brown oil. LCMS MH+ 116.

10200-59-6 2-Thiazolecarboxaldehyde 2734903, athiazole compound, is more and more widely used in various.

Reference£º
Patent; HYDRA BIOSCIENCES, INC.; Chenard, Bertrand L.; Gallaschun, Randall J.; Kimball, Spencer David; US2014/275528; (2014); A1;,
Thiazole | C3H3NS – PubChem
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Downstream synthetic route of 10200-59-6

The synthetic route of 10200-59-6 has been constantly updated, and we look forward to future research findings.

10200-59-6, 2-Thiazolecarboxaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Referential Example 12: thiazole-2-methanol While stirring under ice cooling, sodium borohydride (242 mg, 6.40 mmol) was added to a methanol (10 ml) solution of 2-formylthiazole (483 mg, 4.27 mmol).. After completion of the reaction was confirmed, water was added to the reaction mixture.. The resulting mixture was concentrated under reduced pressure.. Water and ethyl acetate were added to the residue to separate the organic layer.. The organic layer was washed with brine and then dried over anhydrous sodium sulfate.. After filtration, the filtrate was concentrated under reduced pressure.. The residue was subjected to chromatography on a silica gel column.. The fraction obtained from the hexane:ethyl acetate (=1:1) elude was concentrated under reduced pressure, whereby the title compound (324 mg, 66percent) was obtained as a white solid.1H-NMR (400MHz, CDCl3) delta: 3.30-3.70(1H,m), 5.14(2H,s), 7.32(1H,d,J=3.4Hz), 7.74(1H,d,J=3.2Hz). MS (m/z): 116 (M++H).

The synthetic route of 10200-59-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1466898; (2004); A1;,
Thiazole | C3H3NS – PubChem
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Brief introduction of 185613-91-6

As the paragraph descriping shows that 185613-91-6 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.185613-91-6,4-(Benzo[d][1,3]dioxol-5-yl)thiazol-2-amine,as a common compound, the synthetic route is as follows.

(Benzo [d] [1,3] dioxol-5-yl) thiazol-2-amine (2)(1.00 g, 4.54 mmol) and NaH (0.164 g, 6.82 mmol) were dissolved in THF (15 ml) and reacted at room temperature for 1 hour under a nitrogen stream. Benzyl bromide (1.17 g, 6.82 mmol) was then slowly added dropwise at room temperature and allowed to react for 10 minutes. After the reaction was completed, the reaction mixture was concentrated under reduced pressure, dissolved in ethyl acetate, and saturated NaHCO 3 solution was added thereto. The ethyl acetate layer was separated, dried over anhydrous Na2SO4 and then purified by column chromatography (Ethyl acetate: Hexane = 1: 5) to obtain Compound 1a. Yield: 21.2%

As the paragraph descriping shows that 185613-91-6 is playing an increasingly important role.

Reference£º
Patent; Chungbuk National University Industry-Academic Cooperation Foundation; Jung, Jae Kyung; Kim, Young Soo; Lee, Hee Sun; (27 pag.)KR101651208; (2016); B1;,
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Downstream synthetic route of 79836-78-5

The synthetic route of 79836-78-5 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.79836-78-5,Ethyl 2-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

To a stirred solution of ethyl 2-methylthiazole-5-carboxylate (1 eq) in dry THF (5 mL) at 0 Patent; MERCK PATENT GMBH; YU, Henry; LIU-BUJALSKI, Lesley; JOHNSON, Theresa L.; WO2014/159234; (2014); A1;,
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Downstream synthetic route of 247037-82-7

The synthetic route of 247037-82-7 has been constantly updated, and we look forward to future research findings.

247037-82-7, Thiazole-2-carboximidamide hydrochloride is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A 1000 L glass-lined reactor equipped with mechanical stirrer, thermometer and nitrogen bubbler was charged 2-chloro-4-fluoro-benzaldehyde (30.8 kg, 194 mol, compound 11-a) andIPA (188.0 kg). To the solution was then added methyl acetoacetate (22.7 kg, 195 mol, compound 11-b) followed by addition of piperidine (1.74 kg, 20.4 mol) and acetic acid (1.32 kg, 22.0 mol). The reaction mixture was then heated to 43 C-47 C and stirred at such temperature for 5 hours. Then to the reaction mixture was added thiazole-2-carboxamidine hydrochloride salt (19.8 kg, 121.0 mol, compound 8-c) followed by addition of triethylamine (20.0 kg, 198.0 mol).The reaction mixture was heated to 80 C – 85 C and stirred for 7 hours. After reaction was completed, the reaction mixture was cooled to 20 C-25 C and then added water (52.0 kg). The resulting suspension was stirred at 20 C-25 C for 2 hours. The solid was collected by centrifuge and washed with isopropanollwater (42 kg, v/v=10/3). The wet solid was dried in vacuum oven to afford Example 11 (35.05 kg, purity: 95.8%, Yield: 79.2%) as yellow solid. MS mle = 366.2[M+H] .

The synthetic route of 247037-82-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; CHEN, Junli; (58 pag.)WO2017/140750; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

Brief introduction of 61296-22-8

The synthetic route of 61296-22-8 has been constantly updated, and we look forward to future research findings.

61296-22-8, 2-Amino-5-bromothiazole monohydrobromide is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5.9 ml (42.3 mmol) of acetic anhydride are added to a solution of 10 g (38. 5 mmol) of 2-amino-5- bromothiazole hydrobromide in 100 ml of dichloromethane and 11 ml (77 mmol) of triethylamine, cooled to 0oC. The reaction medium is stirred for 30 minutes at 0oC and then for 18 hours at room temperature. After addition of water, the pH is adjusted to pH 8 with aqueous 1M sodium hydroxide solution and the reaction medium is extracted with dichloromethane. The dichloro- methane phase is dried over magnesium sulfate, filtered and evaporated. The residue obtained is used in step b without purification.

The synthetic route of 61296-22-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GALDERMA RESEARCH & DEVELOPMENT, S.N.C.; WO2004/113331; (2004); A1;,
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New learning discoveries about 5464-79-9

The synthetic route of 5464-79-9 has been constantly updated, and we look forward to future research findings.

5464-79-9, 2-Amino-4-methoxybenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step A. A solution of AICl3 (5 mmole) in EtSH (10 mL) was cooled to 0 C. and treated with 2-amino-4-methoxybenzothiazole (1 mmole). The mixture was stirred at 0-5 C. for 2 h. Evaporation and extraction gave 2-amino-4-hydroxybenzothiazole as white solid.

The synthetic route of 5464-79-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; METABASIS THERAPEUTICS, INC.; US2002/173490; (2002); A1;,
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Thiazole | chemical compound | Britannica

Analyzing the synthesis route of 1024583-33-2

1024583-33-2 Methyl 2-bromobenzo[d]thiazole-6-carboxylate 46911877, athiazole compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1024583-33-2,Methyl 2-bromobenzo[d]thiazole-6-carboxylate,as a common compound, the synthetic route is as follows.

4-(((2-Azabicyclo[4.1.0]heptane-5-yl)oxy)methyl)-5-cyclopropyl-3-(2,6-dichlorophenyl) The crude product of the above-mentioned oxazole, 2-bromobenzo[d]thiazolidine methyl-6-carboxylate (240 mg, 0.88 mmol) and cesium carbonate (429 mg,1.32 mmol) was dissolved in DMA (6 mL), and subjected to microwave reaction at 110 C for 40 minutes. After completion of the reaction, 100 mL of water and 30 mL of ethyl acetate were added and the mixture was separated, and the aqueous phase was extracted with ethyl acetate (30 mL¡Á2). concentrate, The residue was subjected to silica gel column chromatography ( petroleum ether: ethyl acetate = 2:1)The product was obtained in 183 mg in two-step yield: 72.9%.

1024583-33-2 Methyl 2-bromobenzo[d]thiazole-6-carboxylate 46911877, athiazole compound, is more and more widely used in various.

Reference£º
Patent; Hainan Xuanzhu Pharmaceutical Technology Co., Ltd.; Fang Wenkui; (39 pag.)CN109575008; (2019); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica