Tag: 100-200

Facile synthesis of the new tripodal tetraamine ligand tris(thiazolylmethyl) amine, and full characterization of two ferrous complexes was written by Thibon, Aurore;Karmazin-Brelot, Lydia;Mandon, Dominique. And the article was included in Dalton Transactions in 2013.Quality Control of Thiazol-2-ylmethanamine This article mentions the following:

The authors report the facile synthesis of the new tris(thiazolylmethyl)amine, TTA ligand (3) and the full characterization in solution and in the solid state of two ferrous complexes, [(TTA)FeCl₂] (1) and [(TTA)Fe(OTf)₂] (2). TTA, the first example of a simple tris(thiazolemethyl)amine chelate – the second one only within this class of tripods – exerts a weak ligand field and the tertiary amine is weakly bound to the metal center. In the experiment, the researchers used many compounds, for example, Thiazol-2-ylmethanamine (cas: 55661-33-1Quality Control of Thiazol-2-ylmethanamine).

Thiazol-2-ylmethanamine (cas: 55661-33-1) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Quality Control of Thiazol-2-ylmethanamine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Dipole moments of phenylthiazoles was written by Bonnier, Jane M.;Arnaud, Roger. And the article was included in Comptes Rendus des Seances de l’Academie des Sciences, Serie C: Sciences Chimiques in 1970.Synthetic Route of C9H7NS This article mentions the following:

Dipole moments of I (where R, R1, and (or) R2 = H or Ph) were measured in in CCl4 or cyclohexane at 20° and calculated by the LCAO method. The dipole moments in CCl4 and cyclohexane were very similar and did not indicate the formation of complexes between I and CCl4. The calculated values were satisfactory, except for I (R = R1 = R2 = Ph). In the experiment, the researchers used many compounds, for example, 5-Phenylthiazole (cas: 1826-13-7Synthetic Route of C9H7NS).

5-Phenylthiazole (cas: 1826-13-7) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Synthetic Route of C9H7NS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

A copper-mediated cross-coupling approach for the synthesis of 3-heteroaryl quinolone and related analogues was written by Shin, Sanghye;Kim, Yechan;Kim, Kiho;Hong, Sungwoo. And the article was included in Organic & Biomolecular Chemistry in 2014.Related Products of 1826-13-7 This article mentions the following:

An efficient and practical method for the direct cross-coupling between quinolones and a range of azoles was developed via copper-mediated C-H functionalization. This synthetic strategy provides a convenient access to a variety of C3-heteroaryl quinolones, quinolinone, nalidixic acid, uracil, pyridone, and chromone derivatives, which are prominent structural motifs in many biol. active compounds E.g., in presence of CuI and LiOCMe₃ in 1,4-dioxane under N₂ at 110 °C, coupling of 1-benzyl-3-iodo-4-quinolone with benzothiazole gave 80% 3-heteroaryl quinolone derivative (I). In the experiment, the researchers used many compounds, for example, 5-Phenylthiazole (cas: 1826-13-7Related Products of 1826-13-7).

5-Phenylthiazole (cas: 1826-13-7) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Related Products of 1826-13-7

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists was written by Walker, Daniel P.;Wishka, Donn G.;Piotrowski, David W.;Jia, Shaojuan;Reitz, Steven C.;Yates, Karen M.;Myers, Jason K.;Vetman, Tatiana N.;Margolis, Brandon J.;Jacobsen, E. Jon;Acker, Brad A.;Groppi, Vincent E.;Wolfe, Mark L.;Thornburgh, Bruce A.;Tinholt, Paula M.;Cortes-Burgos, Luz A.;Walters, Rodney R.;Hester, Matthew R.;Seest, Eric P.;Dolak, Lester A.;Han, Fusen;Olson, Barbara A.;Fitzgerald, Laura;Staton, Brian A.;Raub, Thomas J.;Hajos, Mihaly;Hoffmann, William E.;Li, Kai S.;Higdon, Nicole R.;Wall, Theron M.;Hurst, Raymond S.;Wong, Erik H. F.;Rogers, Bruce N.. And the article was included in Bioorganic & Medicinal Chemistry in 2006.Safety of Benzothiazole-5-carboxylic acid This article mentions the following:

A novel set of azabicyclic aryl amides have been identified as potent and selective agonists of the α7 nAChR. A two-pronged approach was taken to improve the potential hERG liability of previously disclosed α7 nAChR agonist, PNU-282,987, while maintaining the compound’s other desirable pharmacol. properties. The first approach involved further exploration of the aryl carboxylic acid fragment of PNU-282,987, while the second approach focused on modification of the azabicyclic amine portion of PNU-282,987. The best compounds from each series are characterized by rapid brain penetration, good oral bioavailability in rat, and demonstrate in vivo efficacy in a rat P50 auditory sensory gating assay. At least one analog from each series shows an improved hERG safety profile over PNU-282,987. In the experiment, the researchers used many compounds, for example, Benzothiazole-5-carboxylic acid (cas: 68867-17-4Safety of Benzothiazole-5-carboxylic acid).

Benzothiazole-5-carboxylic acid (cas: 68867-17-4) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Safety of Benzothiazole-5-carboxylic acid

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Palladium-Catalyzed Tandem Ester Dance/Decarbonylative Coupling Reactions was written by Kubo, Masayuki;Inayama, Naomi;Ota, Eisuke;Yamaguchi, Junichiro. And the article was included in Organic Letters in 2022.Computed Properties of C9H7NS This article mentions the following:

“Dance reaction” on the aromatic ring is a powerful method in organic chem. to translocate functional groups on arene scaffolds. Notably, dance reactions of halides and pseudohalides offer a unique platform for the divergent synthesis of substituted (hetero)aromatic compounds when combined with transition-metal-catalyzed coupling reactions. Herein, a tandem reaction of ester dance and decarbonylative coupling enabled by palladium catalysis is reported. In this reaction, 1,2-translocation of the ester moiety on the aromatic ring is followed by decarbonylative coupling with nucleophiles to enable the installation of a variety of nucleophiles at the position adjacent to the ester in the starting material. In the experiment, the researchers used many compounds, for example, 5-Phenylthiazole (cas: 1826-13-7Computed Properties of C9H7NS).

5-Phenylthiazole (cas: 1826-13-7) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Computed Properties of C9H7NS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Photochemical rearrangements in heterocyclic series. III. Arythiazoles and arylisothiazoles isomers. Experimental results and theoretical study was written by Vernin, G.;Riou, C.;Dou, H. J. M.;Bouscasse, L.;Metzger, J.;Loridan, G.. And the article was included in Bulletin de la Societe Chimique de France in 1973.COA of Formula: C9H7NS This article mentions the following:

In the presence of I2 the photoisomerization of 3 phenylthiazoles and 3 phenylisothiazoles was selective. Five possible mechanisms from published data were examined; those best fitting the results were a valence isomerization mechanism with or without preliminary opening of weaker bonds in the 1st excited state and a mechanism involving torsion of bonds adjacent to S. In the experiment, the researchers used many compounds, for example, 5-Phenylthiazole (cas: 1826-13-7COA of Formula: C9H7NS).

5-Phenylthiazole (cas: 1826-13-7) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.COA of Formula: C9H7NS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Orally bioavailable small molecule ketoamide-based inhibitors of cathepsin K was written by Barrett, David G.;Catalano, John G.;Deaton, David N.;Long, Stacey T.;Miller, Larry R.;Tavares, Francis X.;Wells-Knecht, Kevin J.;Wright, Lois L.;Zhou, Hui-Qiang Q.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2004.Electric Literature of C4H6N2S This article mentions the following:

An orally available series of ketoamide-based inhibitors of cathepsin K has been identified. Starting from a potent inhibitor with poor oral bioavailability, modifications to P¹ and P¹‘ elements led to enhancements in solubility and permeability. These improvements resulted in orally available cathepsin K inhibitors. In the experiment, the researchers used many compounds, for example, Thiazol-2-ylmethanamine (cas: 55661-33-1Electric Literature of C4H6N2S).

Thiazol-2-ylmethanamine (cas: 55661-33-1) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Electric Literature of C4H6N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Copper-Catalyzed Oxidative Arylation of Heteroarenes under Mild Conditions Using Dioxygen as the Sole Oxidant was written by Yang, Fanzhi;Xu, Zhaoqing;Wang, Zhe;Yu, Zhengkun;Wang, Rui. And the article was included in Chemistry – A European Journal in 2011.Category: thiazole This article mentions the following:

A novel copper-catalyzed oxidative heteroarene arylation reaction is reported. Heteroarene compounds such as benzoxazole and benzothiazole are easily cross-coupled with arylboronic esters under an O₂ atmosphere. In the experiment, the researchers used many compounds, for example, 5-Phenylthiazole (cas: 1826-13-7Category: thiazole).

5-Phenylthiazole (cas: 1826-13-7) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Development of an efficient ruthenium catalyzed synthetic process and mechanism for the facile conversion of benzothiazoles to orthanilic acids was written by Jagadeesh, R. V.;Karthikeyan, P.;Nithya, P.;Sandhya, Y. Sree;Reddy, S. Sudhaker;Reddy, P. Pradeep Kumar;Kumar, M. Vinod;Charan, K. T. Prabhu;Narender, R.;Bhagat, P. R.. And the article was included in Journal of Molecular Catalysis A: Chemical in 2010.HPLC of Formula: 68867-17-4 This article mentions the following:

Ruthenium-Schiff base complex catalyzed efficient protocol has been developed for the synthesis of orthanilic acids from benzothiazoles in good to excellent yields using N-haloamines. Hexa-coordinated ruthenium complex with Schiff base and triphenylphosphine ligands has been prepared and its catalytic function was invented for the synthesis of orthanilic acids. The synthetic process utilizes our efficient method for the selective and preferential oxidation of thiazole ring of benzothiazoles using N-haloamines without effecting Ph ring. The detailed catalytic, mechanistic and kinetic investigations have been made for the synthetic reactions. Solvent isotope studies have been made in H₂O-D₂O and the reactions were carried out at different temperatures Under the identical set of conditions, the kinetics of catalyzed reactions has been compared with uncatalyzed reactions and found that the catalyzed reactions are 9-11 folds faster. The catalytic constants (K_C) have been calculated for each N-haloamine at different temperatures and the values of activation parameters with respect to the catalyst have been evaluated. Spectroscopic evidence for the formation of 1:1 complex between N-haloamine and ruthenium has been obtained. The observed results have been explained by a plausible mechanism and the related rate law has been deduced. In the experiment, the researchers used many compounds, for example, Benzothiazole-5-carboxylic acid (cas: 68867-17-4HPLC of Formula: 68867-17-4).

Benzothiazole-5-carboxylic acid (cas: 68867-17-4) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.HPLC of Formula: 68867-17-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

MOARF, an Integrated Workflow for Multiobjective Optimization: Implementation, Synthesis, and Biological Evaluation was written by Firth, Nicholas C.;Atrash, Butrus;Brown, Nathan;Blagg, Julian. And the article was included in Journal of Chemical Information and Modeling in 2015.Product Details of 55661-33-1 This article mentions the following:

We describe the development and application of an integrated, multiobjective optimization workflow (MOARF) for directed medicinal chem. design. This workflow couples a rule-based mol. fragmentation scheme (SynDiR) with a pharmacophore fingerprint-based fragment replacement algorithm (RATS) to broaden the scope of reconnection options considered in the generation of potential solution structures. Solutions are ranked by a multiobjective scoring algorithm comprising ligand-based (shape similarity) biochem. activity predictions as well as physicochem. property calculations Application of this iterative workflow to optimization of the CDK2 inhibitor Seliciclib (CYC202, R-roscovitine) generated solution mols. in desired physicochem. property space. Synthesis and exptl. evaluation of optimal solution mols. demonstrates CDK2 biochem. activity and improved human metabolic stability. In the experiment, the researchers used many compounds, for example, Thiazol-2-ylmethanamine (cas: 55661-33-1Product Details of 55661-33-1).

Thiazol-2-ylmethanamine (cas: 55661-33-1) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Product Details of 55661-33-1

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica