Tag: 100-200

On January 31, 2004, Muri, E. M. F.; Mishra, H.; Stein, S. M.; Williamson, J. S. published an article.Recommanded Product: 64987-16-2 The title of the article was Molecular modeling, synthesis and biological evaluation of heterocyclic hydroxamic acids designed as Helicobacter pylori urease inhibitors. And the article contained the following:

A computer-generated homol. model of the antimicrobial target Helicobacter pylori urease was derived, using the x-ray crystal structure of Klebsiella aerogenes as a template, in order to design novel urease inhibitors. Based on these computational studies, several heterocyclic hydroxamic acid derivatives have been designed, synthesized, and examined for their ability to inhibit urease activity. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Recommanded Product: 64987-16-2

The Article related to helicobacter urease inhibitor heterocyclic hydroxamate derivative preparation, Pharmacology: Structure-Activity and other aspects.Recommanded Product: 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Bolchi, Cristiano; Pallavicini, Marco; Bernini, Sergio K.; Chiodini, Giuseppe; Corsini, Alberto; Ferri, Nicola; Fumagalli, Laura; Straniero, Valentina; Valoti, Ermanno published an article in 2011, the title of the article was Thiazole- and imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase.SDS of cas: 64987-16-2 And the article contains the following content:

Mimetics of the C-terminal CAAX tetrapeptide of Ras protein were designed replacing internal dipeptide AA with 4-amino-2-phenylbenzoic acid and cysteine (C) with 2-amino-4-thiazolyl-, 2-mercapto-4-thiazolyl-, 2-mercapto-4-imidazolyl- and 2-methylmercapto-4-thiazolyl-acetic or propionic acid. The compound in which C is replaced by 2-amino-4-thiazolylacetic acid inhibited FTase activity in the low nanomolar range and showed antiproliferative effect on rat aortic smooth muscle cells interfering with Ras farnesylation. On the basis of these results, 2-aminothiazole can be considered as an alternative to heterocycles, such as pyridine and imidazole, normally used in FTase inhibitors designed as non-thiol CAAX mimetics. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).SDS of cas: 64987-16-2

The Article related to preparation thiazole imidazole peptidomimetic inhibitor farnesyltransferase, Pharmacology: Structure-Activity and other aspects.SDS of cas: 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On March 31, 2022, Pekdemir, Fatih; Kocak, Izzet; Sengul, Abdurrahman published an article.Electric Literature of 24295-03-2 The title of the article was Copper(II) and Cobalt(II) Tridentate Complexes on Modified Graphene Oxide as Electrochemical Biosensors for Simultaneously Detecting Biomolecules. And the article contained the following:

Two novel coordination compounds, [Cu(L)Cl2] and [Co(L)Cl2] (L= 4-(6-hydroxy-phenyl)-2,6-di(thiazol-2-yl) pyridine), are successfully synthesized. The structure of the compounds was verified by instrumental techniques, including UV-visible spectroscopy, Fourier transform IR spectroscopy, proton NMR spectroscopy, and mass spectrometry. The graphene oxide, previously modified by spontaneous coupling of diazonium salt of 4-amino benzoic acid, was covalently bound with [Cu(L)Cl2] and [Co(L)Cl2] compounds The covalent attachment of the metallic complexes to the graphene oxide was confirmed by Fourier transform IR spectroscopy and cyclic voltammetry. Functionalized surfaces through metallic coordination compounds showed catalytic reactivity to individual electrochem. oxidation of ascorbic acid, dopamine, and uric acid as revealed by the enhancement in the anodic peak current and the shifted oxidation peak potentials of each three analytes in comparison to the plain glassy carbon and graphene oxide. The resulting electrodes were shown to be utilized for the simultaneous detection of ascorbic acid, dopamine, and uric acid due to the appearance of the well-separated and resolved three different anodic peaks. The sensitivity of both modified electrodes for each biol. compound was tested within the linear range of 2 to 15 μM for ascorbic acid, 0.2 to 3 μM for dopamine and uric acid, and the limit of detection values for ascorbic acid, dopamine, and uric acid are found to be 1.84 μM, 0.41 μM, and 0.32 μM, resp. for [Cu(L)Cl2] and 1.94 μM, 0.33 μM, and 0.52 μM for [Co(L)Cl2]. Furthermore, constructed electrochem. sensor platforms exhibited decent stability, selectivity, and reproducibility for the simultaneous detection of target biomols. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Electric Literature of 24295-03-2

The Article related to copper cobalt tridentate complex modified graphene oxide electrochem biosensor, Placeholder for records without volume info and other aspects.Electric Literature of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Stevanovic, Nevena; Jevtovic, Mima; Mitic, Dragana; Matic, Ivana Z.; Crnogorac, Marija Dordjic; Vujcic, Miroslava; Sladic, Dusan; Cobeljic, Bozidar; Andjelkovic, Katarina published an article in 2022, the title of the article was Evaluation of antitumor potential of Cu(II) complex with hydrazone of 2-acetylthiazole and Girard′s T reagent.Formula: C5H5NOS And the article contains the following content:

In this paper, the previously synthesized Cu(II) complex ([CuL1(N3) (CH3OH)]BF4) with N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride, has been characterized and its biol. activity has been studied in detail. The Cu(II) complex consists of ligand coordinated in a deprotonated, formally neutral zwitter-ionic form, via NNO atoms, one azido ligand and one methanol mol. The Cu(II) complex was selected due to results of the cytotoxic activity, the brine shrimp test and DPPH radical scavenging activity, which were previously performed. The effects of Cu(II) complex on cell cycle phase distribution of cervical adenocarcinoma HeLa cells were investigated in order to examine the mechanisms of its anticancer activity. The measurement of intracellular ROS levels in HeLa and HaCaT cell lines were evaluated in order to explore their possible generation and the role in cytotoxic activity. The possible anti-invasive and anti-angiogenic properties of Cu(II) complex were evaluated. DNA binding experiments, including fluorescence displacement study and DNA cleavage experiments, were performed in order to obtain information on the type of DNA-metal complex interactions. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Formula: C5H5NOS

The Article related to copper complex antitumor agent acetylthiazole girard t reagent adenocarcinoma, Placeholder for records without volume info and other aspects.Formula: C5H5NOS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On March 31, 2022, Siutkina, A. I.; Chashchina, S. V.; Makhmudov, R. R.; Novikova, V. V.; Chernov, I. N.; Igidov, N. M. published an article.Synthetic Route of 2010-06-2 The title of the article was Synthesis, analgesic and antimicrobial activity of N-hetarylamides of 2-(2-(diarylmethylene)hydrazono)-5,5-dimethyl-4-oxohexanoic acid. And the article contained the following:

New N-hetaryl substituted 2-((diarylmethylene)hydrazono)-5,5-dimethyl-4-oxohexanamides were obtained in 4 steps: a) Claisen condensation between pinacolone and di-Et oxalate in the presence of sodium methylate; b) the condensation of pivaloyl pyruvic acid with diarylmethylene hydrazones to form 2-diarylmethylenehydrazono-4-oxo-5,5-dimethylhexanoic acid; c) intramol. cyclization of hydrazonoacids in hydrazonofuranones; d) decyclization of the latter under the action of heterocyclic amines. Isolation of N-hetaryl-2-((diarylmethylene)hydrazono)-5,5-dimethyl-4-oxohexanamides was carried out by filtration of the resulting precipitate with subsequent recrystallization from ethanol or propane-2-ol. The structure of the obtained compounds was confirmed by the methods of 1H and 13C NMR spectroscopy and elemental anal. It is established that the obtained substituted hetarylamides exist in solutions of deuterated chloroform and DMSO in hydrazonoform. The analgesic and antimicrobial activity of the synthesized compounds was evaluated. Analgesic activity was studied by the “hot plate” thermal irritation method on outbred white mice of both sexes with i.p. injection. Antimicrobial activity of synthesized compounds was established via two-fold serial dilutions method in a liquid growth medium against two strains – S. aureus ATCC 6538-P and E. soli ATCC 25922. The studied compounds showed pronounced analgesic activity significantly exceeding that of the comparison drug metamizole sodium, and in some cases corresponding to the action of the reference diclofenac sodium. Therefore, pronounced analgesic activity accompanied with weak antimicrobial activity of the synthesized hetarylamides determines the prospects for the development of a new pharmacol. active substance with analgesic properties. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Synthetic Route of 2010-06-2

The Article related to staphylococcus escherichia pain analgesics antimicrobial nhetarylamide, Placeholder for records without volume info and other aspects.Synthetic Route of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On May 31, 2022, He, Xiaona; Wang, Hongbo; Yang, Xiaoling; Xi, Bin; Li, Weihong; Wang, Fang; Li, Hongqiang; Gao, Yaqin published an article.Category: thiazole The title of the article was The effects of frozen storage on fatty acids, amino acids, and volatile compounds in mutton stored for 90 days. And the article contained the following:

Frozen storage can delay mutton meat spoilage to the maximum extent, prolonging its shelf life. In this experiment, mutton refrigerated for 24 h was used as the control group and that stored at -18°C was used as the exptl. group to explore the effects of frozen storage for 90 days on FA, AA, and VOC of the mutton. The results showed that FA, AA, and VOC changed significantly during storage. PUFA and n-3 FA contents were the highest at 3 days of freezing (54.92 and 15.28 mg/100 g, resp.). AA contents were higher in the exptl. group than in the control group, and Glu contents were the highest during the whole storage period, ranging from 2.94% to 3.28%, and the maximum value was on the 3rd day. In total, 38 volatile compounds were detected, and the most abundant volatile compounds were detected at 60 days. The variance contribution rates of PCA were 48.7%, 19.4%, and 14.8%, the PCA model can be used as a separation model. Novelty impact statement : This study simulated the storage of mutton by household users and shortened the detection time point at the initial freezing stage, indicating that the differences in flavor substance changes in mutton at the initial freezing stage was little. On the other hand, GC-IMS was effectively used to visualize flavor substance changes during storage, providing a new method to distinguish the storage time of meat products. In conclusion, this study can provide basic research data for long-term storage of mutton and provide tech. reference for meat storage identification. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Category: thiazole

The Article related to fatty acids threonine valine phenylalanine butyl acetate furfural, Placeholder for records without volume info and other aspects.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On December 31, 2019, Rudrapal, Mithun; Sowmya, Mullapudi P. K. published an article.Related Products of 2010-06-2 The title of the article was Design, synthesis, drug-likeness studies and bio-evaluation of some new chalconeimines. And the article contained the following:

Newly designed chalconeimines were synthesized, characterized and evaluated for their in vitro antioxidant and antibacterial effectiveness. Results of antioxidant activity assay reveal that all the tested compounds possess good to moderate antioxidant activity which is lower in comparison to that of a standard drug (gallic acid). On the other hand, all the synthesized compounds were found to exhibit a considerably wider spectrum of antibacterial activity, but it was also narrower in comparison to that of a standard drug (ciprofloxacin). Elucidation of structure-activity relationships revealed that electron donating groups (-OH, -OCH3) contribute more to antioxidant potency, whereas electron withdrawing groups (-Cl) impart better antibacterial effectiveness. Moreover, results of drug-likeness studies indicate that a reasonable correlation exists between the drug-like properties and antioxidant activity of the synthesized chalconeimines. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Related Products of 2010-06-2

The Article related to chalconeimine drug design synthesis antioxidant antibacterial, Placeholder for records without volume info and other aspects.Related Products of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 31, 2021, Li, Shaohui; Zhao, Wei; Liu, Songyan; Li, Pengliang; Zhang, Aixia; Zhang, Jiali; Wang, Yunting; Liu, Yingying; Liu, Jingke published an article.Product Details of 24295-03-2 The title of the article was Characterization of nutritional properties and aroma compounds in different colored kernel varieties of foxtail millet (Setaria italica). And the article contained the following:

Proximate compositions, color values, total yellow pigment contents, amino acids, fatty acids, mineral elements compositions, and aroma compounds of four foxtail millet varieties, namely Jigu 42, Henggu13, Henglvgu1, and Heinuogu, were evaluated. There were significant differences among the four foxtail millet varieties(p < 0.05). A total of 62 volatile compounds were quant. determined by combination of simultaneous distillation extraction (SDE) and gas chromatog. mass spectrometry (GC-MS). The main flavor components contained 18 aldehydes, six alcs., nine ketones, five acids, 10 hydrocarbons, 10 benzene derivatives, and four other components. Among 30 odor characteristics described compounds, the odor activity value (OAV) of 18 compounds was greater than 1, including nonanal, (Z)-2-nonenal, (E,E)-2,4-nonadienal, naphthalene di-Bu phthalate, and others. Partial least squares discriminant anal. (PLS-DA) showed that minerals and aroma compounds with variable importance in projection (VIP) greater than 1 were the markers that distinguished the difference of foxtail millet varieties. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Product Details of 24295-03-2

The Article related to setaria nonanal 2 4 nonadienal naphthalene dibutyl phthalate, Placeholder for records without volume info and other aspects.Product Details of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On June 30, 2022, Rajeswari, Kannuri; Manturthi, Shireesha; Sirisha, Kalam; Velidandi, Amar nath published an article.Safety of 2-Acetylthiazole The title of the article was Anchoring and Hydrophobic Nature of Coumarin in Newer Coumarin Based Chalcones: Synthesis, In Silico, and In Vitro Cell Viability Studies. And the article contained the following:

Coumarin is active pharmacophore; to enhance the activity of chalcone we inserted coumarin along with other cyclic groups. Fewer pyrazolone aldehydes produced using Wills Maeyer Haack reaction by grinding method. In alc. sodium hydroxide, cyclic ketones react with aldehydes to produce title compounds To treat the ill cell a drug must be with a linker, anchoring group, and hydrophobic group. Herein, the enone group acts as a linker, the rings on both sides are connected, one side ring acts as the anchoring group, and the other side ring acts as the hydrophobic group; anchoring, hydrophobic dual roles played by coumarin ring. In this series, In silico studies results have shown that many compounds of this series potent for anti-cancer activity along with other biol. activities, the In vitro cell viability studies of the series shows that, chalcone (I), (VIII), and (IV) are having IC50 values 2.96, 2.97, and 2.82 μM against call 27 (or) oral cancer cell line. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Safety of 2-Acetylthiazole

The Article related to oral cancer coumarin chalcone cell viability hydrophobic, Placeholder for records without volume info and other aspects.Safety of 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Nizamuddin, Nd; Abdul ahad, Hindustan; Devanna, Nayakanti published an article in 2020, the title of the article was Molecular docking studies of N-methyl- 2, 3 -disubstituted quinazolin-4-ones scaffold.Name: 4-Phenylthiazol-2-amine And the article contains the following content:

In recent days, synthesis of anticancer mols. having both low adverse effects and specific protein targeting are seldom. Synthesis of anticancer mols. having both low adverse effects and specific protein targeting is challenging. The main objective of our study was to develop mols. that can target activated protein kinase P38 alpha and activin receptor (ALK2) kinase for treating carcinoma. P38 alpha is involved in cell differentiation, apoptosis, and autophagy. Activin receptor (ALK2) kinase is responsible for mutations of cancerous cells. The synthesis of N-Me – 2, 3 -Disubstituted Quinazolin-4-Ones was carried out by refluxing of 1-methyl-2-(pyridinyl)-1,2-dihydro-4H-3,1-benzoxazin-4-one with 4-substituted phenyl-1,3-thiazol-2-amines. The mol. docking of 1-methyl-3-(4-substituted phenyl-1,3-thiazol-2-yl)-2-(pyridin-3-yl)-2,3-dihydroquinazolin-4(1H)-one (5Da1-5Dk11) and 1-methyl-3-(4-substituted phenyl-1,3-thiazol-2-yl)-2-(pyridin-4-yl)-2,3-dihydroquinazolin-4(1H)-one (5Ea1-5Ek11) derivatives were carried out using Schrodinger Glide (version 2020_1) software. Twenty-two quinazoline-4-one derivatives were docked into selective P38 alpha and ACVR1 (ALK2) kinase with PDB code 3GC7, 6GI6. Based on the docking score, comparison between quinazolin-4-one derivatives, co-crystallized Ligands interaction was evaluated using 5-Fluorouracil as standard Best activity was found in compounds 5Df6, 5Dd4, 5Ed4 and 5Ef6 with ACVR1 (ALK2) kinase with score of -8.223, -7.936, -8.123, -7.907 and 5Df6, 5Dh8, 5Eb2 and 5Ee5 with P38alpha with score of -7.19, -7.027, -6.698, -6.789 Kcal/mol against enzymes responsible for treatment for cancer compare with reference drug score -5.765 and -6.195. This study will help in the design and development of a drug that gives room for the synthesis of a new selective ACVR1 (ALK2) kinase and P38alpha enzyme inhibitor with predetermined affinity and activity of the compound The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Name: 4-Phenylthiazol-2-amine

The Article related to methyl disubstituted quinazolinone scaffold mol docking, Placeholder for records without volume info and other aspects.Name: 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica