Tag: 100-200

Chen, Zhipeng; Tang, Haiqing; Ou, Changrong; Xie, Cheng; Cao, Jinxuan; Zhang, Xin published an article in 2021, the title of the article was A comparative study of volatile flavor components in four types of zaoyu using comprehensive two-dimensional gas chromatography in combination with time-of-flight mass spectrometry.Category: thiazole And the article contains the following content:

Volatiles of four zaoyu (Chinese traditional fermented fish) products prepared from different species of marine fish were analyzed by headspace solid-phase micro-extraction (HS-SPME) and comprehensive two-dimensional gas chromatog. in combination with time-of-flight mass spectrometry (GC × GC/TOFMS). First, a 50/30Μ m DVB/CAR/PDMS was used and the influence of several parameters on the efficiency of HS-SPME such as extraction temperature, time, salting-out effect, and stirring were optimized, odor activity values (OAVs) of volatile compounds were computed based on the threshold values of aroma constituents; the characteristic volatiles and their odor characteristics of the four zaoyu were investigated. The results demonstrated that the most effective extraction of the analytes was obtained with a 40 min extraction at 50°C with the addition of 20% NaCl and stirring at 300 r/min. Under these conditions, a total of 288 volatile components were tentatively identified based on mass spectra and comparison of linear retention indexes in the four zaoyu products. Authenticated compounds included aldehydes, esters, alcs., ketones, furans, lactones, nitrogen compounds, sulfur compounds, terpenes, phenols, etc. Among the identified types of volatile compounds, the number of esters is the largest, whereas the content of aldehydes is the highest. The results of OAVs comparisons proved that both aldehydes and esters provided the most significant contribution to the aromas of zaoyu, and each zaoyu product had its own unique active flavor components. Moreover, the OAVs of active flavor compounds common to the four examined zaoyu varied significantly. Our results substantiated that GC × GC/TOFMS could provide a robust tech. means to understand the flavor characteristics of zaoyu and allow us to better evaluate and improve the flavor quality of the products with complex food matrix like zaoyu. The method present in this research is suitable to characterize the volatile constituents of aquatic products, and could also be used for component characterization of similar complex samples such as fermented fish and foods. Understanding the key aroma compounds of fermented fish and its formation mechanism could provide a guide of process optimization and flavor regulation, contributing to further studies related to volatile compounds in the field of food flavor anal. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Category: thiazole

The Article related to volatile flavor component zaoyu product gas chromatog, Placeholder for records without volume info and other aspects.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On December 23, 2021, Come, Jon H.; Senter, Timothy J.; Clark, Michael P.; Court, John J.; Gale-Day, Zachary; Gu, Wenxin; Krueger, Elaine; Liang, Jianglin; Morris, Mark; Nanthakumar, Suganthini; O′Dowd, Hardwin; Maltais, Francois; Iyer, Ganesh; Andreassi, John; Boucher, Christina; Considine, Tony; Moody, Cameron S.; Taylor, William; Mohanty, Arun K.; Huang, Yulin; Zuccola, Harmon; Coll, Joyce; Bonanno, Kenneth C.; Gagnon, Kevin J.; Gan, Lu; Lu, Fan; Gao, Hong; Chakilam, Ananthisrinivas; Engtrakul, Juntyma; Song, Bin; Crawford, Dan; Doyle, Elisabeth; Kramer, Tal; Vought, Bryan; Phillips, Jonathan; Kemper, Raymond; Sanders, Martin; Swett, Rebecca; Furey, Brinley; Winquist, Ray; Bunnage, Mark E.; Jackson, Katrina L.; Charifson, Paul S.; Magavi, Sanjay S. published an article.Category: thiazole The title of the article was Discovery and Optimization of Pyrazole Amides as Inhibitors of ELOVL1. And the article contained the following:

Accumulation of very long chain fatty acids (VLCFAs) due to defects in ATP binding cassette protein D1 (ABCD1) is thought to underlie the pathologies observed in adrenoleukodystrophy (ALD). Pursuing a substrate reduction approach based on the inhibition of elongation of very long chain fatty acid 1 enzyme (ELOVL1), we explored a series of thiazole amides that evolved into compound 27-a highly potent, central nervous system (CNS)-penetrant compound with favorable in vivo pharmacokinetics. Compound 27 (I) selectively inhibits ELOVL1, reducing C26:0 VLCFA synthesis in ALD patient fibroblasts, lymphocytes, and microglia. In mouse models of ALD, compound 27 treatment reduced C26:0 VLCFA concentrations to near-wild-type levels in blood and up to 65% in the brain, a disease-relevant tissue. Preclin. safety findings in the skin, eye, and CNS precluded progression; the origin and relevance of these findings require further study. ELOVL1 inhibition is an effective approach for normalizing VLCFAs in models of ALD. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Category: thiazole

The Article related to elovl1 inhibitor vlcfa adrenoleukodystrophy, Placeholder for records without volume info and other aspects.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On April 30, 2022, Li, Juan; Xu, Yuxia; Du, Wenbin; Jin, Linxi; Ren, Peifang; Ren, Fang; Xie, Jian Chun published an article.Name: 2-Acetylthiazole The title of the article was Comparative analysis of aroma compounds in Chinese traditional dry-rendered fat by HS/GC-IMS, SPME/GC-MS, and SPME/GC-O. And the article contained the following:

Aroma compositions of Chinese traditional dry-rendered s.c. chicken, pork, beef, and sheep fats were analyzed by HS/GC-IMS, SPME/GC-MS, and SPME/GC-O. HS/GC-IMS and SPME/GC-MS identified 53 and 86 volatile compounds, resp. SPME/GC-O anal. identified 35 odor-active compounds The identifications included fatty aldehydes, ketones, alcs., acids, and esters from lipid degradation and compounds from the Maillard reaction (e.g., trimethylpyrazine) or other sources (e.g., p-cresol from animal feeds). PCA anal. showed all three approaches could discriminate aroma compositions of the four fats. PCA loading plot suggested the aroma compounds related to each of the four fats and PLS-DA model anal. screened the marker compounds differentiating aroma of the four fats. Notably, SPME/GC-O approach behaved the best in differing aromas of the four fats by PCA. The HS/GC-IMS anal. was biased for the chicken fat and pork fat, and the SPME/GC-MS anal. was biased towards the beef fat and sheep fat in differing the aroma compositions by PCA. PLS-DA model anal. showed that for the SPME/GC-O anal., the marker compounds (VIP scores >1) discriminating aromas of the four fats were hexanal, (E,E)-2,4-decadienal, 2-butanone, 4,5-epoxy-2(E)-decenal, γ-octalactone, γ-undecalactone, heptanal, octanal, 4-ethyloctanoic acid, etc. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Name: 2-Acetylthiazole

The Article related to aroma traditional dry rendered fat china, Placeholder for records without volume info and other aspects.Name: 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Manwatkar, H. P.; Gedam, S. D.; Bhaskar, C. S.; Dhonde, M. G.; Thakare, Sanjay R. published an article in 2020, the title of the article was Synthesis and properties of amino and thiol functionalized graphene oxide.Application of 2010-06-2 And the article contains the following content:

Graphite, an allotrope of carbon, has been extensively researched in varied fields of science due to its typical structure and properties. Many researchers have transformed graphene from graphite in many ways. Functionalized graphene have immense importance because of advancement of properties for technol. applications. =N- and -S- fabricated graphene oxide composite was prepared The amino and thiol functionalized graphene oxide with improved properties is expected to adsorb heavy and toxic metals like Pb, Cd, Hg, and Ag from aqueous solutions The synthesized composite was confirmed and characterized by various characterization techniques like FTIR, SEM, TEM and XRD. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Application of 2010-06-2

The Article related to graphene oxide amino phenylthiazole, Surface Chemistry and Colloids: Other and other aspects.Application of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On June 30, 2017, Hua, Jin published a patent.Recommanded Product: 64987-16-2 The title of the patent was Preparation method of immunoaffinity column (IAC) for detecting sulfonamide residue in animal-derived food. And the patent contained the following:

The title preparation method includes (1) preparing sulfonamide artificial antigens TS-BSA and SM2-BSA by sep. coupling tetramethylthiuram monosulfide (TS) antigen and sulfadimidine SM2 antigen with bovine serum albumin (BSA) and ovalbumin; (2) immunizing mouse, collecting B lymphocytes, fusing with myeloma cells to obtain hybridoma cells, and preparing Batroxobin toxin monoclonal antibody 5H4, NR3C2 monoclonal antibody 2B5 and PPBP monoclonal antibody 5C7 by in vivo induced ascites generation method; and (3) sep. coupling the monoclonal antibodies with cyanogen bromide-activated sepharose 4B, mixing at ratio of 1:1:1, and packing into a column to obtain composite immunoaffinity column (IAC). The composite IAC has good specific adsorption effect on at least 12 kinds of sulfonamides as follows: ulfaquinoxaline, sulfadiazine, sulfapyridine, sulfameter, sulfadimidine, sulfamethoxazole, sulfisoxazole, sulfadimethoxypyrimidine, sulfathiazole, slfamerazine free acid, sodium N-(6-chloropyridazin-3-yl)sulphanilamidate and sulfamonomethoxine. The inventive IAC has high coupling rate, strong specific adsorption and high column capacity and yield, and can be used for detecting the above sulfonamide residues in animal-derived food sensitively, rapidly and simply. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Recommanded Product: 64987-16-2

The Article related to immunoaffinity chromatog animal derived food sulfonamide feed additives spectrometry, Biochemical Methods: Chromatographic and other aspects.Recommanded Product: 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On June 30, 2020, Kullananant, Natnicha; Chaiseri, Siree; Lorjaroenphon, Yaowapa published an article.Synthetic Route of 24295-03-2 The title of the article was The superiority of ultrapasteurization over conventional heat treatments regarding Riceberry beverage aroma. And the article contained the following:

The novel discovery of p-hydroxyphenylbutan-2-one (berry note) in Riceberry aroma was characterized by gas chromatog.-olfactometry and gas chromatog.-time-of-flight mass spectrometry. Furthermore, ultrapasteurization (UP), high-temperature short-time pasteurization, and ultrahigh-temperature (UHT) sterilization effects on rice beverage aroma were analyzed using Riceberry as a sample. Riceberry’s key odorants also remained the primary aromatic contributors in beverage models. Although descriptive sensory anal. showed a slightly lower musty note intensity in HTST beverages compared to the UP sample, their flavor dilution chromatograms were similar. Cluster anal. and R-index ranking test further confirmed aroma similarities during storage. Stored samples sterilized via UHT experienced certain potential off-odors, including acetic acid, propanoic acid, and indole, as opposed to the other beverages. UP was therefore superior to HTST and UHT by extending beverage shelf life without any undesirable odors. Practical Application : Ultrapasteurization (UP) retains Riceberry aroma characteristic in beverages and requires minimal modifications beyond conventional pasteurization. UP beverages also surpass those of high-temperature short-time and ultrahigh-temperature by extending shelf life with no noticeable off-odors. In addition, the discovery of p-hydroxyphenylbutan-2-one and the other aroma-active compounds of Riceberry aroma should prove valuable for flavor creation, rice breeding, and rice quality standards The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Synthetic Route of 24295-03-2

The Article related to riceberry beverage odor phydroxyphenylbutan2one processing storage, p-hydroxyphenylbutan-2-one (raspberry ketone), riceberry, aroma, flavor, ultrapasteurization, Food and Feed Chemistry: Beverages and other aspects.Synthetic Route of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On September 15, 2022, Ma, Yue; Beno, Noelle; Tang, Ke; Li, Yuanyi; Simon, Marie; Xu, Yan; Thomas-Danguin, Thierry published an article.SDS of cas: 24295-03-2 The title of the article was Assessing the contribution of odor-active compounds in icewine considering odor mixture-induced interactions through gas chromatography-olfactometry and Olfactoscan. And the article contained the following:

The sensory impact of odor-active compounds on icewine aroma could be influenced by perceptual interactions with other odor-active compounds The aim of this study was to establish an approach to evaluate the contribution of odor-active compounds found in icewine considering mixture-induced perceptual interactions. By comparing the impact of key odorants detected in icewine following a gas chromatog.-olfactometry approach with an Olfactoscan-based methodol. using a background odor of icewine, 69 odor zones were detected, and their related compounds were further identified. The results revealed that icewine background odor could exert odor masking or enhancement on key odorants when they are considered in the complex wine aroma buffer. Several compounds can induce qual. changes in the overall wine aroma. This study underlined the efficiency of Olfactoscan-like approaches to screen for the real impact of key odorants and to pinpoint specific compounds that could be highly influential once embedded in the aroma buffer. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).SDS of cas: 24295-03-2

The Article related to odor compound icewine olfactometry olfactoscan, aroma buffer, background odor, key odorants, olfactometer, perceptual interactions, Food and Feed Chemistry: Beverages and other aspects.SDS of cas: 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Lin, Wei-Liang; Lin, Chung-Yin; Tai, Dar-Fu published an article in 2021, the title of the article was Preparation of a Molecularly Imprinted Film on Quartz Crystal Microbalance Chip for Determination of Furanic Compounds.Computed Properties of 24295-03-2 And the article contains the following content:

The structural preferences of furanic compounds were studied using a combination of a molecularly imprinted film (MIF) on a piezoelec.-quartz chip. The furanic compounds and their derivatives were used as the templates. Owing to their similar heterocyclic structures, it is difficult to verify the structural differences between the templates. Therefore, a new cross-linker (Methacr-l-Cys-NHBn)2, was employed to generate a platform on a quartz crystal microbalance (QCM) chip. The cross-linker self-assembled to link the surface of the chip to copolymerize with other functional monomers. A layered film with chiral hydrophobicity and rigidity was thus fabricated. Subsequently, Acr-l-Ser-NHBn was utilized as a chiral monomer to construct MIF on a QCM chip. Forcomparison, we synthesized a more hydrophobic monomer, Methacr-l-Ser-NHBn, to enhance the binding ability of the MIF. The QCM flow injection system was handled in an organic solvent system. The proportion of the monomers was adjusted to optimize the recognition ability of these films. As the binding ability of the MIF toward model templates and structurally-related furanic compounds was improved, a MIF derived from 2-furaldehyde (FUL) achieved a lower detection limit (10 ng/mL). The binding properties of MIFs prepared against furanic compounds exhibited strong similarities to the binding properties of other compounds with heterocyclic ring structures. For example, 2-furaldehyde is very similar to 2-formylthiazole, 2-acetylfuran is similar to 2-acetylthiazole, and 2-furfuryl alc. is similar to imidazole-2-methanol. Such recognition ability can help distinguish between the structural counterparts of other small heterocyclic compounds The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Computed Properties of 24295-03-2

The Article related to quartz crystal chip molecularly imprinted film furanic compound determination, Organic Analytical Chemistry: Determinations and other aspects.Computed Properties of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On September 21, 2021, Kshirsagar, Rajendra R.; Gadekar, Pradip K.; Khedkar, Vijay M.; Vijayakumar, Vijayaparthasarathi published an article.Electric Literature of 2010-06-2 The title of the article was Design, Synthesis, and the Effects of (E)-9-Oxooctadec-10-en-12-ynoic Acid Analogues to Promote Glucose Uptake. And the article contained the following:

(E)-9-Oxooctadec-10-en-12-ynoic acid is found to mediate its antidiabetic activity by increasing insulin-stimulated glucose uptake in L6 myotubes by activating the phosphoinositide 3-kinase (PI3K) pathway. A simultaneous study of site-specific modification followed by structure-activity relationship provides a tremendous scope for exploiting the bioactivity of the parent mol. Therefore, in the present study, we focused on site-specific modification of (E)-9-oxooctadec-10-en-12-ynoic acid (1) to generate multiple derivatives and extensive structure-activity relationship (SAR) studies. We have done structural base design and synthesized a series of amides from acid compound 1. Compound 1 consists of an acid functionality, which is known for its metabolism-related liabilities. The SAR has been generated using scaffolds of different antidiabetic drugs such as biguanides, sulfonylureas, thiazolidinediones/glitazones, peroxisome proliferator-activated receptors, K + ATP, α-glucosidase inhibitors, and others. Furthermore, the study demonstrates and explains the promising derivatives and importance of SAR of the compound (E)-9-oxooctadec-10-en-12-ynoic acid. In order to gain mechanistic insights, a mol. docking study was performed against PI3K, which could identify the binding modes and thermodn. interactions governing the binding affinity. According to our research,some compounds are the best compounds from the series having EC50 values of 15.47, 8.89, 7.00, 13.99, 8.70, 12.27, and 16.14μM, resp. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Electric Literature of 2010-06-2

The Article related to oxooctadecenynoic acid analog preparation antidiabetic activity, General Organic Chemistry: Synthetic Methods and other aspects.Electric Literature of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Shaik, Shaheen; Vasa, Sreeja published an article in 2022, the title of the article was Synthesis, characterization and evaluation of semisynthetic derivatives of lawsone.Name: 4-Phenylthiazol-2-amine And the article contains the following content:

Quinones are widely distributed in nature, and several of their synthetic and natural products are very important in many diverse areas of chem. and biochem. They play a fundamental role in several living cells as electron carriers in the respiratory chain, as well as in blood coagulation and carboxylation of glutamates. Due to the intimate relationship between quinones and the biochem. processes of cells, these compounds have been extensively explored in the synthesis 2 of several bioactive compounds with antitumor, molluscicidal, antiparasitic, leishmanicidal, antiinflammatory, antifungal, antimicrobial and trypanocidal activities. In the present work we have synthesized semisynthetic derivatives of lawsone 2(a-d) by Mannich base reaction. Four derivatives of Lawson were synthesized. All the compounds synthesized were obtained in good yields. Purity of compounds was confirmed by TLC and m.ps. and compounds were characterized by preliminary laboratory techniques like chem. tests, m.p., Rf. The synthesized compounds were screened for wound healing activity. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Name: 4-Phenylthiazol-2-amine

The Article related to lawsone semisynthetic derivative synthesis, Pharmaceuticals: Formulation and Compounding and other aspects.Name: 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica