Tag: 100-200

On August 31, 2022, Verma, Diksha; Sharma, Sunita; Sahni, Tanvi; Kaur, Harleen; Kaur, Sukhmanpreet published an article.Synthetic Route of 2010-06-2 The title of the article was Designing, antifungal and structure activity relationship studies of Azomethines and β-lactam derivatives of aza heterocyclic amines. And the article contained the following:

The present investigation deals with the synthesis of seven azomethine derivatives I [R1 = 1,2,4-triazol-4-yl, 2-pyridinyl, 4-phenyl-2-thiazolyl,etc.] of aza heterocyclic amines by carrying out condensation reaction of them with veratraldehyde followed by cyclizing the CH=N moiety in synthesized azomethines of 4-amino-1,2,4-triazole and 4-amino antipyrine to yield β lactam derivatives II [R2 = 1,2,4-triazol-4-yl, 1,5-dimethyl-3-oxo-2-phenyl-pyrazol-4-yl]. The chem. constituents in the synthesized compounds were confirmed by UV, IR, 1H NMR, 13C NMR, and elemental anal. In vitro antifungal activity of all the synthesized products was done against four pathogenic maize fungal strains i.e.Fusarium verticillioides, Macrophomina phaseolina, Rhizoctonia solani, and Dreschlera maydis. It was found that azomethine derivative having 4-amino-1,2,4-triazole ring was as effective as standard carbendazim 50 WP against R. solani and may be considered as promising antifungal agent; therefore further modifications may be done in its structure to get better drug candidate in future. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Synthetic Route of 2010-06-2

The Article related to dimethoxyphenyl methanimine preparation agrochem antifungal sar, dimethoxyphenylazetidinone preparation agrochem antifungal sar, General Organic Chemistry: Synthetic Methods and other aspects.Synthetic Route of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On September 3, 2021, Trofymchuk, Serhii; Bugera, Maksym; Klipkov, Anton A.; Ahunovych, Volodymyr; Razhyk, Bohdan; Semenov, Sergey; Boretskyi, Andrii; Tarasenko, Karen; Mykhailiuk, Pavel K. published an article.HPLC of Formula: 24295-03-2 The title of the article was Scalable Approach to Fluorinated Heterocycles with Sulfur Tetrafluoride (SF4). And the article contained the following:

A general approach to fluorinated (hetero)aromatic derivatives was elaborated. The key reaction was a deoxofluorination of substituted acetophenones with sulfur tetrafluoride (SF4). In contrast to previous deoxofluorination methods, this transformation was fast, scalable (up to 70 g), and high-yielding. More than 100 novel or previously hardly accessible fluorinated heterocycles, interesting for medicinal chem. and agrochem., were synthesized. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).HPLC of Formula: 24295-03-2

The Article related to fluorinated aromatic compound preparation, aryl ketone deoxofluorination sulfur tetrafluoride, General Organic Chemistry: Synthetic Methods and other aspects.HPLC of Formula: 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Sahni, Tanvi; Sharma, Sunita; Verma, Diksha; Kaur, Harleen; Kaur, Amanpreet published an article in 2022, the title of the article was Synthesis and in vitro Fungitoxic Evaluation of Syringaldehyde Schiff Bases and β-Lactams.Safety of 4-Phenylthiazol-2-amine And the article contains the following content:

Syringic Schiff bases I [R = Ph, Bn, 2-pyridyl, etc.] were synthesized by condensation of syringaldehyde with a number of amines, and in exploratory work two β-lactams II and III were further prepared from their progenitor 4-aminoantipyrene and 4-aminophenol imines. All the compounds were fully characterized and evaluated for their fungitoxicity against four principal phytopathogenic fungi of maize, namely R. solani, D. maydis, M. phaseolina and F. verticilloides. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Safety of 4-Phenylthiazol-2-amine

The Article related to syringaldehyde schiff base preparation antifungal, beta lactam preparation antifungal, General Organic Chemistry: Synthetic Methods and other aspects.Safety of 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Bento-Silva, Andreia; Duarte, Noelia; Santos, Magda; Costa, Carina Pedrosa; Vaz Patto, Maria Carlota; Rocha, Silvia M.; Bronze, Maria Rosario published an article in 2022, the title of the article was Comprehensive two-dimensional gas chromatography as a powerful strategy for the exploration of Broas volatile composition.Name: 2-Acetylthiazole And the article contains the following content:

Broa is a Portuguese maize bread with characteristic sensory attributes that can only be achieved using traditional maize varieties. This study intends to disclose the volatile compounds that are mainly associated with the baking process of broas, which can be important contributors to their aroma. Twelve broas were prepared from twelve maize flours (eleven traditional maize varieties and one com. hybrid). Their volatile compounds were analyzed by GCxGC-ToFMS (two-dimensional gas chromatog. coupled with time-of-flight mass spectrometry) for an untargeted screening of the chem. compounds mainly formed during baking. It was possible to identify 128 volatiles that belonged to the main chem. families formed during this stage. Among these, only 16 had been previously detected in broas. The most abundant were furans, furanones, and pyranones, but the most relevant for the aroma of broas were ascribed to sulfur-containing compounds, in particular di-Me trisulfide and methanethiol. Pyrazines might contribute neg. to the aroma of broas since they were present in higher amounts in the com. broa. This work constitutes the most detailed study of the characterization of broas volatile compounds, particularly those formed during the Maillard reaction. These findings may contribute to the characterization of other maize-based foodstuffs, ultimately improving the production of foods with better sensory features. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Name: 2-Acetylthiazole

The Article related to broa volatile composition two dimensional gas chromatog, maillard reaction, baking, broa, comprehensive two-dimensional gas chromatography, maize, maize bread, volatiles, Food and Feed Chemistry: Cereals and Bakery Products and other aspects.Name: 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On September 30, 2021, Wang, Yuan-Hui; Yang, Yue-Ying; Zhang, Jing-Yu; Zhang, Qi-Dong; Xu, Fei; Li, Zhi-Jian published an article.Computed Properties of 24295-03-2 The title of the article was Characterization of volatiles and aroma in Chinese steamed bread during elaboration. And the article contained the following:

Effects of different process steps on volatiles and aroma compounds of “Jiaozi” steamed breads (JSBs) fermented by Jiaozi starter were investigated for finding the key process steps related to aroma formation. Thirty aroma-active compounds were identified using Gas chromatog.-mass spectrometry (GC-MS) and GC-olfactometry, which provided green, fatty, mushroom, mossy, fruity, sweaty, floral odors to JSBs. GC-MS anal. showed that the concentration of volatiles in JSB dough increased gradually during first-mixing and primary fermentation; decreased after second-mixing, kneading, molding and secondary fermentation; and increased greatly after steaming. Cluster anal. indicated that the aroma profile of fresh cooked JSBs was different from that of JSB dough. Fermentation is an important stage of aroma formation of JSBs. Furthermore, steaming is also a key process step in the formation of JSBs aroma, which endows JSBs unique aroma characteristic that is different from those produced by fermentation The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Computed Properties of 24295-03-2

The Article related to bread volatiles octanol aroma kneading molding steaming china, Food and Feed Chemistry: Cereals and Bakery Products and other aspects.Computed Properties of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 15, 2022, Jia, Jie; Xiong, Dandan; Bai, Jie; Yuan, Yirong; Song, Qi; Lan, Tian; Tian, Liangjie; Guo, Chunfeng; Liu, Xuebo; Wang, Caixia; Duan, Xiang published an article.Computed Properties of 24295-03-2 The title of the article was Investigation on flavor and physicochemical properties of angel food cakes prepared by lactic acid fermented egg white. And the article contained the following:

Our recent research revealed that moderate lactic acid fermentation endowed egg white with stronger foaming properties. This inspired us to further investigate the potential application of lactic acid fermented egg white in food system. In this paper, we systematically investigated the flavor and physicochem. properties of angel food cakes prepared by egg white fermented for different times (0, 3, 6 and 9 h). Results proved the utilization of 6 h-fermented egg white decreased the baking loss of cakes. And the flavor profiles of cakes with fermented egg white were significantly improved, resulting from the changed composition of egg white. The lightness, redness and yellowness were higher in cakes with 9 h-fermented egg white compared with control cakes. Meanwhile, the cakes with fermented egg white showed a lower volume and less resilient. These results suggested that fermented egg white could endow angel food cakes with improved aroma, and verified our previous viewpoint that lactic acid fermentation has a potential to be applied in egg products. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Computed Properties of 24295-03-2

The Article related to lactic acid egg white food cake flavor physicochem property, Food and Feed Chemistry: Cereals and Bakery Products and other aspects.Computed Properties of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On June 30, 2020, Ma, Rongrong; Tian, Yaoqi; Chen, Long; Jin, Zhengyu published an article.Electric Literature of 24295-03-2 The title of the article was Impact of cooling rates on the flavor of cooked rice during storage. And the article contained the following:

The results obtained from flash gas chromatog. electronic nose and sensory anal. showed that higher cooling rates prolonged rice fragrance retention, whereas faster deterioration of flavor acceptability of cooked rice was observed at lower cooling rates during storage. The contribution of 43 flavor compounds in cooked rice was validated in three parallel tests by gas chromatog.-mass spectrometry combined with principal component anal., which indicated that 2-acetyl-1-pyrroline and alcs. contributed to the fragrance, while aliphatic aldehydes (at high concentration), benzene derivatives, and acids were responsible for flavor deterioration. Partial least squares regression further identified that eight flavor compounds [(E,E)-2,4-decadienal, 2-butyl-2-octenal, 1-hexanol, 2-propyl-1-pentanol, 2-butyl-furan, geranylacetone, 2-acetylthiazole, and 2-acetyl-1-pyrroline] had significantly pos. contributions to sensory evaluations, while nine flavor compounds [hexanal, octanal, (E)-2-octenal, decanal, (E)-5-methyl-4-hepten-3-one, n-hexadecanoic acid, ethylbenzene, o-xylene and p-xylene] had significantly neg. contributions to sensory evaluations during storage (p < 0.05). The water migration and/or starch crystallization of cooked rice during storage affected by cooling rates were supposed to affect the release of the flavor compounds These findings could provide a reference for the flavor preservation of instant rice. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Electric Literature of 24295-03-2

The Article related to cooked rice flavor storage, Food and Feed Chemistry: Cereals and Bakery Products and other aspects.Electric Literature of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On August 25, 2005, Lynch, John K.; Collins, Christine A.; Freeman, Jennifer C.; Gao, Ju; Iyengar, Rajesh R.; Judd, Andrew Stephen; Kym, Philip R.; Mulhern, Mathew M.; Sham, Hing L.; Souers, Andrew J.; Zhao, Gang published a patent.Name: Benzo[d]thiazol-6-ylmethanol The title of the patent was Preparation of piperidinyl-chromene carboxamides as antagonists of melanin-concentrating hormone. And the patent contained the following:

Title compounds I [L = a bond, alkyl, alkenyl, etc.; W = (CH2)n; X = O or NR13; Y = (CH2)m; Z = CH2, CO, CS, etc.; m = 1-2; n = 0-2; R1, R2 and R3 independently = H, halo, alkoxy, etc.; R4 = H, aryl, alkyl-C(O)-NH-, etc.; R5 = H or alkyl; R6 = H, cycloalkyl, heterocycle, etc.; R7 = aryl, arylalkyl, heterocycloalkyl, etc.; R8 = H, alkyl or alkoxy; R9 = H or alkyl; R10 and R11 independently = H, alkyl, alkoxyalkyl, etc. or together may form 5-7 membered ring; R12 = H or alkyl; R13 = H, alkyl, aryl, etc.] and their pharmaceutically acceptable salts, are prepared and disclosed as antagonists of melanin-concentrating hormone (MCH). Thus, e.g., II was prepared by cyclization of 1-(4-chloro-2-hydroxyphenyl)ethanone (preparation given) with di-Et oxalate followed by hydrolysis and coupling with 4-amino-1-N-Boc-piperidine and subsequent deprotection and coupling with piperonal. The activity of I was evaluated in fluorescence assays following the intracellular calcium release induced by MCH and it was revealed that compounds of the invention inhibit MCH induced fluorescence at a dose of 10 μM. I as antagonists of melanin-concentration hormone should prove useful in the treatment of obesity, depression and psychiatric disorders. Pharmaceutical compositions comprising I are disclosed. The experimental process involved the reaction of Benzo[d]thiazol-6-ylmethanol(cas: 19989-66-3).Name: Benzo[d]thiazol-6-ylmethanol

The Article related to piperidinyl chromene carboxamide preparation antagonist melanin concentration hormone antiobesity, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Name: Benzo[d]thiazol-6-ylmethanol

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On September 22, 2005, Lynch, John K.; Collins, Christine A.; Freeman, Jennifer C.; Gao, Ju; Iyengar, Rajesh R.; Judd, Andrew S.; Kym, Philip R.; Mulhern, Mathew M.; Sham, Hing L.; Souers, Andrew J.; Zhao, Gang; Wodka, Dariusz published a patent.Safety of Benzo[d]thiazol-6-ylmethanol The title of the patent was Preparation of piperidinyl chromenecarboxamides as antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor. And the patent contained the following:

The present invention is directed to compounds of formula (I, variables defined below), which antagonize the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders. The variables for I are: L = a bond or alkylene, alkenylene, alkynylene, CH2O, SO2NH, C(O)NH, NHCO, NHSO2, CO, SO and SO2; X = O and N(R13); Z = CH2, C(N-Rc), CO and CS; m = 1 or 2; n = 0-2; R1, R2 and R3 = H, alkenyl, alkoxy, alkyl, alkylcarbonyl, alkylcarbonyl-NH-, alkyl-NH-carbonyl, alkylsulfonyl-NH-, alkyl-NH-sulfonyl, alkylsulfonyl, alkylthio, alkynyl, cyano, halogen, haloalkyl, haloalkoxy, haloalkylthio, nitro, RaRbN, RaRbNC(O)- or R1 and R2 together with intervening atoms form a heteroaryl or heterocycle; R4 = H, alkyl, alkylcarbonyl-NH-, alkylsulfonyl-NH-, aryl and halogen; R5 = H and alkyl; R6 = H, alkyl, aryl, cycloalkyl, heteroaryl and heterocycle; R7 = aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycle and heterocyclealkyl, or R6 and R7 together with attached atoms form a cycloalkyl or heterocycle; R8 = H, alkyl and alkoxy; R9 = H and alkyl; R10 and R11= H, alkyl, alkoxylalkyl, or R10 and R11 together with intervening atoms form a 5, 6, or 7-membered ring; R12 = H and alkyl; R13 = H, alkyl, aryl, cycloalkyl, heteroaryl and heterocycle; Ra and Rb = H, alkoxycarbonyl, alkyl, alkylcarbonyl, alkyl-NH-carbonyl, alkylsulfonyl, aryl and arylalkyl or Ra and Rb together with the attached N form a heteroaryl or heterocycle; and Rc = H and alkyl; provided that at least one of R1, R2 or R3 are not H. Pharmaceutical formulations containing I are also claimed. The experimental process involved the reaction of Benzo[d]thiazol-6-ylmethanol(cas: 19989-66-3).Safety of Benzo[d]thiazol-6-ylmethanol

The Article related to piperidinyl chromene carboxamide preparation antagonist melanin concentration hormone antiobesity, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Safety of Benzo[d]thiazol-6-ylmethanol

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On February 18, 1993, Lind, Peter Thomas; Morin, John Michael, Jr.; Noreen, Rolf; Ternansky, Robert John published a patent.Recommanded Product: 64987-16-2 The title of the patent was Thiourea derivatives and methods for inhibition of HIV and related viruses. And the patent contained the following:

A method for the inhibition of the replication of HIV is claimed that comprises contacting HIV with thiourea derivatives Among the specifically claimed compounds is N-[2-(2-pyridyl)ethyl]-N’-(5-bromo-2-pyridyl)thiourea (I). The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Recommanded Product: 64987-16-2

The Article related to virucide hiv thiourea preparation, pyridylethyl thiourea preparation virucide hiv, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Recommanded Product: 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica