Tag: 100-200

Du, Wenbin; Zhao, Mengyao; Zhen, Dawei; Tan, Jia; Wang, Tianze; Xie, Jianchun published an article in 2020, the title of the article was Key aroma compounds in Chinese fried food of youtiao.Application In Synthesis of 2-Acetylthiazole And the article contains the following content:

Key aroma compounds in Chinese popular fried food of youtiao were characterized by solvent assisted flavor evaporation combined with gas chromatog.-mass spectrometry (GC-MS) and aroma extract dilution anal. of gas chromatog.-olfactometry (AEDA/GC-O), quantitation, and aroma recombination and omission. Four samples of youtiao fried with sunflower oil, soybean oil, rapeseed oil, and palm oil, resp., differing in fatty acid composition, were selected to be investigated. A total of thirty-five odorants were identified, among which twenty-two odorants were quantitated by aid of authentic chems. and with correction of recovery coefficients Differences in odorants composition and aroma profile were observed among the four samples of youtiao fried with different oils. However, it was demonstrated in common thirteen compounds; i.e., 3-hydroxy-2-butanone, 3-methylbutanal, furfural, 3-(methylthio)propanal, 2-furfurylthiol, phenylacetaldehyde, 2,5-dimethyl-4-hydroxy-3(2H)-furanone, 2-ethyl-3,5-dimethylpyrazine, 3-ethyl-2,5-dimethylpyrazine, (E,E)-2,4-decadienal, 1-octen-3-ol, (E,Z)-2,6-nonadienal, and (E)-2-nonenal contributed significantly to youtiao aroma. The work can provide some guidance to maintain the preferred youtiao flavor when modifying its preparation technol. for safety concerns. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Application In Synthesis of 2-Acetylthiazole

The Article related to youtiao aroma compound chinese fried food, Food and Feed Chemistry: Fats, Oils, and Margarine and other aspects.Application In Synthesis of 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Simic, Dejan; Zaric, Milan; Nikolic, Ivana; Zivkovic-Zaric, Radica; Canovic, Petar; Kocovic, Aleksandar; Radojevic, Ivana; Rakovic, Ivana; Jovicic Milic, Sandra; Petrovic, Djordje; Stojkovic, Danijela; Vukovic, Nenad; Kacaniova, Miroslava; Vukic, Milena; Jevtic, Verica published an article in 2022, the title of the article was Newly synthesized palladium(II) complexes with aminothiazole derivatives: in vitro study of antimicrobial activity and antitumor activity on the human prostate cancer cell line.SDS of cas: 2010-06-2 And the article contains the following content:

Five new complexes of the palladium(II) ion (C1-C5) having the general formula [(PdL2)]Cl2 with some 2-aminothiazoles (L1-L5), where L1 = 2-amino-4-(3,4-difluorophenyl)thiazole, L2 = 2-amino-5-methyl-4-phenylthiazole, L3 = 2-amino-4-phenylthiazole, L4 = 2-amino-4-(4-chlorophenyl)thiazole, and L5 = 2-amino-4-(2,4-difluorophenyl)thiazole, were synthesized and characterized by elemental microanal. and IR, 1H NMR and 13C NMR spectroscopy. The in vitro antimicrobial activity of the five ligands and the corresponding Pd(II) complexes was studied. Testing was performed by the microdilution method and the min. inhibitory concentration (MIC) and min. microbicidal concentration (MMC) were determined Testing is conducted against 11 microorganisms (nine strains of pathogenic bacteria and two yeast species). The tested ligands and palladium(II) complexes show selective, high and moderate activity. There is a difference in antimicrobial activity between the ligands and the corresponding palladium(II) complexes. The complexes have significant anti-staphylococcal activity and activity on Pseudomonas aeruginosa which is better than the pos. control. The interactions of newly synthesized palladium(II) complexes with calf thymus DNA (CT-DNA) were studied using UV-visible absorption and fluorescence spectroscopy. Anal. of UV-absorption and fluorescence spectra indicates the formation of a complex between the palladium(II) complexes and DNA. The high values of intrinsic binding constants, Kb, of the order 104 M-1 and Stern-Volmer quenching constants, KSV, of the order 105 M-1 indicated very good binding of all complexes to CT-DNA. Also, the new Pd(II) complexes show high cytotoxic activity towards the human prostate cancer cell line and insignificant activity towards non-cancerous human fibroblasts. Future research could addnl. explore the biol. activity of Pd(II) complexes presented in this paper and study the possibility of their implementation in clin. practice. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).SDS of cas: 2010-06-2

The Article related to palladium aminothiazole derivative complex preparation antimicrobial antitumor activity, dna interaction palladium aminothiazole derivative complex, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.SDS of cas: 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On May 14, 2009, Elleder, Daniel; Young, John A. T.; Baiga, Thomas J.; Noel, Joseph P. published a patent.Related Products of 64987-16-2 The title of the patent was Non-nucleoside reverse transcriptase inhibitors. And the patent contained the following:

Disclosed herein are antiviral agents, in particular non-nucleoside reverse transcriptase inhibitors (NNRTIs). Also disclosed are methods of making the NNRTIs, as well as compositions that include such NNRTIs and methods of their use for treating viral infections, in particular retroviral infections, such as HIV infection. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Related Products of 64987-16-2

The Article related to nonnucleoside reverse transcriptase inhibitor viral infection treatment, hiv infection treatment nonnucleoside reverse transcriptase inhibitor, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Related Products of 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On October 15, 2022, Darmanovic, Darinka; Radanovic, Dusanka; Jevtovic, Mima; Turel, Iztok; Pevec, Andrej; Milcic, Milos; Gruden, Maja; Zlatar, Matija; Djordjevic, Natasa; Andjelkovic, Katarina; Cobeljic, Bozidar published an article.Application In Synthesis of 2-Acetylthiazole The title of the article was Coordination preferences of NNO and NNS Schiff base ligands with Co(III) complexes: Synthesis, characterization and DFT calculation. And the article contained the following:

Two Co(III) complexes with condensation product of thiosemicarbazide and 2-acetylthiazole (HL1 ligand, (E)-2-(1-(thiazol-2-yl)ethylidene)hydrazine-1-carbothioamide) and the condensation product of 2-acetylpyridine and Girard’s P reagent (HL2Cl ligand, (E)-1-(2-oxo-2-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)ethyl)pyridin-1-ium chloride) have been synthesized and characterized based on the results of single-crystal X-ray diffraction, NMR and IR spectroscopy and elemental anal. Cobalt(III) complex with HL1 ligand, [Co(L1)2]BF4·H2O (1), is bis octahedral complex in which two deprotonated ligand mols. coordinate in a mer arrangement through two NNS sets of donor atoms. In cobalt(III) complex with HL2Cl, [Co(L2)(N3)3] (2), the ligand is coordinated in deprotonated, formally neutral, form to Co(III) ion in tridentate fashion through NNO set of donor atoms, and the other three coordination sites of a monokis octahedron are occupied by meridionally coordinated azide anions. DFT calculations were performed to elucidate coordination preferences of these ligands toward Co(III) ion. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Application In Synthesis of 2-Acetylthiazole

The Article related to cobalt schiff base complex preparation dft, crystal structure cobalt schiff base complex, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.Application In Synthesis of 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 15, 2021, Johnson, Jino; Yardily, A. published an article.Name: 2-Acetylthiazole The title of the article was Spectral, modeling and biological studies on a novel (E)-3-(3-bromo-4-methoxyphenyl)-1-(thiazol-2-yl)prop-2-en-1-one and some bivalent metal(II) complexes. And the article contained the following:

A thiazole-based chalcone ligand (E)-3-(3-bromo-4-methoxyphenyl)-1-(thiazol-2-yl)prop-2-en-1-one (BMTP) and its Co(II), Ni(II), Cu(II) and Zn(II) complexes have been synthesized. The synthesized compounds were characterized by elemental analyses, FT-IR, NMR, mass, molar conductance, UV-Vis, magnetic susceptibility, and thermal techniques. The title compounds were optimized with D. Functional Theory (DFT) computations. The Lewis base character of BMTP, flexibility towards metal ions, structural stabilization on coordination, MO interactions, quantum chem. descriptors, and vibrational frequencies were evaluated. The compounds were screened for antimicrobial activity against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, Aspergillus flavus and Candida albicans. Metal complexes exhibit higher microbial toxicity than the free ligand. The mol. docking interactions were found to be in good agreement with the exptl. microbial activities. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Name: 2-Acetylthiazole

The Article related to transition metal bromomethoxyphenylthiazolylpropenone complex preparation bactericide, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.Name: 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Hamashima, Y. published an article in 1989, the title of the article was Synthesis, biological properties, and pharmacokinetics of 7432-S, a new oral cephem.SDS of cas: 64987-16-2 And the article contains the following content:

A number of cephems with ω-carboxyalkenoylamino substituents were prepared and tested for antibacterial activity and oral absorbability. Of these derivatives, the cephem with 7β-(2-(2-amino-4-thiazolyl)-4-carboxy-2-butenoyl)amino] substituent were well absorbed in mice. 7432-S (I) was finally selected as the clin. candidate having antibacterial activity and excellent oral bioavailability. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).SDS of cas: 64987-16-2

The Article related to cephem 7432s preparation bactericide pharmacokinetics, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.SDS of cas: 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Hu, Yuan-Yuan; Wang, Juan; Li, Tie-Jun; Yadav Bheemanaboina, Rammohan R.; Ansari, Mohammad Fawad; Cheng, Yu; Zhou, Cheng-He published an article in 2020, the title of the article was An unexpected discovery toward novel membrane active sulfonyl thiazoles as potential MRSA DNA intercalators.Formula: C5H5NOS And the article contains the following content:

With the increasing emergence of drug-resistant bacteria, the need for new antimicrobial agents has become extremely urgent. This work was to develop sulfonyl thiazoles as potential antibacterial agents. Novel hybrids of sulfonyl thiazoles were developed from com. acetanilide and acetylthiazole. Hybrids 6e and 6f displayed excellent inhibitory efficacy against clin. methicillin-resistant Staphylococcus aureus (MRSA) (min. inhibitory concentration = 1μg/mL) without obvious toxicity toward normal mammalian cells (RAW 264.7). The combination uses were found to improve the antimicrobial ability. Further preliminary antibacterial mechanism experiments showed that the active mol. 6f could effectively interfere with MRSA membrane and insert into MRSA DNA. Compounds 6e and 6f could serve as potential DNA-targeting templates toward the development of promising antimicrobial agents. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Formula: C5H5NOS

The Article related to staphylococcus aureus methicillin sulfonyl thiazole dna intercalator, dna, mrsa, antibacterial, antifungal, sulfonyl, thiazole, Pharmacology: Drug Interactions and General Pharmacology and other aspects.Formula: C5H5NOS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Kumar, Ajeet; Joshi, Himanshu published an article in 2019, the title of the article was Lead optimization studies on novel thiazole derivatives as CYP-450 inhibitor by using in-silico modulation.Recommanded Product: 2010-06-2 And the article contains the following content:

The In-silico studies considered as complementary to in vivo and in vitro biol. studies are performed by using a computer and are playing increase larger and more important role in drug discovery and development. We describe here in In-silico study of various hypothetical Thiazole and their interactions with CYP450 enzymes by computational methods including chem draw ultra, Avogadro and ochem database software methods. We worked on a chem. reaction scheme of Thiazole and we prepared different 20 Thiazole derivatives The CYP450 super family of heme enzymes plays an important role in the metabolism of a large number of endogenous and exogenous compounds including most of the drugs currently on the market. Comprehensive studies of the quantum approaches on the Thiazole derivatives like TD1, and TD18 was found to be CYP450 enzymes inhibitors interactions. The quantum approaches by lead optimization will require further studies; the data reported in this work may be helpful guide for medicinal chemist who is working in this area. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Recommanded Product: 2010-06-2

The Article related to thiazole td1 td18 modulation, Pharmacology: Drug Interactions and General Pharmacology and other aspects.Recommanded Product: 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 30, 2021, Xia, Bing; Ni, Zhi-Jing; Hu, Long-Teng; Elam, Elnur; Thakur, Kiran; Zhang, Jian-Guo; Wei, Zhao-Jun published an article.Computed Properties of 24295-03-2 The title of the article was Development of meat flavors in peony seed-derived Maillard reaction products with the addition of chicken fat prepared under different conditions. And the article contained the following:

To prepared Maillard reaction products (MRPs) enriched with chicken flavor, the effects of chicken fats on peony seed-derived MRPs were evaluated. The thermal treatments, lipase enzymic hydrolysis and lipoxygenase with subsequent mild thermal treatments were applied to oxidized chicken fats before their use in the Maillard reaction. Different oxidized chicken fats led to diverse chem. properties and varied volatile compounds The addition of oxidized chicken fat increased the meaty of MRPs. The chicken fat promoted the Maillard reaction, which produced more oxygenated compounds; however, it reduced the sulfur compounds Correlation anal. of the chem. properties of chicken fat and the major volatile compounds showed that by controlling the chem. properties of chicken fat, it might be possible to control the content of some volatile compounds of chicken fat and MRPs. Our data elucidated that chicken fat contributes to the development of meat flavors after oxidation and thermal treatments. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Computed Properties of 24295-03-2

The Article related to meat flavor peony seed chicken fat maillard reaction product, maillard reaction, meat flavors, oxidized chicken fats, peony seed, volatile compounds, Food and Feed Chemistry: Meat, Eggs, Fish, and Seafood and other aspects.Computed Properties of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On June 2, 2021, Gasior, Robert; Wojtycza, Krzysztof; Majcher, Malgorzata A.; Bielinska, Halina; Odrzywolska, Angelika; Baczkowicz, Malgorzata; Migdal, Wladyslaw published an article.Application In Synthesis of 2-Acetylthiazole The title of the article was Key Aroma Compounds in Roasted White Koluda Goose. And the article contained the following:

Aroma-active compounds in the roasted leg meat of White Koluda goose were assayed by gas chromatog.-olfactometry, using aroma extract dilution anal. and solvent-assisted flavor evaporation Quantitation, recombination-omission tests, and sensory evaluation were carried out. Thirty aroma compounds, for which odor activity values (OAVs) were calculated and for which the flavor dilution factors were greater than or equal to 1, were identified. The concentration of aroma compounds ranged from 0.06 to 633 (μg/kg). The highest OAVs (>1024) were for 2-furfurylthiol, 2-acetyl-1-pyrroline, and 1-octen-3-one. Nine key aroma compounds were: 2-furfurylthiol, 2-acetyl-2-thiazoline, 1-octen-3-one, 2-phenylethanethiol, 4,5-dimethyl-3-hydroxy-2(5H)-furanone, 4-hydroxy-2,5-dimethyl-3(2H)-furanone, (E,E)-2,4-decadienal, 2-acetyl-1-pyrroline, and 3-(methylthio)propanal. The intensity of the dominating roasted, meaty/broth, and fatty notes in the recombination model consisting of the key odorants were rated (10-point scale) at 4.6-5.8 points, relative to the original roasted goose (5.2-6.2). The aroma compounds defined predominantly the meaty, roasted, and fatty flavors during the descriptive sensory evaluation of the roasted goose meat. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Application In Synthesis of 2-Acetylthiazole

The Article related to aroma compound roasted white koluda goose, aeda, gc−o, white kołuda geese, aroma-active compounds, native breeds, recombination and omission tests, Food and Feed Chemistry: Meat, Eggs, Fish, and Seafood and other aspects.Application In Synthesis of 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica