Tag: 100-200

On November 1, 2021, Flores, Monica; Perea-Sanz, Laura; Lopez-Diez, Jose Javier; Belloch, Carmela published an article.Reference of 2-Acetylthiazole The title of the article was Meaty aroma notes from free amino acids and thiamine in nitrite-reduced, dry-fermented, yeast-inoculated sausages. And the article contained the following:

The contribution of free amino acids and thiamine to the production of potent meat aroma compounds in nitrite-reduced, dry-fermented sausages inoculated with a D. hansenii strain was the objective of this study. For this, three different sausage formulations were manufactured; a control and two formulations reduced by half in nitrate and nitrite and one of them inoculated with D. hansenii. Free amino acids, thiamine content and savoury volatile compounds were analyzed. Eleven savoury volatile compounds were quantitated. Among them, the most potent compounds above their odor thresholds were 2-methyl-3-furanthiol, 2-acetyl-1-pyrroline, methional, di-Me trisulfide and methyl-2-methyl-3-furyl disulfide. Their generation was affected by D. hansenii inoculation as shown by the decrease in methional and Me 2-methyl-3-furyl disulfide content, and the increase of methionol. Nitrate and nitrite reduction did not significantly affect amino acid and thiamine contents. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Reference of 2-Acetylthiazole

The Article related to thiamine amino acid nitrite dry fermented yeast sausage aroma, amino acid, dry sausage, nitrite, savoury, thiamine, yeast, Food and Feed Chemistry: Meat, Eggs, Fish, and Seafood and other aspects.Reference of 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Du, Wenbin; Zhen, Dawei; Wang, Yutong; Cheng, Jie; Xie, Jianchun published an article in 2021, the title of the article was Characterization of the key odorants in grilled mutton shashlik with or without suet brushing during grilling.Recommanded Product: 24295-03-2 And the article contains the following content:

Grilled mutton shashlik is highly preferred by Chinese consumers. In this study, the key odorants in grilled mutton shashlik prepared in the traditional Chinese way under open carbon fire with or without suet (mutton fat) brushing during grilling were identified. Solvent-assisted flavor evaporation (SAFE), combined with gas chromatog.-mass spectrometry (GC-MS) and gas chromatog.-olfactometry (GC-O), quantitation, recovery factor correction, and aroma recombination and omission were performed. In total, 57 odorants were identified, which predominantly included aliphatic aldehydes, sulfur-containing compounds and pyrazines. However, the key odorants in both mutton shashlik with or without suet brushing during grilling were identified to be 3-(methylthio)propanal, 2-methyl-3-furanthiol, 2-acetylthiazole, 2-furfurylthiol, bis(2-methyl-3-furyl)disulfide, 2-acetylpyrazine, 2,5-dimethylpyrazine, 2-ethyl-3,5-dimethylpyrazine, 2,5-dimethyl-4-hydroxy-3(2H)furanone, 3-hydroxy-2-butanone, 1-octen-3-ol, (E)-2-octenal, (E,Z)-2,6-nonadienal, octanal, (E)-2-nonenal, nonanal, 4-methyloctanoic acid and 4-methylphenol. Notably, (E,E)-2,4-decadienal, which usually contributes significantly to cooked meat aroma, was excluded as a key odorant here. The results can help understand effect of fat on meat flavor and provide guidance for preparation of processed meat flavourings with the preferred flavor of grilled mutton shashlik. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Recommanded Product: 24295-03-2

The Article related to grilled mutton shashlik aldehyde ketone acid alc phenol odorant, Food and Feed Chemistry: Meat, Eggs, Fish, and Seafood and other aspects.Recommanded Product: 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On January 31, 2023, Shen, Dong-Yu; Li, Meng-Ke; Zhao, Mu; Li, Jie; Cui, Xinyue; Zou, Ting-Ting; Song, Huan-Lu; Xiong, Jian; Li, Ku published an article.Reference of 2-Acetylthiazole The title of the article was Characterization of key odor-active compounds in pure chicken powder and the effect of yeast extract, using instrumental and sensory techniques. And the article contained the following:

Pure chicken powder (PCP) is a reliable source of mellow chicken soup flavor in seasoning, but it has some unstable compounds and is prone to lipid oxidation, which leads to unpleasant odor. Adding yeast extract (YE) can reduce the off-odor intensity of PCP. Based on the results of gas chromatog.-olfactometry-mass spectrometry (GC-O-MS), two-dimensional comprehensive gas chromatog.-olfactometry-mass spectrometry (GCxGC-O-MS) and combined aroma extract dilution anal. (AEDA), 14 key odor-active compounds were identified. Internal standard curve method was used for quant. anal., and the odor activity value (OAV) was calculated Octanal, 1-octen-3-ol and hexanal were found to be the most vital odor-active compounds in PCP. The odor-active compounds of YE were studied by the same method, and di-Me trisulfide was identified as the most important odor-active compound of YE. Addnl., recombination and omission experiments were carried out with PCP. Finally, it was found that a low concentration of di-Me trisulfide had masking effect on the odor of PCP. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Reference of 2-Acetylthiazole

The Article related to yeast extract gas chromatog olfactometry mass spectrometry, Food and Feed Chemistry: Meat, Eggs, Fish, and Seafood and other aspects.Reference of 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 31, 2022, Wang, Jing; Chen, Le; Liu, Ying; Olajide, Tosin Michael; Jiang, Yuanrong; Cao, Wenming published an article.Quality Control of 2-Acetylthiazole The title of the article was Identification of key aroma-active compounds in beef tallow varieties using flash GC electronic nose and GC x GC-TOF/MS. And the article contained the following:

To uncover the integral flavor characteristics and individual odor active compounds in tallow derived from different beef fats: inguinal (IF), omental (OF), and perirenal fats (PF), we used flash GC electronic nose (flash GC E-nose) to analyze and characterize the samples. GC x GC-TOF/MS identified and quantified 195 volatile compounds with significant differences amongst the three kinds of fats. There were 45 important odorants (ROAV > 0.1) containing 23 key odorants (ROAV > 1), of which 43, 34, 35 important odorants were found in IF, OF, and PF, resp. Our results showed that the key odorants overall probably contribute to a fatty and sweat acid smell in IF, a meaty and slightly sweet taste in OF, and sweetness and slightly meaty taste in PF. Elucidating the distribution of key odorants in beef tallow from different parts of animals could provide a scientific basis for formulating and selecting raw materials of high-quality beef tallow flavor products. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Quality Control of 2-Acetylthiazole

The Article related to aroma active compound beef gc electronic nose, Food and Feed Chemistry: Meat, Eggs, Fish, and Seafood and other aspects.Quality Control of 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Xing, Shuai; Zhang, Xue; Huang, Xia; Xie, Lin; Jiang, Fengchao; Zhou, Ping published an article in 2019, the title of the article was Modulating the conformation of the TIR domain by a neoteric MyD88 inhibitor leads to the separation of GVHD from GVT.Recommanded Product: 4-Phenylthiazol-2-amine And the article contains the following content:

Graft-vs.-host disease (GVHD) remains the least curable complication after allogeneic bone marrow transplantation (BMT). Myeloid differentiation factor 88 (MyD88) is an adaptor mol. critically involved in the toll-like receptor (TLR) signaling pathway. The Toll/IL-1 receptor (TIR) domains of MyD88 and TLR are interactional modules responsible for sorting and signaling via direct or indirect TIR-TIR interactions, which can contribute to all phases of GVHD progression. Here, we describe the mechanisms of the novel MyD88 inhibitor, TJ-M2010-5, and the discovery of its immunosuppressive properties in the context of GVHD and the graft-vs.-tumor (GVT) effect in a fully MHC-mismatched murine model. TJ-M2010-5 potentially interrupted the conformation of the TIR domain through its predicted DD loops, BB loops, and Poc site, and inhibited the homodimerization of MyD88, the LPS-stimulated activation of dendritic cells, and the priming of donor allogeneic T cell proliferation in a dose-dependent manner. Oral administration of TJ-M2010-5 ameliorated the inflammatory environment, decreased the number of apoptotic cells, increased tissue repair in GVHD target organs, and suppressed lethal GVHD. Further, protection against GVHD by TJ-M2010-5 did not abrogate a GVT effect against SP2/0, a myeloma cell line. Our data define the mechanisms of actions and provide novel insight into the potential clin. uses of TJ-M2010-5 for GVHD prevention. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Recommanded Product: 4-Phenylthiazol-2-amine

The Article related to tir domain neoteric inhibitor separation gvhd gvt modulating conformation, gvhd, gvt, myd88, tj-m2010-5, tlr, innate immunity, Immunochemistry: Other (Immunity, Immune Suppression, Tolerance, etc.) and other aspects.Recommanded Product: 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 30, 2019, Joshi, Shrinivas D.; Kumar, S. R. Prem; Patil, Sonali; Vijayakumar, M.; Kulkarni, Venkatarao H.; Nadagouda, Mallikarjuna N.; Badiger, Aravind M.; Lherbet, Christian; Aminabhavi, Tejraj M. published an article.COA of Formula: C9H8N2S The title of the article was Chemical synthesis, molecular modeling and pharmacophore mapping of new pyrrole derivatives as inhibitors of InhA enzyme and Mycobacterium tuberculosis growth. And the article contained the following:

Abstract: Substituted phenylthiazolyl benzamide and pyrrolyl benzamide derivatives were developed using mol. hybridization technique to create novel lead antimycobacterial mols. used to fight against Mycobacteriumtuberculosis. The newly synthesized mols. have inhibited InhA, the enoyl-ACP reductase enzyme from the mycobacterial type II fatty acid biosynthetic pathway. Of these, compound 3b showed H-bonding interactions with Tyr158 and co-factor NAD+ that binds the active site of InhA. All the mols. were screened for in vitro antitubercular activity against M. tuberculosis H37Rv, as well as some representative mols. as the inhibitors of InhA. Thirteen compounds exhibited good anti-TB activities (MIC = 1.6μg/mL), but only few representative mols. showed the moderate InhA enzyme inhibition activity. [Figure not available: see fulltext.]. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).COA of Formula: C9H8N2S

The Article related to pyrrole inhibitor enoylacp reductase, Enzymes: Substrates-Cofactors-Inhibitors-Activators-Coenzymes-Products and other aspects.COA of Formula: C9H8N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On December 21, 2021, Wang, Chunmiao; Gallagher, Daniel L.; Dietrich, Andrea M.; Su, Ming; Wang, Qi; Guo, Qingyuan; Zhang, Junzhi; An, Wei; Yu, Jianwei; Yang, Min published an article.Quality Control of 2-Acetylthiazole The title of the article was Data Analytics Determines Co-occurrence of Odorants in Raw Water and Evaluates Drinking Water Treatment Removal Strategies. And the article contained the following:

A complex dataset with 140 sampling events was generated using triple quadrupole gas chromatog.-mass spectrometer to track the occurrence of 95 odorants in raw and finished water from 98 drinking water treatment plants in 31 cities across China. Data anal. identified more than 70 odorants with concentrations ranging from not detected to thousands of ng/L. In raw water, Pearson correlation anal. determined that thioethers, non-oxygen benzene-containing compounds, and pyrazines were classes of chems. that co-occurred, and geosmin and p(m)-cresol, as well as cyclohexanone and benzaldehyde, also co-occurred, indicating similar natural or industrial sources. Based on classification and regression tree anal., total dissolved organic carbon and geog. location were identified as major factors affecting the occurrence of thioethers. Indoles, phenols, and thioethers were well-removed through conventional and advanced treatment processes, while some aldehydes could be generated. For other odorants, higher removal was achieved by ozonation-biol. activated carbon (39.3%) compared to the conventional treatment process (14.5%). To our knowledge, this is the first study to systematically identify the major odorants in raw water and determine suitable treatment strategies to control their occurrence by applying data analytics and statistical methods to the complex dataset. It will provide informative reference for odor control and water quality management in drinking water industry. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Quality Control of 2-Acetylthiazole

The Article related to odorant drinking water treatment data analytic removal, co-occurrence, data mining, drinking water, odorants, removal efficiency, statistics, Water: Water Purification (Including Treatment For Industrial Uses) and other aspects.Quality Control of 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 1, 2001, Lehmann, Thomas; Fischer, Ruediger; Albers, Markus; Roelle, Thomas; Mueller, Gerhard; Hessler, Gerhard; Tajimi, Masaomi; Ziegelbauer, Karl; Okigami, Hiromi; Bacon, Kevin; Hasegawa, Haruki published a patent.Product Details of 64987-16-2 The title of the patent was Preparation of cyclic carboxylic acid peptides as integrin antagonists. And the patent contained the following:

Peptides R6-X-A-N(R5)CR3R4-Y-DR1R2 [R1 represents a 4-9-membered (un)saturated aromatic cyclic residue which can contain 0-3 heteroatoms N, S or O and may be annulated and/or substituted; R2, R3, R4 and R5 represent H or (un)substituted C1-C10 alkyl, C2-C10 alkenyl or alkynyl, C6 or C10 aryl, C3-C7 cycloalkyl or a 4-9-membered (un)saturated heterocyclic residue containing up to 2 atoms O, N or S; R6 represents Ph or a 5- to 6-membered aromatic heterocyclic residue containing up to 3 atoms O, N and S and which may annulated or substituted; A represents CO, COCO, SO, SO2, PO, PO2, 2- or 4-pyrimidyl, 2-pyridyl, 2- or 4-imidazolyl, 2-benzimidazolyl or certain other rings which may be substituted; X represents CRX-1RX-2 (RX-1 and RX-2 are H, C1-C4 alkyl, C2-C4 alkenyl or alkynyl) or together with R6 forms a 4-7-membered ring, which can include up to 2 heteroatoms, up to two double bonds and be substituted; Y represents a bond, CO, SO, SO2, O, S, CRY-1RY-2 or NRY-3, where RY-1, RY-2 or RY-3 are a bond, H, (un)substituted C1-C4 alkyl, C2-C4 alkenyl or alkynyl] and their pharmaceutically acceptable salts were prepared for the treatment of inflammatory diseases. Thus, 2-MeC6H4NHCONH-p-C6H4CH2CO-L-Leu-NHC6H4CO2H-m was prepared and showed IC50 ≤ 0.5 μM in the Jurkat VCAM-1 assay. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Product Details of 64987-16-2

The Article related to cyclic carboxylic acid peptide preparation integrin antagonist inflammation inhibitor, Amino Acids, Peptides, and Proteins: Poly(Amino Acids) and Peptides and other aspects.Product Details of 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 31, 2019, Farahati, Razieh; Ghaffarinejad, Ali; Mousavi-Khoshdel, S. Morteza; Rezania, Jafar; Behzadi, Hadi; Shockravi, Abbas published an article.Application In Synthesis of 4-Phenylthiazol-2-amine The title of the article was Synthesis and potential applications of some thiazoles as corrosion inhibitor of copper in 1 M HCl: Experimental and theoretical studies. And the article contained the following:

Thiazoles continue to attend in synthetic organic chem. due to their wide applications in the development of corrosion inhibitors. This study presents synthesis and corrosion inhibition ability of three thiazoles-4-(2-aminothiazole-4-yl) phenol (ATP), 4-phenylthiazole-2-amine (PTA) and 4,4′-(thiobis(2-aminothiazole-5,4-diyl)) diphenol (TATD) on the copper surface, where TATD is a dimer form of ATP. The inhibition efficiencies were evaluated by potentiodynamic polarization, electrochem. impedance spectroscopy (EIS), at. force microscopy (AFM) and SEM (SEM) in various concentrations of thiazoles containing 1 M HCl solution Computational studies (d. functional theory (DFT) and mol. dynamics (MD) simulation) were also performed. The corrosion inhibition efficiencies of these compounds at optimum concentration were about 90%, indicating that ATP, PTA and TATD could be employed as effective corrosion inhibitors. Comparing the corrosion inhibition efficiencies of monomer ATP and dimer form TATD of thiazole also indicated that dimerization of inhibitor did not cause better interaction with the copper surface and more efficiency. The adsorption of inhibitors could be successfully described by the Langmuir adsorption isotherm. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Application In Synthesis of 4-Phenylthiazol-2-amine

The Article related to phenylthiazole copper adsorption potential energy corrosion inhibition ir spectra, Physical Organic Chemistry: Other Reactions, Processes, and Spectra and other aspects.Application In Synthesis of 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Ghabbour, Hazem A.; Fahim, Asmaa M.; Abu El-Enin, Mohammed A.; Al-Rashood, Sara T.; Abdel-Aziz, Hatem A. published an article in 2022, the title of the article was Crystal structure, Hirshfeld surface analysis and computational study of three 2-(4-arylthiazol-2-yl)isoindoline-1,3-dione derivatives.COA of Formula: C9H8N2S And the article contains the following content:

In these studies, we investigated the importance of isoindoline in pharmacol. evaluation, so we studied the crystal structure, packing, Hirshfeld anal. and computational calculations of 2-(4-arylthiazol-2-yl)isoindoline-1,3-dione derivatives . All single crystal structures of these isoindoline-1,3-dione were shown monoclinic system; P21/n space group and their net diploe moment 2.20, 3.73, 2.02 Debye, resp. Furthermore, Hirshfeld surface anal. was useful technique for visualization and analyze the intermol. interaction between atoms in mol., therefore, the isoindoline derivatives showed different contacts were mostly in H….H range (24.4%-36.5%), H range (8.7%-121.1%), S….H range (4.5%-5.6%) and C….H range (5.4%-10.6%); resp. The isoindoline 4c showed higher intermol. interaction dur to presence of two OCH3 groups. These single crystal structures of dione derivatives were comparable with theor. studies utilized DFT/6-311(G)d,p basis set and determination their phys. descriptors, MEP, HOMO-LUMO band energy gap and charge distribution. Moreover, the correlation studies of the 1HNMR spectral anal. between exptl. and theor. and they were excellent fitted with each other’s. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).COA of Formula: C9H8N2S

The Article related to arylthiazole iosindolinedione crystal structure homo lumo nmr chem shift, Physical Organic Chemistry: Other Reactions, Processes, and Spectra and other aspects.COA of Formula: C9H8N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica