Tag: 100-200

Poola, Sreelakshmi; Gundluru, Mohan; Nadiveedhi, Maheshwara Reddy; Saddala, Madhu Sudhana; P. T. S. R. K., Prasada Rao; Cirandur, Suresh Reddy published an article in 2020, the title of the article was Nano silver particles catalyzed synthesis, molecular docking and bioactivity of α-thiazolyl aminomethylene bisphosphonates.Recommanded Product: 4-Phenylthiazol-2-amine And the article contains the following content:

A new series of α-thiazolyl aminomethylene bisphosphonates I (R1 = H, OCH3, F, Br; R2 = OMe, OEt, OBu, OPh)were synthesized by a three component reaction of 4-aryl substituted thiazol-2-amine with different dialkyl/aryl phosphites and tri-Et orthoformate in the presence of Ag NPs (nano particles) as a catalyst under solvent free conditions. The target compounds were screened for their in vitro antioxidant, antibacterial and antifungal activity. Mol. docking studies were also performed. The results revealed that among the synthesized compounds I (R1 = OCH3, F, Br; R2 = Me) showed remarkably higher antioxidant activity by DPPH and H2O2 than the standard ascorbic acid. Compounds I (R1 = H, OCH3, F; R2 = Me) showed good antibacterial activity and also showed rather higher antifungal activity than the standard flucanozole. Computational docking methods have been used to predict how several aminomethylene bisphosphonate derivatives compete against the inhibitor BPH-1330 at the crystal enzyme structure of the 4H3A protein active site and how substituents influence their binding ability. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Recommanded Product: 4-Phenylthiazol-2-amine

The Article related to thiazolyl aminomethylene bisphosphonate preparation mol docking antioxidant antibacterial antifungal, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Recommanded Product: 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On September 8, 2010, Fang, Weizheng; Zhang, Hongjian; Qian, Dongbo published a patent.COA of Formula: C6H8N2O2S The title of the patent was Method for synthesis of Ceftibuten side chain from 2-aminothiazolylacetic acid. And the patent contained the following:

A process for preparation of Ceftibuten side chain I from 2-aminothiazolylacetic acid via carboxylic group protection, amino protection, hydroxymethylation, Wittig reaction, and mono esterification in five steps (detail procedure given) is disclosed. The process has advantages of no employment of expensive Me 3-methoxyacrylate, lower cost, reduced pollution to environment, simple process, good controllability, high and stable yield, suitability for industrial production The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).COA of Formula: C6H8N2O2S

The Article related to ceftibuten side chain preparation aminothiazolylacetic acid hydroxymethylation wittig esterification, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.COA of Formula: C6H8N2O2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 23, 2020, de Andrade, Vitor S. C.; de Mattos, Marcio C. S. published an article.Formula: C9H8N2S The title of the article was One-pot synthesis of 4-aryl-2-aminothiazoles from styrenes and thioureas promoted by tribromoisocyanuric acid. And the article contained the following:

A simple and efficient one-pot protocol has been developed for the conversion of styrenes into 4-aryl-2-aminothiazoles using readily available starting materials. Tribromoisocyanuric acid was successfully used for the co-bromination and oxidation of styrenes to give phenacyl bromides, which in the presence of thioureas produced the corresponding 4-aryl-2-aminothiazoles in 48-70% yield. The protocol involves three reactions in one process: a tandem (formation of phenacyl bromides from styrenes) followed by a telescoped (conversion to thiazole) reaction. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Formula: C9H8N2S

The Article related to aryl aminothiazole preparation tribromoisocyanuric acid promoter, styrene thiourea tandem reaction, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Formula: C9H8N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On March 31, 2020, Borthakur, Susanta Kumar; Kalita, Pabitra Kumar; Borthakur, Sukanya published an article.Category: thiazole The title of the article was Synthesis and antifungal activities of 3,5-diphenyl-7-amino-[1,3]-thiazolo[3,2-a]pyrimidine-6-nitrile derivatives. And the article contained the following:

A series of novel 3,7-diphenyl-7-amino[1,3]thiazolo[3,2-a]pyrimidine-6-nitrile derivatives I [R = H, 4-Me, 4-OMe, etc.] was synthesized by refluxing 2-amino-4-phenyl-1,3-thiazole and arylidinemalononitriles in propanol using NaOH as catalyst. Antifungal activities of the synthesized compounds were done by testing against Rhizoctonia solani and Drechslera orazae, two fungal pathogens causing diseases on rice crops. Among the tested compounds, compounds I [R = 4-Cl, 4-NMe2, 4-OMe, 3-OMe-4-OH] showed good to moderate antifungal activity. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Category: thiazole

The Article related to diphenyl amino thiazolopyrimidine nitrile preparation antifungal, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On December 12, 2019, Lo, Wen-Ting; Belabed, Hassane; Haucke, Volker; Nazare, Marc; Kuecuekdisli, Murat published a patent.Application of 64987-16-2 The title of the patent was Preparation of fused pyrimidinones as class II phosphoinositide 3-kinase inhibitors useful in treatment of diseases. And the patent contained the following:

The invention relates to preparation of fused pyrimidinones of formula (I) as class II phosphoinositide 3-kinase inhibitors. Compounds I wherein R1, R2, and R3 each independently is N or C; R4 is H, halo, alkoxy, etc.; R5 can be absent (covalent bond to R6), C1-5 alkyl-cycloalkyl; R6 is H, alkyl, aryl, etc.; R7is S, absent (covalent bond to R8), NR, wherein R is H, etc.; R8 cycloalkyl, C1-5 alkyl, etc.; R9 is amide, amine, urea, etc.; R10 is 5-membered heterocyclyl or heteroaryl (except for pyrazolyl, tetrahydrofurfuryl), preferably a 5-membered aromatic heterocycle comprising one or more of N, O and/or S, etc.; n is 0-5, are claimed. The example compound II was prepared by multistep synthesis starting from Me 3-aminopyrazine-2-carboxylate (procedure given). Compounds I were evaluated for PI3K inhibiting activity (data given). Compounds I can be used as medicaments, in particular for the treatment of a medical condition associated with defective PI3K signalling. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Application of 64987-16-2

The Article related to fused pyrimidinone preparation pi3k inhibitor disease treatment, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Application of 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 30, 2021, Sanad, Sherif M. H.; Mekky, Ahmed E. M. published an article.Application In Synthesis of 4-Phenylthiazol-2-amine The title of the article was Synthesis and antibacterial evaluation of new pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(3H)-one hybrids linked to different heteroarene units. And the article contained the following:

A three-component protocol involving the reaction of 3-aminothieno[2,3-b]pyridine-2-carboxylate, Me2NCH(OMe)2 and heteroaryl (bis)amines in dioxane under microwave irradiation yielded a new series of pyrimidinones. The target hybrids were formed by an initial formamidine formation, followed by cross-imidination and [5+1] heterocyclization. Pyrazole-linked pyrimidinones displayed the best antibacterial activity against all gram-pos. and neg. strains tested. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Application In Synthesis of 4-Phenylthiazol-2-amine

The Article related to pyridothienopyrimidinone preparation microwave antibacterial, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Application In Synthesis of 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Lepe-Balsalobre, Esperanza; Rubio-Sanchez, Ricardo; Ubeda, Cristina; Lepe, Jose Antonio published an article in 2022, the title of the article was Volatile compounds from in vitro metabolism of seven Listeria monocytogenes isolates belonging to different clonal complexes.Reference of 2-Acetylthiazole And the article contains the following content:

Microorganisms produce a wide variety of volatile organic compounds (VOCs) as products of their metabolism and some of them can be specific VOCs linked to the microorganism’s identity, which have proved to be helpful for the diagnosis of infection via odor fingerprinting. The aim of this study was to determine the VOCs produced and consumed to characterize the volatile metabolism of seven isolates of different clonal complexes (CCs) of Listeria monocytogenes. For this purpose, dichloromethane extracts from the thioglycolate broth medium were analyzed by gas chromatog. coupled to mass spectrometry (GC/MS). Also, multivariate analyses were applied to the data obtained. Results showed that all the isolates of L. monocytogenes produced de novo isobutanol, 2-methyl-1-butanol, 3-methyl-1-butanol, 3-(methylthio)-1-propanol, acetic acid, isobutyric acid, butanoic acid, and isovaleric acid. Significant differences were found among isolates for the production amount of these volatiles, which allowed their differentiation. Thus, CC4 (ST-219/CT-3650) and CC87 (ST-87/CT-4557) showed an active volatile compounds metabolism with high consumption nitrogen and sulfur compounds and production of alcs. and acids, and CC8 (ST-8/CT-8813) and CC3 (ST-3/CT-8722) presented a less active volatile metabolism Moreover, within the VOCs determined, huge differences were found in the production of butanol among the seven isolates analyzed, being probably a good biomarker to discriminate among isolates belonging to different CCs. Hence, the anal. of volatile profile generated by the growth of L. monocytogenes in vitro could be a useful tool to differentiate among CCs isolates. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Reference of 2-Acetylthiazole

The Article related to listeria monocytogenes volatile compound metabolism clonal complex, gc-ms, listeria monocytogenes, vocs, biomarkers, volatile compounds, Microbial, Algal, and Fungal Biochemistry: Metabolism and Microbial Nutrition and other aspects.Reference of 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

McKillop, Alexander; Sayer, Trevor S. B.; Bellinger, Geoffrey C. A. published an article in 1976, the title of the article was Reaction of benzothiazole and substituted benzothiazoles with dimethyl acetylenedicarboxylate. A novel heterocyclic ring transformation.Safety of Benzo[d]thiazol-6-ylmethanol And the article contains the following content:

Addnl. data considered in abstracting and indexing are available from a source cited in the original document. Reaction of benzothiazole with MeO2CCCCO2Me in aqueous methanol gave trans-dimethyl 4-formyl-2,3-dihydro-1,4-benzothiazine-2,3-dicarboxylate (I) in high yield, and a mechanism via intermediates II and III was proposed for this novel transformation. The scope and limitations of the process were defined by examination of the reactions of a wide range of substituted (e.g., 5- and 6-cyano, 5- and 6-Br, 5- and 6-AcNH) benzothiazoles with MeO2CCCCO2Me in aqueous methanol; the results are fully consistent with the postulated mechanism. The experimental process involved the reaction of Benzo[d]thiazol-6-ylmethanol(cas: 19989-66-3).Safety of Benzo[d]thiazol-6-ylmethanol

The Article related to ring enlargement benzothiazole, benzothiazinedicarboxylate, acetylenedicarboxylate reaction benzothiazole, thiazole benzo ring enlargement, thiazinedicarboxylate benzo, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Safety of Benzo[d]thiazol-6-ylmethanol

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 5, 1988, Kinast, Guenther published a patent.Related Products of 64987-16-2 The title of the patent was Preparation of aminothiazole derivatives as cephalosporin antibiotic intermediates. And the patent contained the following:

The title compounds [I; R1 = (substituted) alkyl, cycloalkyl, (hetero)aryl; R2 = CO2R3; R3, R4 = alkyl, alkenyl, cycloalkyl, cycloalkenyl, (hetero)aryl], useful as intermediates for cephalosporin antibiotics, were prepared from iminothiazolineacetates II. A mixture of Et 2-[(tert-butoxycarbonyl)imino]-3-(tert-butoxycarbonyl)-4-thiazoline-4-acetate, BuLi, and AcH in THF was stirred 2 h at -50 to -60° to give Et 2-[2-[(tert-butoxycarbonyl)amino]thiazol-4-yl]-3-[(tert-butoxycarbonyl)oxybutyrate. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Related Products of 64987-16-2

The Article related to thiazole amino preparation antibiotic intermediate, cephalosporin intermediate aminothiazole preparation, antibiotic intermediate aminothiazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Related Products of 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On January 27, 1998, Iwasaki, Fumiaki; Miharu, Michiko published a patent.Related Products of 64987-16-2 The title of the patent was Preparation of 2-aminothiazoleacetic acids as intermediates for cephem antibiotics. And the patent contained the following:

Title compounds I (R1 = CO2H-protecting group; R2 = alkyl) are prepared by reaction of thiazoles II (R1 = same as I) with dialkyl carbonates in the presence of aminopyridines. II (R1 = Et) was treated with (t-BuO)2CO in PhMe in the presence of 4-N,N-dimethylaminopyridine at 50° for 7 h to give 77.0% I (R1 = Et, R2 = t-Bu). The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Related Products of 64987-16-2

The Article related to aminothiazoleacetic acid preparation cephem antibiotic intermediate, aminothiazole alkoxycarbonylation alkyl carbonate aminopyridine catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Related Products of 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica