Tag: 100-200

On March 31, 2021, Masih, Anup; Agnihotri, Amol K.; Srivastava, Jitendra K.; Pandey, Nidhi; Bhat, Hans R.; Singh, Udaya P. published an article.Recommanded Product: 4-Phenylthiazol-2-amine The title of the article was Discovery of novel 1,3,5-triazine as adenosine A2A receptor antagonist for benefit in Parkinson’s disease. And the article contained the following:

Parkinson’s disease (PD) is a chronic neuro-degenerative ailment characterized by impairment in various motor and nonmotor functions of the body. In the past few years, adenosine A2A receptor (A2AR) antagonists have attracted much attention due to significant relief in PD. Therefore, in the current study, we intend to disclose the development of novel 1,3,5-triazines as A2AR antagonist. The radioligand binding and selectivity of analogs were tested in HEK293 (human embryonic kidney) and the cells were transfected with pcDNA 3.1(+) containing full-length human A2AR cDNA and pcDNA 3.1(+) containing full-length human A1R cDNA, where they exhibit selective affinity for A2AR. Mol. docking anal. was also conducted to rationalize the probable mode of action, binding affinity, and orientation of the most potent mol. (7c) at the active site of A2AR. It has been shown that compound 7c form numerous nonbonded interactions in the active site of A2AR by interacting with Ala59, Ala63, Ile80, Val84 Glu169, Phe168, Met270, and Ile274. The study revealed 1,3,5-triazines as a novel class of A2AR antagonists. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Recommanded Product: 4-Phenylthiazol-2-amine

The Article related to parkinson disease 123 triazine adenosine a2a receptor antagonist, 1,3,5-triazine, parkinson’s disease, adenosine a2a receptor, antagonist, docking, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Recommanded Product: 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On March 31, 2021, Godugu, Kumar; Shaik, Sultana; Mohinuddin Pinjari, Mohammad Khaja; Gundala, Trivikram Reddy; Chellappa Subramanyam, Dwaraka Viswanath; Loka, Subramanyam Sarma; Divi, Haranath; Vemula, Venkatramu; Reddy Nallagondu, Chinna Gangi published an article.COA of Formula: C9H8N2S The title of the article was Solid state thiazole-based fluorophores: Promising materials for white organic light emitting devices. And the article contained the following:

A facile and more efficient solvent-free mechanochem. synthetic route has been developed for the synthesis of a series of solid state white light emissive thiazole-based donor-acceptor (D-A) type fluorophores, 2-(3-pyridyl)/2-aminothiazoles from ω-bromomethylketones and pyridine-3-carbothioamide/thiourea in the presence of silica-supported HClO4 as a reusable solid Bronsted acid catalyst at RT. The photophys. and electrochem. properties of these compounds have been derived. Most of the studied D-A type solid thiazole-based fluorophores emitted white light and it can be tuned from warm – ideal – cold white light by introduction of a variety of substituents at 4th position of 2-(3-pyridyl)/2-aminothiazoles. Further, HOMO and LUMO energy levels of the titled compounds are found to be in the range -5.52 eV to -5.72 eV and -1.84 eV to -2.45 eV, resp. The lifetimes of these levels of thiazole-based fluorophores have been determined through luminescence decay curves and are found to be in the range of 7.7-11μs. The photophys. and electrochem. properties of the synthesized thiazole-based fluorophores indicate that the compounds could be promising materials for white organic light emitting devices. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).COA of Formula: C9H8N2S

The Article related to solid state thiazole fluorophore organic light emitting device, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Structure Correlation With Physical Properties and other aspects.COA of Formula: C9H8N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Koohgard, Mehdi; Hosseinpour, Zeinab; Sarvestani, Abdollah Masoudi; Hosseini-Sarvari, Mona published an article in 2020, the title of the article was ARS-TiO2 photocatalyzed direct functionalization of sp2 C-H bonds toward thiocyanation and cyclization reactions under visible light.Electric Literature of 2010-06-2 And the article contains the following content:

An ARS-TiO2 photocatalyst has been prepared by a simple method through stirring a mixture of ARS and TiO2 at room temperature in the dark to extend the photocatalytic response of titanium dioxide toward the visible light spectrum. The synergic effect of ARS and TiO2 in the photocatalyst system has catalyzed direct C-H functionalization of sp2 C-H bonds toward thiocyanation and cyclization reactions. Several aromatic and heteroaromatic scaffolds (2-phenylamino-thiazoles I (R = H, 2-Cl, 4-Ph, etc.), phenols R1OH (R1 = Ph, 3-ethylphenyl, 2-formylphenyl, etc.), anilines R2C6H4N(R3)(R4) (R2 = 2-Me, 3-Cl, 3-OMe, etc.; R3 = H, Me, Et, Ph; R4 = H, Me, Et), indoles II (R5 = H, Me; R6 = H, Me; R7 = H, 5-MeO, 6-methoxycarbonyl, 5-Br, 5-Me) and pyrroles such as 1H-pyrrole and 1-methyl-1H-pyrrole) were treated with the ammonium thiocyanate at room temperature Thiocyanation of phenol and synthesis of 2-aminobenzothiazole derivatives III (R8 = Me, I, prop-1-en-2-yl, etc.) under visible light are presented. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Electric Literature of 2010-06-2

The Article related to thiocyanation cyclization visible light ars photocatalyst regioselective, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ethers, Sulfides, and The Corresponding Onium Compounds and other aspects.Electric Literature of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On April 22, 2004, Shi, Qian; Wang, Hui-kang; Oyama, Masayoshi; Vance, John Robert; Chen, Ming S. published a patent.Application In Synthesis of Methyl 2-(2-aminothiazol-4-yl)acetate The title of the patent was Preparation of podophyllotoxin derivatives as anticancer compounds. And the patent contained the following:

Podophyllotoxin derivatives, such as I [R1, R2, R3, R7 = H, alkyl; R4, R6 = alkyl; R5 = H, P(O)(ORa)2; Ra = H, alkyl; T = H; XT = :N; X = bond, O, S, NRb; Rb = H, alkyl; Y = 5-membered heteroaryl or heterocyclyl, optionally substituted with one or more halogen, alkyl, cyclyl, aryl, heteroaryl, heterocyclyl, etc.], were prepared for their therapeutic use as anticancer agents. Thus, podophyllotoxin derivative II was prepared via a multistep synthetic sequence starting from 4′-demethyl-4β-bromo-4-desoxypodophyllotoxin (prepared from podophyllotoxin), 2-aminothiazole-4-acetic acid and (trimethylsilyl)diazomethane. II showed unexpectedly high levels of cellular protein-linked DNA breaks (PLDB) induction in KB cells when tested at 5μg/mL. This invention also features a method for treating cancer. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Application In Synthesis of Methyl 2-(2-aminothiazol-4-yl)acetate

The Article related to podophyllotoxin derivative preparation anticancer, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Application In Synthesis of Methyl 2-(2-aminothiazol-4-yl)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On December 1, 2020, Zhang, Wenjuan; Wei, Zhao; Huang, Guozhi; Xie, Fei; Zheng, Zhibing; Li, Song published an article.Synthetic Route of 2010-06-2 The title of the article was Study of triaryl-based sulfamic acid derivatives as HPTPβ inhibitors. And the article contained the following:

A series of novel triaryl-based sulfamic acid analogs I [R = H, 3-FC6H4CH2C(O), 4-MeOC6H4SO2, etc.; Ar = Ph, 4-phenylthiazol-2-yl, 4-(2-thienyl)thiazol-2-yl] was designed, synthesized and evaluated as inhibitors of human protein tyrosine phosphatase beta (HPTPβ). A novel, easy and efficient synthetic method was developed for target compounds I, and the activity determination results showed that most of compounds were good HPTPβ inhibitors. Interestingly, the compounds I [R = 1-tert-butoxycarbonylpiperidine-4-carbonyl, Ar = Ph; R = H, Ar = 4-(2-thienyl)thiazol-2-yl] with simple structure not only showed potent inhibitory activity on HPTPβ but also had good inhibitory selectivity over other PTPs (PTP1B, SHP2, LAR and TC-PTP). The mol. docking simulation of compounds with the protein HPTPβ helped to understand the structure-activity relationship and clarified some confusing assay results. This research provided references for further drug design of HPTPβ and other PTPs inhibitors. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Synthetic Route of 2010-06-2

The Article related to triaryl based sulfamic acid preparation sar docking hptpbeta inhibitor, docking simulation, drug design, hptpβ inhibitor, synthesis, triaryl-based derivatives, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Sulfenic, Sulfinic, and Sulfonic Acids and Derivatives and other aspects.Synthetic Route of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On January 31, 2020, Shahrivari, Somaye; Kowsari, Elaheh; Shockravi, Abbas; Ehsani, Ali published an article.Safety of 4-Phenylthiazol-2-amine The title of the article was Synthesis and electrochemical capacitor characterization of new copolyimides containing thiazole ring and their composites with conductive polymer. And the article contained the following:

Abstract: In this research work, copolyimides (PIa,b) were synthesized by chem. routs. We used perylene-3,4,9,10-tetracarboxylic dianhydride and synthesized diamines (DAa,b) containing thiazole ring as monomers to obtain PIa,b which were characterized by 1HNMR and FTIR spectroscopies. We prepared POAP/PIa and POAP/PIb by depositing poly ortho amino phenol (POAP) as conductive polymer on the surface of PIa,b via in situ electropolymerization To evaluate the effect of the PIa,b in terms of the electrochem. performance of composites, we used galvanostatic charge/discharge, cyclic voltammetry, and electrochem. impedance spectroscopy. The specific capacitance of 207.2 and 322.4 F/g are obtained for POAP/PIa and POAP/PIb, resp. All these evidences prove that POAP/PI composites have long cycle life as well as high specific capacitance, which are indicative for being a good candidate in terms of application in supercapacitors. Graphic abstract: [Figure not available: see fulltext.]. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Safety of 4-Phenylthiazol-2-amine

The Article related to supercapacitor electrode polyimide thiazolamine ptcda, Electrochemical, Radiational, and Thermal Energy Technology: Energy-Conversion Devices and Their Components and other aspects.Safety of 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 7, 2011, Su, Wei-Guo; Jia, Hong; Dai, Guangxiu published a patent.Application of 19989-66-3 The title of the patent was Preparation of triazolopyrazine derivatives and analogs for use as c-MET kinase activity inhibitors. And the patent contained the following:

Title compounds I [X = N or CR6; Y = absent, O, S, or NR7; R1 = (un)substituted fused bicyclic heteroaryl, when X is CR6 and Y is absent; or (un)substituted aryl or heteroaryl, when X is N and Y is o, S, or NR7; or (un)substituted heteroaryl, when X is CR6 and Y is O, S, or NR7; R2 and R3 independently = H, or alkyl; or together with the C atom to which they are attached form a cycloalkyl or heterocyclyl; R4 = halo, (un)substituted alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl; R6 = H, OH, NH2, halo, etc.; R5 = H, halo, OH NH2, CF3, etc.; R7 = H or alkyl; with provisions], and their pharmaceutically acceptable salts, are prepared and disclosed as c-MET kinase activity inhibitors. Thus, e.g., II was prepared by a multistep procedure (preparation given). Select I were evaluated in c-MET kinase activity inhibition assays (using transcreener FP) (data given). The experimental process involved the reaction of Benzo[d]thiazol-6-ylmethanol(cas: 19989-66-3).Application of 19989-66-3

The Article related to pyrazine triazolo derivative preparation cmet kinase activity inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Application of 19989-66-3

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 1, 2021, Pan, Zhixiang; He, Haiying; Jiang, Zhigan; Xia, Jianhua; Zhang, Lei; Zhang, Chen; Li, Jian; Chen, Shuhui published a patent.Product Details of 64987-16-2 The title of the patent was Pyrimidine-based compound having inhibitory effect of ketohexokinase (KHK). And the patent contained the following:

Disclosed in the present invention are a compound (e.g., I) having a KHK inhibitory effect or a pharmaceutically acceptable salt thereof, and use thereof in the preparation of drugs for diseases related to abnormal expression of KHK. For instance, the invention compound I was prepared and gave a KHK inhibition IC50 value of 22nM. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Product Details of 64987-16-2

The Article related to pyrimidine heteroaryl preparation ketohexokinase inhibitor nafld nash, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Product Details of 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 20, 2011, Su, Weiguo; Jia, Hong; Dai, Guangxiu published a patent.Safety of Benzo[d]thiazol-6-ylmethanol The title of the patent was Preparation of triazolo[b]pyridine and triazolo[b]pyrazine derivatives as antitumor agents. And the patent contained the following:

Title compounds I [X = N or C(R6); Y = O, S, or NR7; R1 = (un)substituted aryl, aromatic heterocyclic group, or fused aromatic hetero-bicyclic group; R2 and R3 = H or alkyl; or R2 and R3 with the carbon which they connect to form 3- to 7-membered cycloalkyl or heterocycloalkyl; R4 = alkyl, cycloalkyl, heterocyclic group, aryl, or aromatic heterocyclic group; R6 = H, OH, NH2, halo, etc.; R7 = H or alkyl], and their pharmaceutically acceptable salts as antitumor agents, which show inhibitor effects on C-Met expression. Thus, e.g., II was prepared by condensation reaction of 3,5-dibromo-2-pyrazinamine with 1H-pyrrolo[2,3-b]pyridine-3-methanamine followed by cyclization and Suzuki reaction with 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. Compounds of the invention were evaluated for their inhibitory activity of c-Met kinase with IC50 values of typically ranging from 0.001 μM to 1 μM. The experimental process involved the reaction of Benzo[d]thiazol-6-ylmethanol(cas: 19989-66-3).Safety of Benzo[d]thiazol-6-ylmethanol

The Article related to triazolopyridine triazolopyrazine preparation c met kinase antitumor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Safety of Benzo[d]thiazol-6-ylmethanol

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On June 24, 1999, Bierer, Donald E.; Moinet, Gerard G.; Botton, Gerard; Dubenko, Larisa; Patereau, Gerard; Doare, Liliane; Kergoat, Micheline; Mesangeau, Didier; Lu, Qing published a patent.Safety of Methyl 2-(2-aminothiazol-4-yl)acetate The title of the patent was Piperazine derivatives useful as hypoglycemic agents. And the patent contained the following:

A variety of piperazine derivatives useful as antihyperglycemic agents, pharmaceutical compositions comprising them, and methods for their use are described. For example, compounds I are disclosed [wherein Ar = certain mono- and polycyclic aryl and heteroaryl groups; R1, R2, R3 = H, alkyl, alkoxyalkyl, cycloalkyl, aryl, heteroaryl, arylalkoxy, aryloxy, etc.; or ArNR1 = indolinyl, quinolyl, indolyl, or tetrahydroquinolyl; R4, R5, R6 = H, cycloalkyl, alkyl, alkoxy, halo, CF3, aryl, aryloxy, cyano, CO2H, OH, NH2, NO2, etc.]. The compounds are useful for the treatment of insulin-dependent diabetes mellitus (IDDM or Type I) and non-insulin dependent diabetes mellitus (NIDDM or Type II). For instance, coupling of 4-chloro-2-(chloroacetamido)benzoic acid with 1-(2-methoxyphenyl)piperazine in DMF in the presence of Et3N gave title compound II. Compounds I gave significant reductions of blood glucose in a variety of animal diabetes models. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Safety of Methyl 2-(2-aminothiazol-4-yl)acetate

The Article related to piperazine preparation hypoglycemic antidiabetic, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Safety of Methyl 2-(2-aminothiazol-4-yl)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica