Tag: 100-200

On May 25, 2022, Dass, Reuben; Singleton, Justin D.; Peterson, Matt A. published an article.Reference of 4-Phenylthiazol-2-amine The title of the article was An efficient synthesis of 4-Thiocyanato anilines using benzyltrimethylammonium dichloroiodate and ammonium thiocyanate in DMSO:H2O. And the article contained the following:

Treatment of a variety of 2(3)-mono-substituted anilines with benzyltrimethylammonium dichloroiodate (1.2 equiv) and ammonium thiocyanate (1.2 equiv) in DMSO:H2O (9:1) at 70°C gave the corresponding 4-thiocyanato-2(3)-substituted anilines ArSC≡N [Ar = 4-OH-3-MeC6H3, 4-NH2-3-BrC6H3, 3-isoquinolyl, etc.] in excellent isolated yields (60-99%; ave. yield for all anilines = 90%). The reaction worked well for substrates with 2-halo, 2-alkoxy, 2-aryloxy, 2-alkyl, 2-dialkylamino, 2-N-sulfonylamino, 2-alkyn-1-yl, 2-cyano, 2-acyl, 2-sulfonyl, and 2-heteroaryl substitution. 3-Substituted, 3,5- or 2,6-disubstituted anilines and substituted phenols were also well tolerated. 4-Substituted anilines gave the corresponding 2-aminobenzothiazole products ArSC≡N, whereas 4-, 5-, 6-, or 7-substituted indoles were not reactive. Regioselective thiocyanation of 2-quinoline, 3-amino-1-methylpyrazole, 2-amino-4-phenylthiazole, and 2-phenylimidazo[1,2-a] pyridine was achieved in 93-99% yield, thus demonstrating the broad-substrate scope for this thiocyanation reaction. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Reference of 4-Phenylthiazol-2-amine

The Article related to thiocyanatoaniline preparation, aniline ammonium thiocyanate thiocyanation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Nitriles, Isonitriles, and Acyl Cyanides and other aspects.Reference of 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On August 31, 2022, Nasli Esfahani, Anita; Iraji, Aida; Alamir, Amir; Moradi, Shahram; Asgari, Mohammad Sadegh; Hosseini, Samanesadat; Mojtabavi, Somayeh; Nasli-Esfahani, Ensieh; Faramarzi, Mohammad Ali; Bandarian, Fatemeh; Larijani, Bagher; Hamedifar, Haleh; Hajimiri, Mir Hamed; Mahdavi, Mohammad published an article.Application of 2010-06-2 The title of the article was Design and synthesis of phenoxymethybenzoimidazole incorporating different aryl thiazole-triazole acetamide derivatives as α-glycosidase inhibitors. And the article contained the following:

A novel series of phenoxymethybenzimidazole derivatives I (R1 = H, 4-F, 4-Br, 4-CH3, 3-OCH3, 4-OCH3; R2 = H, CH3; R3 = H, OCH3) were rationally designed, synthesized, and evaluated for their α-glycosidase inhibitory activity. All tested compounds displayed promising α-glycosidase inhibitory potential with IC50 values in the range of 6.31 to 49.89μM compared to standard drug acarbose (IC50 = 750.0 ± 10.0μM). Enzyme kinetic studies on I (R1 = 4-Br, R2 = R3 = H; R1 = R2 = H, R3 = OCH3; R1 = 4-CH3, R2 = CH3, R3 = H) as the most potent compounds revealed that these compounds were uncompetitive inhibitors into α-glycosidase. Docking studies confirmed the important role of benzimidazole and triazole rings of the synthesized compounds I to fit properly into the α-glycosidase active site. This study showed that this scaffold can be considered as a highly potent α-glycosidase inhibitor. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Application of 2010-06-2

The Article related to phenoxymethybenzimidazole preparation glycosidase inhibitor docking study sar, benzimidazole, enzyme inhibition, synthesis, triazole-acetamide, α-glycosidase, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 27, 2008, Mitchell, Jeffrey Peter; Lilly, Michael John; Lambert, John Nicholas; Draffan, Alistair George; Bond, Silas; Hufton, Richard; Jahangiri, Saba published a patent.Application In Synthesis of Methyl 2-(2-aminothiazol-4-yl)acetate The title of the patent was Preparation of substituted arylindazolinone derivative and analogs as viral polymerase inhibitors. And the patent contained the following:

Title compounds I [L = absent or linker; each Y independently = N, NO, or CR4; Z = O, S, or R5; R1 = (un)substituted alkyl, cycloalkyl, aryl, etc.; R2 = (un)substituted cycloalkyl, aryl, or heterocyclyl; R3 = halo, CN, (un)substituted alkyl, etc.; R4 = H, halo, SH, OH, etc.; R5 = H, OH, (un)substituted alkyl, etc.; n = 0 to 4], and their pharmaceutically acceptable salts, are prepared and disclosed as viral polymerase inhibitors. Thus, e.g., II was prepared by amidation of 2-amino-5-bromobenzoic acid with 4-benzyloxyaniline hydrochloride followed by arylation with bromobenzene and cyclization. Select I were evaluated in HCV polymerase inhibition assays (data given). I were disclosed as therapeutic agents for use as viral polymerase inhibitors, in particular inhibitors of viral polymerases within the Flaviviridae family such as hepatitis C virus (HCV). The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Application In Synthesis of Methyl 2-(2-aminothiazol-4-yl)acetate

The Article related to indazolinone aryl derivative preparation viral polymerase inhibitor, arylindazolinone analog preparation viral polymerase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application In Synthesis of Methyl 2-(2-aminothiazol-4-yl)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On June 30, 2022, Elmaaty, Tarek Abou; El-Taweel, Fathy; El-Farh, Abeer Abou; Ramadan, Shaimaa M. published an article.Electric Literature of 2010-06-2 The title of the article was Dyeing Nylon-6 Fabric with New 2-Chloro-N-(4-Aryl-5-Arylazo-Thiazol-2-Yl)-Acetamide Dyes in Supercritical Carbon Dioxide. And the article contained the following:

Abstract: A number of new reactive disperse dyes were synthesized from 2-chloro-N-(4-aryl-5-arylazo-thiazol-2-yl)-acetamide derivatives (5a-d). The new dyestuffs were applied to dye the nylon-6 fabric in supercritical carbon dioxide (scCO2). The chem. structures of these new dyes were explained by elemental and spectroscopic analyses. Then, the suitability of dyestuffs under study for textile dyeing as disperse reactive dyes was reported. All four dyes (5a-5d) exhibited strong color strength, which may be attributed to excellent dye penetration in the fabric afforded by scCO2. The color fastness of dyed samples was measured, and the results demonstrated excellent values and extremely satisfactory washing durability. The dyed samples showed excellent antibacterial activity against Bacillus cereus, Staphylococcus aureus (G+ bacteria), and Escherichia coli (G- bacteria) compared with selected antibiotics as a reference standard; the retention of this excellent antibacterial activity was still satisfactory even after five washing cycles. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Electric Literature of 2010-06-2

The Article related to dyeing nylon fabric chloroarylarylazothiazolylacetamide dye supercritical carbon dioxide, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Azo Dyes and Pigments and other aspects.Electric Literature of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Eko, Ishegbe Joyce; Ademola, Bello Kasali; Obinna, Nkeonye Peter; Kogo, A. A. published an article in 2019, the title of the article was Synthesis and structural-reactivity studies of bifunctional MCT/SES (monochlorotriazine/sulphatoethylsulphone) azo reactive disperse dyes applied to wool and polyester fabric.Quality Control of 4-Phenylthiazol-2-amine And the article contains the following content:

Reactive disperse dyes containing monochlorotriazine/sulphatoethylsulfone reactive moieties were synthesized by condensing aniline with cyanuric chloride and further reacting it with a series of monoazo dyes obtained by diazotising 1-aminobenzene-4-β-sulphatoethylsulfone and coupling with various substituted 2-amino-4-phenylthiazole derivatives The dyeing performance of the dyes was evaluated on polyester and wool fabrics. The dyes obtained gave various shades ranging from reddish to bright red colors. They had good depth and good leveling properties. They dyed fabrics showed moderate to good light fastness properties and very good to excellent fastness to washing and perspiration. The dye bath exhaustion on the polyester and wool fabrics were found to be very good and their fixation values were moderate. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Quality Control of 4-Phenylthiazol-2-amine

The Article related to monochlorotriazine sulfatoethylsulfone azo reactive disperse dye wool polyester fabric, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Azo Dyes and Pigments and other aspects.Quality Control of 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Wei, Meng; Liu, Xiaochang; Xie, Peng; Lei, Yuanhua; Yu, Haojie; Han, Aiyun; Xie, Libin; Jia, Hongliang; Lin, Shaohua; Bai, Yueyu; Sun, Baozhong; Zhang, Songshan published an article in 2022, the title of the article was Characterization of Volatile Profiles and Correlated Contributing Compounds in Pan-Fried Steaks from Different Chinese Yellow Cattle Breeds through GC-Q-Orbitrap, E-Nose, and Sensory Evaluation.Category: thiazole And the article contains the following content:

This study focused on characterizing the volatile profiles and contributing compounds in pan-fried steaks from different Chinese yellow cattle breeds. The volatile organic compounds (VOCs) of six Chinese yellow cattle breeds (bohai, jiaxian, yiling, wenshan, xinjiang, and pingliang) were analyzed by GC-Q-Orbitrap spectrometry and electronic nose (E-nose). Multivariate statistical anal. was performed to identify the differences in VOCs profiles among breeds. The relationship between odor-active volatiles and sensory evaluation was analyzed by partial least square regression (PLSR) to identify contributing volatiles in pan-fried steaks of Chinese yellow cattle. The results showed that samples were divided into two groups, and 18 VOCs were selected as potential markers for the differentiation of the two groups by GC-Q-Orbitrap combined multivariate statistical anal. YL and WS were in one group comprising mainly aliphatic compounds, while the rest were in the other group with more cyclic compounds Steaks from different breeds were better differentiated by GC-Q-Orbitrap in combination with chemometrics than by E-nose. Six highly predictive compounds were selected, including 3-methyl-butanal, benzeneacetaldehyde, 2-ethyl-6-methyl-pyrazine, 2-acetylpyrrole, 2-acetylthiazole, and 2-acetyl-2-thiazoline. Sensory recombination difference and preference testing revealed that the addition of highly predictive compounds induced a perceptible difference to panelists. This study provides valuable data to characterize and discriminate the flavor profiles in pan-fried steaks of Chinese yellow cattle. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Category: thiazole

The Article related to benzeneacetaldehyde panfried steak gc qorbitrap, chinese yellow cattle, e-nose, gc-q-orbitrap, multivariate statistical analysis, sensory evaluation, volatile organic compounds and other aspects.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On January 27, 1998, Iwasaki, Fumiaki; Miharu, Michiko published a patent.SDS of cas: 64987-16-2 The title of the patent was Preparation of 2-aminothiazoleacetic acids as intermediates for cephem antibiotics.. And the patent contained the following:

Title compounds I (R1 = H; X = two H, O, NOR2; R2 = H, alkyl, OH-protecting group; R3 = NH2-protecting group) are prepared by reaction of heterocycles I (R3 = H; R1 = CO2H-protecting group; X, R2, = same as above) with NH2-protecting agents in organic solvents incompatible with H2O, saponification of thiazoles I (R1 = CO2H-protecting group; R3 = NH2-protecting group; R2, X = same as above) (II) with basic aqueous solution, dissolution of II alkali metal salts in basic aqueous solution, neutralizing them with acids, and isolation. I (R3 = H, X = two H, R1 = Et) was treated with (t-BuO)2CO in PhMe in the presence of 4-N,N-dimethylaminopyridine at 50° for 7 h, saponified with NaOH in H2O at 20° for 1 h, and neutralized with HCl in H2O at ≤20° to give 82.5% I (R1 = H, X = two H, R3 = t-BuO2C). The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).SDS of cas: 64987-16-2

The Article related to amino protecting agent condensation thiazoleacetate, thiazoleacetate saponification base aqueous solution, aminothiazoleacetic acid preparation cephem antibiotic intermediate and other aspects.SDS of cas: 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On September 30, 2022, Guneser, Onur; Yuceer, Yonca Karagul; Hosoglu, Muge Isleten; Togay, Sine Ozmen; Elibol, Murat published an article.Synthetic Route of 24295-03-2 The title of the article was Production of flavor compounds from rice bran by yeasts metabolisms of Kluyveromyces marxianus and Debaryomyces hansenii. And the article contained the following:

The aim of this study was to evaluate the biosynthesis of flavor compounds from rice bran by fermentation facilitated by Kluyveromyces marxianus and Debaryomyces hansenii. The growth of both yeasts was assessed by specific growth rates and doubling time. The biosynthesis of flavor compounds was evaluated by gas chromatog.-olfactometry (GC-O), gas chromatog.-mass spectrometry (GC-MS), and Spectrum sensory anal. The specific growth rate (μ) and doubling time (td) of K. marxianus was calculated as 0.16/h and 4.21h, resp., whereas that of D. hansenii was determined as 0.13/h and 5.33h, resp. K. marxianus and D. hansenii produced significant levels of higher alcs. and acetate esters from rice bran. Results showed that K. marxianus can produce 827.27μg/kg of isoamyl alc., 169.77μg/kg of Ph Et alc., and 216.08μg/kg of Ph Et acetate after 24-h batch fermentation A significant amount of isovaleric acid was also synthesized by K. marxianus (4013μg/kg) after the batch fermentation of 96 h. 415.64μg/kg of isoamyl alc. and 135.77μg/kg of Ph Et acetate was determined in rice bran fermented by D. hansenii after 24-h fermentation Fermented cereals and rose were the characteristic flavor descriptors of the fermented rice bran samples. Rose flavor in fermented rice bran samples was found to be associated with Ph Et alc., Ph Et acetate, isoamyl acetate, and guaiacol. Thus, the findings of this study demonstrate that the valorization of rice bran can be achieved with the production of natural flavor compounds by yeast metabolism The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Synthetic Route of 24295-03-2

The Article related to kluyveromyces debaryomyces yeasts metabolism rice bran flavor compound, bioflavor, gas chromatography–olfactometry, microbial fermentation, sensory analysis, yeast metabolism and other aspects.Synthetic Route of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On March 15, 2022, Li, Xinzhi; Liu, Shao-Quan published an article.Quality Control of 2-Acetylthiazole The title of the article was Effect of thermal treatment on aroma compound formation in yeast fermented pork hydrolysate supplemented with xylose and cysteine. And the article contained the following:

The present study has revealed an innovative method of coupling enzyme hydrolysis, yeast fermentation and thermal treatment to transform pork trimmings into a seasoning product. The pork trimmings were first enzymically hydrolyzed and fermented into liquid pork hydrolyzates, followed by adding xylose and cysteine, then heat treatment. Approx. 28% of xylose and 7% of glucose were consumed, and amino acids increased by around 31% after thermal treatment. The heated yeast fermented pork hydrolyzates possessed a characteristic ′savoury, roasted-meat and fruity sweet′ aroma as a result of the formation of thermally induced sulfur-containing volatiles such as 2-furfurylthiol, as well as retention of yeast generated esters including isoamyl acetate and hexyl acetate. The heat-treated fermented pork hydrolyzates impart an attractive and innovative aroma because of yeast fermentation and heat treatment. The innovative heated fermented pork hydrolyzates could be further processed into a nutritional and savoury pork broth and/or a meat sauce. 2021 Society of Chem. Industry. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Quality Control of 2-Acetylthiazole

The Article related to xylose cysteine thermal treatment aroma yeast fermented pork hydrolyzate, maillard reaction, cysteine, pork by-product, volatile flavour compounds, xylose, yeast fermentation and other aspects.Quality Control of 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Abdallah, Amira E. M.; Mohareb, Rafat M.; Helal, Maher H. E.; Mofeed, Germeen J. published an article in 2021, the title of the article was Synthesis and anticancer evaluations of novel thiazole derivatives derived from 4-phenylthiazol-2-amine.Application of 2010-06-2 And the article contains the following content:

Many novel thiazole derivatives were designed and synthesized using 4-phenylthiazol-2-amine. The reactivity of the latter compound toward different chem. reagents was studied. The structure of the newly synthesized compounds was established based on elemental anal. and spectral data. Furthermore, twenty compounds of the synthesized systems were selected and evaluated in (μM) as significant anticancer agents towards three human cancer cell lines [MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer), and SF-268 (CNS cancer)] and normal fibroblasts human cell line (WI-38). The results showed that compounds displayed higher efficiency than the reference doxorubicin. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Application of 2010-06-2

The Article related to heteroaryl thiozole preparation antitumor cytotoxicity structure activity relationship, thiazolopyrimidine preparation antitumor cytotoxicity structure activity relationship and other aspects.Application of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica