Tag: 100-200

Gari Divya, Kuppi Reddy; Lakshmi Teja, Gaddam; Yamini, Gudi; Padmaja, Adivireddy; Padmavathi, Venkatapuram published an article in 2019, the title of the article was Synthesis of amido sulfonamido heteroaromatics under ultrasonication and their antimicrobial activity.Related Products of 2010-06-2 And the article contains the following content:

A convenient and facile methodol. for N-sulfonylation of heteroaryl amines with Et chlorosulfonylacetate in the presence of dispersed sodium in THF under ultrasonication is reported. The corresponding heteroaryl sulfonamido esters are directly condensed with heteroaryl amines to get amido sulfonamido heteroaromatics in the presence of a mild base in THF under ultrasonication. Utilization of easy reaction conditions, shorter reaction times, and isolation of products in high yields under ultrasonication make this process as economically viable. The compounds 12c, 12d, 12f and 13f are potential antibacterial agents against B. subtilis and the compounds 12f, 13c and 13f are potential antifungal agents against A. niger. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Related Products of 2010-06-2

The Article related to antimicrobial amido sulfonamido heteroaromatic synthesis ultrasonication, n-sulfonylation, antimicrobial activity, azolyl pyrimidines, bispyrimidines, ultrasound irradiation and other aspects.Related Products of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On April 22, 2021, Nguyen, Minh T.; Jones, Richard A.; Holliday, Bradley J. published an article.SDS of cas: 24295-03-2 The title of the article was Incorporation of spin-crossover cobalt(II) complexes into conducting metallopolymers: Towards redox-controlled spin change. And the article contained the following:

Metal complexes from cobalt(II/III) ions with two tridentate ligands and the corresponding conducting metallopolymers have been synthesized, characterized and subjected to magnetic studies which revealed a redox-controlled spin change. These complexes were designed to contain both a possible spin-crossover metal complex core and an electropolymerizable group for the production of the corresponding conducting metallopolymers. SQUID magnetic measurements revealed a gradual thermal spin crossover (T1/2 = 170 K) and a low spin state up to 400 K for the two complexes with terpyridine ligand cores chelating to Co(II) and Co(III) centers, resp., supporting the viability of a spin change from paramagnetic (Co(II), S = 3/2) to diamagnetic (Co(III), S = 0) states via redox chem. We have also demonstrated that the reported cobalt(II) complexes can undergo a facile polymer growth process under electropolymerization conditions. Electrochem. studies revealed that the Co(II) and Co(III) metal centers in poly-CoIIL1 could be reversibly interconverted, which demonstrates that the magnetic properties of the conducting metallopolymers can be switched between paramagnetic and diamagnetic. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).SDS of cas: 24295-03-2

The Article related to cobalt terpyridine thiazolylpyridine complex preparation electropolymerization electrochem magnetic property, crystal structure cobalt terpyridine thiazolylpyridine complex and other aspects.SDS of cas: 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On December 31, 2020, Sun, Huahua; Liu, Feng; Ye, Zi; Baker, Adam; Zwiebel, Laurence J. published an article.Reference of 2-Acetylthiazole The title of the article was Mutagenesis of the orco odorant receptor co-receptor impairs olfactory function in the malaria vector Anopheles coluzzii. And the article contained the following:

Mosquitoes rely heavily on their olfactory systems for host seeking, selection of oviposition sites, and avoiding predators and other environmental dangers. Of these behaviors, the preferential selection of a human blood-meal host drives the vectorial capacity of anthropophilic female Anopheles coluzzii mosquitoes. Olfactory receptor neurons (ORNs) are dispersed across several appendages on the head and express an obligate odorant receptor co-receptor (Orco) coupled with a ”tuning” odorant receptor (OR) to form heteromeric, odor-gated ion channels in the membrane of these neurons. To examine the mechanistic and functional contributions of Orco/OR complexes to the chemosensory processes of An. coluzzii, we utilized CRISPR/Cas9 gene editing to create a line of homozygous, Orco-knockout, mutant mosquitoes. As expected, orco-/- ORNs across both adult and larval stages of An. coluzzii display significantly lower background activity and lack nearly all odor-evoked responses. In addition, blood-meal-seeking, adult female, orco-/- mutant mosquitoes exhibit severely reduced attraction to human- and non-human-derived odors while gravid females are significantly less responsive to established oviposition attractants. These results reinforce observations in other insects that Orco is crucial in maintaining the activity of ORNs. In that light, it significantly influences a range of olfactory-driven behaviors central to the anthropophilic host preference that is critical to the vectorial capacity of An. coluzzii as a primary vector for human malaria. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Reference of 2-Acetylthiazole

The Article related to anopheles coluzzii orco odorant receptor mutagenesis olfactory function, anopheles coluzzii, crispr/cas9, host seeking, odorant receptor co-receptor, olfaction, oviposition and other aspects.Reference of 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Althagafi, Ismail; El-Metwaly, Nashwa M.; Farghaly, Thoraya published an article in 2019, the title of the article was Characterization of new Pt(IV)-thiazole complexes: Analytical, spectral, molecular modeling and molecular docking studies and applications in two opposing pathways.Application of 2010-06-2 And the article contains the following content:

New thiazole derivatives were synthesized and fully characterized, then coordinated with PtCl4 salt. Also, the newly synthesized Pt(IV) complexes were studied anal. (elemental and thermogravimetric analyses), spectrally (IR, UV-visible, mass, 1H NMR, 13C NMR, x-ray diffraction) as well as theor. (kinetics, modeling and docking). The data extracted led to the establishment of the best chem. and structural forms. Octahedral geometry was the only formula proposed for all complexes, which is favorable for d6 systems. The mol. ion peaks from mass spectral anal. coincide with all anal. data, confirming the mol. formula proposed. XRD and SEM allowed discrimination of features between crystalline particles and other amorphous morphol. By applying Gaussian09 as well as HyperChem 8.2 programs, the best structural forms were obtained, as well as computed significant parameters. Computed parameters such as softness, hardness, surface area and reactivity led the authors towards application in two opposing pathways: tumor inhibition and oxidation activation. The catalytic oxidation for CO was conducted over PtO2, which was yielded from calcination of the most reactive complex. The success of catalytic role for synthesized PtO2 was due to its particulate size and surface morphol., which were estimated from XRD patterns and SEM images, resp. The antitumor activity was tested vs. HCT-116 and HepG-2 cell lines. Mild toxicity was recorded for two of the derivatives and their corresponding complexes. This degree of toxicity is more favorable in most cases, due to exclusion of serious side effects, which is coherently attached with known antitumor drugs. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Application of 2010-06-2

The Article related to aminothiazole derivative platinum complexation electronic structure mol docking, platinum aminothiazole derivative preparation antitumor activity thermolysis kinetics qsar and other aspects.Application of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On December 31, 2021, Li, Zhuoke; Cao, Jun; Mao, Ting; Dan, Ni published an article.Name: 2-Acetylthiazole The title of the article was Synthesis of bimannich base with thiazole and its corrosion inhibition effect on H2S and CO2 at high temperature. And the article contained the following:

A bimannich-based TZBM containing a thiazole ring was obtained by synthesis of mannich bases. TZBM featured a stable structure at 260 °C, and corrosion inhibition effect on carbon steel in a gas-liquid environment with Cl- + H2S + CO2 at 180 °C. By analyzing the weight loss of steel exposed to different TZBM concentrations, the coverages of the inhibitor adsorbed on the surfaces were determined, and the results conformed to Langmuir isotherm model. Furthermore, the neg. Gibbs free energy indicated that the adsorption was a spontaneous process. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Name: 2-Acetylthiazole

The Article related to thiazole bimannich base hydrogen sulfide carbon dioxide, high temperature corrosion inhibition, bimannich base, corrosion inhibitor, high temperature resistance, thiazole and other aspects.Name: 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On October 15, 2020, Api, A. M.; Belsito, D.; Botelho, D.; Bruze, M.; Burton, G. A. Jr.; Buschmann, J.; Dagli, M. L.; Date, M.; Dekant, W.; Deodhar, C.; Francis, M.; Fryer, A. D.; Jones, L.; Joshi, K.; La Cava, S.; Lapczynski, A.; Liebler, D. C.; O′Brien, D.; Patel, A.; Penning, T. M.; Ritacco, G.; Romine, J.; Sadekar, N.; Salvito, D.; Schultz, T. W.; Sipes, I. G.; Sullivan, G.; Thakkar, Y.; Tokura, Y.; Tsang, S. published an article.Application of 24295-03-2 The title of the article was RIFM fragrance ingredient safety assessment, 2-acetylthiazole, CAS Registry Number 24295-03-2. And the article contained the following:

The existing information supports the use of this material as described in this safety assessment. 2-Acetylthiazole was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that 2-acetylthiazole is not genotoxic. The skin sensitization endpoint was completed using the dermal sensitization threshold (DST) for non-reactive materials (900 μg/cm2); exposure is below the DST. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the threshold of toxicol. concern (TTC) for a Cramer Class II material, and the exposure to 2-acetylthiazole is below the TTC (0.009 mg/kg/day, 0.009 mg/kg/day, and 0.47 mg/day, resp.). The phototoxicity/photoallergenicity endpoints were evaluated based on UV spectra; 2-acetylthiazole is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated, 2-acetylthiazole was found not to be persistent, bioaccumulative, and toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current Volume of Use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]) are <1. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Application of 24295-03-2

The Article related to developmental, environmental safety, genotoxicity, local respiratory toxicity, phototoxicity/photoallergenicity, repeated dose, reproductive, skin sensitization, toxicity and other aspects.Application of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 9, 2020, Maccallini, Cristina; Arias, Fabio; Gallorini, Marialucia; Amoia, Pasquale; Ammazzalorso, Alessandra; De Filippis, Barbara; Fantacuzzi, Marialuigia; Giampietro, Letizia; Cataldi, Amelia; Camacho, Maria Encarnacion; Amoroso, Rosa published an article.SDS of cas: 2010-06-2 The title of the article was Antiglioma Activity of Aryl and Amido-Aryl Acetamidine Derivatives Targeting iNOS: Synthesis and Biological Evaluation. And the article contained the following:

In the present work a set of aryl and amido-aryl acetamidine derivatives were synthesized to obtain new potent and selective inducible Nitric Oxide Synthase inhibitors with improved physicochem. parameters with respect to the previously published mols. Compound I emerged as the most promising inhibitor, and was evaluated on C6 rat glioma cell line, showing antiproliferative effects and high selectivity over astrocytes. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).SDS of cas: 2010-06-2

The Article related to aryl acetamidine hydrobromide preparation nitric oxide synthase inhibition sar, amidoaryl acetamidine preparation antitumor nitric oxide synthase inhibition sar, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.SDS of cas: 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 15, 2001, Corbett, Wendy Lea; Haynes, Nancy-Ellen; Sarabu, Ramakanth published a patent.Formula: C6H8N2O2S The title of the patent was Preparation of substituted phenylacetamides and their use as glucokinase activators. And the patent contained the following:

The title compounds 4-R[(CH2)yX]zC6H4CH(CH2R1)CONHR2 [X = O, SO2; R is a ring; R1 is cycloalkyl; y and z are 0 or 1; R2 is -CONHR3 or a heteroaromatic ring having a ring nitrogen atom adjacent to the connecting ring carbon atom], active as glucokinase activators to increase insulin secretion, were prepared E.g., 2-biphenyl-4-yl-3-cyclopentyl-N-thiazol-2-ylpropionamide was prepared by reaction of 4-biphenylacetic acid with iodomethylcyclopentane, followed by treatment with 2-aminothiazole. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Formula: C6H8N2O2S

The Article related to phenylacetamide preparation glucokinase activator, acetamide phenyl preparation glucokinase activator, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Formula: C6H8N2O2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On February 27, 2003, Boyd, Scott; Caulkett, Peter William Rodney; Hargreaves, Rodney Brian; Bowker, Suzanne Saxon; James, Roger; Johnstone, Craig; Jones, Clifford David; McKerrecher, Darren; Block, Michael Howard published a patent.HPLC of Formula: 64987-16-2 The title of the patent was Preparation of benzamides affecting glucokinase for combined treatment or prevention of type 2 diabetes and obesity. And the patent contained the following:

The invention relates to the use of benzamides (shown as I; variables defined below; e.g. 2-[[3,5-di(2-chlorobenzyloxy)benzoyl]amino]thiazole) or a salt, solvate or prodrug thereof, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK; no data), such as type 2 diabetes, and to the compounds I and methods for preparing them. Twelve pharmaceutical compositions are included. For I: m is 0-2; n is 0-4; and n + m > 0; each R1 = OH, -(CH2)1-4OH, -CH3-aFa, -(CH2)1-44CH3-aFa, -OCH3-aFa, halo, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, NH2, -NH-C1-4alkyl, -N-di(C1-4alkyl), CN, formyl, Ph or heterocyclyl optionally substituted by C1-6alkyl. Each R2 is the group Y-X- wherein each X is a linker = -O-Z-, -O-Z-O-Z-, -C(O)O-Z-, -OC(O)-Z-, -S-Z-, -SO-Z-, -SO2-Z-, -N(R6)-Z-, -N(R6)SO2-Z-, -SO2N(R6)-Z-, -(CH2)1-4-, -CH:CH-Z-, -CC-Z-, -N(R6)CO-Z-, -CON(R6)-Z-, -C(O)N(R6)S(O)2-Z-, -S(O)2N(R6)C(O)-Z-, -C(O)-Z-, -Z-, -C(O)-Z-O-Z-, -N(R6)-C(O)-Z-O-Z-, -O-Z-N(R6)-Z-, -O-C(O)-Z-O-Z- or a direct bond; each Z = a direct bond, C2-6alkenylene or -(CH2)p-C(R6a)2-(CH2)q-; each Y = aryl-Z1-, heterocyclyl-Z1-, C3-7cycloalkyl-Z1-, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, -(CH2)1-4CH3-aFa or -CH(OH)CH3-aFa; R3 = Ph or a heterocyclyl; addnl. details are given in the claims. More than 30 example preparations of I are included and >300 specific examples of I are included with characterization data. For example, to prepare 2-[[3,5-di(2-chlorobenzyloxy)benzoyl]amino]thiazole, diisopropylethylamine (2.0 mmol) then 4-dimethylaminopyridine (0.1 mmol) were added to a solution of 2-aminothiazole (1.0 mmol) and 3,5-di(2-chlorobenzyloxy)benzoic acid chloride (1.0 mmol) in CH2Cl2 (10 mL) under Ar at ambient temperature After 80 mins the reaction mixture was filtered, washed with CH2Cl2 and dried under high vacuum to give the title compound as a colorless solid (41%). The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).HPLC of Formula: 64987-16-2

The Article related to benzamide preparation glucokinase inhibitor type 2 diabetes obesity, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.HPLC of Formula: 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On April 30, 2019, Gong, Weinan; Xu, Bin; Yin, Xiaoshuang; Liu, Ying; Chen, Yun; Yang, Wenzhong published an article.Computed Properties of 2010-06-2 The title of the article was Halogen-substituted thiazole derivatives as corrosion inhibitors for mild steel in 0.5 M sulfuric acid at high temperature. And the article contained the following:

The inhibitory effects of three halogen-substituted thiazole derivatives named 2-amino-4-(4-fluorophenyl)-thiazole (FPT), 2-amino-4-(4-chlorophenyl)-thiazole (CPT) and 2-amino-(4-bromophenyl)-thiazole (BPT) on mild steel corrosion were investigated in 0.5 M H2SO4 from 30°C to 60°C. Electrochem. measurements demonstrated that these thiazoles can effectively inhibit the corrosion of mild steel in 0.5 M H2SO4 solution at 30°C. With the increase of temperature, the inhibition efficiency (η) of FPT at 60°C reduced to 22.62% while those of CPT and BPT under the same temperature were nearly unchanged, which were as high as 95.16% and 95.45%, resp. The adsorptions of three thiazoles on the surface of mild steel were all found to adhere to Langmuir adsorption isotherm at 30°C while only CPT and BPT obeyed at 60°C. Quantum calculations results indicated that CPT and BPT had the better adsorption ability on mild steel than FPT. Mol. dynamic stimulations were taken out to investigate the adsorption configurations of three thiazoles on the surface of Fe (0 0 1) at 30°C and 60°C, and the results implied that the binding energy of protonated BPT and CPT were nearly unchanged at studied temperatures while that of protonated FPT apparently became lower at 60°C. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Computed Properties of 2010-06-2

The Article related to halogen substituted thiazole derivative corrosion inhibitor mild steel temperature, Ferrous Metals and Alloys: Corrosion (If The Primary Interest Is In The Metal), Erosion, Cavitation, Tribology, and Oxidation and other aspects.Computed Properties of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica