Tag: 100-200

Stevanovic, Nevena; Zlatar, Matija; Novakovic, Irena; Pevec, Andrej; Radanovic, Dusanka; Matic, Ivana Z.; Djordjic Crnogorac, Marija; Stanojkovic, Tatjana; Vujcic, Miroslava; Gruden, Maja; Sladic, Dusan; Andjelkovic, Katarina; Turel, Iztok; Cobeljic, Bozidar published an article in 2022, the title of the article was Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity.Category: thiazole And the article contains the following content:

Cu(II), Mn(II) and Zn(II) complexes with N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride (HL1Cl) were synthesized and characterized by single-crystal x-ray diffraction, IR spectroscopy, elemental anal. and DFT calculations In all three complexes, a ligand (L1) is coordinated in a deprotonated formally neutral zwitterionic form via NNO donor set atoms. Cu(II) and Zn(II) form mononuclear pentacoordinated complexes [CuL1(N3)(CH3OH)]BF4 and [ZnL1(N3)2], resp., while Mn(II) forms a binuclear [Mn2L12(μ-1,1-N3)2(N3)2]·2CH3OH complex, with unusual distorted trigonal-prismatic geometry around the metal centers. The antimicrobial activity of these complexes was tested against a panel of Gram-neg. and Gram-pos. bacteria, two yeasts and one fungal strain. The binuclear Mn(II) complex showed antifungal activity of similar intensity to amphotericin B. Based on the results of the brine shrimp test and DPPH radical scavenging activity, the most active Cu(II) and Mn(II) complexes were selected for evaluation of cytotoxic activity against five malignant cancer cell lines (HeLa, A375, MCF7, PC-3 and A549) and one normal cell line HaCaT. Both complexes showed significant activity. It should be pointed out that the activity of the Mn(II) complex against the MCF7 breast cancer cell line is only slightly weaker than that of cisplatin, but with selectivity to the tumor cell line in comparison to normal HaCaT cells, which is non-existent in the case of cisplatin. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Category: thiazole

The Article related to transition metal quaternary ammonium thiazolyl hydrazone complex preparation, crystal structure transition metal quaternary ammonium thiazolyl hydrazone complex, antimicrobial activity transition metal quaternary ammonium thiazolyl hydrazone complex, antitumor activity transition metal quaternary ammonium thiazolyl hydrazone complex and other aspects.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On January 31, 2022, Johnson, Jino; Yardily, Amose published an article.Recommanded Product: 2-Acetylthiazole The title of the article was Co(II), Ni(II), Cu(II), and Zn(II) metal complexes of chalcone: Synthesis, characterization, thermal, antimicrobial, photocatalytic degradation of dye and molecular modeling studies. And the article contained the following:

A thiazole-based chalcone ligand and its bidentate Co(II), Ni(II), Cu(II), and Zn(II) complexes of general formula [M(DMTP)2], (DMTP = (E)-3-(3,4-dimethoxyphenyl)-1-(thiazol-2-yl)prop-2-en-1-one) have been synthesized. The compounds were characterized by elemental analyses, molar conductance, fourier-transform IR (FTIR) spectra, 1H NMR, 13C NMR, mass, UV-Vis., magnetic susceptibility, and thermal and powder x-ray diffraction (XRD) techniques. Based on spectral data, tetrahedral geometry is assigned for Co(II), Ni(II), and Zn(II) complexes. Square planar geometry was observed for Cu(II) complex. Mol. geometries of the compounds were fully optimized with d. functional theory (DFT) computations. Addnl., the Lewis base character of DMTP, flexibility toward metal ions, structural stabilization on coordination, frontier MOs (FMO), quantum chem. parameters, and theor. vibrational frequencies were evaluated. The antibacterial and antifungal (in vitro and in silico) activities of the complexes were studied and compared with those of DMTP. Finally, the metal(II) complexes of DMTP were successfully used to enhance the removal of methylene blue (MB) dye from an aqueous solution The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Recommanded Product: 2-Acetylthiazole

The Article related to cobalt nickel copper zinc thiazolyl chalcone complex preparation antimicrobial, photocatalysis dye degradation cobalt nickel copper zinc thiazolyl chalcone, mol structure calculation cobalt nickel copper zinc thiazolyl chalcone, dimethoxyphenyl thiazolyl propenone cobalt nickel copper zinc preparation antimicrobial and other aspects.Recommanded Product: 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On October 30, 2022, Keawkim, Kannika; Na Jom, Kriskamol published an article.COA of Formula: C5H5NOS The title of the article was Metabolomics and flavoromics analysis of chemical constituent changes during roasting of germinated Sacha inchi (Plukenetia volubilis L.). And the article contained the following:

This study examined the changes in metabolites together with the flavor profiles of germinated Sacha inchi seeds during roasting by using gas chromatog. The results indicated that roasting partially increased the browning index, amino acid levels, total phenolic content, and antioxidant capacity, but slightly decreased the levels of reducing sugars. Oxidized and rancid compounds were significantly decreased at a 180 °C roasting temperature Pyrazine, furan, and pyrrole were Maillard reaction products that were increased at 180 °C of roasting. Roasting at 145 °C for 45 min after germination for 4 days was determined to be the optimal conditions for roasting germinated Sacha inchi seeds, which reduced the off-flavor and burned taste. The roasted germinated Sacha inchi seed contains higher amino acids than raw seed, which could be used as an alternative source for food products and supplements. In addition, the roasted germinated seeds at 4 days were recommended for food applications. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).COA of Formula: C5H5NOS

The Article related to metabolome flavorome roasting browning germination plukenetia, bi, browning index, dvb/car/pdms, divinylbenzene/carboxen/polydimethylsiloxane, essential amino acids, fame, fatty acid methyl esters, ffa, free fatty acid, gc, gas chromatography, germination, hs-spme, autosampler headspace solid-phase microextraction and other aspects.COA of Formula: C5H5NOS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On August 31, 2021, Choroba, Katarzyna; Kotowicz, Sonia; Maron, Anna; Switlicka, Anna; Szlapa-Kula, Agata; Siwy, Mariola; Grzelak, Justyna; Sulowska, Karolina; Mackowski, Sebastian; Schab-Balcerzak, Ewa; Machura, Barbara published an article.Product Details of 24295-03-2 The title of the article was Ground- and excited-state properties of Re(I) carbonyl complexes – Effect of triimine ligand core and appended heteroaromatic groups. And the article contained the following:

In this work, a series of six rhenium(I) complexes bearing 2,2′:6′,2”-terpyridine (terpy), 2,6-di(thiazol-2-yl)pyridine (dtpy), and 2,6-di(pyrazin-2-yl)pyridine (dppy) with appended quinolin-2-yl and N-ethylcarbazol-3-yl groups were prepared and spectroscopically investigated to evaluate the photophys. consequences of both the trisheterocyclic core (terpy, dtpy and dppy) and the heterocyclic substituent. The [ReCl(CO)3(Ln-κ2N)] complexes are regarded as ideal candidates for getting structure-property relationships, while terpy-like framework represents an excellent structural backbone for structural modifications. The replacement of the peripheral pyridine rings of 2,2′:6′,2”-terpyridine by thiazoles and pyrazines resulted in a significant red-shift of the absorption and emission of [ReCl(CO)3(Ln-κ2N)] due to stabilization of the ligand-centered LUMO orbital. Both quinoline and N-ethylcarbazole are extended π-conjugation organic chromophores, but they differ in electron-donating abilities. The low-energy absorption band of Re(I) complexes with the triimine ligands bearing quinolin-2-yl group was contributed by the metal-to-ligand charge-transfer (MLCT) electronic transitions. The introduction of electron-donating N-ethylcarbazol-3-yl substituent into the triimine acceptor core resulted in the change of the character of the HOMO of Re(I) complexes and a significant increase of molar absorption coefficients of the long-wavelength absorption, which was assigned to a combination of 1MLCT and 1ILCT (intraligand charge-transfer) transitions. Regardless of the appended heteroaromatic group, the emitting excited state of Re(I) terpy-based complexes was demonstrated to have predominant 3MLCT character, as evidenced by comprehensive studies including static and time-resolved emission spectroscopy along with ultrafast transient absorption measurements. The diodes with Re(I) complexes dispersed molecularly in a PVK:PBD matrix were emissive and effects of the complex structure on color of emitted light and its intensity was pronounced. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Product Details of 24295-03-2

The Article related to quinolinyl carbazolyl terpyridine thiazolylpyridine pyrazinylpyridine rhenium carbonyl complex preparation, crystal mol structure quinolinyl carbazolyl terpyridine thiazolylpyridine pyrazinylpyridine rhenium, electrochem redox quinolinyl carbazolyl terpyridine thiazolylpyridine pyrazinylpyridine rhenium carbonyl and other aspects.Product Details of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On January 5, 2012, Uchida, Hiroshi; Asagarasu, Akira; Matsui, Teruaki published a patent.SDS of cas: 19989-66-3 The title of the patent was Preparation of heterocyclic carbamate and carboxylic acid hydrazide compounds as p27Kip1 degradation inhibitors. And the patent contained the following:

There are provided novel heterocyclic compounds and salts thereof applicable in the selective inhibition of the degradation of cyclin-dependent kinase inhibitor protein (p27Kip1) for the prevention and/or treatment of cell proliferative diseases such as cancer, rheumatism, diabetes, obesity, endometriosis, prostatic hypertrophy (prostatic hyperplasia), and inflammation. The title compounds and salts thereof represented in formula [I; A represents an alkyl group, a cycloalkyl group, an aryl group, or a heterocyclic group, and group A can have a substituent group; ring B represents a 5- to 8- membered monocyclic heterocyclic ring or a condensed ring containing this monocyclic heterocyclic ring, and ring B can have a substituent group; ring C represents an aromatic ring, and ring C can have a substituent group; L represents a linker having 3-5 atoms in the main chain selected from carbon atoms, nitrogen atoms, oxygen atoms, and sulfur atoms, and having at least one heteroatom selected from nitrogen atoms, oxygen atoms, and sulfur atoms, and linker L can have a substituent group; and n represents 0 or 1.] are prepared Thus, 1.11 g 2-(4-chloro-2-methoxyphenyl)-4-methylthiazole-5-carboxylic acid and 870 mg (1,2,3,4-Tetrahydrobenzo[d]pyrido[2,1-b]imidazol-7-yl)methanol were suspended in 50 mL toluene, successively treated with 475 mg Et3N and 1.18 g diphenylphosphoryl azide, and refluxed for 2 h to give, after workup and silica gel chromatog., 71% [2-(4-chloro-2-methoxyphenyl)-4-methylthiazol-5-yl]carbamic acid 1,2,3,4-tetrahydrobenzo[d]pyrido[2,1-b]imidazol-7-ylmethyl ester (II). II and 3-pyrazolylmethyl 5-benzimidazolylcarbamate derivative (III) in vitro induced apoptosis of human prostatic cancer cells (PC-3 cells) at 0.025 and 0.00625 μM, resp., and in vitro showed IC50 of 6.70 and 0.43 nM, resp., against PC-3 cells. The experimental process involved the reaction of Benzo[d]thiazol-6-ylmethanol(cas: 19989-66-3).SDS of cas: 19989-66-3

The Article related to p27kip1 degradation inhibitor heterocyclic carbamate preparation, heterocyclic carboxylic acid hydrazide preparation, cyclin dependent kinase inhibitor protein p27kip1 degradation inhibitor, cell proliferative disease prevention treatment, cancer rheumatism diabetes obesity endometriosis prevention treatment and other aspects.SDS of cas: 19989-66-3

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On August 30, 2022, Krause, Svenja; Asamoah, Eugenia Ayebea; Huc-Mathis, Delphine; Moulin, Gabrielle; Jakobi, Ralf; Rega, Barbara; Bonazzi, Catherine published an article.Quality Control of 2-Acetylthiazole The title of the article was Applicability of pea ingredients in baked products: Links between formulation, reactivity potential and physicochemical properties. And the article contained the following:

This study aimed to evaluate the applicability of purified pea ingredients (starch and protein isolate) by assessing their potential to form volatile compounds during the different steps of sponge cake development compared to pea flour and wheat flour. While pea flour was highly susceptible to lipid oxidation during batter beating, the combination of purified pea starch and pea protein yielded significantly fewer oxidation markers with known green-beany off-odors. This was due more to the inactivation of lipoxygenase during flour fractionation than to differences in batter structure. However, fractionated ingredients were highly prone to participating in the Maillard reaction and caramelization during baking, leading to a more complex mixture of pyrazines, Strecker aldehydes and furanic compounds with potential malty and roasted notes compared to cakes based on pea flour or wheat flour. These findings confirm that using purified pea fractions can create high-quality products with an attractive composition The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Quality Control of 2-Acetylthiazole

The Article related to pea starch flour cake aldehydes lipoxygenase lipid physicochem property, 1-hexanol, 1-octen-3-ol, 2,4-decadienal, 2,5-dimethylpyrazine, 2-ethyl-3,5-dimethylpyrazine, 2-methylpropanal, 3-methylbutanal, furan, furfural, hexanal, lipid oxidation, maillard reaction, pea protein, pea starch, structure and other aspects.Quality Control of 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Choroba, Katarzyna; Maron, Anna; Switlicka, Anna; Szlapa-Kula, Agata; Siwy, Mariola; Grzelak, Justyna; Mackowski, Sebastian; Pedzinski, Tomasz; Schab-Balcerzak, Ewa; Machura, Barbara published an article in 2021, the title of the article was Carbazole effect on ground- and excited-state properties of rhenium(I) carbonyl complexes with extended terpy-like ligands.Application In Synthesis of 2-Acetylthiazole And the article contains the following content:

The ground- and excited-state properties of three [ReCl(CO)3(Ln-κ2N)] bearing 2,2′:6′,2”-terpyridine, 2,6-di(thiazol-2-yl)pyridine and 2,6-di(pyrazin-2-yl)pyridine functionalized with 9-carbazole attached to the central pyridine ring of the triimine core via phenylene linkage were investigated by spectroscopic and electrochem. methods and were simulated using d. functional theory (DFT) and time-dependent DFT. To get a deeper and broader understanding of structure-property relations, the designed Re(I) carbonyl complexes were compared with previously reported analogous systems – without any groups attached to the Ph ring and bearing pyrrolidine instead of 9-carbazole. Attachment of the N-carbazolyl substituent to the triimine core has less influence on the nature of the triplet excited state of [ReCl(CO)3(Ln-κ2N)] than the pyrrolidine group. Addnl., the impact of the ligand structural modifications on the light emission of the Re(I) complexes under external voltage was preliminarily examined with electroluminescence spectra of diodes containing the synthesized new mols. in an active layer. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Application In Synthesis of 2-Acetylthiazole

The Article related to rhenium carbonyl carbazolylterpyridine carbazolylpyridinediylbisthiazol carbazolylpyridinediylbispyrazine complex preparation crystal structure, electrochem dft calculation rhenium carbonyl carbazolylterpyridine carbazolylpyridinediylbisthiazol carbazolylpyridinediylbispyrazine complex and other aspects.Application In Synthesis of 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

《The Reaction of N -Trimethylsilyl-Substituted Heteroarylamines with Esters and Thioesters: An Efficient Protocol To Access Diheteroarylamides》 was written by Koperniku, Ana; Zamiri, Maryam; Grierson, David S.. Quality Control of 6-Chlorobenzothiazol-2-ylamine And the article was included in Synthesis on April 30 ,2019. The article conveys some information:

The S-benzyl thioester and Me ester derivatives of a representative 4-pyridinone-based carboxylic acid were sufficiently activated to react efficiently in amide coupling reactions with the amide anion generated in situfrom the N-trimethylsilyl derivative of different weakly nucleophilic heteroarylamines. In acetonitrile as solvent, the precipitated diheteroarylamide products were isolated in pure form by vacuum filtration. This simple amide bond forming protocol can be readily adapted to the parallel synthesis of compound libraries. In addition to this study using 6-Chlorobenzothiazol-2-ylamine, there are many other studies that have used 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Quality Control of 6-Chlorobenzothiazol-2-ylamine) was used in this study.

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Quality Control of 6-Chlorobenzothiazol-2-ylamineThiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

《Convenient and efficient synthesis of novel 11H-benzo[5,6][1,4]thiazino[3,4-a]isoindol-11-ones derived from 2-bromo-(2/3-substituted phenyl)-1H-indene-1,3(2H)-diones》 was published in RSC Advances in 2019. These research results belong to Mor, Satbir; Sindhu, Suchita. COA of Formula: C7H5ClN2S The article mentions the following:

An unprecedented formation of 11H-benzo[5,6][1,4]thiazino[3,4-a]isoindol-11-ones I (R1 = 2-Me, 2-MeO, 2-F, 3-F; R2 = H, Me, OMe, Cl, Br) through a one-step reaction of differently substituted 2-aminobenzenethiols 2-H2N-5-R2C6H4SH and 2-bromo-(2/3-substituted phenyl)-1H-indene-1,3(2H)-diones II in freshly dried ethanol under reflux conditions has been investigated. This unique transformation probably occurs through an initial nucleophilic substitution followed by ring opening and subsequent intramol. cyclization. The structures of all the synthesized benzo[1,4]thiazino isoindolinones I were established by FTIR, 1H NMR, 13C NMR, HRMS, and X-ray crystallog. anal. This approach was found to be simple and convenient and provides several advantages such as substantial atom economy, short reaction time and operational simplicity. The experimental process involved the reaction of 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9COA of Formula: C7H5ClN2S)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.COA of Formula: C7H5ClN2SThiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

The author of 《In vitro and in silico evaluation of anticancer activity of new indole-based 1,3,4-oxadiazoles as EGFR and COX-2 inhibitors》 were Sever, Belgin; Altintop, Mehlika Dilek; Ozdemir, Ahmet; Ciftci, Gulsen Akalin; Ellakwa, Doha E.; Tateishi, Hiroshi; Radwan, Mohamed O.; Ibrahim, Mahmoud A. A.; Otsuka, Masami; Fujita, Mikako; Ciftci, Halil I.; Ali, Taha F. S.. And the article was published in Molecules in 2020. Reference of 6-Chlorobenzothiazol-2-ylamine The author mentioned the following in the article:

Epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) are crucial targetable enzymes in cancer management. Therefore, herein, new 2-[(5-((1H-indol-3-yl)methyl)-1,3,4-oxadiazol-2-yl)thio]-N-(thiazol/benzothiazol-2-yl)acetamides (2a-i) were designed and synthesized as EGFR and COX-2 inhibitors. The cytotoxic effects of compounds 2a-i on HCT116 human colorectal carcinoma, A549 human lung adenocarcinoma, and A375 human melanoma cell lines were determined using MTT assay. 2-[(5-((1H-Indol-3-yl)methyl)-1,3,4-oxadiazol-2-yl)thio]-N-(6-ethoxybenzothiazol-2-yl)acetamide (2e) exhibited the most significant anticancer activity against HCT116, A549, and A375 cell lines with IC50 values of 6.43 ± 0.72μM, 9.62 ± 1.14μM, and 8.07 ± 1.36μM, resp., when compared with erlotinib (IC50 = 17.86 ± 3.22μM, 19.41 ± 2.38μM, and 23.81 ± 4.17μM, resp.). Further mechanistic assays demonstrated that compound 2e enhanced apoptosis (28.35%) in HCT116 cells more significantly than erlotinib (7.42%) and caused notable EGFR inhibition with an IC50 value of 2.80 ± 0.52μM when compared with erlotinib (IC50 = 0.04 ± 0.01μM). However, compound 2e did not cause any significant COX-2 inhibition, indicating that this compound showed COX-independent anticancer activity. The mol. docking study of compound 2e emphasized that the benzothiazole ring of this compound occupied the allosteric pocket in the EGFR active site. In conclusion, compound 2e is a promising EGFR inhibitor that warrants further clin. investigations. In the experiment, the researchers used 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Reference of 6-Chlorobenzothiazol-2-ylamine)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Reference of 6-Chlorobenzothiazol-2-ylamineThe thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica