Tag: 100-200

Zheng, Jun;Woerl, Benjamin;Breit, Bernhard published 《Rhodium-Catalyzed Chemo-, Regio-, and Enantioselective Allylation of 2-Aminothiazoles with Terminal Allenes》 in 2019. The article was appeared in 《European Journal of Organic Chemistry》. They have made some progress in their research.Electric Literature of C7H5N3O2S The article mentions the following:

A rhodium-catalyzed chemo-, regio- and enantioselective intermol. coupling reaction of 2-aminobenzothiazoles with terminal allenes is reported. The new reaction displays a wide substrate scope for both reaction partners to deliver the allylation products in good yields, with excellent regio- and enantioselectivity. This novel methodol. was further applied in an efficient synthesis of chiral isothiourea. And 6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) was used in the research process.

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0) has been used:
as model analyte for voltammetric determination of electrochemically reducible organic substances;in the synthesis of 2-methyl-4-nitro-2H-pyrazole-3-carboxylic acid[2-(cyclohexanecarbonylamino)benzothiazol-6-yl]amide derivatives;in the preparation of push-pull nonlinear optical chromophores containing thiazole and benzothiazole acceptors;as a base in dye production by diazotation reaction.
in the synthesis of 2-methyl-4-nitro-2H-pyrazole-3-carboxylic acid[2-(cyclohexanecarbonylamino)benzothiazol-6-yl]amide derivatives;
in the preparation of push-pull nonlinear optical chromophores containing thiazole and benzothiazole acceptors;
as a base in dye production by diazotation reaction.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Electric Literature of C7H5N3O2SIn 2018, Ahlawat, Aarti;Khatkar, Priyanka;Singh, Vikramjeet;Asija, Sonika published 《Diorganotin(IV) complexes of Schiff bases derived from salicylaldehyde and 2-amino-6-substituted benzothiazoles: synthesis, spectral studies, in vitro antimicrobial evaluation and QSAR studies》. 《Research on Chemical Intermediates》published the findings. The article contains the following contents:

In the present work, Schiff base ligands (1–4) were prepared by condensation of 2-amino-6-substituted-benzothiazole and salicylaldehyde in a 1:1 molar ratio and were further treated with diorganotindichloride R’₂SnCl₂ leading to a series of organotin(IV) complexes (5–20) of type R’₂SnL^1-4Cl [R’ = Ph, Bu, Et, Me]. The prepared Schiff base ligands and the organotin(IV) complexes were characterized by various spectroscopic techniques (¹H, ¹³C, ¹¹⁹Sn NMR, FT-IR) and phys. techniques. All the synthesized compounds were evaluated for in vitro antibacterial and antifungal activity against two Gram pos. bacterial strains B. cereus, S. aureus, two Gram neg. bacterial strains E. coli, P. aeruginosa and two fungal strains A. niger and A. flavus by serial dilution method. The spectral data revealed that the complexes were pentacoordinated with bidentate ligands coordinated through oxygen and nitrogen. The results of antimicrobial activity revealed that the synthesized complexes were more toxic towards Gram pos. bacterial strains as compared to Gram neg. bacterial strains. From the results of QSAR anal., it was indicated that the antimicrobial activity of the synthesized compounds were controlled by topol. parameters (mol. connectivity indexes). To complete the study, the researchers used 6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) .

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0Electric Literature of C7H5N3O2S) has been shown to lower blood pressure in mice by inhibiting angiotensin converting enzyme and potassium channels. This drug also has a protective effect on the heart and brain from ischemia reperfusion injury.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Alom, Nur-E.;Kaur, Navdeep;Wu, Fan;Saluga, Shannon Jasmine;Li, Wei published 《Catalytic Regio- and Stereoselective Alkene Sulfenoamination for 1,4-Benzothiazine Synthesis》 in 2019. The article was appeared in 《Chemistry – A European Journal》. They have made some progress in their research.Synthetic Route of C7H5N3O2S The article mentions the following:

An alkene sulfenoamination reaction with 2-aminothiophenol was developed using iodide catalysis. This reaction rendered access to useful 1,4-benzothiazines such as I [R¹ = H, Ph, 1-naphthyl, etc.; R² = H, Me, Ph; R³ = H, Me, n-Pr, n-hexyl, (CH₂)₂Ph] with good functional group compatibility including both electron-donating and electron-withdrawing substituents. The reaction was proposed to proceeded through an inversion of the polarity of the thiol functionality. Our mechanistic studies revealed that both thiiranium and thiyl radical pathways were plausible and that the disulfide reagent could also function as a viable substrate in this reaction. To complete the study, the researchers used 6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) .

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0Synthetic Route of C7H5N3O2S) has been shown to lower blood pressure in mice by inhibiting angiotensin converting enzyme and potassium channels. This drug also has a protective effect on the heart and brain from ischemia reperfusion injury.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Jana, Asim;Bhaumick, Prabhas;Panday, Anoop Kumar;Mishra, Richa;Choudhury, Lokman H. published 《I₂/DMSO mediated multicomponent reaction for the synthesis of 2-arylbenzo[d]imidazo[2,1-b]thiazole derivatives》 in 2019. The article was appeared in 《Organic & Biomolecular Chemistry》. They have made some progress in their research.HPLC of Formula: 6285-57-0 The article mentions the following:

Synthesis of a series of 2-arylbenzo[d]imidazo[2,1-b]thiazoles tethered with barbituric acid moiety was reported from the three component reaction of 2-aminobenzothiazoles, barbituric acids and terminal aryl acetylenes or aryl Me ketones in the presence of I₂ in DMSO medium. Both conventional and microwave heating conditions was used for this multicomponent reaction. The salient features of this methodol. are: (i) formation of one C-C and two C-N bonds in one-pot under metal-free oxidation followed by cyclization (ii) selective formation of the fused imidazole ring, (iii) wide substrate scope (iv) easy purification of the products (v) products having more than one pharmaceutically important motifs and (vi) gram scale synthesis possible.6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) were involved in the experimental procedure.

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0) has been used:
as model analyte for voltammetric determination of electrochemically reducible organic substances;
in the synthesis of 2-methyl-4-nitro-2H-pyrazole-3-carboxylic acid[2-(cyclohexanecarbonylamino)benzothiazol-6-yl]amide derivatives;
in the preparation of push-pull nonlinear optical chromophores containing thiazole and benzothiazole acceptors;
as a base in dye production by diazotation reaction.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Behera, Ahalya;Rakshit, Amitava;Sahoo, Ashish K.;Patel, Bhisma K. published 《One Pot Sequential Synthesis of N-[2-(Phenylsulfinyl)phenyl]acetamides: A Ring Opening Rearrangement Functionalization (RORF)》 in 2019. The article was appeared in 《European Journal of Organic Chemistry》. They have made some progress in their research.Safety of 6-Nitrobenzo[d]thiazol-2-amine The article mentions the following:

A Cu^II catalyzed one-pot sequential synthesis of N-[2-(phenylthio)phenyl]acetamides from benzo[d]thiazol-2-amines, iodoarenes and carboxylic acids (RCOOH) has been accomplished via ring opening rearrangement functionalization (RORF). Here, the ring opening is associated with the loss of carbon and nitrogen atoms with concurrent S-arylation and N-acylation leading to ortho-bifunctionalized products. A further sequential addition of tert-Bu hydroperoxide (TBHP) results in the formation of a sulfur oxidized product, N-[2-(phenylsulfinyl)phenyl]acetamide. A plausible mechanism has been proposed for this unprecedented ring opening rearrangement functionalization (RORF).6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) were involved in the experimental procedure.

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0 Safety of 6-Nitrobenzo[d]thiazol-2-amine) inhibits the activity of amines, which are small molecules found in many pharmaceuticals. The chemical structure of this drug contains one or more methylene groups that can be activated by diazonium salt to form an intermediate molecule with a reactive amine group.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Cindric, Maja;Peric, Mihaela;Kralj, Marijeta;Martin-Kleiner, Irena;David-Cordonnier, Marie-Helene;Paljetak, Hana Cipcic;Matijasic, Mario;Verbanac, Donatella;Karminski-Zamola, Grace;Hranjec, Marijana published 《Antibacterial and antiproliferative activity of novel 2-benzimidazolyl- and 2-benzothiazolyl-substituted benzo[b]thieno-2-carboxamides》. The research results were published in《Molecular Diversity》 in 2018.Application In Synthesis of 6-Nitrobenzo[d]thiazol-2-amine The article conveys some information:

Novel (nitro/amino)substituted 2-benzimidazolyl and 2-benzothiazolyl benzo[b]thieno-2-carboxamides I and I • HCl [R¹ = R² = H, NH₂, NO₂; X = NH, S] were designed and synthesized as potential antibacterial agents. The antibacterial activity of these compounds I were evaluated against Gram-pos. (Staphylococcus aureus and Enterococcus faecalis) and Gram-neg. bacteria (Escherichia coli and Moraxella catarrhalis). The most promising antibacterial activity was observed for the nitro- and amino-substituted benzimidazole derivatives I [R¹ = H; R² = NH₂, NO₂; X = NH] and I •Hcl [R¹ = H, R² = NH₂, X = NH; R¹ = NH₂, R² = H, X = NH] with MICs 2-8 μg/mL. Addnl., compounds with inferior antibacterial activity were further tested for their antiproliferative activity in-vitro against three human cancer cell lines. Amino-substituted benzothiazole hydrochloride salt I [R¹ = H, R² = NH₂, X = S] displayed the most pronounced and selective activity against the MCF-7 cell line with an IC₅₀ of 40 nM. Furthermore, DNA binding experiments of selected derivatives indicated that DNA cannot be considered as a primary biol. target for this type of compounds6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) were involved in the experimental procedure.

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0 Application In Synthesis of 6-Nitrobenzo[d]thiazol-2-amine) is an antimicrobial agent that inhibits bacterial growth by cleaving the peptide bonds of proteins. It has been shown to be active against a number of microorganisms, including Gram-positive and Gram-negative bacteria, as well as fungi.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Name: 6-Nitrobenzo[d]thiazol-2-amine《Synthesis, Characterization and Biological Evaluation of 2-(p-Nitrophenyl)quinazolin-4(3H)-one Derivatives》 was published in 2020. The authors were Giradkar, V. N.;Kabra, U. D.;Diwakar, R. S.;Lohiya, R. T.;Umekar, M. J., and the article was included in《Russian Journal of Organic Chemistry》. The author mentioned the following in the article:

A series of novel 2-(4-nitrophenyl)-3-(R-benzothiazol-2-yl)quinazolin-4(3H)-ones I [R = H, 5-Br, 6-NO₂, etc.] was synthesized from the 2-aminobenzothiazoles and 2-(4-nitrophenyl)-4H-3,1-benzoxazin-4-one via a nucleophilic addition reaction. The synthesized compounds I were tested for anticonvulsant, antimicrobial, and antioxidant activities. All the compounds I increased the seizure latency compared to control. Compound I [R = 6-NO₂] exhibited significant anticonvulsant activity, comparable to that of the standard drug Phenytoin. Antimicrobial activity testing revealed moderate to good activity in all the test compounds, I and I [R = H, 6-NO₂] compared in activity with the standard drug Chloramphenicol. The antioxidant activity of compounds I [R = H], I [R = 5-Br] and I [ R = 4,6-Me₂] IC₅₀ 39.30, 15.55, and 42.95μg/mL, resp. was found to be higher compared to the standard drug ascorbic acid (IC50 48.30μg/mL). To complete the study, the researchers used 6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) .

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0Name: 6-Nitrobenzo[d]thiazol-2-amine) has been shown to lower blood pressure in mice by inhibiting angiotensin converting enzyme and potassium channels. This drug also has a protective effect on the heart and brain from ischemia reperfusion injury.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Ahmadi, Fereshteh;Imani, Kaveh;Mozafari, Hadi;Bazgir, Ayoob published 《Metal-free isocyanide insertion reaction to benzothiazolyl urea derivatives》. The research results were published in《Journal of Molecular Structure》 in 2022.Name: 6-Nitrobenzo[d]thiazol-2-amine The article conveys some information:

An efficient iodine-catalyzed reaction of 2-aminobenzothiazole and isocyanides for the synthesis of benzothiazolyl urea derivatives via a metal-free isocyanide insertion reaction is reported. Introducing a simple method for the synthesis of desired benzothiazolyl urea skeletons and use of more acceptable iodine mol. instead of expensive transition metal catalysts are the most important advantages of this strategy. To complete the study, the researchers used 6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) .

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0Name: 6-Nitrobenzo[d]thiazol-2-amine) has been shown to lower blood pressure in mice by inhibiting angiotensin converting enzyme and potassium channels. This drug also has a protective effect on the heart and brain from ischemia reperfusion injury.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Song, Xiyu;Hou, Aiqin;Xie, Kongliang;Hu, Tingli published 《Synthesis and Dyeing Properties of New Bi-heterocyclic Disperse Dyes Containing Pyridone Group for Polyester Fabrics》 in 2020. The article was appeared in 《Fibers and Polymers》. They have made some progress in their research.Product Details of 6285-57-0 The article mentions the following:

A series of novel bi-heterocyclic disperse dyes containing N-ethyl-3-cyano-4-methyl-6-hydroxy-2-pyridine group were synthesized. The structures of the bi-heterocyclic dyes were characterized by Fourier transform IR spectroscopy (FT-IR), NMR spectroscopy (¹H-NMR), UV-vis spectrophotometry, and elemental anal. The distinct spectral behavior and solvatochromic effect of the dyes were discussed. The dyeing properties of the dyes for polyethylene terephthalate (PET) fabric were investigated. Novel bi-heterocyclic disperse dyes had higher molar absorption coefficient, good color strength, and excellent fastness properties, especially light fastness. The bi-heterocyclic disperse dyes have potential research value in the development of high light resistant dyes and functional dyes. The experimental procedure involved many compounds, such as 6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) .

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0 Product Details of 6285-57-0) inhibits the activity of amines, which are small molecules found in many pharmaceuticals. The chemical structure of this drug contains one or more methylene groups that can be activated by diazonium salt to form an intermediate molecule with a reactive amine group.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Zhang, Qing;Zhao, Kuantao;Zhang, Lixun;Jiao, Xiaoyu;Zhang, Yongjie;Tang, Chunlei published 《Synthesis and biological evaluation of diaryl urea derivatives as FLT3 inhibitors》 in 2020. The article was appeared in 《Bioorganic & Medicinal Chemistry Letters》. They have made some progress in their research.Reference of 6-Nitrobenzo[d]thiazol-2-amine The article mentions the following:

As a class III receptor tyrosine kinase (RTK), FMS-like tyrosine kinase 3 (FLT3) is always overexpressed in many cases of acute leukemia. This paper studies the structure-based synthesis and biol. evaluation of diaryl urea derivatives as FLT3 inhibitors. Encouragingly, compounds 1-(3-(tert-butyl)isoxazol-5-yl)-3-(4-(7-methoxybenzo[d]imidazo[2,1-b]thiazol-2-yl)phenyl)urea , 1-(3-(tert-butyl)isoxazol-5-yl)-3-(4-(7-(2-morpholinoethoxy)benzo[d]imidazo[2,1-b]thiazol-2-yl)phenyl)urea , 1-(5-(tert-butyl)isoxazol-3-yl)-3-(2-(4-(2-morpholinoethoxy)phenyl)benzo[d]imidazo[2,1-b]thiazol-7-yl)urea , and 1-(3-(tert-butyl)isoxazol-5-yl)-3-(2-(4-(2-morpholinoethoxy)phenyl)benzo[d]imidazo[2,1-b]thiazol-7-yl)urea showed excellent biol. activities in a low nanomolar range. In particular, compound 1-(3-(tert-butyl)isoxazol-5-yl)-3-(4-(7-(2-morpholinoethoxy)benzo[d]imidazo[2,1-b]thiazol-2-yl)phenyl)urea demonstrated significant inhibitory potency against FLT3-ITD (IC₅₀ = 5.60 nM) and better antiproliferative activity than quizartinib against MV4-11 cell line (IC₅₀ = 0.176 nM). Compound 1-(3-(tert-butyl)isoxazol-5-yl)-3-(4-(7-(2-morpholinoethoxy)benzo[d]imidazo[2,1-b]thiazol-2-yl)phenyl)urea for the treatment of acute myeloid leukemia could be very promising. The experimental procedure involved many compounds, such as 6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) .

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0) has been used:
as model analyte for voltammetric determination of electrochemically reducible organic substances;
in the synthesis of 2-methyl-4-nitro-2H-pyrazole-3-carboxylic acid[2-(cyclohexanecarbonylamino)benzothiazol-6-yl]amide derivatives;
in the preparation of push-pull nonlinear optical chromophores containing thiazole and benzothiazole acceptors;
as a base in dye production by diazotation reaction.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica