Tag: 100-200

Pisal, Pooja;Deodhar, Meenakshi;Kale, Amol;Nigade, Ganesh;Pawar, Smita published 《Design, synthesis, docking studies and biological evaluation of 2-phenyl-3-(substituted benzo[d]thiazol-2-ylamino)-quinazoline-4(3H)-one derivatives as antimicrobial agents》. The research results were published in《International Journal of Pharmacy and Pharmaceutical Sciences》 in 2018.COA of Formula: C7H5N3O2S The article conveys some information:

A new series 2-phenyl-3-(substituted benzo[d] thiazol-2-ylamino)-quinazoline-4(3H)-ones, compounds I [R = H, Cl, MeO, etc.] was prepared by the fusion method by reacting 2-Ph benzoxazine with 2-hydrazinobenzothiazole and it was evaluated for their antimicrobial activity against Gram pos., Gram neg. bacteria and fungi. These compounds were evaluated by in-vitro antibacterial and antifungal activity using the min. inhibitory concentration and zone of inhibition methods. The synthesized compounds were characterized with the help of IR, NMR and mass spectral studies. The benzothiazole moiety and the quinazoline ring have previously shown DNA gyrase inhibition and target related antibacterial activity. Thus, mol. docking studies of synthesized compounds were carried out (PDB: 3G75) to study the possible interaction of compounds with the target. The batch grid docking was performed to determine the probable. These compounds showed significant activity against gram pos. and gram neg. bacteria as well against the fungi. Compound I [R = NO₂] was found to be active against B. subtilis, P aeruginosa and C. albicans at 12.5 μg/mL MIC. Compound I [R = Cl] was found to be active against all microbial strains selected at 25 and 12.5 μg/mL MIC. Though the relationship between the activities shown by these compounds in, the antimicrobial study is still to be established, the docking studies conducted found to be consistent with antimicrobial results. Thus the results indicate that the designed structure can be a potential lead as an antimicrobial agent. And 6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) was used in the research process.

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0 COA of Formula: C7H5N3O2S) is an antimicrobial agent that inhibits bacterial growth by cleaving the peptide bonds of proteins. It has been shown to be active against a number of microorganisms, including Gram-positive and Gram-negative bacteria, as well as fungi.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Name: 6-Nitrobenzo[d]thiazol-2-amineIn 2022, Sheetal;Sengupta, Sirsendu;Singh, Manjeet;Thakur, Sanjeeve;Pani, Balaram;Banerjee, Priyabrata;Kaya, Savas;Singh, Ashish Kumar published 《An insight about the interaction of Aryl Benzothiazoles with mild steel surface in aqueous HCl solution》. 《Journal of Molecular Liquids》published the findings. The article contains the following contents:

The arrival of organic moieties as corrosion inhibitors has expanded the research in the past few years which, as a result; involved different heteroatoms to be tested for their anti-corrosive potential. The presented research is focused on the synthesis of the aryl-substituted benzothiazoles namely 6-(4-Chlorophenyl) benzo[d]thiazol-2-amine (CBTA), 6-(p-tolyl) benzo[d]thiazol-2-amine (TBTA), and 6-(4-methoxyphenyl) benzo[d]thiazol-2-amine (MBTA), and investigation of their anti-corrosive behavior on mild steel in 1 M HCl particularly. Here, gravimetric and electrochem. analyses have been employed to examine the tendency of benzothiazoles to safeguard mild steel. Corrosion impeding efficacies were found to follow a significant order; MBTA > TBTA > CBTA. Further, exptl. anal. unveiled the effect of substituents on corrosion mitigating potential i.e., MBTA employed the ligation of methoxy group; an enhanced electron cloud thus providing a maximum shield. The addition of corrosion inhibitors in acidic solution brought an elevation in activation energy thus retarded the rate of corrosion. Surface anal. via at. force microscopy (AFM) and XPS confirmed the exptl. results and attributed the presence of an adsorbed layer over mild steel surface thus providing protection from corrosion. Addnl., Quantum calculations such as d. functional theory (DFT) and mol. dynamics (MD) provided an insight into the adsorption of inhibitors over mild steel at a mol. level. The experimental procedure involved many compounds, such as 6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) .

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0 Name: 6-Nitrobenzo[d]thiazol-2-amine) inhibits the activity of amines, which are small molecules found in many pharmaceuticals. The chemical structure of this drug contains one or more methylene groups that can be activated by diazonium salt to form an intermediate molecule with a reactive amine group.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Wu, Yue;Guo, Peng;Chen, Long;Duan, Weijie;Yang, Zengzhuan;Wang, Tao;Chen, Ting;Xiong, Fei published 《Iron-catalyzed tandem oxidative coupling and acetal hydrolysis reaction to prepare formylated benzothiazoles and isoquinolines》 in 2021. The article was appeared in 《Chemical Communications (Cambridge, United Kingdom)》. They have made some progress in their research.Recommanded Product: 6-Nitrobenzo[d]thiazol-2-amine The article mentions the following:

The direct formylation of benzothiazoles and isoquinolines was reported. The reaction features a novel iron-catalyzed Minisci-type oxidative coupling process using com. available 1,3-dioxolane as a formylated reagent followed by acetal hydrolysis without a separation process. The reaction was performed under exceedingly mild reaction conditions and exhibited broad functional group tolerance. The experimental procedure involved many compounds, such as 6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) .

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0Recommanded Product: 6-Nitrobenzo[d]thiazol-2-amine) has been shown to lower blood pressure in mice by inhibiting angiotensin converting enzyme and potassium channels. This drug also has a protective effect on the heart and brain from ischemia reperfusion injury.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Sahu, Pramod K.;Sahu, Praveen K.;Kaurav, Manvendra S.;Messali, Mouslim;Almutairi, Saud M.;Sahu, Puran L.;Agarwal, Dau D. published 《Metal-Free Construction of Fused Pyrimidines via Consecutive C-C and C-N Bond Formation in Water》 in 2018. The article was appeared in 《ACS Omega》. They have made some progress in their research.Synthetic Route of C7H5N3O2S The article mentions the following:

A facile and efficient protocol has been developed for mild construction of fused pyrimidines I (R = Ph, 4-ClC₆H₄, 2-MeC₆H₄, etc.) via L-proline catalyzed reaction of 4-hydroxy coumarins, aldehydes and 2-aminobenzothiazoles/urea. Reaction has been carried out rapidly and efficiently in water under mild and metal free conditions. Current etiquette has efficiently synthesized the heterocycles and avoids the use of hazardous solvents over conventional organic solvents. A plausible reaction mechanism has established in this study. This study represents the first case in which L-proline as homogeneous catalyst has been explored in synthesis of fused pyrimidines in water in view of simple procedure and acceptable efficiency. This method gives the target product in excellent yield with ease of workup. And 6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) was used in the research process.

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0 Synthetic Route of C7H5N3O2S) is an antimicrobial agent that inhibits bacterial growth by cleaving the peptide bonds of proteins. It has been shown to be active against a number of microorganisms, including Gram-positive and Gram-negative bacteria, as well as fungi.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Sever, Belgin;Altintop, Mehlika Dilek;Ozdemir, Ahmet;Ciftci, Gulsen Akalin;Ellakwa, Doha E.;Tateishi, Hiroshi;Radwan, Mohamed O.;Ibrahim, Mahmoud A. A.;Otsuka, Masami;Fujita, Mikako;Ciftci, Halil I.;Ali, Taha F. S. published 《In vitro and in silico evaluation of anticancer activity of new indole-based 1,3,4-oxadiazoles as EGFR and COX-2 inhibitors》 in 2020. The article was appeared in 《Molecules》. They have made some progress in their research.Safety of 6-Nitrobenzo[d]thiazol-2-amine The article mentions the following:

Epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) are crucial targetable enzymes in cancer management. Therefore, herein, new 2-[(5-((1H-indol-3-yl)methyl)-1,3,4-oxadiazol-2-yl)thio]-N-(thiazol/benzothiazol-2-yl)acetamides (2a-i) were designed and synthesized as EGFR and COX-2 inhibitors. The cytotoxic effects of compounds 2a-i on HCT116 human colorectal carcinoma, A549 human lung adenocarcinoma, and A375 human melanoma cell lines were determined using MTT assay. 2-[(5-((1H-Indol-3-yl)methyl)-1,3,4-oxadiazol-2-yl)thio]-N-(6-ethoxybenzothiazol-2-yl)acetamide (2e) exhibited the most significant anticancer activity against HCT116, A549, and A375 cell lines with IC₅₀ values of 6.43 ± 0.72μM, 9.62 ± 1.14μM, and 8.07 ± 1.36μM, resp., when compared with erlotinib (IC₅₀ = 17.86 ± 3.22μM, 19.41 ± 2.38μM, and 23.81 ± 4.17μM, resp.). Further mechanistic assays demonstrated that compound 2e enhanced apoptosis (28.35%) in HCT116 cells more significantly than erlotinib (7.42%) and caused notable EGFR inhibition with an IC₅₀ value of 2.80 ± 0.52μM when compared with erlotinib (IC₅₀ = 0.04 ± 0.01μM). However, compound 2e did not cause any significant COX-2 inhibition, indicating that this compound showed COX-independent anticancer activity. The mol. docking study of compound 2e emphasized that the benzothiazole ring of this compound occupied the allosteric pocket in the EGFR active site. In conclusion, compound 2e is a promising EGFR inhibitor that warrants further clin. investigations.6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) were involved in the experimental procedure.

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0) has been used:
as model analyte for voltammetric determination of electrochemically reducible organic substances;
in the synthesis of 2-methyl-4-nitro-2H-pyrazole-3-carboxylic acid[2-(cyclohexanecarbonylamino)benzothiazol-6-yl]amide derivatives;
in the preparation of push-pull nonlinear optical chromophores containing thiazole and benzothiazole acceptors;
as a base in dye production by diazotation reaction.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Formula: C7H5N3O2S《Synthesis, Characterization and Biological Potency of Butyl-Pyridone Based Azo Dyes》 was published in 2020. The authors were Kumar, Vinod;Keshavayya, J.;Matada, Mallikarjuna N.;Srinivasa, Sudhanva M.;Rangappa, S., and the article was included in《ChemistrySelect》. The author mentioned the following in the article:

A series of heterocyclic disperse azo dyes having pyridone architecture was prepared by a simple, economical and highly efficient diazo-coupling method. In this method, Bu pyridone was used as a common coupling component by changing the five heterocyclic amine moieties. The structural investigations of the analogous compounds were accomplished by various spectroscopic techniques. Further, all the azo dyes were examined for their potency towards antibacterial, antituberculosis and anticancer activities. The results revealed that all the dye mols. exhibited excellent tuberculosis activity and also very promising anticancer activity. In the case of the antibacterial assay, only a few azo dyes displayed good inhibition effect towards the tested bacterial strains. And 6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) was used in the research process.

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0 Formula: C7H5N3O2S) inhibits the activity of amines, which are small molecules found in many pharmaceuticals. The chemical structure of this drug contains one or more methylene groups that can be activated by diazonium salt to form an intermediate molecule with a reactive amine group.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Category: thiazole《Shortened alkaline dyeing of polyester fabric using heterocyclic benzothiazole dyes》 was published in 2021. The authors were Jiang, Tingting;Hou, Aiqin;Zheng, Changwu;Xie, Kongliang;Gao, Aiqin, and the article was included in《Yinran》. The author mentioned the following in the article:

Alk. dyeing of polyester fabric can shorten the traditional dyeing process, save energy and water. It is an important direction of energy conservation and emission reduction But alk. dyeing has a higher requirement on the structural stability of dyes. With 2-amino-6-nitrobenzothiazole as diazo component and N-substituted aniline as coupling component, five disperse dyes containing different N-substituents were designed and synthesized. The dyeing properties of polyester fabric with disperse dyes under different NaOH concentrations (1-5 g/L) were tested. The relationship between dye structure and dyeing stability under basic dyeing conditions was discussed. The dyeing properties of dyes with different structures under acid and alkali conditions were compared. The results show that the hybrid dyes with Et and benzyl structure has good alkali resistance stability, acid and alkali dyeing condition does not have obvious influence on the dyeing rate of the two dyes, and the dyeing fastness is good. The experimental procedure involved many compounds, such as 6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) .

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0Category: thiazole) has been shown to lower blood pressure in mice by inhibiting angiotensin converting enzyme and potassium channels. This drug also has a protective effect on the heart and brain from ischemia reperfusion injury.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Application In Synthesis of 6-Nitrobenzo[d]thiazol-2-amineIn 2021, Pandey, Himanshu;Shrivastava, S. P. published 《One pot synthesis, characterization of benzothiazole/benzimidazole tethered imidazole derivatives using clay as catalyst》. 《Oriental Journal of Chemistry》published the findings. The article contains the following contents:

A green approach for benzothiazole/benzimidazole tethered imidazole derivative synthesis utilizing brick derived clay as a catalyst were reported. Brick clay catalyst used in this synthesis were shown excellent catalytic activity by increasing efficiency, reducing the reaction time and most importantly it was reusable for further reaction runs. These derivatives were synthesized by multi component condensation reaction that involved benzil, aldehyde, 2-aminobenzimidazole/2-amino-6-nitrobenzothiazole and ammonium acetate. The clay catalyst was characterized by FT-IR while the synthesized derivatives were characterized by FT-IR, ¹H NMR and ¹³C NMR. Brick clay was a cheap, non-hazardous catalyst and were reused up to many reaction runs with good to excellent yields. And 6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) was used in the research process.

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0 Application In Synthesis of 6-Nitrobenzo[d]thiazol-2-amine) is an antimicrobial agent that inhibits bacterial growth by cleaving the peptide bonds of proteins. It has been shown to be active against a number of microorganisms, including Gram-positive and Gram-negative bacteria, as well as fungi.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of C7H5N3O2SIn 2021, Giovannucci, Tatiana A.;Salomons, Florian A.;Haraldsson, Martin;Elfman, Lotta H. M.;Wickstroem, Malin;Young, Patrick;Lundbaeck, Thomas;Eirich, Jurgen;Altun, Mikael;Jafari, Rozbeh;Gustavsson, Anna-Lena;Johnsen, John Inge;Dantuma, Nico P. published 《Inhibition of the ubiquitin-proteasome system by an NQO1-activatable compound》. 《Cell Death & Disease》published the findings. The article contains the following contents:

Malignant cells display an increased sensitivity towards drugs that reduce the function of the ubiquitin-proteasome system (UPS), which is the primary proteolytic system for destruction of aberrant proteins. Here, we report on the discovery of the bioactivatable compound CBK77, which causes an irreversible collapse of the UPS, accompanied by a general accumulation of ubiquitylated proteins and caspase-dependent cell death. CBK77 caused accumulation of ubiquitin-dependent, but not ubiquitin-independent, reporter substrates of the UPS, suggesting a selective effect on ubiquitin-dependent proteolysis. In a genome-wide CRISPR interference screen, we identified the redox enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1) as a critical mediator of CBK77 activity, and further demonstrated its role as the compound bioactivator. Through affinity-based proteomics, we found that CBK77 covalently interacts with ubiquitin. In vitro experiments showed that CBK77-treated ubiquitin conjugates were less susceptible to disassembly by deubiquitylating enzymes. In vivo efficacy of CBK77 was validated by reduced growth of NQO1-proficient human adenocarcinoma cells in nude mice treated with CBK77. This first-in-class NQO1-activatable UPS inhibitor suggests that it may be possible to exploit the intracellular environment in malignant cells for leveraging the impact of compounds that impair the UPS.6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) were involved in the experimental procedure.

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0 Synthetic Route of C7H5N3O2S) inhibits the activity of amines, which are small molecules found in many pharmaceuticals. The chemical structure of this drug contains one or more methylene groups that can be activated by diazonium salt to form an intermediate molecule with a reactive amine group.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

SDS of cas: 6285-57-0In 2020, Tiwari, Monika R.;Patel, Navin B. published 《Synthesis, characterization and biological studies of thiazolidinone analogues》. 《Journal of Applicable Chemistry (Lumami, India)》published the findings. The article contains the following contents:

A new series of 2-(4-substituted phenyl)-3-(6-substituted benzo [d]thiazol-2-yl)thiazolidin-4-one derivatives I [R = pyridin-4-yl, 4-hydroxy-3-methylphenyl, 4-chlorophenyl, etc.; R¹ = MeO, O₂N] were prepared by hybridization of two different biol. active moieties benzothiazole and thiazolidinone. The structures of the newly synthesized compounds I were established on the basis of spectral data (IR, ¹H and ¹³C NMR) and elemental anal. All the synthesized compounds I were tested for antibacterial activity against Gram-pos. bacteria (S. aureus, S. pyogenes) and Gram-neg. bacteria (C. albicans, A. niger, A. clavatus), antifungal activity against three fungi (C. albicans, A. niger, A. clavatus) using the MIC (Minimal Inhibitory Concentration) method, anti-tubercular activity H37Rv using L. J. Slope Method. Results of biol. screening revealed that compounds I [R1 = O₂N; R = 4-chlorophenyl, 4-methylthiophenyl, 4-methylphenyl, 3-methyl-4-hydroxyphenyl, R1 = MeO; R = 4-fluorophenyl, 4-trifluoromethylphenyl] showed good antibacterial activity where as I [R1 = O₂N; 4-chlorophenyl, R1 = MeO, R = furan-2-yl] and showed good antifungal activity and compound I [R1 = O₂N; R = 4-bromophenyl] showed good antitubercular activity. To complete the study, the researchers used 6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) .

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0 SDS of cas: 6285-57-0) is an antimicrobial agent that inhibits bacterial growth by cleaving the peptide bonds of proteins. It has been shown to be active against a number of microorganisms, including Gram-positive and Gram-negative bacteria, as well as fungi.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica